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Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene

Ror2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei507 – 5071ATPPROSITE-ProRule annotation
Active sitei615 – 6151Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4879ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • frizzled binding Source: BHF-UCL
  • transmembrane receptor protein tyrosine kinase activity Source: MGI
  • Wnt-protein binding Source: MGI

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • cartilage condensation Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic genitalia morphogenesis Source: MGI
  • inner ear morphogenesis Source: MGI
  • JNK cascade Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • peptidyl-tyrosine phosphorylation Source: GOC
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of cell migration Source: MGI
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of canonical Wnt signaling pathway Source: MGI
  • skeletal system development Source: MGI
  • SMAD protein signal transduction Source: MGI
  • smoothened signaling pathway Source: MGI
  • somitogenesis Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
  • Wnt signaling pathway, calcium modulating pathway Source: MGI
  • Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_330043. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_333985. PCP/CE pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.1)
Short name:
mROR2
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene namesi
Name:Ror2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347521. Ror2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 403370ExtracellularSequence AnalysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence AnalysisAdd
BLAST
Topological domaini425 – 944520CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 944911Tyrosine-protein kinase transmembrane receptor ROR2PRO_0000024461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi83 ↔ 135By similarity
Disulfide bondi174 ↔ 239By similarity
Disulfide bondi182 ↔ 232By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 264By similarity
Disulfide bondi252 ↔ 300By similarity
Disulfide bondi256 ↔ 286By similarity
Disulfide bondi316 ↔ 394By similarity
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi337 ↔ 377By similarity
Disulfide bondi365 ↔ 389By similarity
Modified residuei646 – 6461Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z138.
PRIDEiQ9Z138.

PTM databases

PhosphoSiteiQ9Z138.

Expressioni

Developmental stagei

From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level).1 Publication

Gene expression databases

BgeeiQ9Z138.
CleanExiMM_ROR2.
ExpressionAtlasiQ9Z138. baseline and differential.

Interactioni

Subunit structurei

Homodimer; promotes osteogenesis (By similarity). Binds YWHAB (By similarity). Interacts with WTIP.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021918.

Structurei

3D structure databases

ProteinModelPortaliQ9Z138.
SMRiQ9Z138. Positions 33-153, 283-765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 14591Ig-like C2-typeAdd
BLAST
Domaini169 – 303135FZPROSITE-ProRule annotationAdd
BLAST
Domaini316 – 39479KringlePROSITE-ProRule annotationAdd
BLAST
Domaini473 – 746274Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi753 – 78230Ser/Thr-richAdd
BLAST
Compositional biasi784 – 85774Pro-richAdd
BLAST
Compositional biasi859 – 88224Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000049104.
HOVERGENiHBG017736.
InParanoidiQ9Z138.
OMAiFIPMKGQ.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP
60 70 80 90 100
DSPLPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA
110 120 130 140 150
PVVQEPRRVI IRKTEYGSRL RIQDLDTTDT GYYQCVATNG LKTITATGVL
160 170 180 190 200
YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
210 220 230 240 250
EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE
260 270 280 290 300
LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC
310 320 330 340 350
MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL
360 370 380 390 400
SSTEFPELGG GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS
410 420 430 440 450
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ
460 470 480 490 500
DMEMPLISQH KQAKLKEISL STVRFMEELG EDRFGKVYKG HLFGPAPGEP
510 520 530 540 550
TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL GVVTKDQPLS
560 570 580 590 600
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA
610 620 630 640 650
AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG
660 670 680 690 700
NSLLPIRWMS PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD
710 720 730 740 750
VVEMIRSRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRSWG
760 770 780 790 800
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYMAPK QKAQPFPQPQ
810 820 830 840 850
FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ
860 870 880 890 900
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI
910 920 930 940
AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA
Length:944
Mass (Da):105,005
Last modified:July 27, 2011 - v2
Checksum:i03B00784CFFF4489
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101I → V in BAA75481 (PubMed:10231392).Curated
Sequence conflicti242 – 2421R → C in BAA75481 (PubMed:10231392).Curated
Sequence conflicti372 – 3721V → M in BAA75481 (PubMed:10231392).Curated
Sequence conflicti398 – 3981D → Y in BAA75481 (PubMed:10231392).Curated
Sequence conflicti612 – 6121V → C in BAA75481 (PubMed:10231392).Curated
Sequence conflicti897 – 8971A → V in BAA75481 (PubMed:10231392).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010384 mRNA. Translation: BAA75481.1.
AC111017 Genomic DNA. No translation available.
CCDSiCCDS26520.1.
UniGeneiMm.342774.

Genome annotation databases

EnsembliENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010384 mRNA. Translation: BAA75481.1.
AC111017 Genomic DNA. No translation available.
CCDSiCCDS26520.1.
UniGeneiMm.342774.

3D structure databases

ProteinModelPortaliQ9Z138.
SMRiQ9Z138. Positions 33-153, 283-765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021918.

PTM databases

PhosphoSiteiQ9Z138.

Proteomic databases

MaxQBiQ9Z138.
PRIDEiQ9Z138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.

Organism-specific databases

MGIiMGI:1347521. Ror2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000049104.
HOVERGENiHBG017736.
InParanoidiQ9Z138.
OMAiFIPMKGQ.
TreeFamiTF106465.

Enzyme and pathway databases

ReactomeiREACT_330043. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_333985. PCP/CE pathway.

Miscellaneous databases

PROiQ9Z138.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z138.
CleanExiMM_ROR2.
ExpressionAtlasiQ9Z138. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamiPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system."
    Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y.
    Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development."
    DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., Yancopoulos G.D.
    Nat. Genet. 24:271-274(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling."
    van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S.
    Biochem. Biophys. Res. Commun. 390:211-216(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WTIP, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiROR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z138
Secondary accession number(s): E9QKB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.