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Q9Z138

- ROR2_MOUSE

UniProt

Q9Z138 - ROR2_MOUSE

Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene

Ror2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei507 – 5071ATPPROSITE-ProRule annotation
    Active sitei615 – 6151Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi479 – 4879ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. frizzled binding Source: BHF-UCL
    3. protein binding Source: MGI
    4. transmembrane receptor protein tyrosine kinase activity Source: MGI
    5. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. cartilage condensation Source: MGI
    2. cell differentiation Source: MGI
    3. embryonic genitalia morphogenesis Source: MGI
    4. inner ear morphogenesis Source: MGI
    5. JNK cascade Source: MGI
    6. negative regulation of canonical Wnt signaling pathway Source: MGI
    7. negative regulation of cell proliferation Source: Ensembl
    8. peptidyl-tyrosine phosphorylation Source: GOC
    9. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    10. positive regulation of cell migration Source: Ensembl
    11. positive regulation of transcription, DNA-templated Source: BHF-UCL
    12. skeletal system development Source: MGI
    13. somitogenesis Source: MGI
    14. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
    15. Wnt signaling pathway, calcium modulating pathway Source: MGI
    16. Wnt signaling pathway, planar cell polarity pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_214043. PCP/CE pathway.
    REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.1)
    Short name:
    mROR2
    Alternative name(s):
    Neurotrophic tyrosine kinase, receptor-related 2
    Gene namesi
    Name:Ror2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1347521. Ror2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 944911Tyrosine-protein kinase transmembrane receptor ROR2PRO_0000024461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi83 ↔ 135By similarity
    Disulfide bondi174 ↔ 239By similarity
    Disulfide bondi182 ↔ 232By similarity
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 264By similarity
    Disulfide bondi252 ↔ 300By similarity
    Disulfide bondi256 ↔ 286By similarity
    Disulfide bondi316 ↔ 394By similarity
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi337 ↔ 377By similarity
    Disulfide bondi365 ↔ 389By similarity
    Modified residuei646 – 6461Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9Z138.

    PTM databases

    PhosphoSiteiQ9Z138.

    Expressioni

    Developmental stagei

    From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9Z138.
    BgeeiQ9Z138.
    CleanExiMM_ROR2.
    GenevestigatoriQ9Z138.

    Interactioni

    Subunit structurei

    Homodimer; promotes osteogenesis By similarity. Binds YWHAB By similarity. Interacts with WTIP.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z138.
    SMRiQ9Z138. Positions 33-153, 283-765.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 403370ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini425 – 944520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei404 – 42421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 14591Ig-like C2-typeAdd
    BLAST
    Domaini169 – 303135FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini316 – 39479KringlePROSITE-ProRule annotationAdd
    BLAST
    Domaini473 – 746274Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi753 – 78230Ser/Thr-richAdd
    BLAST
    Compositional biasi784 – 85774Pro-richAdd
    BLAST
    Compositional biasi859 – 88224Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 kringle domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117239.
    HOGENOMiHOG000049104.
    HOVERGENiHBG017736.
    InParanoidiQ9Z138.
    OMAiLQLPKCE.
    TreeFamiTF106465.

    Family and domain databases

    Gene3Di2.40.20.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR020067. Frizzled_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016247. Tyr_kinase_rcpt_ROR.
    [Graphical view]
    PfamiPF01392. Fz. 1 hit.
    PF07679. I-set. 1 hit.
    PF00051. Kringle. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 1 hit.
    SM00130. KR. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z138-1 [UniParc]FASTAAdd to Basket

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    MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP    50
    DSPLPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA 100
    PVVQEPRRVI IRKTEYGSRL RIQDLDTTDT GYYQCVATNG LKTITATGVL 150
    YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG 200
    EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE 250
    LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 300
    MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL 350
    SSTEFPELGG GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS 400
    KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ 450
    DMEMPLISQH KQAKLKEISL STVRFMEELG EDRFGKVYKG HLFGPAPGEP 500
    TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL GVVTKDQPLS 550
    MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 600
    AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG 650
    NSLLPIRWMS PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD 700
    VVEMIRSRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRSWG 750
    NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYMAPK QKAQPFPQPQ 800
    FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ 850
    VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI 900
    AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA 944
    Length:944
    Mass (Da):105,005
    Last modified:July 27, 2011 - v2
    Checksum:i03B00784CFFF4489
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101I → V in BAA75481. (PubMed:10231392)Curated
    Sequence conflicti242 – 2421R → C in BAA75481. (PubMed:10231392)Curated
    Sequence conflicti372 – 3721V → M in BAA75481. (PubMed:10231392)Curated
    Sequence conflicti398 – 3981D → Y in BAA75481. (PubMed:10231392)Curated
    Sequence conflicti612 – 6121V → C in BAA75481. (PubMed:10231392)Curated
    Sequence conflicti897 – 8971A → V in BAA75481. (PubMed:10231392)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010384 mRNA. Translation: BAA75481.1.
    AC111017 Genomic DNA. No translation available.
    CCDSiCCDS26520.1.
    UniGeneiMm.342774.

    Genome annotation databases

    EnsembliENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010384 mRNA. Translation: BAA75481.1 .
    AC111017 Genomic DNA. No translation available.
    CCDSi CCDS26520.1.
    UniGenei Mm.342774.

    3D structure databases

    ProteinModelPortali Q9Z138.
    SMRi Q9Z138. Positions 33-153, 283-765.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z138.

    Proteomic databases

    PRIDEi Q9Z138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021918 ; ENSMUSP00000021918 ; ENSMUSG00000021464 .

    Organism-specific databases

    MGIi MGI:1347521. Ror2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117239.
    HOGENOMi HOG000049104.
    HOVERGENi HBG017736.
    InParanoidi Q9Z138.
    OMAi LQLPKCE.
    TreeFami TF106465.

    Enzyme and pathway databases

    Reactomei REACT_214043. PCP/CE pathway.
    REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

    Miscellaneous databases

    PROi Q9Z138.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z138.
    Bgeei Q9Z138.
    CleanExi MM_ROR2.
    Genevestigatori Q9Z138.

    Family and domain databases

    Gene3Di 2.40.20.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR020067. Frizzled_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016247. Tyr_kinase_rcpt_ROR.
    [Graphical view ]
    Pfami PF01392. Fz. 1 hit.
    PF07679. I-set. 1 hit.
    PF00051. Kringle. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000624. TyrPK_TMrec_ROR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 1 hit.
    SM00130. KR. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system."
      Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y.
      Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development."
      DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., Yancopoulos G.D.
      Nat. Genet. 24:271-274(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling."
      van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S.
      Biochem. Biophys. Res. Commun. 390:211-216(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WTIP, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiROR2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z138
    Secondary accession number(s): E9QKB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3