Q9Z138 (ROR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2
Short name=mROR2
EC=2.7.10.1

Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2

Gene names

Name:

Ror2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	944 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Homodimer; promotes osteogenesis By similarity. Binds YWHAB By similarity. Interacts with WTIP. Ref.4
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.4.
Developmental stage	From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level). Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Contains 1 FZ (frizzled) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 kringle domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Kringle Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	JNK cascade Inferred from direct assay PubMed 12839624. Source: MGI Wnt receptor signaling pathway, calcium modulating pathway Inferred from physical interaction PubMed 12839624. Source: MGI Wnt receptor signaling pathway, planar cell polarity pathway Inferred from mutant phenotype PubMed 18606138. Source: MGI cartilage condensation Inferred from mutant phenotype PubMed 14745966. Source: MGI cell differentiation Inferred from mutant phenotype PubMed 14745966. Source: MGI embryonic genitalia morphogenesis Inferred from mutant phenotype PubMed 14745966. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 18606138. Source: MGI negative regulation of canonical Wnt receptor signaling pathway Inferred from genetic interaction PubMed 16602827. Source: MGI negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 18215320. Source: BHF-UCL positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 18215320. Source: BHF-UCL somitogenesis Inferred from mutant phenotype PubMed 14745966. Source: MGI transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Inferred from sequence or structural similarity Ref.1. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Traceable author statement Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 944	911	Tyrosine-protein kinase transmembrane receptor ROR2		PRO_0000024461
Regions
	Topological domain	34 – 403	370	Extracellular Potential
	Transmembrane	404 – 424	21	Helical; Potential
	Topological domain	425 – 944	520	Cytoplasmic Potential
	Domain	55 – 145	91	Ig-like C2-type
	Domain	169 – 303	135	FZ
	Domain	316 – 394	79	Kringle
	Domain	473 – 746	274	Protein kinase
	Nucleotide binding	479 – 487	9	ATP By similarity
	Compositional bias	753 – 782	30	Ser/Thr-rich
	Compositional bias	784 – 857	74	Pro-rich
	Compositional bias	859 – 882	24	Ser/Thr-rich
Sites
	Active site	615	1	Proton acceptor By similarity
	Binding site	507	1	ATP By similarity
Amino acid modifications
	Modified residue	646	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Glycosylation	318	1	N-linked (GlcNAc...) Potential
	Disulfide bond	83 ↔ 135		By similarity
	Disulfide bond	174 ↔ 239		By similarity
	Disulfide bond	182 ↔ 232		By similarity
	Disulfide bond	223 ↔ 264		By similarity
	Disulfide bond	252 ↔ 300		By similarity
	Disulfide bond	256 ↔ 286		By similarity
	Disulfide bond	316 ↔ 394		By similarity
	Disulfide bond	337 ↔ 377		By similarity
	Disulfide bond	365 ↔ 389		By similarity
Experimental info
	Sequence conflict	110	1	I → V in BAA75481. Ref.1
	Sequence conflict	242	1	R → C in BAA75481. Ref.1
	Sequence conflict	372	1	V → M in BAA75481. Ref.1
	Sequence conflict	398	1	D → Y in BAA75481. Ref.1
	Sequence conflict	612	1	V → C in BAA75481. Ref.1
	Sequence conflict	897	1	A → V in BAA75481. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z138 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 03B00784CFFF4489	FASTA	944	105,005
	10 20 30 40 50 60 MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP DSPLPTLKGY 70 80 90 100 110 120 FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRVI IRKTEYGSRL 130 140 150 160 170 180 RIQDLDTTDT GYYQCVATNG LKTITATGVL YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI 190 200 210 220 230 240 ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD 250 260 270 280 290 300 ARSRAPKPRE LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 310 320 330 340 350 360 MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL SSTEFPELGG 370 380 390 400 410 420 GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS KMGILYILVP SIAIPLVIAC 430 440 450 460 470 480 LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLISQH KQAKLKEISL STVRFMEELG 490 500 510 520 530 540 EDRFGKVYKG HLFGPAPGEP TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL 550 560 570 580 590 600 GVVTKDQPLS MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 610 620 630 640 650 660 AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG NSLLPIRWMS 670 680 690 700 710 720 PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRSRQV LPCPDDCPAW 730 740 750 760 770 780 VYALMIECWN EFPSRRPRFK DIHSRLRSWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN 790 800 810 820 830 840 VSNARYMAPK QKAQPFPQPQ FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV 850 860 870 880 890 900 QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI 910 920 930 940 AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system." Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y. Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development." DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., Yancopoulos G.D. Nat. Genet. 24:271-274(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[4]	"The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling." van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S. Biochem. Biophys. Res. Commun. 390:211-216(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WTIP, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB010384 mRNA. Translation: BAA75481.1. AC111017 Genomic DNA. No translation available.
IPI	IPI00129431.
UniGene	Mm.342774.
3D structure databases
ProteinModelPortal	Q9Z138.
SMR	Q9Z138. Positions 33-153, 283-395, 421-751.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z138.
Proteomic databases
PRIDE	Q9Z138.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.
Organism-specific databases
MGI	MGI:1347521. Ror2.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00690000101688.
HOGENOM	HOG000049104.
HOVERGEN	HBG017736.
InParanoid	Q9Z138.
OMA	PKPRELC.
OrthoDB	EOG4C5CHQ.
Gene expression databases
ArrayExpress	Q9Z138.
Bgee	Q9Z138.
CleanEx	MM_ROR2.
Genevestigator	Q9Z138.
GermOnline	ENSMUSG00000021464. Mus musculus.
Family and domain databases
Gene3D	2.40.20.10. 1 hit. 2.60.40.10. 1 hit.
InterPro	IPR020067. Frizzled_dom. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000001. Kringle. IPR013806. Kringle-like. IPR018056. Kringle_CS. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016247. Tyr_kinase_rcpt_ROR. [Graphical view]
Pfam	PF01392. Fz. 1 hit. PF07679. I-set. 1 hit. PF00051. Kringle. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00408. IGc2. 1 hit. SM00130. KR. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF57440. Kringle-like. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50835. IG_LIKE. 1 hit. PS00021. KRINGLE_1. 1 hit. PS50070. KRINGLE_2. 1 hit. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ROR2_MOUSE

Accession

Primary (citable) accession number: Q9Z138
Secondary accession number(s): E9QKB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program