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Protein

Semaphorin-4F

Gene

Sema4f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: RGD
  2. negative regulation of axon extension Source: MGI
  3. retinal ganglion cell axon guidance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:Sema4f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3658. Sema4f.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 665626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei666 – 68621HelicalSequence AnalysisAdd
BLAST
Topological domaini687 – 77690CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: MGI
  3. postsynaptic membrane Source: MGI
  4. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 776737Semaphorin-4FPRO_0000032332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi278 ↔ 389PROSITE-ProRule annotation
Disulfide bondi302 ↔ 348PROSITE-ProRule annotation
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi592 ↔ 633PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z143.
PRIDEiQ9Z143.

Expressioni

Tissue specificityi

Expressed at low levels in the developing embryo. Expressed at high levels in the adult central nervous system and lung.

Gene expression databases

GenevestigatoriQ9Z143.

Interactioni

Protein-protein interaction databases

MINTiMINT-1542065.
STRINGi10116.ENSRNOP00000009269.

Structurei

3D structure databases

ProteinModelPortaliQ9Z143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 515469SemaPROSITE-ProRule annotationAdd
BLAST
Domaini517 – 56852PSIAdd
BLAST
Domaini585 – 64056Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258001.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG093234.
InParanoidiQ9Z143.
KOiK06521.
OMAiCNRGLPV.
OrthoDBiEOG7KM5S4.
PhylomeDBiQ9Z143.
TreeFamiTF352903.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARAERPRP GPRPPPVFPF PPPLSLLLLL AILSAPVCGR VPRSVPRTSL
60 70 80 90 100
PISEADSYLT RFAASHTYNY SALLVDPASH TLYVGARDSI FALTLPFSGE
110 120 130 140 150
RPRRIDWMVP ETHRQNCRKK GKKEDECHNF IQILAIVNAS HLLTCGTFAF
160 170 180 190 200
DPKCGVIDVS SFQQVERLES GRGKCPFEPA QRSAAVMAGG VLYTATVKNF
210 220 230 240 250
LGTEPIISRA VGRAEDWIRT ETLSSWLNAP AFVAAMVLSP AEWGDEDGDD
260 270 280 290 300
EIFFFFTETS RVLDSYERIK VPRVARVCAG DLGGRKTLQQ RWTTFLKADL
310 320 330 340 350
LCPGPEHGRA SGVLQAMAEL RPQPGAGTPI FYGIFSSQWE GAAISAVCAF
360 370 380 390 400
RPQDIRAVLN GPFRELKHDC NRGLPVMDNE VPQPRPGECI ANNMKLQQFG
410 420 430 440 450
SSLSLPDRVL TFIRDHPLMD RPVFPADGRP LLVTTDTAYL RVVAHRVTSL
460 470 480 490 500
SGKEYDVLYL GTEDGHLHRA VRIGAQLSVL EDLALFPEPQ PVESMKLYHD
510 520 530 540 550
WLLVGSHTEV TQVNTSNCGR LQSCSECILA QDPVCAWSFR LDACVAHAGE
560 570 580 590 600
HRGMVQDIES ADVSSLCPKE PGEHPVVFEV PVATVGHVVL PCSPSSAWAS
610 620 630 640 650
CVWHQPSGVT ALTPRRDGLE VVVTPGAMGA YACECQEGGA ARVVAAYSLV
660 670 680 690 700
WGSQRGPSNR AHTVVGAGLV GFLLGVLAAS LTLLLIGRRQ QRRRQRELLA
710 720 730 740 750
RDKVGLDLGA PPSGTTSYSQ DPPSPSPEDE RLPLALGKRG SGFGGFPPPF
760 770
LLDSCPSPAH IRLTGAPLAT CDETSI
Length:776
Mass (Da):84,298
Last modified:May 1, 1999 - v1
Checksum:i20763182CC6C93CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002563 mRNA. Translation: BAA75629.1.
RefSeqiNP_062145.1. NM_019272.1.
UniGeneiRn.42885.

Genome annotation databases

EnsembliENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784.
GeneIDi29745.
KEGGirno:29745.
UCSCiRGD:3658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002563 mRNA. Translation: BAA75629.1.
RefSeqiNP_062145.1. NM_019272.1.
UniGeneiRn.42885.

3D structure databases

ProteinModelPortaliQ9Z143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1542065.
STRINGi10116.ENSRNOP00000009269.

Proteomic databases

PaxDbiQ9Z143.
PRIDEiQ9Z143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784.
GeneIDi29745.
KEGGirno:29745.
UCSCiRGD:3658. rat.

Organism-specific databases

CTDi10505.
RGDi3658. Sema4f.

Phylogenomic databases

eggNOGiNOG258001.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG093234.
InParanoidiQ9Z143.
KOiK06521.
OMAiCNRGLPV.
OrthoDBiEOG7KM5S4.
PhylomeDBiQ9Z143.
TreeFamiTF352903.

Miscellaneous databases

NextBioi610260.
PROiQ9Z143.

Gene expression databases

GenevestigatoriQ9Z143.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
    Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
    Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSEM4F_RAT
AccessioniPrimary (citable) accession number: Q9Z143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.