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Q9Z111

- GA45G_MOUSE

UniProt

Q9Z111 - GA45G_MOUSE

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Protein

Growth arrest and DNA damage-inducible protein GADD45 gamma

Gene

Gadd45g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. apoptotic process Source: UniProtKB-KW
  3. interferon-gamma biosynthetic process Source: MGI
  4. negative regulation of protein kinase activity Source: MGI
  5. regulation of cell cycle Source: MGI
  6. response to stress Source: InterPro
  7. T-helper 1 cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 gamma
Alternative name(s):
Cytokine-responsive protein CR6
Gene namesi
Name:Gadd45g
Synonyms:Cr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1346325. Gadd45g.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Growth arrest and DNA damage-inducible protein GADD45 gammaPRO_0000148337Add
BLAST

Proteomic databases

PRIDEiQ9Z111.

Expressioni

Gene expression databases

CleanExiMM_GADD45G.
GenevestigatoriQ9Z111.

Interactioni

Subunit structurei

Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdkn1aP396892EBI-1173616,EBI-1174103
PCNAP120049EBI-1173616,EBI-358311From a different organism.
PcnaP179182EBI-1173616,EBI-1173716

Protein-protein interaction databases

DIPiDIP-29978N.
IntActiQ9Z111. 3 interactions.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3615Combined sources
Beta strandi39 – 424Combined sources
Helixi43 – 5210Combined sources
Helixi54 – 563Combined sources
Beta strandi57 – 637Combined sources
Helixi67 – 704Combined sources
Helixi72 – 8716Combined sources
Beta strandi91 – 955Combined sources
Helixi98 – 1047Combined sources
Beta strandi118 – 1236Combined sources
Helixi133 – 14715Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CG6X-ray1.70A/B15-159[»]
ProteinModelPortaliQ9Z111.
SMRiQ9Z111. Positions 15-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z111.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 8644HomodimerizationBy similarityAdd
BLAST

Domaini

Two central helices mediate homodimerization through parallel packing.By similarity

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiNOG79725.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiQ9Z111.
PhylomeDBiQ9Z111.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAHGQGCLT AGVYESAKVL
60 70 80 90 100
NVDPDNVTFC VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR
110 120 130 140 150
LAAIVGADEE GGAPGDLHCI LISNPNEDTW KDPALEKLSL FCEESRSFND

WVPSITLPE
Length:159
Mass (Da):17,211
Last modified:May 1, 1999 - v1
Checksum:i4B5996927C57988F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055638 mRNA. Translation: AAD15798.1.
AK002237 mRNA. Translation: BAB21955.1.
UniGeneiMm.281298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055638 mRNA. Translation: AAD15798.1 .
AK002237 mRNA. Translation: BAB21955.1 .
UniGenei Mm.281298.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CG6 X-ray 1.70 A/B 15-159 [» ]
ProteinModelPortali Q9Z111.
SMRi Q9Z111. Positions 15-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29978N.
IntActi Q9Z111. 3 interactions.

Proteomic databases

PRIDEi Q9Z111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1346325. Gadd45g.

Phylogenomic databases

eggNOGi NOG79725.
HOGENOMi HOG000013221.
HOVERGENi HBG051684.
InParanoidi Q9Z111.
PhylomeDBi Q9Z111.

Miscellaneous databases

ChiTaRSi Gadd45g. mouse.
EvolutionaryTracei Q9Z111.
PROi Q9Z111.
SOURCEi Search...

Gene expression databases

CleanExi MM_GADD45G.
Genevestigatori Q9Z111.

Family and domain databases

Gene3Di 3.30.1330.30. 1 hit.
InterProi IPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view ]
PANTHERi PTHR10411. PTHR10411. 1 hit.
Pfami PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view ]
SUPFAMi SSF55315. SSF55315. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control."
    Zhang W., Bae I., Krishnaraju K., Azam N., Fan W., Smith K., Hoffman B., Liebermann D.A.
    Oncogene 18:4899-4907(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiGA45G_MOUSE
AccessioniPrimary (citable) accession number: Q9Z111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3