ID   GA45G_MOUSE             Reviewed;         159 AA.
AC   Q9Z111;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   08-NOV-2023, entry version 118.
DE   RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 gamma;
DE   AltName: Full=Cytokine-responsive protein CR6;
GN   Name=Gadd45g; Synonyms=Cr6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10490824; DOI=10.1038/sj.onc.1202885;
RA   Zhang W., Bae I., Krishnaraju K., Azam N., Fan W., Smith K., Hoffman B.,
RA   Liebermann D.A.;
RT   "CR6: a third member in the MyD118 and Gadd45 gene family which functions
RT   in negative growth control.";
RL   Oncogene 18:4899-4907(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC       activation of stress-responsive MTK1/MEKK4 MAPKKK.
CC   -!- SUBUNIT: Undergoes concentration-dependent homodimerization, which is
CC       required for growth inhibititory activity and enhances interaction with
CC       PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9Z111; P39689: Cdkn1a; NbExp=2; IntAct=EBI-1173616, EBI-1174103;
CC       Q9Z111; Q9Z111: Gadd45g; NbExp=5; IntAct=EBI-1173616, EBI-1173616;
CC       Q9Z111; P17918: Pcna; NbExp=2; IntAct=EBI-1173616, EBI-1173716;
CC       Q9Z111; P12004: PCNA; Xeno; NbExp=9; IntAct=EBI-1173616, EBI-358311;
CC   -!- DOMAIN: Two central helices mediate homodimerization through parallel
CC       packing. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR   EMBL; AF055638; AAD15798.1; -; mRNA.
DR   EMBL; AK002237; BAB21955.1; -; mRNA.
DR   PDB; 3CG6; X-ray; 1.70 A; A/B=15-159.
DR   PDBsum; 3CG6; -.
DR   AlphaFoldDB; Q9Z111; -.
DR   SMR; Q9Z111; -.
DR   DIP; DIP-29978N; -.
DR   IntAct; Q9Z111; 3.
DR   STRING; 10090.ENSMUSP00000021903; -.
DR   PaxDb; 10090-ENSMUSP00000021903; -.
DR   AGR; MGI:1346325; -.
DR   MGI; MGI:1346325; Gadd45g.
DR   eggNOG; ENOG502RXKU; Eukaryota.
DR   InParanoid; Q9Z111; -.
DR   PhylomeDB; Q9Z111; -.
DR   ChiTaRS; Gadd45g; mouse.
DR   EvolutionaryTrace; Q9Z111; -.
DR   PRO; PR:Q9Z111; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9Z111; Protein.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISO:MGI.
DR   GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; TAS:MGI.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR024824; GADD45.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR   PANTHER; PTHR10411; GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45; 1.
DR   PANTHER; PTHR10411:SF4; GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Apoptosis; Developmental protein; Differentiation;
KW   Reference proteome.
FT   CHAIN           1..159
FT                   /note="Growth arrest and DNA damage-inducible protein
FT                   GADD45 gamma"
FT                   /id="PRO_0000148337"
FT   REGION          43..86
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   HELIX           22..36
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   STRAND          39..42
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           43..52
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           54..56
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   STRAND          57..63
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           67..70
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           72..87
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   STRAND          91..95
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           98..104
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   STRAND          118..123
FT                   /evidence="ECO:0007829|PDB:3CG6"
FT   HELIX           133..147
FT                   /evidence="ECO:0007829|PDB:3CG6"
SQ   SEQUENCE   159 AA;  17211 MW;  4B5996927C57988F CRC64;
     MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAHGQGCLT AGVYESAKVL NVDPDNVTFC
     VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGADEE GGAPGDLHCI
     LISNPNEDTW KDPALEKLSL FCEESRSFND WVPSITLPE
//