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Protein

Activity-dependent neuroprotector homeobox protein

Gene

Adnp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24424C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 50922C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64626C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68525C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi753 – 81361HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • copper ion binding Source: Ensembl
  • DNA binding Source: UniProtKB-KW
  • peptide binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein
Alternative name(s):
Activity-dependent neuroprotective protein
Gene namesi
Name:Adnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338758. Adnp.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • axon Source: Ensembl
  • cytoplasm Source: Ensembl
  • dendrite Source: Ensembl
  • extracellular space Source: MGI
  • neuronal cell body Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11081108Activity-dependent neuroprotector homeobox proteinPRO_0000048808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981PhosphoserineBy similarity
Cross-linki144 – 144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266 – 266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki279 – 279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki367 – 367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki407 – 407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei408 – 4081PhosphoserineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity
Cross-linki426 – 426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki599 – 599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki605 – 605Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei607 – 6071PhosphoserineBy similarity
Cross-linki620 – 620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei708 – 7081PhosphoserineCombined sources
Cross-linki715 – 715Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki730 – 730Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei737 – 7371PhosphoserineCombined sources
Modified residuei804 – 8041PhosphoserineBy similarity
Modified residuei875 – 8751PhosphoserineBy similarity
Modified residuei877 – 8771PhosphoserineBy similarity
Modified residuei885 – 8851PhosphoserineBy similarity
Modified residuei888 – 8881PhosphoserineCombined sources
Modified residuei904 – 9041PhosphoserineCombined sources
Cross-linki928 – 928Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei959 – 9591PhosphoserineCombined sources
Modified residuei961 – 9611PhosphoserineBy similarity
Modified residuei1041 – 10411N6-acetyllysine; alternateBy similarity
Cross-linki1041 – 1041Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1048 – 10481N6-acetyllysineBy similarity
Modified residuei1077 – 10771PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z103.
MaxQBiQ9Z103.
PaxDbiQ9Z103.
PeptideAtlasiQ9Z103.
PRIDEiQ9Z103.

PTM databases

iPTMnetiQ9Z103.
PhosphoSiteiQ9Z103.

Expressioni

Tissue specificityi

Expressed in the brain, with a higher expression in cerebellum and hippocampus. Weakly expressed in lung, kidney and intestine, and expressed at intermediate level in testis.

Inductioni

By the neuroprotective peptide VIP.

Gene expression databases

BgeeiQ9Z103.
CleanExiMM_ADNP.

Interactioni

Protein-protein interaction databases

IntActiQ9Z103. 1 interaction.
MINTiMINT-4087285.
STRINGi10090.ENSMUSP00000056809.

Structurei

3D structure databases

ProteinModelPortaliQ9Z103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni354 – 3618Neuroprotective peptide1 Publication

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi879 – 95072Glu-richAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24424C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 50922C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64626C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68525C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIIX. Eukaryota.
ENOG410XYDF. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9Z103.
OMAiSTGVNMM.
OrthoDBiEOG7GJ6C7.
PhylomeDBiQ9Z103.
TreeFamiTF328818.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
60 70 80 90 100
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
110 120 130 140 150
FENRILLNCP YCTFNADKKT LETHIKIFHA PNSSAPSSSL STFKDKNKND
160 170 180 190 200
GLKPKQADNV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
210 220 230 240 250
GEKSLNGAVS LGTNAREECN IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
260 270 280 290 300
VTAMIGHTNV VVPRAKPLML IAPKPQDKKG MGLPPRISSL ASGNVRSLPS
310 320 330 340 350
QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS YGVGQSVRLG
360 370 380 390 400
LGGNAPVSIP QQSQSVKQLL PSGNGRSFGL GAEQRPPAAA RYSLQTANTS
410 420 430 440 450
LPPGQVKSPS VSQSQASRVL GQSSSKPPPA ATGPPPSNHC ATQKWKICTI
460 470 480 490 500
CNELFPENVY SVHFEKEHKA EKVPAVANYI MKIHNFTSKC LYCNRYLPTD
510 520 530 540 550
TLLNHMLIHG LSCPYCRSTF NDVEKMAAHM RMVHIDEEMG PKTDSTLSFD
560 570 580 590 600
LTLQQGSHTN IHLLVTTYNL RDAPAESVAY HAQNNAPVPP KPQPKVQEKA
610 620 630 640 650
DVPVKSSPQA AVPYKKDVGK TLCPLCFSIL KGPISDALAH HLRERHQVIQ
660 670 680 690 700
TVHPVEKKLT YKCIHCLGVY TSNMTASTIT LHLVHCRGVG KTQNGQDKTN
710 720 730 740 750
APSRLNQSPG LAPVKRTYEQ MEFPLLKKRK LEEDADSPSC FEEKPEEPVV
760 770 780 790 800
LALDPKGHED DSYEARKSFL TKYFNKQPYP TRREIEKLAA SLWLWKSDIA
810 820 830 840 850
SHFSNKRKKC VRDCEKYKPG VLLGFNMKEL NKVKHEMDFD AEWLFENHDE
860 870 880 890 900
KDSRVNASKT VDKKHNLGKE DDSFSDSFEH LEEESNGSGS PFDPVFEVEP
910 920 930 940 950
KIPSDNLEEP VPKVIPEGAL ESEKLDQKEE EEEEEEEDGS KYETIHLTEE
960 970 980 990 1000
PAKLMHDASD SEVDQDDVVE WKDGASPSES GPGSQQISDF EDNTCEMKPG
1010 1020 1030 1040 1050
TWSDESSQSE DARSSKPAAK KKATVQDDTE QLKWKNSSYG KVEGFWSKDQ
1060 1070 1080 1090 1100
SQWENASENA ERLPNPQIEW QNSTIDSEDG EQFDSMTDGV ADPMHGSLTG

