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Q9Z129

- RECQ1_MOUSE

UniProt

Q9Z129 - RECQ1_MOUSE

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Protein

ATP-dependent DNA helicase Q1

Gene
Recql, Recql1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Isoform alpha is a DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Isoform beta may have important roles in the meiotic process. Both isoforms exhibit a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 1208ATP Reviewed prediction

GO - Molecular functioni

  1. annealing helicase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. ATP-dependent 3'-5' DNA helicase activity Source: InterPro
  4. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: InterPro
  2. DNA repair Source: InterPro
  3. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase Q1 (EC:3.6.4.12)
Alternative name(s):
DNA-dependent ATPase Q1
RecQ protein-like 1
Gene namesi
Name:Recql
Synonyms:Recql1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103021. Recql.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. microtubule cytoskeleton Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648ATP-dependent DNA helicase Q1PRO_0000205050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141N6-acetyllysine By similarity
Modified residuei522 – 5221N6-acetyllysine By similarity
Modified residuei633 – 6331Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z129.
PRIDEiQ9Z129.

PTM databases

PhosphoSiteiQ9Z129.

Expressioni

Tissue specificityi

Isoform alpha is expressed in all tissues examined. Isoform beta is only expressed in spermatocytes, expression increases at pachytene (17 days old) and decreases after completion of meiosis II (7 weeks old).1 Publication

Gene expression databases

ArrayExpressiQ9Z129.
BgeeiQ9Z129.
CleanExiMM_RECQL.
GenevestigatoriQ9Z129.

Interactioni

Subunit structurei

Interacts with EXO1 and MLH1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9Z129.
SMRiQ9Z129. Positions 64-593.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 275176Helicase ATP-bindingAdd
BLAST
Domaini299 – 451153Helicase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi219 – 2224DEVH box

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0514.
GeneTreeiENSGT00550000074520.
HOGENOMiHOG000044388.
HOVERGENiHBG057654.
InParanoidiQ3TPI5.
KOiK10899.
OMAiQKFRPLQ.
OrthoDBiEOG7K0ZC0.
TreeFamiTF323555.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q9Z129-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASVSALTEE LESVASELHA IDIQIQELTE RRQELLQRKS VLTGKIKQYL    50
EDSSAEASSD LDTSPAAWNK EDFPWFGKVK DVLQNVFKLQ KFRPLQLETI 100
NVTMARKDIF LVMPTGGGKS LCYQLPALCS DGFTLVICPL ISLMEDQLMV 150
LKQLGISATM LNASSSKEHV KWVHAEMVNK NSQLKLIYVT PEKIAKSKMF 200
MSRLEKAYEA GRLTGAAVDE VHCCSQWGHD FRPDYKALGI LKRQFPNASL 250
MGLTATATNH VLKDVQKILC VGKCLTFTAS FNRPNLFYEV RQKPSSAEDF 300
TEDIVKLING RYKGQSGIIY CFSQKDSEQI TISLQKLGIH AGTYHANMEP 350
EDKTKVHTQW SANELQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ 400
ESGRAGRDDS RADCILYYGF GDIFRISSMV VMENVGQQKL YEMVSYCQNV 450
SKCRRVLIAQ HFDEVWNADA CNKMCDNCCK DVSFEKKNVT QHCRDLIKIL 500
KQAEGLNEKL TPLKLIDAWM GKGAAKLRVA GVVAPALPRE DLERIVAHAL 550
LQQYLKEDYS FTAYATISYL KVGPRACLLS NEAHAVTMQV KKSAQSSVRG 600
ALSEARQVEQ VDSKGEEQSS GNSQKSKSRL QPSGSKNAGA KKRKLDDA 648
Length:648
Mass (Da):72,484
Last modified:July 27, 2011 - v2
Checksum:iDF84B5E9097BF3F3
GO
Isoform Beta (identifier: Q9Z129-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-648: NSQKSKSRLQPSGSKNAGAKKRKLDDA → SHAADTAANV

