Q9Z111 (GA45G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 gamma

Alternative name(s):
Cytokine-responsive protein CR6

Gene names

Name:	Gadd45g
Synonyms:	Cr6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Subunit structure	Interacts with GADD45GIP1 By similarity.
Sequence similarities	Belongs to the GADD45 family.

Ontologies

Keywords
Biological process	Apoptosis Differentiation
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T-helper 1 cell differentiation Traceable author statement PubMed 12213961. Source: MGI activation of MAPKK activity Inferred from direct assay PubMed 12213961. Source: MGI apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW interferon-gamma biosynthetic process Traceable author statement PubMed 12213961. Source: MGI negative regulation of protein kinase activity Inferred from direct assay PubMed 12124778. Source: MGI regulation of cell cycle Inferred from direct assay PubMed 12124778. Source: MGI response to stress Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Traceable author statement PubMed 12124778. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cdkn1a	P39689	2	EBI-1173616,EBI-1174103
PCNA	P12004	9	EBI-1173616,EBI-358311	From a different organism.
Pcna	P17918	2	EBI-1173616,EBI-1173716

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 159

159

Growth arrest and DNA damage-inducible protein GADD45 gamma

PRO_0000148337

Secondary structure

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159

Helix Strand Turn

Details...

Helix

22 – 36

15

Beta strand

39 – 42

4

Helix

43 – 52

10

Helix

54 – 56

3

Beta strand

57 – 63

7

Helix

67 – 70

4

Helix

72 – 87

16

Beta strand

91 – 95

5

Helix

98 – 104

7

Beta strand

118 – 123

6

Helix

133 – 147

15

Sequences

	Sequence		Length	Mass (Da)
	Q9Z111 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 4B5996927C57988F	FASTA	159	17,211
	10 20 30 40 50 60 MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAHGQGCLT AGVYESAKVL NVDPDNVTFC 70 80 90 100 110 120 VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGADEE GGAPGDLHCI 130 140 150 LISNPNEDTW KDPALEKLSL FCEESRSFND WVPSITLPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control." Zhang W., Bae I., Krishnaraju K., Azam N., Fan W., Smith K., Hoffman B., Liebermann D.A. Oncogene 18:4899-4907(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF055638 mRNA. Translation: AAD15798.1.
AK002237 mRNA. Translation: BAB21955.1.

IPI

IPI00129352.

UniGene

Mm.281298.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3CG6	X-ray	1.70	A/B	15-159	[»]

ProteinModelPortal

Q9Z111.

SMR

Q9Z111. Positions 15-159.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29978N.

IntAct

Q9Z111. 3 interactions.

Proteomic databases

PRIDE

Q9Z111.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:1346325. Gadd45g.

Phylogenomic databases

eggNOG

NOG79725.

HOGENOM

HOG000013221.

HOVERGEN

HBG051684.

InParanoid

Q9Z111.

OrthoDB

EOG4KWJV5.

Gene expression databases

CleanEx

MM_GADD45G.

Genevestigator

Q9Z111.

GermOnline

ENSMUSG00000021453. Mus musculus.

Family and domain databases

InterPro

IPR024824. GADD45.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]

PANTHER

PTHR10411. PTHR10411. 1 hit.

Pfam

PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

GADD45G. mouse.

EvolutionaryTrace

Q9Z111.

SOURCE

Search...

Entry information

Entry name

GA45G_MOUSE

Accession

Primary (citable) accession number: Q9Z111

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program