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Protein

Probable carboxypeptidase X1

Gene

Cpxm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi349ZincBy similarity1
Metal bindingi352ZincBy similarity1
Metal bindingi487ZincBy similarity1
Active sitei580NucleophileBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase X1 (EC:3.4.17.-)
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene namesi
Name:Cpxm1
Synonyms:Cpx1, Cpxm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1934569. Cpxm1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000440821 – 722Probable carboxypeptidase X1Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 263PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z100.
PaxDbiQ9Z100.
PRIDEiQ9Z100.

PTM databases

iPTMnetiQ9Z100.
PhosphoSitePlusiQ9Z100.

Expressioni

Tissue specificityi

Strongly expressed in testis and spleen. Moderatly expressed in salivary gland, brain, heart, lung, and kidney. Extremely low expression in liver and muscle. No expression in eye, adrenal, and white adipose tissues.1 Publication

Developmental stagei

First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures.1 Publication

Gene expression databases

BgeeiENSMUSG00000027408.
GenevisibleiQ9Z100. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028897.

Structurei

3D structure databases

ProteinModelPortaliQ9Z100.
SMRiQ9Z100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 263F5/8 type CPROSITE-ProRule annotationAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 65Poly-Lys4
Compositional biasi358 – 362Poly-Leu5

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ9Z100.
KOiK08638.
OMAiDGYEIAY.
OrthoDBiEOG091G06A9.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGLLLAVTA FAPSVGLGLG APSASVPGLA PGSTLAPHSS VAQPSTKANE
60 70 80 90 100
TSERHVRLRV IKKKKIVVKK RKKLRHPGPL GTARPVVPTH PAKTLTLPEK
110 120 130 140 150
QEPGCPPLGL ESLRVSDSQL EASSSQSFGL GAHRGRLNIQ SGLEDGDLYD
160 170 180 190 200
GAWCAEQQDT EPWLQVDAKN PVRFAGIVTQ GRNSVWRYDW VTSFKVQFSN
210 220 230 240 250
DSQTWWKSRN STGMDIVFPA NSDAETPVLN LLPEPQVARF IRLLPQTWFQ
260 270 280 290 300
GGAPCLRAEI LACPVSDPND LFPEAHTLGS SNSLDFRHHN YKAMRKLMKQ
310 320 330 340 350
VNEQCPNITR IYSIGKSHQG LKLYVMEMSD HPGEHELGEP EVRYVAGMHG
360 370 380 390 400
NEALGRELLL LLMQFLCHEF LRGDPRVTRL LTETRIHLLP SMNPDGYETA
410 420 430 440 450
YHRGSELVGW AEGRWTHQGI DLNHNFADLN TQLWYAEDDG LVPDTVPNHH
460 470 480 490 500
LPLPTYYTLP NATVAPETWA VIKWMKRIPF VLSANLHGGE LVVSYPFDMT
510 520 530 540 550
RTPWAARELT PTPDDAVFRW LSTVYAGTNR AMQDTDRRPC HSQDFSLHGN
560 570 580 590 600
VINGADWHTV PGSMNDFSYL HTNCFEVTVE LSCDKFPHEK ELPQEWENNK
610 620 630 640 650
DALLTYLEQV RMGITGVVRD KDTELGIADA VIAVEGINHD VTTAWGGDYW
660 670 680 690 700
RLLTPGDYVV TASAEGYHTV RQHCQVTFEE GPVPCNFLLT KTPKERLREL
710 720
LATRGKLPPD LRRKLERLRG QK
Length:722
Mass (Da):80,907
Last modified:July 27, 2011 - v2
Checksum:iCC365C119420A9D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253A → V in AAD15985 (PubMed:10073577).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077738 mRNA. Translation: AAD15985.1.
BX890605 Genomic DNA. Translation: CAM20117.1.
CH466519 Genomic DNA. Translation: EDL28262.1.
BC003713 mRNA. Translation: AAH03713.1.
CCDSiCCDS16740.1.
RefSeqiNP_062670.2. NM_019696.2.
UniGeneiMm.112701.

Genome annotation databases

EnsembliENSMUST00000028897; ENSMUSP00000028897; ENSMUSG00000027408.
GeneIDi56264.
KEGGimmu:56264.
UCSCiuc008mir.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077738 mRNA. Translation: AAD15985.1.
BX890605 Genomic DNA. Translation: CAM20117.1.
CH466519 Genomic DNA. Translation: EDL28262.1.
BC003713 mRNA. Translation: AAH03713.1.
CCDSiCCDS16740.1.
RefSeqiNP_062670.2. NM_019696.2.
UniGeneiMm.112701.

3D structure databases

ProteinModelPortaliQ9Z100.
SMRiQ9Z100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028897.

Protein family/group databases

MEROPSiM14.952.

PTM databases

iPTMnetiQ9Z100.
PhosphoSitePlusiQ9Z100.

Proteomic databases

MaxQBiQ9Z100.
PaxDbiQ9Z100.
PRIDEiQ9Z100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028897; ENSMUSP00000028897; ENSMUSG00000027408.
GeneIDi56264.
KEGGimmu:56264.
UCSCiuc008mir.2. mouse.

Organism-specific databases

CTDi56265.
MGIiMGI:1934569. Cpxm1.

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ9Z100.
KOiK08638.
OMAiDGYEIAY.
OrthoDBiEOG091G06A9.
TreeFamiTF315592.

Miscellaneous databases

PROiQ9Z100.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027408.
GenevisibleiQ9Z100. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPXM1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z100
Secondary accession number(s): A2BI86, Q99LA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.