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Q9Z104

- HM20B_MOUSE

UniProt

Q9Z104 - HM20B_MOUSE

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Protein
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Gene
Hmg20b, Braf35, Hmgx2, Smarce1r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 13869HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. four-way junction DNA binding Source: MGI
  3. protein binding Source: IntAct
  4. protein heterodimerization activity Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. chromatin organization Source: UniProtKB
  3. chromatin remodeling Source: ProtInc
  4. negative regulation of protein sumoylation Source: MGI
  5. positive regulation of neuron differentiation Source: MGI
  6. regulation of transcription, DNA-templated Source: UniProtKB
  7. skeletal muscle cell differentiation Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Short name:
SMARCE1-related protein
Alternative name(s):
BRCA2-associated factor 35
HMG box-containing protein 20B
Structural DNA-binding protein BRAF35
Gene namesi
Name:Hmg20b
Synonyms:Braf35, Hmgx2, Smarce1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1341190. Hmg20b.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: Localized to condensed chromosomes in mitosis in conjunction with BRCA2 By similarity.

GO - Cellular componenti

  1. BRCA2-BRAF35 complex Source: MGI
  2. chromosome Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
PRO_0000048576Add
BLAST

Proteomic databases

PRIDEiQ9Z104.

PTM databases

PhosphoSiteiQ9Z104.

Expressioni

Tissue specificityi

Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain.

Gene expression databases

ArrayExpressiQ9Z104.
BgeeiQ9Z104.
CleanExiMM_HMG20B.
GenevestigatoriQ9Z104.

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf1P394283EBI-646920,EBI-520123

Protein-protein interaction databases

BioGridi200335. 1 interaction.
IntActiQ9Z104. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi76 – 9116
Helixi97 – 10913
Helixi115 – 13824
Helixi141 – 1444

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRJNMR-A70-148[»]
ProteinModelPortaliQ9Z104.
SMRiQ9Z104. Positions 68-148.

Miscellaneous databases

EvolutionaryTraceiQ9Z104.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili190 – 25768 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG241877.
GeneTreeiENSGT00730000110938.
HOGENOMiHOG000247029.
HOVERGENiHBG059870.
InParanoidiQ9Z104.
OMAiMKELREY.
OrthoDBiEOG72G18C.
PhylomeDBiQ9Z104.
TreeFamiTF106440.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z104-1 [UniParc]FASTAAdd to Basket

« Hide

MSHGPRQPGA ATAPAGGKTP GQHGAFVVAV KQERSEGSRA GEKGPQEEEP    50
VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI 100
TKMLGAEWSK LQPAEKQRYL DEAEKEKQQY LKELWAYQQS EAYKVCTEKI 150
QENKIKKEDS SSGLMNTLLN GHKGVDCDGF STFDVPIFTE EFLDQNKARE 200
AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ 250
QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHER 300
LIARVKEILA RVASEHL 317
Length:317
Mass (Da):35,870
Last modified:May 1, 1999 - v1
Checksum:i6C4D45D2EB1D403B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067430 Genomic DNA. Translation: AAD15897.1.
AF146224 mRNA. Translation: AAF66708.1.
AL355734 mRNA. Translation: CAB90813.1.
AL355735 mRNA. Translation: CAB90814.1.
BC011334 mRNA. Translation: AAH11334.1.
CCDSiCCDS24055.1.
RefSeqiNP_001156637.1. NM_001163165.1.
NP_001156638.1. NM_001163166.1.
NP_034570.1. NM_010440.3.
UniGeneiMm.38474.

Genome annotation databases

EnsembliENSMUST00000020454; ENSMUSP00000020454; ENSMUSG00000020232.
ENSMUST00000105323; ENSMUSP00000100960; ENSMUSG00000020232.
ENSMUST00000105324; ENSMUSP00000100961; ENSMUSG00000020232.
ENSMUST00000167481; ENSMUSP00000128807; ENSMUSG00000020232.
GeneIDi15353.
KEGGimmu:15353.
UCSCiuc007ghj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067430 Genomic DNA. Translation: AAD15897.1 .
AF146224 mRNA. Translation: AAF66708.1 .
AL355734 mRNA. Translation: CAB90813.1 .
AL355735 mRNA. Translation: CAB90814.1 .
BC011334 mRNA. Translation: AAH11334.1 .
CCDSi CCDS24055.1.
RefSeqi NP_001156637.1. NM_001163165.1.
NP_001156638.1. NM_001163166.1.
NP_034570.1. NM_010440.3.
UniGenei Mm.38474.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CRJ NMR - A 70-148 [» ]
ProteinModelPortali Q9Z104.
SMRi Q9Z104. Positions 68-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200335. 1 interaction.
IntActi Q9Z104. 1 interaction.

PTM databases

PhosphoSitei Q9Z104.

Proteomic databases

PRIDEi Q9Z104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020454 ; ENSMUSP00000020454 ; ENSMUSG00000020232 .
ENSMUST00000105323 ; ENSMUSP00000100960 ; ENSMUSG00000020232 .
ENSMUST00000105324 ; ENSMUSP00000100961 ; ENSMUSG00000020232 .
ENSMUST00000167481 ; ENSMUSP00000128807 ; ENSMUSG00000020232 .
GeneIDi 15353.
KEGGi mmu:15353.
UCSCi uc007ghj.2. mouse.

Organism-specific databases

CTDi 10362.
MGIi MGI:1341190. Hmg20b.

Phylogenomic databases

eggNOGi NOG241877.
GeneTreei ENSGT00730000110938.
HOGENOMi HOG000247029.
HOVERGENi HBG059870.
InParanoidi Q9Z104.
OMAi MKELREY.
OrthoDBi EOG72G18C.
PhylomeDBi Q9Z104.
TreeFami TF106440.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi HMG20B. mouse.
EvolutionaryTracei Q9Z104.
NextBioi 287960.
PROi Q9Z104.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z104.
Bgeei Q9Z104.
CleanExi MM_HMG20B.
Genevestigatori Q9Z104.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family."
    Wattler F., Wattler S., Kelly M., Skinner H.B., Nehls M.
    Genomics 60:172-178(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."
    Sumoy L., Carim-Todd L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B.
    Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. "Solution structure of the HMG domain of mouse HMG domain protein HMGX2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 69-148.

Entry informationi

Entry nameiHM20B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z104
Secondary accession number(s): Q9NSF7, Q9NSF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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