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Q9Z108 (STAU1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Double-stranded RNA-binding protein Staufen homolog 1
Gene names
Name:Stau1
Synonyms:Stau
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

Subunit structure

Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner By similarity.

Subcellular location

Cytoplasm By similarity. Rough endoplasmic reticulum. Note: Localizes exclusively with the rough reticulum endoplasmic (RER).

Domain

One of the DRDB could be involved in RER binding.

The C-terminal contains the tubulin binding domain (TBD).

Sequence similarities

Contains 2 DRBM (double-stranded RNA-binding) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Double-stranded RNA-binding protein Staufen homolog 1
PRO_0000072244

Regions

Domain96 – 16368DRBM 1
Domain196 – 26469DRBM 2

Sequences

Sequence LengthMass (Da)Tools
Q9Z108 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 840260693DC49180

FASTA48753,925
        10         20         30         40         50         60 
MYKPVDPHSR MQSTYSYGMR GGAYPPRYFY PFPVPPLLYQ VELSVGGQQF NGKGKMRPPV 

        70         80         90        100        110        120 
KHDAPARALR TLQSEPLPER LEVNGREAEE ENLNKSEISQ VFEIALKRNL PVNFEVARES 

       130        140        150        160        170        180 
GPPHMKNFVT RVSVGEFVGE GEGKSKKISK KNAARAVLEQ LRRLPPLPAV ERVKPRIKKK 

       190        200        210        220        230        240 
SQPTCKTAPD YGQGMNPISR LAQIQQAKKE KEPEYMLLTE RGLPRRREFV MQVKVGHHTA 

       250        260        270        280        290        300 
EGVGTNKKVA KRNAAENMLE ILGFKVPQAQ PAKPALKSEE KTPVKKPGDG RKVTFFEPSP 

       310        320        330        340        350        360 
GDENGTSNKD EEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT 

       370        380        390        400        410        420 
VTAMIARELL YGGTSPTAET ILKSNISSGH VPHGPRTRPS EQLYYLSRAQ GFQVEYKDFP 

       430        440        450        460        470        480 
KNNKNECVSL INCSSQPPLV SHGIGKDVES CHDMAALNIL KLLSELDQQS TEMPRTGNGP 


VSACGRC 

« Hide

References

[1]"Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum."
Wickham L., Duchaine T., Luo M., Nabi I.R., DesGroseillers L.
Mol. Cell. Biol. 19:2220-2230(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF061942 mRNA. Translation: AAD17529.1.
CCDSCCDS17093.1.
RefSeqNP_035620.1. NM_011490.4.
UniGeneMm.73276.

3D structure databases

ProteinModelPortalQ9Z108.
SMRQ9Z108. Positions 98-164, 197-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203528. 3 interactions.
IntActQ9Z108. 2 interactions.

PTM databases

PhosphoSiteQ9Z108.

Proteomic databases

MaxQBQ9Z108.
PaxDbQ9Z108.
PRIDEQ9Z108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536.
GeneID20853.
KEGGmmu:20853.
UCSCuc008nyv.2. mouse.

Organism-specific databases

CTD6780.
MGIMGI:1338864. Stau1.

Phylogenomic databases

eggNOGNOG299502.
GeneTreeENSGT00730000110890.
HOGENOMHOG000231025.
HOVERGENHBG005013.
KOK17597.

Gene expression databases

BgeeQ9Z108.
GenevestigatorQ9Z108.

Family and domain databases

Gene3D3.30.160.20. 3 hits.
InterProIPR014720. dsRNA-bd_dom.
[Graphical view]
PfamPF00035. dsrm. 2 hits.
[Graphical view]
SMARTSM00358. DSRM. 2 hits.
[Graphical view]
PROSITEPS50137. DS_RBD. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTAU1. mouse.
NextBio299647.
PROQ9Z108.
SOURCESearch...

Entry information

Entry nameSTAU1_MOUSE
AccessionPrimary (citable) accession number: Q9Z108
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot