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Q9Z121

- CCL8_MOUSE

UniProt

Q9Z121 - CCL8_MOUSE

Protein

C-C motif chemokine 8

Gene

Ccl8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes. This protein can bind heparin By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 8
    Alternative name(s):
    Monocyte chemoattractant protein 2
    Monocyte chemotactic protein 2
    Short name:
    MCP-2
    Small-inducible cytokine A8
    Gene namesi
    Name:Ccl8
    Synonyms:Mcp2, Scya8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:101878. Ccl8.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 9778C-C motif chemokine 8PRO_0000005190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9Z121.
    PRIDEiQ9Z121.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z121.
    BgeeiQ9Z121.
    CleanExiMM_CCL8.
    GenevestigatoriQ9Z121.

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z121.
    SMRiQ9Z121. Positions 29-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75507.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ9Z121.
    KOiK16596.
    OMAiYERINNI.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiQ9Z121.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z121-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIYAVLLCL LLIAVPVSPE KLTGPDKAPV TCCFHVLKLK IPLRVLKSYE   50
    RINNIQCPME AVVFQTKQGM SLCVDPTQKW VSEYMEILDQ KSQILQP 97
    Length:97
    Mass (Da):11,017
    Last modified:May 1, 1999 - v1
    Checksum:i65BB3722F2F98D54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023418 mRNA. Translation: BAA75014.1.
    AK007942 mRNA. Translation: BAB25365.1.
    CCDSiCCDS36248.1.
    RefSeqiNP_067418.1. NM_021443.3.
    XP_006542947.1. XM_006542884.1.
    UniGeneiMm.42029.

    Genome annotation databases

    EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185.
    GeneIDi102641794.
    20307.
    KEGGimmu:102641794.
    mmu:20307.
    UCSCiuc007kmt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023418 mRNA. Translation: BAA75014.1 .
    AK007942 mRNA. Translation: BAB25365.1 .
    CCDSi CCDS36248.1.
    RefSeqi NP_067418.1. NM_021443.3.
    XP_006542947.1. XM_006542884.1.
    UniGenei Mm.42029.

    3D structure databases

    ProteinModelPortali Q9Z121.
    SMRi Q9Z121. Positions 29-97.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9Z121.
    PRIDEi Q9Z121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009329 ; ENSMUSP00000009329 ; ENSMUSG00000009185 .
    GeneIDi 102641794.
    20307.
    KEGGi mmu:102641794.
    mmu:20307.
    UCSCi uc007kmt.2. mouse.

    Organism-specific databases

    CTDi 6355.
    MGIi MGI:101878. Ccl8.

    Phylogenomic databases

    eggNOGi NOG75507.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q9Z121.
    KOi K16596.
    OMAi YERINNI.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi Q9Z121.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298067.
    PROi Q9Z121.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z121.
    Bgeei Q9Z121.
    CleanExi MM_CCL8.
    Genevestigatori Q9Z121.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Nomiyama H.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiCCL8_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z121
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3