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Protein

C-C motif chemokine 8

Gene

Ccl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell chemotaxis Source: GOC
  • immune response Source: InterPro
  • inflammatory response Source: UniProtKB-KW
  • positive regulation of myoblast differentiation Source: MGI
  • positive regulation of myoblast fusion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:Ccl8
Synonyms:Mcp2, Scya8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101878. Ccl8.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 9778C-C motif chemokine 8PRO_0000005190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z121.
PaxDbiQ9Z121.
PRIDEiQ9Z121.

Expressioni

Gene expression databases

BgeeiQ9Z121.
CleanExiMM_CCL8.
ExpressionAtlasiQ9Z121. baseline and differential.
GenevestigatoriQ9Z121.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Z121.
SMRiQ9Z121. Positions 29-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9Z121.
KOiK16596.
OMAiYERINNI.
OrthoDBiEOG7CVQ1F.
PhylomeDBiQ9Z121.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYAVLLCL LLIAVPVSPE KLTGPDKAPV TCCFHVLKLK IPLRVLKSYE
60 70 80 90
RINNIQCPME AVVFQTKQGM SLCVDPTQKW VSEYMEILDQ KSQILQP
Length:97
Mass (Da):11,017
Last modified:May 1, 1999 - v1
Checksum:i65BB3722F2F98D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023418 mRNA. Translation: BAA75014.1.
AK007942 mRNA. Translation: BAB25365.1.
CCDSiCCDS36248.1.
RefSeqiNP_067418.1. NM_021443.3.
UniGeneiMm.42029.

Genome annotation databases

EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185.
GeneIDi20307.
KEGGimmu:102641794.
mmu:20307.
UCSCiuc007kmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023418 mRNA. Translation: BAA75014.1.
AK007942 mRNA. Translation: BAB25365.1.
CCDSiCCDS36248.1.
RefSeqiNP_067418.1. NM_021443.3.
UniGeneiMm.42029.

3D structure databases

ProteinModelPortaliQ9Z121.
SMRiQ9Z121. Positions 29-97.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9Z121.
PaxDbiQ9Z121.
PRIDEiQ9Z121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185.
GeneIDi20307.
KEGGimmu:102641794.
mmu:20307.
UCSCiuc007kmt.2. mouse.

Organism-specific databases

CTDi6355.
MGIiMGI:101878. Ccl8.

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9Z121.
KOiK16596.
OMAiYERINNI.
OrthoDBiEOG7CVQ1F.
PhylomeDBiQ9Z121.
TreeFamiTF334888.

Miscellaneous databases

NextBioi298067.
PROiQ9Z121.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z121.
CleanExiMM_CCL8.
ExpressionAtlasiQ9Z121. baseline and differential.
GenevestigatoriQ9Z121.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Nomiyama H.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.

Entry informationi

Entry nameiCCL8_MOUSE
AccessioniPrimary (citable) accession number: Q9Z121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.