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Q9Z108

- STAU1_MOUSE

UniProt

Q9Z108 - STAU1_MOUSE

Protein

Double-stranded RNA-binding protein Staufen homolog 1

Gene

Stau1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. RNA binding Source: MGI

    GO - Biological processi

    1. intracellular mRNA localization Source: MGI

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Double-stranded RNA-binding protein Staufen homolog 1
    Gene namesi
    Name:Stau1
    Synonyms:Stau
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1338864. Stau1.

    Subcellular locationi

    Cytoplasm By similarity. Rough endoplasmic reticulum
    Note: Localizes exclusively with the rough reticulum endoplasmic (RER).

    GO - Cellular componenti

    1. cytoplasmic stress granule Source: BHF-UCL
    2. ribonucleoprotein complex Source: MGI
    3. rough endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Double-stranded RNA-binding protein Staufen homolog 1PRO_0000072244Add
    BLAST

    Proteomic databases

    MaxQBiQ9Z108.
    PaxDbiQ9Z108.
    PRIDEiQ9Z108.

    PTM databases

    PhosphoSiteiQ9Z108.

    Expressioni

    Gene expression databases

    BgeeiQ9Z108.
    GenevestigatoriQ9Z108.

    Interactioni

    Subunit structurei

    Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203528. 3 interactions.
    IntActiQ9Z108. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z108.
    SMRiQ9Z108. Positions 98-164, 197-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 16368DRBM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 26469DRBM 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    One of the DRDB could be involved in RER binding.
    The C-terminal contains the tubulin binding domain (TBD).

    Sequence similaritiesi

    Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299502.
    GeneTreeiENSGT00730000110890.
    HOGENOMiHOG000231025.
    HOVERGENiHBG005013.
    KOiK17597.

    Family and domain databases

    Gene3Di3.30.160.20. 3 hits.
    InterProiIPR014720. dsRNA-bd_dom.
    [Graphical view]
    PfamiPF00035. dsrm. 2 hits.
    [Graphical view]
    SMARTiSM00358. DSRM. 2 hits.
    [Graphical view]
    PROSITEiPS50137. DS_RBD. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKPVDPHSR MQSTYSYGMR GGAYPPRYFY PFPVPPLLYQ VELSVGGQQF    50
    NGKGKMRPPV KHDAPARALR TLQSEPLPER LEVNGREAEE ENLNKSEISQ 100
    VFEIALKRNL PVNFEVARES GPPHMKNFVT RVSVGEFVGE GEGKSKKISK 150
    KNAARAVLEQ LRRLPPLPAV ERVKPRIKKK SQPTCKTAPD YGQGMNPISR 200
    LAQIQQAKKE KEPEYMLLTE RGLPRRREFV MQVKVGHHTA EGVGTNKKVA 250
    KRNAAENMLE ILGFKVPQAQ PAKPALKSEE KTPVKKPGDG RKVTFFEPSP 300
    GDENGTSNKD EEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT 350
    RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKSNISSGH VPHGPRTRPS 400
    EQLYYLSRAQ GFQVEYKDFP KNNKNECVSL INCSSQPPLV SHGIGKDVES 450
    CHDMAALNIL KLLSELDQQS TEMPRTGNGP VSACGRC 487
    Length:487
    Mass (Da):53,925
    Last modified:May 1, 1999 - v1
    Checksum:i840260693DC49180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061942 mRNA. Translation: AAD17529.1.
    CCDSiCCDS17093.1.
    RefSeqiNP_035620.1. NM_011490.4.
    UniGeneiMm.73276.

    Genome annotation databases

    EnsembliENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536.
    GeneIDi20853.
    KEGGimmu:20853.
    UCSCiuc008nyv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061942 mRNA. Translation: AAD17529.1 .
    CCDSi CCDS17093.1.
    RefSeqi NP_035620.1. NM_011490.4.
    UniGenei Mm.73276.

    3D structure databases

    ProteinModelPortali Q9Z108.
    SMRi Q9Z108. Positions 98-164, 197-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203528. 3 interactions.
    IntActi Q9Z108. 2 interactions.

    PTM databases

    PhosphoSitei Q9Z108.

    Proteomic databases

    MaxQBi Q9Z108.
    PaxDbi Q9Z108.
    PRIDEi Q9Z108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109236 ; ENSMUSP00000104859 ; ENSMUSG00000039536 .
    GeneIDi 20853.
    KEGGi mmu:20853.
    UCSCi uc008nyv.2. mouse.

    Organism-specific databases

    CTDi 6780.
    MGIi MGI:1338864. Stau1.

    Phylogenomic databases

    eggNOGi NOG299502.
    GeneTreei ENSGT00730000110890.
    HOGENOMi HOG000231025.
    HOVERGENi HBG005013.
    KOi K17597.

    Miscellaneous databases

    ChiTaRSi STAU1. mouse.
    NextBioi 299647.
    PROi Q9Z108.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z108.
    Genevestigatori Q9Z108.

    Family and domain databases

    Gene3Di 3.30.160.20. 3 hits.
    InterProi IPR014720. dsRNA-bd_dom.
    [Graphical view ]
    Pfami PF00035. dsrm. 2 hits.
    [Graphical view ]
    SMARTi SM00358. DSRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50137. DS_RBD. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum."
      Wickham L., Duchaine T., Luo M., Nabi I.R., DesGroseillers L.
      Mol. Cell. Biol. 19:2220-2230(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetus.

    Entry informationi

    Entry nameiSTAU1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z108
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3