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Protein

Polypyrimidine tract-binding protein 3

Gene

Ptbp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity).By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: RGD

GO - Biological processi

  • erythrocyte maturation Source: UniProtKB-KW
  • mRNA processing Source: UniProtKB-KW
  • regulation of cell differentiation Source: RGD
  • RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Erythrocyte maturation, mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polypyrimidine tract-binding protein 3
Alternative name(s):
Regulator of differentiation 1
Short name:
Rod1
Gene namesi
Name:Ptbp3
Synonyms:Rod1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621671. Ptbp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Polypyrimidine tract-binding protein 3PRO_0000081875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei394 – 3941N6-acetyllysineBy similarity
Modified residuei425 – 4251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z118.
PRIDEiQ9Z118.

PTM databases

iPTMnetiQ9Z118.
PhosphoSiteiQ9Z118.

Expressioni

Tissue specificityi

Detected specifically in spleen, thymus, lungs, and bone marrow.1 Publication

Developmental stagei

At E18 and P1 expressed predominantly in thymus and liver, and at lower levels in brain, muscle and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000016334.
ExpressionAtlasiQ9Z118. baseline and differential.
GenevisibleiQ9Z118. RN.

Interactioni

Subunit structurei

Interacts with THBS4 (via the acidic amphipathic C-terminus).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022107.

Structurei

3D structure databases

ProteinModelPortaliQ9Z118.
SMRiQ9Z118. Positions 28-117, 141-267, 315-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 11485RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini153 – 22977RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 40375RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini446 – 52176RRM 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1190. Eukaryota.
ENOG410XPMZ. LUCA.
GeneTreeiENSGT00550000074508.
HOGENOMiHOG000231699.
HOVERGENiHBG069548.
InParanoidiQ9Z118.
KOiK17844.
PhylomeDBiQ9Z118.
TreeFamiTF319824.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L/PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033110. PTBP3.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR24012:SF376. PTHR24012:SF376. 3 hits.
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 1 hit.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSTSAGVY ANGNDNKKFK GDRPPCSPSR VLHLRKIPCD VTEAEVISLG
60 70 80 90 100
LPFGKVTNLL MLKGKSQAFL EMASEEAAVT MINYYTPVTP HLRSQPVYIQ
110 120 130 140 150
YSNHRELKTD NLPNQARAQA ALQAVSAVQS GNLSLPGATS NEGTLLPGQS
160 170 180 190 200
PVLRIIIENL FYPVTLEVLH QIFSKFGTVL KIITFTKNNQ FQALLQYADP
210 220 230 240 250
VNAQYAKMAL DGQNIYNACC TLRIDFSKLT SLNVKYNNDK SRDFTRLDLP
260 270 280 290 300
TGDGQPSLEP PMAAAFGAPG IMSSPYAGAA GFAPAIAFPQ AAGLSVSAVP
310 320 330 340 350
GALGPLTLTS SAVSGRMAIP GASGIPGNSV LLVTNLNPDF ITPHGLFILF
360 370 380 390 400
GVYGDVHRVK IMFNKKENAL VQMADASQAQ IAMNHLSGQR LYGKVLRATL
410 420 430 440 450
SKHQAVQLPR EGQEDQGLTK DFSNSPLHRF KKPGSKNFQN IFPPSATLHL
460 470 480 490 500
SNIPPSVTMD DLKNLFTEAG CSVKAFKFFQ KDRKMALIQL GSVEEAIQAL
510 520
IELHNHDLGE NHHLRVSFSK STI
Length:523
Mass (Da):56,716
Last modified:May 1, 1999 - v1
Checksum:iA2B9D5B427D316DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023966 mRNA. Translation: BAA75465.1.
RefSeqiNP_112636.1. NM_031346.1.
UniGeneiRn.162818.
Rn.51103.

Genome annotation databases

EnsembliENSRNOT00000022107; ENSRNOP00000022107; ENSRNOG00000016334.
GeneIDi83515.
KEGGirno:83515.
UCSCiRGD:621671. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023966 mRNA. Translation: BAA75465.1.
RefSeqiNP_112636.1. NM_031346.1.
UniGeneiRn.162818.
Rn.51103.

3D structure databases

ProteinModelPortaliQ9Z118.
SMRiQ9Z118. Positions 28-117, 141-267, 315-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022107.

PTM databases

iPTMnetiQ9Z118.
PhosphoSiteiQ9Z118.

Proteomic databases

PaxDbiQ9Z118.
PRIDEiQ9Z118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022107; ENSRNOP00000022107; ENSRNOG00000016334.
GeneIDi83515.
KEGGirno:83515.
UCSCiRGD:621671. rat.

Organism-specific databases

CTDi9991.
RGDi621671. Ptbp3.

Phylogenomic databases

eggNOGiKOG1190. Eukaryota.
ENOG410XPMZ. LUCA.
GeneTreeiENSGT00550000074508.
HOGENOMiHOG000231699.
HOVERGENiHBG069548.
InParanoidiQ9Z118.
KOiK17844.
PhylomeDBiQ9Z118.
TreeFamiTF319824.

Miscellaneous databases

PROiQ9Z118.

Gene expression databases

BgeeiENSRNOG00000016334.
ExpressionAtlasiQ9Z118. baseline and differential.
GenevisibleiQ9Z118. RN.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR006536. HnRNP-L/PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033110. PTBP3.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR24012:SF376. PTHR24012:SF376. 3 hits.
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 4 hits.
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 1 hit.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTBP3_RAT
AccessioniPrimary (citable) accession number: Q9Z118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.