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Protein

Probable carboxypeptidase X1

Gene

Cpxm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi349ZincBy similarity1
Metal bindingi352ZincBy similarity1
Metal bindingi487ZincBy similarity1
Active sitei580NucleophileBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.015

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase X1 (EC:3.4.17.-)
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene namesi
Name:Cpxm1
Synonyms:Cpx1, Cpxm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1934569 Cpxm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000440821 – 722Probable carboxypeptidase X1Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 263PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z100
PaxDbiQ9Z100
PRIDEiQ9Z100

PTM databases

iPTMnetiQ9Z100
PhosphoSitePlusiQ9Z100

Expressioni

Tissue specificityi

Strongly expressed in testis and spleen. Moderatly expressed in salivary gland, brain, heart, lung, and kidney. Extremely low expression in liver and muscle. No expression in eye, adrenal, and white adipose tissues.1 Publication

Developmental stagei

First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures.1 Publication

Gene expression databases

BgeeiENSMUSG00000027408
GenevisibleiQ9Z100 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028897

Structurei

3D structure databases

ProteinModelPortaliQ9Z100
SMRiQ9Z100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 263F5/8 type CPROSITE-ProRule annotationAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 65Poly-Lys4
Compositional biasi358 – 362Poly-Leu5

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649 Eukaryota
ENOG410XX0H LUCA
GeneTreeiENSGT00760000119124
HOGENOMiHOG000232185
HOVERGENiHBG003410
InParanoidiQ9Z100
KOiK08638
OMAiQVNEQCP
OrthoDBiEOG091G06A9
TreeFamiTF315592

Family and domain databases

CDDicd03869 M14_CPX_like, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR034243 AEBP1/CPX_M14_CPD
IPR008969 CarboxyPept-like_regulatory
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF00246 Peptidase_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00231 FA58C, 1 hit
SM00631 Zn_pept, 1 hit
SUPFAMiSSF49464 SSF49464, 1 hit
SSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit
PS01285 FA58C_1, 1 hit
PS50022 FA58C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGLLLAVTA FAPSVGLGLG APSASVPGLA PGSTLAPHSS VAQPSTKANE
60 70 80 90 100
TSERHVRLRV IKKKKIVVKK RKKLRHPGPL GTARPVVPTH PAKTLTLPEK
110 120 130 140 150
QEPGCPPLGL ESLRVSDSQL EASSSQSFGL GAHRGRLNIQ SGLEDGDLYD
160 170 180 190 200
GAWCAEQQDT EPWLQVDAKN PVRFAGIVTQ GRNSVWRYDW VTSFKVQFSN
210 220 230 240 250
DSQTWWKSRN STGMDIVFPA NSDAETPVLN LLPEPQVARF IRLLPQTWFQ
260 270 280 290 300
GGAPCLRAEI LACPVSDPND LFPEAHTLGS SNSLDFRHHN YKAMRKLMKQ
310 320 330 340 350
VNEQCPNITR IYSIGKSHQG LKLYVMEMSD HPGEHELGEP EVRYVAGMHG
360 370 380 390 400
NEALGRELLL LLMQFLCHEF LRGDPRVTRL LTETRIHLLP SMNPDGYETA
410 420 430 440 450
YHRGSELVGW AEGRWTHQGI DLNHNFADLN TQLWYAEDDG LVPDTVPNHH
460 470 480 490 500
LPLPTYYTLP NATVAPETWA VIKWMKRIPF VLSANLHGGE LVVSYPFDMT
510 520 530 540 550
RTPWAARELT PTPDDAVFRW LSTVYAGTNR AMQDTDRRPC HSQDFSLHGN
560 570 580 590 600
VINGADWHTV PGSMNDFSYL HTNCFEVTVE LSCDKFPHEK ELPQEWENNK
610 620 630 640 650
DALLTYLEQV RMGITGVVRD KDTELGIADA VIAVEGINHD VTTAWGGDYW
660 670 680 690 700
RLLTPGDYVV TASAEGYHTV RQHCQVTFEE GPVPCNFLLT KTPKERLREL
710 720
LATRGKLPPD LRRKLERLRG QK
Length:722
Mass (Da):80,907
Last modified:July 27, 2011 - v2
Checksum:iCC365C119420A9D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253A → V in AAD15985 (PubMed:10073577).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077738 mRNA Translation: AAD15985.1
BX890605 Genomic DNA Translation: CAM20117.1
CH466519 Genomic DNA Translation: EDL28262.1
BC003713 mRNA Translation: AAH03713.1
CCDSiCCDS16740.1
RefSeqiNP_062670.2, NM_019696.2
UniGeneiMm.112701

Genome annotation databases

EnsembliENSMUST00000028897; ENSMUSP00000028897; ENSMUSG00000027408
GeneIDi56264
KEGGimmu:56264
UCSCiuc008mir.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCPXM1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z100
Secondary accession number(s): A2BI86, Q99LA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health