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Q9Z139 (ROR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transmembrane receptor ROR1

Short name=mROR1
EC=2.7.10.1
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 1
Gene names
Name:Ror1
Synonyms:Ntrkr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine-protein kinase receptor whose role is not yet clear.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Contains 1 FZ (frizzled) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 kringle domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 937908Tyrosine-protein kinase transmembrane receptor ROR1
PRO_0000024459

Regions

Topological domain30 – 406377Extracellular Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 937510Cytoplasmic Potential
Domain42 – 141100Ig-like C2-type
Domain165 – 299135FZ
Domain312 – 39180Kringle
Domain473 – 746274Protein kinase
Nucleotide binding479 – 4879ATP By similarity
Compositional bias753 – 78230Ser/Thr-rich
Compositional bias784 – 85168Pro-rich
Compositional bias853 – 87624Ser/Thr-rich

Sites

Active site6151Proton acceptor By similarity
Binding site5061ATP By similarity

Amino acid modifications

Modified residue6451Phosphotyrosine; by autocatalysis By similarity
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Disulfide bond79 ↔ 131 By similarity
Disulfide bond170 ↔ 235 By similarity
Disulfide bond178 ↔ 228 By similarity
Disulfide bond219 ↔ 260 By similarity
Disulfide bond248 ↔ 296 By similarity
Disulfide bond252 ↔ 282 By similarity
Disulfide bond313 ↔ 391 By similarity
Disulfide bond334 ↔ 374 By similarity
Disulfide bond362 ↔ 386 By similarity

Experimental info

Sequence conflict8601S → R in BAA75480. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z139 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: D6F2D84E67D03C69

FASTA937104,088
        10         20         30         40         50         60 
MHRPRRRGTR PPPLALLAAL LLAARGADAQ ETELSVSAEL VPTSSWNTSS EIDKGSYLTL 

        70         80         90        100        110        120 
DEPMNNITTS LGQTAELHCK VSGNPPPSIR WFKNDAPVVQ EPRRISFRAT NYGSRLRIRN 

       130        140        150        160        170        180 
LDTTDTGYFQ CVATNGKKVV STTGVLFVKF GPPPTASPGS SDEYEEDGFC QPYRGIACAR 

       190        200        210        220        230        240 
FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS 

       250        260        270        280        290        300 
VPKPRDLCRD ECEVLENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 

       310        320        330        340        350        360 
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHSFTAL RFPELNGGHS 

       370        380        390        400        410        420 
YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAF 

       430        440        450        460        470        480 
LFFFICVCRN NQKSSSPPVQ RQPKPVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG 

       490        500        510        520        530        540 
ECTFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG 

       550        560        570        580        590        600 
AVTQEQPVCM LFEYMNQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 

       610        620        630        640        650        660 
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSSLPIRWMP 

       670        680        690        700        710        720 
PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR 

       730        740        750        760        770        780 
MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN 

       790        800        810        820        830        840 
LSNPRFPNYM FPSQGITPQG QIAGFIGPAI PQNQRFIPIN GYPIPPGYAA FPAAHYQPAG 

       850        860        870        880        890        900 
PPRVIQHCPP PKSRSPSSAS GSTSTGHVAS LPSSGSNQEA NVPLLPHMSI PNHPGGMGIT 

       910        920        930 
VFGNKSQKPY KIDSKQSSLL GDSHIHGHTE SMISAEV 

« Hide

References

« Hide 'large scale' references
[1]"Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system."
Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y.
Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Adipose tissue.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010383 mRNA. Translation: BAA75480.1.
AK046699 mRNA. Translation: BAC32840.1.
AK049369 mRNA. Translation: BAC33714.1.
AL670246, AL772259 Genomic DNA. Translation: CAM20163.1.
AL772259, AL670246 Genomic DNA. Translation: CAM23558.1.
BC138794 mRNA. Translation: AAI38795.1.
BC138810 mRNA. Translation: AAI38811.1.
RefSeqNP_038873.2. NM_013845.4.
UniGeneMm.485829.
Mm.57252.

3D structure databases

ProteinModelPortalQ9Z139.
SMRQ9Z139. Positions 60-165, 278-393, 405-750.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205021. 1 interaction.
STRING10090.ENSMUSP00000048171.

Chemistry

ChEMBLCHEMBL2176781.

PTM databases

PhosphoSiteQ9Z139.

Proteomic databases

PRIDEQ9Z139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039630; ENSMUSP00000048171; ENSMUSG00000035305.
GeneID26563.
KEGGmmu:26563.
UCSCuc008tvd.1. mouse.

Organism-specific databases

CTD4919.
MGIMGI:1347520. Ror1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117239.
HOGENOMHOG000049104.
HOVERGENHBG017736.
InParanoidQ8BG10.
KOK05122.
OMAHYQPAGP.
OrthoDBEOG76739G.
TreeFamTF106465.

Gene expression databases

BgeeQ9Z139.
CleanExMM_ROR1.
GenevestigatorQ9Z139.

Family and domain databases

Gene3D2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304635.
PROQ9Z139.
SOURCESearch...

Entry information

Entry nameROR1_MOUSE
AccessionPrimary (citable) accession number: Q9Z139
Secondary accession number(s): Q8BG10
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot