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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Gene

Hmg20b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 138HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • four-way junction DNA binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin modification Source: UniProtKB-KW
  • chromatin organization Source: UniProtKB
  • chromatin remodeling Source: ProtInc
  • negative regulation of protein sumoylation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Short name:
SMARCE1-related protein
Alternative name(s):
BRCA2-associated factor 35
HMG box-containing protein 20B
Structural DNA-binding protein BRAF35
Gene namesi
Name:Hmg20b
Synonyms:Braf35, Hmgx2, Smarce1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1341190. Hmg20b.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

  • Note: Localized to condensed chromosomes in mitosis in conjunction with BRCA2.By similarity

GO - Cellular componenti

  • BRCA2-BRAF35 complex Source: MGI
  • chromosome Source: UniProtKB-SubCell
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485761 – 317SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z104.
MaxQBiQ9Z104.
PaxDbiQ9Z104.
PRIDEiQ9Z104.

PTM databases

iPTMnetiQ9Z104.
PhosphoSitePlusiQ9Z104.

Expressioni

Tissue specificityi

Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain.

Gene expression databases

BgeeiENSMUSG00000020232.
CleanExiMM_HMG20B.
ExpressionAtlasiQ9Z104. baseline and differential.
GenevisibleiQ9Z104. MM.

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf1P394283EBI-646920,EBI-520123

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi200335. 1 interactor.
IntActiQ9Z104. 1 interactor.
STRINGi10090.ENSMUSP00000020454.

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 91Combined sources16
Helixi97 – 109Combined sources13
Helixi115 – 138Combined sources24
Helixi141 – 144Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRJNMR-A70-148[»]
ProteinModelPortaliQ9Z104.
SMRiQ9Z104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z104.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 257Sequence analysisAdd BLAST68

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00730000110938.
HOGENOMiHOG000247029.
HOVERGENiHBG059870.
InParanoidiQ9Z104.
OMAiMKELREY.
OrthoDBiEOG091G0IHZ.
PhylomeDBiQ9Z104.
TreeFamiTF106440.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGPRQPGA ATAPAGGKTP GQHGAFVVAV KQERSEGSRA GEKGPQEEEP
60 70 80 90 100
VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI
110 120 130 140 150
TKMLGAEWSK LQPAEKQRYL DEAEKEKQQY LKELWAYQQS EAYKVCTEKI
160 170 180 190 200
QENKIKKEDS SSGLMNTLLN GHKGVDCDGF STFDVPIFTE EFLDQNKARE
210 220 230 240 250
AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ
260 270 280 290 300
QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHER
310
LIARVKEILA RVASEHL
Length:317
Mass (Da):35,870
Last modified:May 1, 1999 - v1
Checksum:i6C4D45D2EB1D403B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067430 Genomic DNA. Translation: AAD15897.1.
AF146224 mRNA. Translation: AAF66708.1.
AL355734 mRNA. Translation: CAB90813.1.
AL355735 mRNA. Translation: CAB90814.1.
BC011334 mRNA. Translation: AAH11334.1.
CCDSiCCDS24055.1.
RefSeqiNP_001156637.1. NM_001163165.1.
NP_001156638.1. NM_001163166.1.
NP_034570.1. NM_010440.3.
UniGeneiMm.38474.

Genome annotation databases

EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232.
ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232.
ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232.
ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232.
GeneIDi15353.
KEGGimmu:15353.
UCSCiuc007ghj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067430 Genomic DNA. Translation: AAD15897.1.
AF146224 mRNA. Translation: AAF66708.1.
AL355734 mRNA. Translation: CAB90813.1.
AL355735 mRNA. Translation: CAB90814.1.
BC011334 mRNA. Translation: AAH11334.1.
CCDSiCCDS24055.1.
RefSeqiNP_001156637.1. NM_001163165.1.
NP_001156638.1. NM_001163166.1.
NP_034570.1. NM_010440.3.
UniGeneiMm.38474.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRJNMR-A70-148[»]
ProteinModelPortaliQ9Z104.
SMRiQ9Z104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200335. 1 interactor.
IntActiQ9Z104. 1 interactor.
STRINGi10090.ENSMUSP00000020454.

PTM databases

iPTMnetiQ9Z104.
PhosphoSitePlusiQ9Z104.

Proteomic databases

EPDiQ9Z104.
MaxQBiQ9Z104.
PaxDbiQ9Z104.
PRIDEiQ9Z104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232.
ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232.
ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232.
ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232.
GeneIDi15353.
KEGGimmu:15353.
UCSCiuc007ghj.2. mouse.

Organism-specific databases

CTDi10362.
MGIiMGI:1341190. Hmg20b.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00730000110938.
HOGENOMiHOG000247029.
HOVERGENiHBG059870.
InParanoidiQ9Z104.
OMAiMKELREY.
OrthoDBiEOG091G0IHZ.
PhylomeDBiQ9Z104.
TreeFamiTF106440.

Miscellaneous databases

ChiTaRSiHmg20b. mouse.
EvolutionaryTraceiQ9Z104.
PROiQ9Z104.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020232.
CleanExiMM_HMG20B.
ExpressionAtlasiQ9Z104. baseline and differential.
GenevisibleiQ9Z104. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHM20B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z104
Secondary accession number(s): Q9NSF7, Q9NSF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.