Q9Z108 (STAU1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Double-stranded RNA-binding protein Staufen homolog 1

Gene names

Name:	Stau1
Synonyms:	Stau

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Subunit structure	Binds tubulin. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner By similarity.
Subcellular location	Cytoplasm By similarity. Rough endoplasmic reticulum. Note: Localizes exclusively with the rough reticulum endoplasmic (RER).
Domain	One of the DRDB could be involved in RER binding. The C-terminal contains the tubulin binding domain (TBD).
Sequence similarities	Contains 2 DRBM (double-stranded RNA-binding) domains.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular mRNA localization Inferred from direct assay PubMed 12843282. Source: MGI
Cellular_component	cytoplasmic stress granule Inferred from direct assay PubMed 19825938. Source: BHF-UCL rough endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from direct assay PubMed 12843282. Source: MGI double-stranded RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Double-stranded RNA-binding protein Staufen homolog 1		PRO_0000072244
Regions
	Domain	96 – 163	68	DRBM 1
	Domain	196 – 264	69	DRBM 2

Sequences

	Sequence		Length	Mass (Da)
	Q9Z108 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 840260693DC49180	FASTA	487	53,925
	10 20 30 40 50 60 MYKPVDPHSR MQSTYSYGMR GGAYPPRYFY PFPVPPLLYQ VELSVGGQQF NGKGKMRPPV 70 80 90 100 110 120 KHDAPARALR TLQSEPLPER LEVNGREAEE ENLNKSEISQ VFEIALKRNL PVNFEVARES 130 140 150 160 170 180 GPPHMKNFVT RVSVGEFVGE GEGKSKKISK KNAARAVLEQ LRRLPPLPAV ERVKPRIKKK 190 200 210 220 230 240 SQPTCKTAPD YGQGMNPISR LAQIQQAKKE KEPEYMLLTE RGLPRRREFV MQVKVGHHTA 250 260 270 280 290 300 EGVGTNKKVA KRNAAENMLE ILGFKVPQAQ PAKPALKSEE KTPVKKPGDG RKVTFFEPSP 310 320 330 340 350 360 GDENGTSNKD EEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT 370 380 390 400 410 420 VTAMIARELL YGGTSPTAET ILKSNISSGH VPHGPRTRPS EQLYYLSRAQ GFQVEYKDFP 430 440 450 460 470 480 KNNKNECVSL INCSSQPPLV SHGIGKDVES CHDMAALNIL KLLSELDQQS TEMPRTGNGP VSACGRC

References

[1]	"Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum." Wickham L., Duchaine T., Luo M., Nabi I.R., DesGroseillers L. Mol. Cell. Biol. 19:2220-2230(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF061942 mRNA. Translation: AAD17529.1.
IPI	IPI00323319.
RefSeq	NP_001103375.1. NM_001109905.1. NP_001103376.1. NM_001109906.1. NP_035620.1. NM_011490.3.
UniGene	Mm.73276.
3D structure databases
ProteinModelPortal	Q9Z108.
SMR	Q9Z108. Positions 25-71, 98-164, 197-265, 396-467.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z108.
Proteomic databases
PaxDb	Q9Z108.
PRIDE	Q9Z108.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000109236; ENSMUSP00000104859; ENSMUSG00000039536.
GeneID	20853.
KEGG	mmu:20853.
Organism-specific databases
CTD	6780.
MGI	MGI:1338864. Stau1.
Phylogenomic databases
eggNOG	NOG299502.
GeneTree	ENSGT00530000063014.
HOGENOM	HOG000231025.
HOVERGEN	HBG005013.
Gene expression databases
ArrayExpress	Q9Z108.
Bgee	Q9Z108.
Genevestigator	Q9Z108.
GermOnline	ENSMUSG00000039536. Mus musculus.
Family and domain databases
Gene3D	3.30.160.20. 3 hits.
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like_dom. [Graphical view]
Pfam	PF00035. dsrm. 2 hits. [Graphical view]
SMART	SM00358. DSRM. 2 hits. [Graphical view]
PROSITE	PS50137. DS_RBD. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STAU1. mouse.
NextBio	299647.
SOURCE	Search...

Entry information

Entry name

STAU1_MOUSE

Accession

Primary (citable) accession number: Q9Z108

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program