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Q9Z111

- GA45G_MOUSE

UniProt

Q9Z111 - GA45G_MOUSE

Protein

Growth arrest and DNA damage-inducible protein GADD45 gamma

Gene

Gadd45g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPKK activity Source: MGI
    2. apoptotic process Source: UniProtKB-KW
    3. interferon-gamma biosynthetic process Source: MGI
    4. negative regulation of protein kinase activity Source: MGI
    5. regulation of cell cycle Source: MGI
    6. response to stress Source: InterPro
    7. T-helper 1 cell differentiation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Apoptosis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 gamma
    Alternative name(s):
    Cytokine-responsive protein CR6
    Gene namesi
    Name:Gadd45g
    Synonyms:Cr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1346325. Gadd45g.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Growth arrest and DNA damage-inducible protein GADD45 gammaPRO_0000148337Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z111.

    Expressioni

    Gene expression databases

    CleanExiMM_GADD45G.
    GenevestigatoriQ9Z111.

    Interactioni

    Subunit structurei

    Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cdkn1aP396892EBI-1173616,EBI-1174103
    PCNAP120049EBI-1173616,EBI-358311From a different organism.
    PcnaP179182EBI-1173616,EBI-1173716

    Protein-protein interaction databases

    DIPiDIP-29978N.
    IntActiQ9Z111. 3 interactions.

    Structurei

    Secondary structure

    1
    159
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi22 – 3615
    Beta strandi39 – 424
    Helixi43 – 5210
    Helixi54 – 563
    Beta strandi57 – 637
    Helixi67 – 704
    Helixi72 – 8716
    Beta strandi91 – 955
    Helixi98 – 1047
    Beta strandi118 – 1236
    Helixi133 – 14715

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CG6X-ray1.70A/B15-159[»]
    ProteinModelPortaliQ9Z111.
    SMRiQ9Z111. Positions 15-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Z111.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 8644HomodimerizationBy similarityAdd
    BLAST

    Domaini

    Two central helices mediate homodimerization through parallel packing.By similarity

    Sequence similaritiesi

    Belongs to the GADD45 family.Curated

    Phylogenomic databases

    eggNOGiNOG79725.
    HOGENOMiHOG000013221.
    HOVERGENiHBG051684.
    InParanoidiQ9Z111.
    PhylomeDBiQ9Z111.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    InterProiIPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view]
    PANTHERiPTHR10411. PTHR10411. 1 hit.
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAHGQGCLT AGVYESAKVL    50
    NVDPDNVTFC VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR 100
    LAAIVGADEE GGAPGDLHCI LISNPNEDTW KDPALEKLSL FCEESRSFND 150
    WVPSITLPE 159
    Length:159
    Mass (Da):17,211
    Last modified:May 1, 1999 - v1
    Checksum:i4B5996927C57988F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055638 mRNA. Translation: AAD15798.1.
    AK002237 mRNA. Translation: BAB21955.1.
    UniGeneiMm.281298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055638 mRNA. Translation: AAD15798.1 .
    AK002237 mRNA. Translation: BAB21955.1 .
    UniGenei Mm.281298.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CG6 X-ray 1.70 A/B 15-159 [» ]
    ProteinModelPortali Q9Z111.
    SMRi Q9Z111. Positions 15-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29978N.
    IntActi Q9Z111. 3 interactions.

    Proteomic databases

    PRIDEi Q9Z111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1346325. Gadd45g.

    Phylogenomic databases

    eggNOGi NOG79725.
    HOGENOMi HOG000013221.
    HOVERGENi HBG051684.
    InParanoidi Q9Z111.
    PhylomeDBi Q9Z111.

    Miscellaneous databases

    ChiTaRSi GADD45G. mouse.
    EvolutionaryTracei Q9Z111.
    PROi Q9Z111.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GADD45G.
    Genevestigatori Q9Z111.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    InterProi IPR024824. GADD45.
    IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    [Graphical view ]
    PANTHERi PTHR10411. PTHR10411. 1 hit.
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control."
      Zhang W., Bae I., Krishnaraju K., Azam N., Fan W., Smith K., Hoffman B., Liebermann D.A.
      Oncogene 18:4899-4907(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.

    Entry informationi

    Entry nameiGA45G_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3