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Q9Z138 (ROR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transmembrane receptor ROR2

Short name=mROR2
EC=2.7.10.1
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene names
Name:Ror2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Homodimer; promotes osteogenesis By similarity. Binds YWHAB By similarity. Interacts with WTIP. Ref.4

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.4.

Developmental stage

From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level). Ref.4

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Contains 1 FZ (frizzled) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 kringle domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainImmunoglobulin domain
Kringle
Signal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJNK cascade

Inferred from direct assay PubMed 12839624. Source: MGI

Wnt signaling pathway, calcium modulating pathway

Inferred from physical interaction PubMed 12839624. Source: MGI

Wnt signaling pathway, planar cell polarity pathway

Inferred from mutant phenotype PubMed 18606138. Source: MGI

cartilage condensation

Inferred from mutant phenotype PubMed 14745966. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 14745966. Source: MGI

embryonic genitalia morphogenesis

Inferred from mutant phenotype PubMed 14745966. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 18606138. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 16602827. Source: MGI

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

peptidyl-tyrosine phosphorylation

Traceable author statement Ref.1. Source: GOC

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 18215320. Source: BHF-UCL

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 18215320. Source: BHF-UCL

skeletal system development

Inferred from mutant phenotype Ref.3. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 14745966. Source: MGI

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of plasma membrane

Inferred from sequence or structural similarity Ref.1. Source: MGI

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Wnt-protein binding

Inferred from physical interaction PubMed 18606138. Source: MGI

frizzled binding

Inferred from physical interaction PubMed 12839624. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 12839624PubMed 18606138. Source: MGI

transmembrane receptor protein tyrosine kinase activity

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 944911Tyrosine-protein kinase transmembrane receptor ROR2
PRO_0000024461

Regions

Topological domain34 – 403370Extracellular Potential
Transmembrane404 – 42421Helical; Potential
Topological domain425 – 944520Cytoplasmic Potential
Domain55 – 14591Ig-like C2-type
Domain169 – 303135FZ
Domain316 – 39479Kringle
Domain473 – 746274Protein kinase
Nucleotide binding479 – 4879ATP By similarity
Compositional bias753 – 78230Ser/Thr-rich
Compositional bias784 – 85774Pro-rich
Compositional bias859 – 88224Ser/Thr-rich

Sites

Active site6151Proton acceptor By similarity
Binding site5071ATP By similarity

Amino acid modifications

Modified residue6461Phosphotyrosine; by autocatalysis By similarity
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 135 By similarity
Disulfide bond174 ↔ 239 By similarity
Disulfide bond182 ↔ 232 By similarity
Disulfide bond223 ↔ 264 By similarity
Disulfide bond252 ↔ 300 By similarity
Disulfide bond256 ↔ 286 By similarity
Disulfide bond316 ↔ 394 By similarity
Disulfide bond337 ↔ 377 By similarity
Disulfide bond365 ↔ 389 By similarity

Experimental info

Sequence conflict1101I → V in BAA75481. Ref.1
Sequence conflict2421R → C in BAA75481. Ref.1
Sequence conflict3721V → M in BAA75481. Ref.1
Sequence conflict3981D → Y in BAA75481. Ref.1
Sequence conflict6121V → C in BAA75481. Ref.1
Sequence conflict8971A → V in BAA75481. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z138 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 03B00784CFFF4489

FASTA944105,005
        10         20         30         40         50         60 
MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP DSPLPTLKGY 

        70         80         90        100        110        120 
FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRVI IRKTEYGSRL 

       130        140        150        160        170        180 
RIQDLDTTDT GYYQCVATNG LKTITATGVL YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI 

       190        200        210        220        230        240 
ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD 

       250        260        270        280        290        300 
ARSRAPKPRE LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 

       310        320        330        340        350        360 
MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL SSTEFPELGG 

       370        380        390        400        410        420 
GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS KMGILYILVP SIAIPLVIAC 

       430        440        450        460        470        480 
LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLISQH KQAKLKEISL STVRFMEELG 

       490        500        510        520        530        540 
EDRFGKVYKG HLFGPAPGEP TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL 

       550        560        570        580        590        600 
GVVTKDQPLS MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 

       610        620        630        640        650        660 
AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG NSLLPIRWMS 

       670        680        690        700        710        720 
PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRSRQV LPCPDDCPAW 

       730        740        750        760        770        780 
VYALMIECWN EFPSRRPRFK DIHSRLRSWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN 

       790        800        810        820        830        840 
VSNARYMAPK QKAQPFPQPQ FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV 

       850        860        870        880        890        900 
QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI 

       910        920        930        940 
AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA 

« Hide

References

« Hide 'large scale' references
[1]"Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system."
Oishi I., Takeuchi S., Hashimoto R., Nagabukuro A., Ueda T., Liu Z.J., Hatta T., Akira S., Matsuda Y., Yamamura H., Otani H., Minami Y.
Genes Cells 4:41-56(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development."
DeChiara T.M., Kimble R.B., Poueymirou W.T., Rojas J., Masiakowski P., Valenzuela D.M., Yancopoulos G.D.
Nat. Genet. 24:271-274(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling."
van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S.
Biochem. Biophys. Res. Commun. 390:211-216(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WTIP, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010384 mRNA. Translation: BAA75481.1.
AC111017 Genomic DNA. No translation available.
CCDSCCDS26520.1.
UniGeneMm.342774.

3D structure databases

ProteinModelPortalQ9Z138.
SMRQ9Z138. Positions 33-153, 283-765.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Z138.

Proteomic databases

PRIDEQ9Z138.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021918; ENSMUSP00000021918; ENSMUSG00000021464.

Organism-specific databases

MGIMGI:1347521. Ror2.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117239.
HOGENOMHOG000049104.
HOVERGENHBG017736.
InParanoidQ9Z138.
OMALQLPKCE.
TreeFamTF106465.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressQ9Z138.
BgeeQ9Z138.
CleanExMM_ROR2.
GenevestigatorQ9Z138.

Family and domain databases

Gene3D2.40.20.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR020067. Frizzled_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016247. Tyr_kinase_rcpt_ROR.
[Graphical view]
PfamPF01392. Fz. 1 hit.
PF07679. I-set. 1 hit.
PF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000624. TyrPK_TMrec_ROR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 1 hit.
SM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9Z138.
SOURCESearch...

Entry information

Entry nameROR2_MOUSE
AccessionPrimary (citable) accession number: Q9Z138
Secondary accession number(s): E9QKB3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot