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Protein

Semaphorin-4F

Gene

Sema4f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons.

GO - Biological processi

  • axon guidance Source: RGD
  • negative chemotaxis Source: GO_Central
  • negative regulation of axon extension Source: MGI
  • retinal ganglion cell axon guidance Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:Sema4f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3658 Sema4f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 665ExtracellularSequence analysisAdd BLAST626
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Topological domaini687 – 776CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000003233240 – 776Semaphorin-4FAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi278 ↔ 389PROSITE-ProRule annotation
Disulfide bondi302 ↔ 348PROSITE-ProRule annotation
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi592 ↔ 633PROSITE-ProRule annotation
Modified residuei724PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z143
PRIDEiQ9Z143

PTM databases

iPTMnetiQ9Z143
PhosphoSitePlusiQ9Z143

Expressioni

Tissue specificityi

Expressed at low levels in the developing embryo. Expressed at high levels in the adult central nervous system and lung.

Gene expression databases

BgeeiENSRNOG00000006784
GenevisibleiQ9Z143 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009269

Structurei

3D structure databases

ProteinModelPortaliQ9Z143
SMRiQ9Z143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 515SemaPROSITE-ProRule annotationAdd BLAST469
Domaini517 – 568PSIAdd BLAST52
Domaini585 – 640Ig-like C2-typeAdd BLAST56

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG093234
InParanoidiQ9Z143
KOiK06521
OMAiCNRGLPV
OrthoDBiEOG091G01W0
PhylomeDBiQ9Z143
TreeFamiTF352903

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015512 Semaphorin_4F
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF72 PTHR11036:SF72, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARAERPRP GPRPPPVFPF PPPLSLLLLL AILSAPVCGR VPRSVPRTSL
60 70 80 90 100
PISEADSYLT RFAASHTYNY SALLVDPASH TLYVGARDSI FALTLPFSGE
110 120 130 140 150
RPRRIDWMVP ETHRQNCRKK GKKEDECHNF IQILAIVNAS HLLTCGTFAF
160 170 180 190 200
DPKCGVIDVS SFQQVERLES GRGKCPFEPA QRSAAVMAGG VLYTATVKNF
210 220 230 240 250
LGTEPIISRA VGRAEDWIRT ETLSSWLNAP AFVAAMVLSP AEWGDEDGDD
260 270 280 290 300
EIFFFFTETS RVLDSYERIK VPRVARVCAG DLGGRKTLQQ RWTTFLKADL
310 320 330 340 350
LCPGPEHGRA SGVLQAMAEL RPQPGAGTPI FYGIFSSQWE GAAISAVCAF
360 370 380 390 400
RPQDIRAVLN GPFRELKHDC NRGLPVMDNE VPQPRPGECI ANNMKLQQFG
410 420 430 440 450
SSLSLPDRVL TFIRDHPLMD RPVFPADGRP LLVTTDTAYL RVVAHRVTSL
460 470 480 490 500
SGKEYDVLYL GTEDGHLHRA VRIGAQLSVL EDLALFPEPQ PVESMKLYHD
510 520 530 540 550
WLLVGSHTEV TQVNTSNCGR LQSCSECILA QDPVCAWSFR LDACVAHAGE
560 570 580 590 600
HRGMVQDIES ADVSSLCPKE PGEHPVVFEV PVATVGHVVL PCSPSSAWAS
610 620 630 640 650
CVWHQPSGVT ALTPRRDGLE VVVTPGAMGA YACECQEGGA ARVVAAYSLV
660 670 680 690 700
WGSQRGPSNR AHTVVGAGLV GFLLGVLAAS LTLLLIGRRQ QRRRQRELLA
710 720 730 740 750
RDKVGLDLGA PPSGTTSYSQ DPPSPSPEDE RLPLALGKRG SGFGGFPPPF
760 770
LLDSCPSPAH IRLTGAPLAT CDETSI
Length:776
Mass (Da):84,298
Last modified:May 1, 1999 - v1
Checksum:i20763182CC6C93CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002563 mRNA Translation: BAA75629.1
RefSeqiNP_062145.1, NM_019272.1
UniGeneiRn.42885

Genome annotation databases

EnsembliENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784
GeneIDi29745
KEGGirno:29745
UCSCiRGD:3658 rat

Similar proteinsi

Entry informationi

Entry nameiSEM4F_RAT
AccessioniPrimary (citable) accession number: Q9Z143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome