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Protein

Transmembrane protein 33

Gene

Tmem33

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 33
Alternative name(s):
Protein DB83
Gene namesi
Name:Tmem33
Synonyms:Db83
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708371. Tmem33.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Melanosome By similarity
  • Nucleus envelope By similarity

  • Note: Co-localizes with RTN4 at the ER sheets.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31LumenalCuratedAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 100CytoplasmicCuratedAdd BLAST48
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 155LumenalCuratedAdd BLAST34
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 247CytoplasmicCuratedAdd BLAST71

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002209012 – 247Transmembrane protein 33Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9Z142.
PRIDEiQ9Z142.

Expressioni

Tissue specificityi

Highly expressed in the liver and significantly in brain, lungs and kidneys.

Gene expression databases

BgeeiENSRNOG00000002254.
GenevisibleiQ9Z142. RN.

Interactioni

Subunit structurei

Interacts with EIF2AK3. Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1.By similarity

Protein-protein interaction databases

BioGridi248752. 1 interactor.
IntActiQ9Z142. 1 interactor.
MINTiMINT-4566929.
STRINGi10116.ENSRNOP00000003128.

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
HOGENOMiHOG000007460.
HOVERGENiHBG054225.
InParanoidiQ9Z142.
KOiK20724.
OrthoDBiEOG091G0IX8.
PhylomeDBiQ9Z142.
TreeFamiTF314068.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE
60 70 80 90 100
AASFYQRALL ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL
110 120 130 140 150
IFVNSYPVTM SIFPVLLFSL LHAATYTKKV LDAKGSNSLP LLRSVLDKLS
160 170 180 190 200
TNQQNILKFI ACNEIFLMPA TVFMLFSGQG SLLQPFIYYR FLTLRYSSRR
210 220 230 240
NPYCRNLFNE LRIVVEHIIM KPSCPLFVRR LCLQSIAFIS RLAPTVA
Length:247
Mass (Da):27,983
Last modified:May 1, 1999 - v1
Checksum:i0D07BE5911CAD6AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006135 mRNA. Translation: BAA75068.1.
PIRiJE0307.
RefSeqiNP_067703.1. NM_021671.3.
UniGeneiRn.203963.

Genome annotation databases

GeneIDi59303.
KEGGirno:59303.
UCSCiRGD:708371. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006135 mRNA. Translation: BAA75068.1.
PIRiJE0307.
RefSeqiNP_067703.1. NM_021671.3.
UniGeneiRn.203963.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248752. 1 interactor.
IntActiQ9Z142. 1 interactor.
MINTiMINT-4566929.
STRINGi10116.ENSRNOP00000003128.

Proteomic databases

PaxDbiQ9Z142.
PRIDEiQ9Z142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi59303.
KEGGirno:59303.
UCSCiRGD:708371. rat.

Organism-specific databases

CTDi55161.
RGDi708371. Tmem33.

Phylogenomic databases

eggNOGiKOG4002. Eukaryota.
ENOG4111BM3. LUCA.
HOGENOMiHOG000007460.
HOVERGENiHBG054225.
InParanoidiQ9Z142.
KOiK20724.
OrthoDBiEOG091G0IX8.
PhylomeDBiQ9Z142.
TreeFamiTF314068.

Miscellaneous databases

PROiQ9Z142.

Gene expression databases

BgeeiENSRNOG00000002254.
GenevisibleiQ9Z142. RN.

Family and domain databases

InterProiIPR005344. Per33/Pom33.
[Graphical view]
PfamiPF03661. UPF0121. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM33_RAT
AccessioniPrimary (citable) accession number: Q9Z142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.