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Q9Z143

- SEM4F_RAT

UniProt

Q9Z143 - SEM4F_RAT

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Protein

Semaphorin-4F

Gene

Sema4f

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Has growth cone collapse activity against retinal ganglion-cell axons.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: RGD
  2. negative regulation of axon extension Source: MGI
  3. retinal ganglion cell axon guidance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-W
Short name:
Sema W
Gene namesi
Name:Sema4f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3658. Sema4f.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: MGI
  3. postsynaptic membrane Source: MGI
  4. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 776737Semaphorin-4FPRO_0000032332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi278 ↔ 389PROSITE-ProRule annotation
Disulfide bondi302 ↔ 348PROSITE-ProRule annotation
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi592 ↔ 633PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z143.
PRIDEiQ9Z143.

Expressioni

Tissue specificityi

Expressed at low levels in the developing embryo. Expressed at high levels in the adult central nervous system and lung.

Gene expression databases

GenevestigatoriQ9Z143.

Interactioni

Protein-protein interaction databases

MINTiMINT-1542065.
STRINGi10116.ENSRNOP00000009269.

Structurei

3D structure databases

ProteinModelPortaliQ9Z143.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 665626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini687 – 77690CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei666 – 68621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 515469SemaPROSITE-ProRule annotationAdd
BLAST
Domaini517 – 56852PSIAdd
BLAST
Domaini585 – 64056Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258001.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000116087.
HOVERGENiHBG093234.
InParanoidiQ9Z143.
KOiK06521.
OMAiCNRGLPV.
OrthoDBiEOG7KM5S4.
PhylomeDBiQ9Z143.
TreeFamiTF352903.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z143 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARAERPRP GPRPPPVFPF PPPLSLLLLL AILSAPVCGR VPRSVPRTSL
60 70 80 90 100
PISEADSYLT RFAASHTYNY SALLVDPASH TLYVGARDSI FALTLPFSGE
110 120 130 140 150
RPRRIDWMVP ETHRQNCRKK GKKEDECHNF IQILAIVNAS HLLTCGTFAF
160 170 180 190 200
DPKCGVIDVS SFQQVERLES GRGKCPFEPA QRSAAVMAGG VLYTATVKNF
210 220 230 240 250
LGTEPIISRA VGRAEDWIRT ETLSSWLNAP AFVAAMVLSP AEWGDEDGDD
260 270 280 290 300
EIFFFFTETS RVLDSYERIK VPRVARVCAG DLGGRKTLQQ RWTTFLKADL
310 320 330 340 350
LCPGPEHGRA SGVLQAMAEL RPQPGAGTPI FYGIFSSQWE GAAISAVCAF
360 370 380 390 400
RPQDIRAVLN GPFRELKHDC NRGLPVMDNE VPQPRPGECI ANNMKLQQFG
410 420 430 440 450
SSLSLPDRVL TFIRDHPLMD RPVFPADGRP LLVTTDTAYL RVVAHRVTSL
460 470 480 490 500
SGKEYDVLYL GTEDGHLHRA VRIGAQLSVL EDLALFPEPQ PVESMKLYHD
510 520 530 540 550
WLLVGSHTEV TQVNTSNCGR LQSCSECILA QDPVCAWSFR LDACVAHAGE
560 570 580 590 600
HRGMVQDIES ADVSSLCPKE PGEHPVVFEV PVATVGHVVL PCSPSSAWAS
610 620 630 640 650
CVWHQPSGVT ALTPRRDGLE VVVTPGAMGA YACECQEGGA ARVVAAYSLV
660 670 680 690 700
WGSQRGPSNR AHTVVGAGLV GFLLGVLAAS LTLLLIGRRQ QRRRQRELLA
710 720 730 740 750
RDKVGLDLGA PPSGTTSYSQ DPPSPSPEDE RLPLALGKRG SGFGGFPPPF
760 770
LLDSCPSPAH IRLTGAPLAT CDETSI
Length:776
Mass (Da):84,298
Last modified:May 1, 1999 - v1
Checksum:i20763182CC6C93CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002563 mRNA. Translation: BAA75629.1.
RefSeqiNP_062145.1. NM_019272.1.
UniGeneiRn.42885.

Genome annotation databases

EnsembliENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784.
GeneIDi29745.
KEGGirno:29745.
UCSCiRGD:3658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002563 mRNA. Translation: BAA75629.1 .
RefSeqi NP_062145.1. NM_019272.1.
UniGenei Rn.42885.

3D structure databases

ProteinModelPortali Q9Z143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1542065.
STRINGi 10116.ENSRNOP00000009269.

Proteomic databases

PaxDbi Q9Z143.
PRIDEi Q9Z143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009269 ; ENSRNOP00000009269 ; ENSRNOG00000006784 .
GeneIDi 29745.
KEGGi rno:29745.
UCSCi RGD:3658. rat.

Organism-specific databases

CTDi 10505.
RGDi 3658. Sema4f.

Phylogenomic databases

eggNOGi NOG258001.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000116087.
HOVERGENi HBG093234.
InParanoidi Q9Z143.
KOi K06521.
OMAi CNRGLPV.
OrthoDBi EOG7KM5S4.
PhylomeDBi Q9Z143.
TreeFami TF352903.

Miscellaneous databases

NextBioi 610260.
PROi Q9Z143.

Gene expression databases

Genevestigatori Q9Z143.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF72. PTHR11036:SF72. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
    Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
    Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSEM4F_RAT
AccessioniPrimary (citable) accession number: Q9Z143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3