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Q9Z138

- ROR2_MOUSE

UniProt

Q9Z138 - ROR2_MOUSE

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Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene
Ror2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei507 – 5071ATP By similarity
Active sitei615 – 6151Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4879ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. frizzled binding Source: BHF-UCL
  3. protein binding Source: MGI
  4. transmembrane receptor protein tyrosine kinase activity Source: MGI
  5. Wnt-protein binding Source: MGI

GO - Biological processi

  1. cartilage condensation Source: MGI
  2. cell differentiation Source: MGI
  3. embryonic genitalia morphogenesis Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. JNK cascade Source: MGI
  6. negative regulation of canonical Wnt signaling pathway Source: MGI
  7. negative regulation of cell proliferation Source: Ensembl
  8. peptidyl-tyrosine phosphorylation Source: GOC
  9. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  10. positive regulation of cell migration Source: Ensembl
  11. positive regulation of transcription, DNA-templated Source: BHF-UCL
  12. skeletal system development Source: MGI
  13. somitogenesis Source: MGI
  14. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
  15. Wnt signaling pathway, calcium modulating pathway Source: MGI
  16. Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_214043. PCP/CE pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.1)
Short name:
mROR2
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene namesi
Name:Ror2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1347521. Ror2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 403370Extracellular Reviewed predictionAdd
BLAST
Transmembranei404 – 42421Helical; Reviewed predictionAdd
BLAST
Topological domaini425 – 944520Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 944911Tyrosine-protein kinase transmembrane receptor ROR2PRO_0000024461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi83 ↔ 135 By similarity
Disulfide bondi174 ↔ 239 By similarity
Disulfide bondi182 ↔ 232 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 264 By similarity
Disulfide bondi252 ↔ 300 By similarity
Disulfide bondi256 ↔ 286 By similarity
Disulfide bondi316 ↔ 394 By similarity
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi337 ↔ 377 By similarity
Disulfide bondi365 ↔ 389 By similarity
Modified residuei646 – 6461Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9Z138.

PTM databases

PhosphoSiteiQ9Z138.

Expressioni

Developmental stagei

From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ9Z138.
BgeeiQ9Z138.
CleanExiMM_ROR2.
GenevestigatoriQ9Z138.

Interactioni

Subunit structurei

Homodimer; promotes osteogenesis By similarity. Binds YWHAB By similarity. Interacts with WTIP.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9Z138.
SMRiQ9Z138. Positions 33-153, 283-765.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 14591Ig-like C2-typeAdd
BLAST
Domaini169 – 303135FZAdd
BLAST
Domaini316 – 39479KringleAdd
BLAST
Domaini473 – 746274Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi753 – 78230Ser/Thr-richAdd
BLAST
Compositional biasi784 – 85774Pro-richAdd
BLAST
Compositional biasi859 – 88224Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 kringle domain.

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117239.
HOGENOMiHOG000049104.
HOVERGENiHBG017736.
InParanoidiQ9Z138.
OMAiLQLPKCE.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z138-1 [UniParc]FASTAAdd to Basket

« Hide

MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP    50
DSPLPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA 100
PVVQEPRRVI IRKTEYGSRL RIQDLDTTDT GYYQCVATNG LKTITATGVL 150
YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG 200
EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE 250
LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 300
MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL 350
SSTEFPELGG GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS 400
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ 450
DMEMPLISQH KQAKLKEISL STVRFMEELG EDRFGKVYKG HLFGPAPGEP 500
TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL GVVTKDQPLS 550
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 600
AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG 650
NSLLPIRWMS PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD 700
VVEMIRSRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRSWG 750
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYMAPK QKAQPFPQPQ 800
FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ 850
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI 900
AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA 944
Length:944
Mass (Da):105,005
Last modified:July 27, 2011 - v2
Checksum:i03B00784CFFF4489
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101I → V in BAA75481. 1 Publication
Sequence conflicti242 – 2421R → C in BAA75481. 1 Publication
Sequence conflicti372 – 3721V → M in BAA75481. 1 Publication
Sequence conflicti398 – 3981D → Y in BAA75481. 1 Publication
Sequence conflicti612 – 6121V → C in BAA75481. 1 Publication
Sequence conflicti897 – 8971A → V in BAA75481. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010384 mRNA. Translation: BAA75481.1.
AC111017 Genomic DNA. No translation available.
CCDSiCCDS26520.1.
UniGeneiMm.342774.

Genome annotation databases

EnsembliENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010384 mRNA. Translation: BAA75481.1 .
AC111017 Genomic DNA. No translation available.
CCDSi CCDS26520.1.
UniGenei Mm.342774.

3D structure databases

ProteinModelPortali Q9Z138.
SMRi Q9Z138. Positions 33-153, 283-765.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z138.

Proteomic databases

PRIDEi Q9Z138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021918 ; ENSMUSP00000021918 ; ENSMUSG00000021464 .

Organism-specific databases

MGIi MGI:1347521. Ror2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117239.
HOGENOMi HOG000049104.
HOVERGENi HBG017736.
InParanoidi Q9Z138.
OMAi LQLPKCE.
TreeFami TF106465.

Enzyme and pathway databases

Reactomei REACT_214043. PCP/CE pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Miscellaneous databases

PROi Q9Z138.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z138.
Bgeei Q9Z138.
CleanExi MM_ROR2.
Genevestigatori Q9Z138.

Family and domain databases

Gene3Di 2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view ]
Pfami PF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system."
    Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y.
    Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development."
    DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., Yancopoulos G.D.
    Nat. Genet. 24:271-274(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling."
    van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S.
    Biochem. Biophys. Res. Commun. 390:211-216(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WTIP, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiROR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z138
Secondary accession number(s): E9QKB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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