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Q9Z120

- TRMB_MOUSE

UniProt

Q9Z120 - TRMB_MOUSE

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
Mettl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei154 – 1541S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei157 – 1571 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Methyltransferase-like protein 1
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:Mettl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1339986. Mettl1.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine; by PKB and RPS6KA3 By similarity

Post-translational modificationi

Phosphorylation at Ser-21 inactivates its catalytic activity but does not affect the interaction with WDR4 By similarity.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z120.
PaxDbiQ9Z120.
PRIDEiQ9Z120.

PTM databases

PhosphoSiteiQ9Z120.

Expressioni

Gene expression databases

ArrayExpressiQ9Z120.
BgeeiQ9Z120.
CleanExiMM_METTL1.
GenevestigatoriQ9Z120.

Interactioni

Subunit structurei

Forms a complex with WDR4 By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9Z120.
SMRiQ9Z120. Positions 31-259.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1022S-adenosyl-L-methionine binding By similarity
Regioni134 – 1352S-adenosyl-L-methionine binding By similarity
Regioni232 – 2343S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
GeneTreeiENSGT00390000017840.
HOGENOMiHOG000260965.
HOVERGENiHBG044569.
InParanoidiQ3TU83.
KOiK03439.
OMAiRAHSNPI.
PhylomeDBiQ9Z120.
TreeFamiTF314083.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z120-1 [UniParc]FASTAAdd to Basket

« Hide

MMAGAEAPQP QKRYYRQRAH SNPMADHTLR YPVKPEEMDW SELYPEFFAP    50
LIQNKSHDDP KDEKEKHSGA QVEFADIGCG YGGLLVALSP LFPDTLILGL 100
EIRVKVSDYV QDRIRALRAA PGGGFQNIAC LRSNAMKHLP NFFRKGQLAK 150
MFFLFPDPHF KRTKHKWRII SPTLLAEYAY VLRVGGLVYT VTDVPELHEW 200
MCTHFEEHPL FERVPLEELS EDPIVEHLGS STEEGKKVLR NGGKNFPAVF 250
RRIQDPLLQA VTPNPTLP 268
Length:268
Mass (Da):30,603
Last modified:May 1, 1999 - v1
Checksum:i1DAE1EEAA4A07627
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521I → N in AAH12649. 1 Publication
Sequence conflicti56 – 561S → N in AAH12649. 1 Publication
Sequence conflicti213 – 2131R → C in AAH12649. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023619 mRNA. Translation: BAA75230.1.
AK160914 mRNA. Translation: BAE36088.1.
CH466578 Genomic DNA. Translation: EDL24462.1.
BC012649 mRNA. Translation: AAH12649.1.
Y18644 mRNA. Translation: CAA77240.1.
CCDSiCCDS24223.1.
RefSeqiNP_034922.1. NM_010792.1.
UniGeneiMm.251593.

Genome annotation databases

EnsembliENSMUST00000006915; ENSMUSP00000006915; ENSMUSG00000006732.
GeneIDi17299.
KEGGimmu:17299.
UCSCiuc007hhq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023619 mRNA. Translation: BAA75230.1 .
AK160914 mRNA. Translation: BAE36088.1 .
CH466578 Genomic DNA. Translation: EDL24462.1 .
BC012649 mRNA. Translation: AAH12649.1 .
Y18644 mRNA. Translation: CAA77240.1 .
CCDSi CCDS24223.1.
RefSeqi NP_034922.1. NM_010792.1.
UniGenei Mm.251593.

3D structure databases

ProteinModelPortali Q9Z120.
SMRi Q9Z120. Positions 31-259.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z120.

Proteomic databases

MaxQBi Q9Z120.
PaxDbi Q9Z120.
PRIDEi Q9Z120.

Protocols and materials databases

DNASUi 17299.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006915 ; ENSMUSP00000006915 ; ENSMUSG00000006732 .
GeneIDi 17299.
KEGGi mmu:17299.
UCSCi uc007hhq.1. mouse.

Organism-specific databases

CTDi 4234.
MGIi MGI:1339986. Mettl1.

Phylogenomic databases

eggNOGi COG0220.
GeneTreei ENSGT00390000017840.
HOGENOMi HOG000260965.
HOVERGENi HBG044569.
InParanoidi Q3TU83.
KOi K03439.
OMAi RAHSNPI.
PhylomeDBi Q9Z120.
TreeFami TF314083.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Miscellaneous databases

NextBioi 291830.
PROi Q9Z120.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z120.
Bgeei Q9Z120.
CleanExi MM_METTL1.
Genevestigatori Q9Z120.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Methyltransferase related protein."
    Tamura M., Nashimoto M., Kaspar R.L.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Extraembryonic tissue and Placenta.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation."
    Bahr A., Hankeln T., Fiedler T., Hegemann J., Schmidt E.R.
    Genomics 57:424-428(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-268.
    Tissue: Brain.

Entry informationi

Entry nameiTRMB_MOUSE
AccessioniPrimary (citable) accession number: Q9Z120
Secondary accession number(s): Q3TU83, Q921G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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