Show »
Length:631
Mass (Da):70,540
Checksum:i633BAB8A1CA86761
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei622 – 64827NSQKS…KLDDA → SHAADTAANV in isoform Beta. VSP_005567Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161A → V in BAA75085. 1 Publication
Sequence conflicti216 – 2161A → V in BAA75086. 1 Publication
Sequence conflicti518 – 5181A → T in BAA75085. 1 Publication
Sequence conflicti518 – 5181A → T in BAA75086. 1 Publication
Sequence conflicti525 – 5251A → P in BAA75085. 1 Publication
Sequence conflicti525 – 5251A → P in BAA75086. 1 Publication
Sequence conflicti602 – 6021L → P in BAA75085. 1 Publication
Sequence conflicti602 – 6021L → P in BAA75086. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017104 mRNA. Translation: BAA75085.1.
AB017105 mRNA. Translation: BAA75086.1.
AK137589 mRNA. Translation: BAE23422.1.
AK164344 mRNA. Translation: BAE37751.1.
CH466572 Genomic DNA. Translation: EDL10638.1.
CCDSiCCDS39695.1. [Q9Z129-1]
CCDS57465.1. [Q9Z129-2]
RefSeqiNP_001191836.1. NM_001204907.1. [Q9Z129-2]
NP_075529.2. NM_023042.3. [Q9Z129-1]
XP_006506989.1. XM_006506926.1. [Q9Z129-1]
XP_006506990.1. XM_006506927.1. [Q9Z129-1]
UniGeneiMm.27407.

Genome annotation databases

EnsembliENSMUST00000032370; ENSMUSP00000032370; ENSMUSG00000030243. [Q9Z129-2]
ENSMUST00000111803; ENSMUSP00000107434; ENSMUSG00000030243. [Q9Z129-1]
GeneIDi19691.
KEGGimmu:19691.
UCSCiuc009epf.2. mouse. [Q9Z129-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017104 mRNA. Translation: BAA75085.1 .
AB017105 mRNA. Translation: BAA75086.1 .
AK137589 mRNA. Translation: BAE23422.1 .
AK164344 mRNA. Translation: BAE37751.1 .
CH466572 Genomic DNA. Translation: EDL10638.1 .
CCDSi CCDS39695.1. [Q9Z129-1 ]
CCDS57465.1. [Q9Z129-2 ]
RefSeqi NP_001191836.1. NM_001204907.1. [Q9Z129-2 ]
NP_075529.2. NM_023042.3. [Q9Z129-1 ]
XP_006506989.1. XM_006506926.1. [Q9Z129-1 ]
XP_006506990.1. XM_006506927.1. [Q9Z129-1 ]
UniGenei Mm.27407.

3D structure databases

ProteinModelPortali Q9Z129.
SMRi Q9Z129. Positions 64-593.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z129.

Proteomic databases

PaxDbi Q9Z129.
PRIDEi Q9Z129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032370 ; ENSMUSP00000032370 ; ENSMUSG00000030243 . [Q9Z129-2 ]
ENSMUST00000111803 ; ENSMUSP00000107434 ; ENSMUSG00000030243 . [Q9Z129-1 ]
GeneIDi 19691.
KEGGi mmu:19691.
UCSCi uc009epf.2. mouse. [Q9Z129-1 ]

Organism-specific databases

CTDi 5965.
MGIi MGI:103021. Recql.

Phylogenomic databases

eggNOGi COG0514.
GeneTreei ENSGT00550000074520.
HOGENOMi HOG000044388.
HOVERGENi HBG057654.
InParanoidi Q3TPI5.
KOi K10899.
OMAi QKFRPLQ.
OrthoDBi EOG7K0ZC0.
TreeFami TF323555.

Miscellaneous databases

NextBioi 297024.
PROi Q9Z129.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z129.
Bgeei Q9Z129.
CleanExi MM_RECQL.
Genevestigatori Q9Z129.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00614. recQ_fam. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; alpha form is expressed ubiquitously and beta form specifically in the testis."
    Wang W.-S., Seki M., Yamaoka T., Seki T., Tada S., Katada T., Fujimoto H., Enomoto T.
    Biochim. Biophys. Acta 1443:198-202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Spermatocyte and Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Strain: C57BL/6J.
    Tissue: Bone and Spinal ganglion.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 186-196 AND 502-509, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRECQ1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z129
Secondary accession number(s): Q3TPI5, Q9Z128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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