Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 8

Gene

Ccl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:Ccl8
Synonyms:Mcp2, Scya8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101878. Ccl8.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000519024 – 97C-C motif chemokine 8Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z121.
PRIDEiQ9Z121.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009185.
CleanExiMM_CCL8.
ExpressionAtlasiQ9Z121. baseline and differential.
GenevisibleiQ9Z121. MM.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009329.

Structurei

3D structure databases

ProteinModelPortaliQ9Z121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9Z121.
KOiK16596.
OMAiYERINNI.
OrthoDBiEOG091G14KV.
PhylomeDBiQ9Z121.
TreeFamiTF334888.

Family and domain databases

InterProiIPR033225. CCL8.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF74. PTHR12015:SF74. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYAVLLCL LLIAVPVSPE KLTGPDKAPV TCCFHVLKLK IPLRVLKSYE
60 70 80 90
RINNIQCPME AVVFQTKQGM SLCVDPTQKW VSEYMEILDQ KSQILQP
Length:97
Mass (Da):11,017
Last modified:May 1, 1999 - v1
Checksum:i65BB3722F2F98D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023418 mRNA. Translation: BAA75014.1.
AK007942 mRNA. Translation: BAB25365.1.
CCDSiCCDS36248.1.
RefSeqiNP_067418.1. NM_021443.3.
UniGeneiMm.42029.

Genome annotation databases

EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185.
GeneIDi20307.
KEGGimmu:20307.
UCSCiuc007kmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023418 mRNA. Translation: BAA75014.1.
AK007942 mRNA. Translation: BAB25365.1.
CCDSiCCDS36248.1.
RefSeqiNP_067418.1. NM_021443.3.
UniGeneiMm.42029.

3D structure databases

ProteinModelPortaliQ9Z121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009329.

Proteomic databases

PaxDbiQ9Z121.
PRIDEiQ9Z121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009329; ENSMUSP00000009329; ENSMUSG00000009185.
GeneIDi20307.
KEGGimmu:20307.
UCSCiuc007kmt.2. mouse.

Organism-specific databases

CTDi6355.
MGIiMGI:101878. Ccl8.

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9Z121.
KOiK16596.
OMAiYERINNI.
OrthoDBiEOG091G14KV.
PhylomeDBiQ9Z121.
TreeFamiTF334888.

Miscellaneous databases

PROiQ9Z121.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009185.
CleanExiMM_CCL8.
ExpressionAtlasiQ9Z121. baseline and differential.
GenevisibleiQ9Z121. MM.

Family and domain databases

InterProiIPR033225. CCL8.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF74. PTHR12015:SF74. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL8_MOUSE
AccessioniPrimary (citable) accession number: Q9Z121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.