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Protein

Double-stranded RNA-binding protein Staufen homolog 1

Gene

Stau1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-binding protein Staufen homolog 1
Gene namesi
Name:Stau1
Synonyms:Stau
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338864. Stau1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Double-stranded RNA-binding protein Staufen homolog 1PRO_0000072244Add
BLAST

Proteomic databases

MaxQBiQ9Z108.
PaxDbiQ9Z108.
PRIDEiQ9Z108.

PTM databases

PhosphoSiteiQ9Z108.

Expressioni

Gene expression databases

BgeeiQ9Z108.
ExpressionAtlasiQ9Z108. baseline and differential.
GenevisibleiQ9Z108. MM.

Interactioni

Subunit structurei

Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi203528. 3 interactions.
IntActiQ9Z108. 2 interactions.
STRINGi10090.ENSMUSP00000104861.

Structurei

3D structure databases

ProteinModelPortaliQ9Z108.
SMRiQ9Z108. Positions 98-164, 197-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 16368DRBM 1PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 26469DRBM 2PROSITE-ProRule annotationAdd
BLAST

Domaini

One of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).

Sequence similaritiesi

Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299502.
GeneTreeiENSGT00760000119275.
HOGENOMiHOG000231025.
HOVERGENiHBG005013.
InParanoidiQ9Z108.

Family and domain databases

Gene3Di3.30.160.20. 3 hits.
InterProiIPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKPVDPHSR MQSTYSYGMR GGAYPPRYFY PFPVPPLLYQ VELSVGGQQF
60 70 80 90 100
NGKGKMRPPV KHDAPARALR TLQSEPLPER LEVNGREAEE ENLNKSEISQ
110 120 130 140 150
VFEIALKRNL PVNFEVARES GPPHMKNFVT RVSVGEFVGE GEGKSKKISK
160 170 180 190 200
KNAARAVLEQ LRRLPPLPAV ERVKPRIKKK SQPTCKTAPD YGQGMNPISR
210 220 230 240 250
LAQIQQAKKE KEPEYMLLTE RGLPRRREFV MQVKVGHHTA EGVGTNKKVA
260 270 280 290 300
KRNAAENMLE ILGFKVPQAQ PAKPALKSEE KTPVKKPGDG RKVTFFEPSP
310 320 330 340 350
GDENGTSNKD EEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT
360 370 380 390 400
RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKSNISSGH VPHGPRTRPS
410 420 430 440 450
EQLYYLSRAQ GFQVEYKDFP KNNKNECVSL INCSSQPPLV SHGIGKDVES
460 470 480
CHDMAALNIL KLLSELDQQS TEMPRTGNGP VSACGRC
Length:487
Mass (Da):53,925
Last modified:May 1, 1999 - v1
Checksum:i840260693DC49180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061942 mRNA. Translation: AAD17529.1.
CCDSiCCDS17093.1.
RefSeqiNP_035620.1. NM_011490.4.
UniGeneiMm.73276.

Genome annotation databases

EnsembliENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536.
GeneIDi20853.
UCSCiuc008nyv.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061942 mRNA. Translation: AAD17529.1.
CCDSiCCDS17093.1.
RefSeqiNP_035620.1. NM_011490.4.
UniGeneiMm.73276.

3D structure databases

ProteinModelPortaliQ9Z108.
SMRiQ9Z108. Positions 98-164, 197-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203528. 3 interactions.
IntActiQ9Z108. 2 interactions.
STRINGi10090.ENSMUSP00000104861.

PTM databases

PhosphoSiteiQ9Z108.

Proteomic databases

MaxQBiQ9Z108.
PaxDbiQ9Z108.
PRIDEiQ9Z108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536.
GeneIDi20853.
UCSCiuc008nyv.3. mouse.

Organism-specific databases

CTDi6780.
MGIiMGI:1338864. Stau1.

Phylogenomic databases

eggNOGiNOG299502.
GeneTreeiENSGT00760000119275.
HOGENOMiHOG000231025.
HOVERGENiHBG005013.
InParanoidiQ9Z108.

Miscellaneous databases

ChiTaRSiStau1. mouse.
NextBioi299647.
PROiQ9Z108.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z108.
ExpressionAtlasiQ9Z108. baseline and differential.
GenevisibleiQ9Z108. MM.

Family and domain databases

Gene3Di3.30.160.20. 3 hits.
InterProiIPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum."
    Wickham L., Duchaine T., Luo M., Nabi I.R., DesGroseillers L.
    Mol. Cell. Biol. 19:2220-2230(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetus.

Entry informationi

Entry nameiSTAU1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.