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Q9Z104

- HM20B_MOUSE

UniProt

Q9Z104 - HM20B_MOUSE

Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Gene

Hmg20b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi70 – 13869HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. four-way junction DNA binding Source: MGI
    3. protein binding Source: IntAct
    4. protein heterodimerization activity Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. chromatin organization Source: UniProtKB
    3. chromatin remodeling Source: ProtInc
    4. negative regulation of protein sumoylation Source: MGI
    5. positive regulation of neuron differentiation Source: MGI
    6. regulation of transcription, DNA-templated Source: UniProtKB
    7. skeletal muscle cell differentiation Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
    Short name:
    SMARCE1-related protein
    Alternative name(s):
    BRCA2-associated factor 35
    HMG box-containing protein 20B
    Structural DNA-binding protein BRAF35
    Gene namesi
    Name:Hmg20b
    Synonyms:Braf35, Hmgx2, Smarce1r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1341190. Hmg20b.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity
    Note: Localized to condensed chromosomes in mitosis in conjunction with BRCA2.By similarity

    GO - Cellular componenti

    1. BRCA2-BRAF35 complex Source: MGI
    2. chromosome Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedPRO_0000048576Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z104.

    PTM databases

    PhosphoSiteiQ9Z104.

    Expressioni

    Tissue specificityi

    Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain.

    Gene expression databases

    ArrayExpressiQ9Z104.
    BgeeiQ9Z104.
    CleanExiMM_HMG20B.
    GenevestigatoriQ9Z104.

    Interactioni

    Subunit structurei

    Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Traf1P394283EBI-646920,EBI-520123

    Protein-protein interaction databases

    BioGridi200335. 1 interaction.
    IntActiQ9Z104. 1 interaction.

    Structurei

    Secondary structure

    1
    317
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 9116
    Helixi97 – 10913
    Helixi115 – 13824
    Helixi141 – 1444

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CRJNMR-A70-148[»]
    ProteinModelPortaliQ9Z104.
    SMRiQ9Z104. Positions 68-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Z104.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili190 – 25768Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG241877.
    GeneTreeiENSGT00730000110938.
    HOGENOMiHOG000247029.
    HOVERGENiHBG059870.
    InParanoidiQ9Z104.
    OMAiMKELREY.
    OrthoDBiEOG72G18C.
    PhylomeDBiQ9Z104.
    TreeFamiTF106440.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHGPRQPGA ATAPAGGKTP GQHGAFVVAV KQERSEGSRA GEKGPQEEEP    50
    VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI 100
    TKMLGAEWSK LQPAEKQRYL DEAEKEKQQY LKELWAYQQS EAYKVCTEKI 150
    QENKIKKEDS SSGLMNTLLN GHKGVDCDGF STFDVPIFTE EFLDQNKARE 200
    AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ 250
    QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHER 300
    LIARVKEILA RVASEHL 317
    Length:317
    Mass (Da):35,870
    Last modified:May 1, 1999 - v1
    Checksum:i6C4D45D2EB1D403B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067430 Genomic DNA. Translation: AAD15897.1.
    AF146224 mRNA. Translation: AAF66708.1.
    AL355734 mRNA. Translation: CAB90813.1.
    AL355735 mRNA. Translation: CAB90814.1.
    BC011334 mRNA. Translation: AAH11334.1.
    CCDSiCCDS24055.1.
    RefSeqiNP_001156637.1. NM_001163165.1.
    NP_001156638.1. NM_001163166.1.
    NP_034570.1. NM_010440.3.
    UniGeneiMm.38474.

    Genome annotation databases

    EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232.
    ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232.
    ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232.
    ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232.
    GeneIDi15353.
    KEGGimmu:15353.
    UCSCiuc007ghj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067430 Genomic DNA. Translation: AAD15897.1 .
    AF146224 mRNA. Translation: AAF66708.1 .
    AL355734 mRNA. Translation: CAB90813.1 .
    AL355735 mRNA. Translation: CAB90814.1 .
    BC011334 mRNA. Translation: AAH11334.1 .
    CCDSi CCDS24055.1.
    RefSeqi NP_001156637.1. NM_001163165.1.
    NP_001156638.1. NM_001163166.1.
    NP_034570.1. NM_010440.3.
    UniGenei Mm.38474.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CRJ NMR - A 70-148 [» ]
    ProteinModelPortali Q9Z104.
    SMRi Q9Z104. Positions 68-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200335. 1 interaction.
    IntActi Q9Z104. 1 interaction.

    PTM databases

    PhosphoSitei Q9Z104.

    Proteomic databases

    PRIDEi Q9Z104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020454 ; ENSMUSP00000020454 ; ENSMUSG00000020232 .
    ENSMUST00000105323 ; ENSMUSP00000100960 ; ENSMUSG00000020232 .
    ENSMUST00000105324 ; ENSMUSP00000100961 ; ENSMUSG00000020232 .
    ENSMUST00000167481 ; ENSMUSP00000128807 ; ENSMUSG00000020232 .
    GeneIDi 15353.
    KEGGi mmu:15353.
    UCSCi uc007ghj.2. mouse.

    Organism-specific databases

    CTDi 10362.
    MGIi MGI:1341190. Hmg20b.

    Phylogenomic databases

    eggNOGi NOG241877.
    GeneTreei ENSGT00730000110938.
    HOGENOMi HOG000247029.
    HOVERGENi HBG059870.
    InParanoidi Q9Z104.
    OMAi MKELREY.
    OrthoDBi EOG72G18C.
    PhylomeDBi Q9Z104.
    TreeFami TF106440.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi HMG20B. mouse.
    EvolutionaryTracei Q9Z104.
    NextBioi 287960.
    PROi Q9Z104.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z104.
    Bgeei Q9Z104.
    CleanExi MM_HMG20B.
    Genevestigatori Q9Z104.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family."
      Wattler F., Wattler S., Kelly M., Skinner H.B., Nehls M.
      Genomics 60:172-178(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."
      Sumoy L., Carim-Todd L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B.
      Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. "Solution structure of the HMG domain of mouse HMG domain protein HMGX2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 69-148.

    Entry informationi

    Entry nameiHM20B_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z104
    Secondary accession number(s): Q9NSF7, Q9NSF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3