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Q9Z143

- SEM4F_RAT

UniProt

Q9Z143 - SEM4F_RAT

Protein

Semaphorin-4F

Gene

Sema4f

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Has growth cone collapse activity against retinal ganglion-cell axons.

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: RGD
    2. negative regulation of axon extension Source: MGI
    3. retinal ganglion cell axon guidance Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-4F
    Alternative name(s):
    Semaphorin-W
    Short name:
    Sema W
    Gene namesi
    Name:Sema4f
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi3658. Sema4f.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: MGI
    3. postsynaptic membrane Source: MGI
    4. synapse Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 776737Semaphorin-4FPRO_0000032332Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
    Disulfide bondi278 ↔ 389PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 348PROSITE-ProRule annotation
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
    Disulfide bondi592 ↔ 633PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Z143.
    PRIDEiQ9Z143.

    Expressioni

    Tissue specificityi

    Expressed at low levels in the developing embryo. Expressed at high levels in the adult central nervous system and lung.

    Gene expression databases

    GenevestigatoriQ9Z143.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1542065.
    STRINGi10116.ENSRNOP00000009269.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z143.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini40 – 665626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini687 – 77690CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei666 – 68621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 515469SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 56852PSIAdd
    BLAST
    Domaini585 – 64056Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258001.
    GeneTreeiENSGT00560000076864.
    HOGENOMiHOG000116087.
    HOVERGENiHBG093234.
    InParanoidiQ9Z143.
    KOiK06521.
    OMAiCNRGLPV.
    OrthoDBiEOG7KM5S4.
    PhylomeDBiQ9Z143.
    TreeFamiTF352903.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR015512. Seamphorin_4F.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF72. PTHR11036:SF72. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z143-1 [UniParc]FASTAAdd to Basket

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    MLARAERPRP GPRPPPVFPF PPPLSLLLLL AILSAPVCGR VPRSVPRTSL    50
    PISEADSYLT RFAASHTYNY SALLVDPASH TLYVGARDSI FALTLPFSGE 100
    RPRRIDWMVP ETHRQNCRKK GKKEDECHNF IQILAIVNAS HLLTCGTFAF 150
    DPKCGVIDVS SFQQVERLES GRGKCPFEPA QRSAAVMAGG VLYTATVKNF 200
    LGTEPIISRA VGRAEDWIRT ETLSSWLNAP AFVAAMVLSP AEWGDEDGDD 250
    EIFFFFTETS RVLDSYERIK VPRVARVCAG DLGGRKTLQQ RWTTFLKADL 300
    LCPGPEHGRA SGVLQAMAEL RPQPGAGTPI FYGIFSSQWE GAAISAVCAF 350
    RPQDIRAVLN GPFRELKHDC NRGLPVMDNE VPQPRPGECI ANNMKLQQFG 400
    SSLSLPDRVL TFIRDHPLMD RPVFPADGRP LLVTTDTAYL RVVAHRVTSL 450
    SGKEYDVLYL GTEDGHLHRA VRIGAQLSVL EDLALFPEPQ PVESMKLYHD 500
    WLLVGSHTEV TQVNTSNCGR LQSCSECILA QDPVCAWSFR LDACVAHAGE 550
    HRGMVQDIES ADVSSLCPKE PGEHPVVFEV PVATVGHVVL PCSPSSAWAS 600
    CVWHQPSGVT ALTPRRDGLE VVVTPGAMGA YACECQEGGA ARVVAAYSLV 650
    WGSQRGPSNR AHTVVGAGLV GFLLGVLAAS LTLLLIGRRQ QRRRQRELLA 700
    RDKVGLDLGA PPSGTTSYSQ DPPSPSPEDE RLPLALGKRG SGFGGFPPPF 750
    LLDSCPSPAH IRLTGAPLAT CDETSI 776
    Length:776
    Mass (Da):84,298
    Last modified:May 1, 1999 - v1
    Checksum:i20763182CC6C93CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002563 mRNA. Translation: BAA75629.1.
    RefSeqiNP_062145.1. NM_019272.1.
    UniGeneiRn.42885.

    Genome annotation databases

    EnsembliENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784.
    GeneIDi29745.
    KEGGirno:29745.
    UCSCiRGD:3658. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002563 mRNA. Translation: BAA75629.1 .
    RefSeqi NP_062145.1. NM_019272.1.
    UniGenei Rn.42885.

    3D structure databases

    ProteinModelPortali Q9Z143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1542065.
    STRINGi 10116.ENSRNOP00000009269.

    Proteomic databases

    PaxDbi Q9Z143.
    PRIDEi Q9Z143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009269 ; ENSRNOP00000009269 ; ENSRNOG00000006784 .
    GeneIDi 29745.
    KEGGi rno:29745.
    UCSCi RGD:3658. rat.

    Organism-specific databases

    CTDi 10505.
    RGDi 3658. Sema4f.

    Phylogenomic databases

    eggNOGi NOG258001.
    GeneTreei ENSGT00560000076864.
    HOGENOMi HOG000116087.
    HOVERGENi HBG093234.
    InParanoidi Q9Z143.
    KOi K06521.
    OMAi CNRGLPV.
    OrthoDBi EOG7KM5S4.
    PhylomeDBi Q9Z143.
    TreeFami TF352903.

    Miscellaneous databases

    NextBioi 610260.
    PROi Q9Z143.

    Gene expression databases

    Genevestigatori Q9Z143.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR015512. Seamphorin_4F.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF72. PTHR11036:SF72. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
      Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
      Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiSEM4F_RAT
    AccessioniPrimary (citable) accession number: Q9Z143
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3