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Reviewed, UniProtKB/Swiss-Prot Q9Z111 (GA45G_MOUSE)

Last modified February 9, 2010. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Growth arrest and DNA-damage-inducible protein GADD45 gamma
Alternative name(s):
    Cytokine-responsive protein CR6
Gene names
Name: Gadd45g
Synonyms: Cr6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Subunit structure

Interacts with GADD45GIP1 By similarity.

Sequence similarities

Belongs to the GADD45 family.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdkn1aP396891EBI-1173616,EBI-1174103
PCNAP120044EBI-1173616,EBI-358311From a different organism.
PcnaP179181EBI-1173616,EBI-1173716

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Growth arrest and DNA-damage-inducible protein GADD45 gamma
PRO_0000148337

Secondary structure

1 .................... 159
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q9Z111-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 4B5996927C57988F

FASTA15917,211
        10         20         30         40         50         60 
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAHGQGCLT AGVYESAKVL NVDPDNVTFC 

        70         80         90        100        110        120 
VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGADEE GGAPGDLHCI 

       130        140        150 
LISNPNEDTW KDPALEKLSL FCEESRSFND WVPSITLPE

« Hide

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References

« Hide 'large scale' references
[1]"CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control."
Zhang W., Bae I., Krishnaraju K., Azam N., Fan W., Smith K., Hoffman B., Liebermann D.A.
Oncogene 18:4899-4907(1999) [PubMed: 10490824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF055638 mRNA. Translation: AAD15798.1.
AK002237 mRNA. Translation: BAB21955.1.
IPIIPI00129352.
UniGeneMm.281298

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CG6X-ray1.70A/B15-159[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29978N.
IntActQ9Z111. 3 interactions.
STRINGQ9Z111.

Proteomic databases

PRIDEQ9Z111.

Genome annotation databases

EnsemblENSMUST00000021903; ENSMUSP00000021903; ENSMUSG00000021453; Mus musculus. [Genome view]
UCSCuc007qmq.1. mouse.

Organism-specific databases

MGIMGI:1346325. Gadd45g.

Phylogenomic databases

HOGENOMHBG445270.
HOVERGENQ9Z111.
InParanoidQ9Z111.

Gene expression databases

ArrayExpressQ9Z111.
BgeeQ9Z111.
CleanExMM_GADD45G.
GenevestigatorQ9Z111.
GermOnlineENSMUSG00000021453. Mus musculus.

Family and domain databases

InterProIPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio303623.
SOURCESearch...

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Entry information

Entry nameGA45G_MOUSE
AccessionPrimary (citable) accession number: Q9Z111
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents