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Q9Z143 (SEM4F_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Semaphorin-4F
Alternative name(s):
Semaphorin-W
Short name=Sema W
Gene names
Name:Sema4f
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has growth cone collapse activity against retinal ganglion-cell axons.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed at low levels in the developing embryo. Expressed at high levels in the adult central nervous system and lung.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 PSI domain.

Contains 1 Sema domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Chain40 – 776737Semaphorin-4F
PRO_0000032332

Regions

Topological domain40 – 665626Extracellular Potential
Transmembrane666 – 68621Helical; Potential
Topological domain687 – 77690Cytoplasmic Potential
Domain47 – 515469Sema
Domain517 – 56852PSI
Domain585 – 64056Ig-like C2-type

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 127 By similarity
Disulfide bond145 ↔ 154 By similarity
Disulfide bond278 ↔ 389 By similarity
Disulfide bond302 ↔ 348 By similarity
Disulfide bond518 ↔ 535 By similarity
Disulfide bond527 ↔ 544 By similarity
Disulfide bond592 ↔ 633 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z143 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 20763182CC6C93CA

FASTA77684,298
        10         20         30         40         50         60 
MLARAERPRP GPRPPPVFPF PPPLSLLLLL AILSAPVCGR VPRSVPRTSL PISEADSYLT 

        70         80         90        100        110        120 
RFAASHTYNY SALLVDPASH TLYVGARDSI FALTLPFSGE RPRRIDWMVP ETHRQNCRKK 

       130        140        150        160        170        180 
GKKEDECHNF IQILAIVNAS HLLTCGTFAF DPKCGVIDVS SFQQVERLES GRGKCPFEPA 

       190        200        210        220        230        240 
QRSAAVMAGG VLYTATVKNF LGTEPIISRA VGRAEDWIRT ETLSSWLNAP AFVAAMVLSP 

       250        260        270        280        290        300 
AEWGDEDGDD EIFFFFTETS RVLDSYERIK VPRVARVCAG DLGGRKTLQQ RWTTFLKADL 

       310        320        330        340        350        360 
LCPGPEHGRA SGVLQAMAEL RPQPGAGTPI FYGIFSSQWE GAAISAVCAF RPQDIRAVLN 

       370        380        390        400        410        420 
GPFRELKHDC NRGLPVMDNE VPQPRPGECI ANNMKLQQFG SSLSLPDRVL TFIRDHPLMD 

       430        440        450        460        470        480 
RPVFPADGRP LLVTTDTAYL RVVAHRVTSL SGKEYDVLYL GTEDGHLHRA VRIGAQLSVL 

       490        500        510        520        530        540 
EDLALFPEPQ PVESMKLYHD WLLVGSHTEV TQVNTSNCGR LQSCSECILA QDPVCAWSFR 

       550        560        570        580        590        600 
LDACVAHAGE HRGMVQDIES ADVSSLCPKE PGEHPVVFEV PVATVGHVVL PCSPSSAWAS 

       610        620        630        640        650        660 
CVWHQPSGVT ALTPRRDGLE VVVTPGAMGA YACECQEGGA ARVVAAYSLV WGSQRGPSNR 

       670        680        690        700        710        720 
AHTVVGAGLV GFLLGVLAAS LTLLLIGRRQ QRRRQRELLA RDKVGLDLGA PPSGTTSYSQ 

       730        740        750        760        770 
DPPSPSPEDE RLPLALGKRG SGFGGFPPPF LLDSCPSPAH IRLTGAPLAT CDETSI

« Hide

References

[1]"Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family."
Encinas J.A., Kikuchi K., Chedotal A., de Castro F., Goodman C.S., Kimura T.
Proc. Natl. Acad. Sci. U.S.A. 96:2491-2496(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB002563 mRNA. Translation: BAA75629.1.
IPIIPI00208178.
RefSeqNP_062145.1. NM_019272.1.
UniGeneRn.42885.

3D structure databases

ProteinModelPortalQ9Z143.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009269.

Proteomic databases

PaxDbQ9Z143.
PRIDEQ9Z143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009269; ENSRNOP00000009269; ENSRNOG00000006784.
GeneID29745.
KEGGrno:29745.
UCSCRGD:3658. rat.

Organism-specific databases

CTD10505.
RGD3658. Sema4f.

Phylogenomic databases

eggNOGNOG258001.
GeneTreeENSGT00560000076864.
HOGENOMHOG000116087.
HOVERGENHBG093234.
InParanoidQ9Z143.
KOK06521.
OMACNRGLPV.
OrthoDBEOG4J117K.

Gene expression databases

GenevestigatorQ9Z143.
GermOnlineENSRNOG00000006784. Rattus norvegicus.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR015512. Seamphorin_4F.
IPR027231. Semaphorin.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF13. PTHR11036:SF13. 1 hit.
PfamPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF103575. Plexin-like_fold. 1 hit.
SSF101912. Sema. 1 hit.
PROSITEPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610260.

Entry information

Entry nameSEM4F_RAT
AccessionPrimary (citable) accession number: Q9Z143
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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