VKLSSQQA
Length:1,108
Mass (Da):124,308
Last modified:October 14, 2015 - v2
Checksum:iC69498C5DFC9150B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA. No translation available.
AF068198 mRNA. Translation: AAD19843.1.
CCDSiCCDS38342.1.
RefSeqiNP_001297015.1. NM_001310086.1.
NP_033758.2. NM_009628.3.
UniGeneiMm.201322.

Genome annotation databases

EnsembliENSMUST00000057793; ENSMUSP00000056809; ENSMUSG00000051149.
ENSMUST00000088001; ENSMUSP00000085316; ENSMUSG00000051149.
GeneIDi11538.
KEGGimmu:11538.
UCSCiuc008oaq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA. No translation available.
AF068198 mRNA. Translation: AAD19843.1.
CCDSiCCDS38342.1.
RefSeqiNP_001297015.1. NM_001310086.1.
NP_033758.2. NM_009628.3.
UniGeneiMm.201322.

3D structure databases

ProteinModelPortaliQ9Z103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z103. 1 interaction.
MINTiMINT-4087285.
STRINGi10090.ENSMUSP00000056809.

PTM databases

iPTMnetiQ9Z103.
PhosphoSiteiQ9Z103.

Proteomic databases

EPDiQ9Z103.
MaxQBiQ9Z103.
PaxDbiQ9Z103.
PeptideAtlasiQ9Z103.
PRIDEiQ9Z103.

Protocols and materials databases

DNASUi11538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057793; ENSMUSP00000056809; ENSMUSG00000051149.
ENSMUST00000088001; ENSMUSP00000085316; ENSMUSG00000051149.
GeneIDi11538.
KEGGimmu:11538.
UCSCiuc008oaq.1. mouse.

Organism-specific databases

CTDi23394.
MGIiMGI:1338758. Adnp.

Phylogenomic databases

eggNOGiENOG410IIIX. Eukaryota.
ENOG410XYDF. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9Z103.
OMAiSTGVNMM.
OrthoDBiEOG7GJ6C7.
PhylomeDBiQ9Z103.
TreeFamiTF328818.

Miscellaneous databases

ChiTaRSiAdnp. mouse.
PROiQ9Z103.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z103.
CleanExiMM_ADNP.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide."
    Bassan M., Zamostiano R., Davidson A., Pinhasov A., Giladi E., Perl O., Bassan H., Blat C., Gibney G., Glazner G., Brenneman D.E., Gozes I.
    J. Neurochem. 72:1283-1293(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-1108, SYNTHESIS OF 354-361.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-959, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708; SER-737; SER-888; SER-904; SER-959 AND SER-1077, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiADNP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z103
Secondary accession number(s): A2BDX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 14, 2015
Last modified: July 6, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

When isolated from the sequence, the neuroprotective peptide provides neuroprotection at subfemtomolar concentrations against toxicity associated with tetrodoxin (electrical blockade), the beta-amyloid peptide (the Alzheimer disease neurotoxin), N-methyl-aspartate (excitotoxicity), and the human immunideficiency virus (HIV) envelope protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.