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Q9Z100

- CPXM1_MOUSE

UniProt

Q9Z100 - CPXM1_MOUSE

Protein

Probable carboxypeptidase X1

Gene

Cpxm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi349 – 3491ZincBy similarity
    Metal bindingi352 – 3521ZincBy similarity
    Metal bindingi487 – 4871ZincBy similarity
    Active sitei580 – 5801NucleophileBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM14.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable carboxypeptidase X1 (EC:3.4.17.-)
    Alternative name(s):
    Metallocarboxypeptidase CPX-1
    Gene namesi
    Name:Cpxm1
    Synonyms:Cpx1, Cpxm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1934569. Cpxm1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 722702Probable carboxypeptidase X1PRO_0000004408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 263PROSITE-ProRule annotation
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9Z100.

    PTM databases

    PhosphoSiteiQ9Z100.

    Expressioni

    Tissue specificityi

    Strongly expressed in testis and spleen. Moderatly expressed in salivary gland, brain, heart, lung, and kidney. Extremely low expression in liver and muscle. No expression in eye, adrenal, and white adipose tissues.1 Publication

    Developmental stagei

    First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z100.
    BgeeiQ9Z100.
    GenevestigatoriQ9Z100.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000028897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z100.
    SMRiQ9Z100. Positions 107-263, 284-667.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 263161F5/8 type CPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 654Poly-Lys
    Compositional biasi358 – 3625Poly-Leu

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG322453.
    GeneTreeiENSGT00730000110373.
    HOGENOMiHOG000232185.
    HOVERGENiHBG003410.
    InParanoidiA2BI86.
    KOiK08638.
    OMAiRYDWVTS.
    OrthoDBiEOG7B8S32.
    TreeFamiTF315592.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProiIPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view]
    PRINTSiPR00765. CRBOXYPTASEA.
    SMARTiSM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS00133. CARBOXYPEPT_ZN_2. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGLLLAVTA FAPSVGLGLG APSASVPGLA PGSTLAPHSS VAQPSTKANE    50
    TSERHVRLRV IKKKKIVVKK RKKLRHPGPL GTARPVVPTH PAKTLTLPEK 100
    QEPGCPPLGL ESLRVSDSQL EASSSQSFGL GAHRGRLNIQ SGLEDGDLYD 150
    GAWCAEQQDT EPWLQVDAKN PVRFAGIVTQ GRNSVWRYDW VTSFKVQFSN 200
    DSQTWWKSRN STGMDIVFPA NSDAETPVLN LLPEPQVARF IRLLPQTWFQ 250
    GGAPCLRAEI LACPVSDPND LFPEAHTLGS SNSLDFRHHN YKAMRKLMKQ 300
    VNEQCPNITR IYSIGKSHQG LKLYVMEMSD HPGEHELGEP EVRYVAGMHG 350
    NEALGRELLL LLMQFLCHEF LRGDPRVTRL LTETRIHLLP SMNPDGYETA 400
    YHRGSELVGW AEGRWTHQGI DLNHNFADLN TQLWYAEDDG LVPDTVPNHH 450
    LPLPTYYTLP NATVAPETWA VIKWMKRIPF VLSANLHGGE LVVSYPFDMT 500
    RTPWAARELT PTPDDAVFRW LSTVYAGTNR AMQDTDRRPC HSQDFSLHGN 550
    VINGADWHTV PGSMNDFSYL HTNCFEVTVE LSCDKFPHEK ELPQEWENNK 600
    DALLTYLEQV RMGITGVVRD KDTELGIADA VIAVEGINHD VTTAWGGDYW 650
    RLLTPGDYVV TASAEGYHTV RQHCQVTFEE GPVPCNFLLT KTPKERLREL 700
    LATRGKLPPD LRRKLERLRG QK 722
    Length:722
    Mass (Da):80,907
    Last modified:July 27, 2011 - v2
    Checksum:iCC365C119420A9D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti253 – 2531A → V in AAD15985. (PubMed:10073577)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077738 mRNA. Translation: AAD15985.1.
    BX890605 Genomic DNA. Translation: CAM20117.1.
    CH466519 Genomic DNA. Translation: EDL28262.1.
    BC003713 mRNA. Translation: AAH03713.1.
    CCDSiCCDS16740.1.
    RefSeqiNP_062670.2. NM_019696.2.
    UniGeneiMm.112701.

    Genome annotation databases

    EnsembliENSMUST00000028897; ENSMUSP00000028897; ENSMUSG00000027408.
    GeneIDi56264.
    KEGGimmu:56264.
    UCSCiuc008mir.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077738 mRNA. Translation: AAD15985.1 .
    BX890605 Genomic DNA. Translation: CAM20117.1 .
    CH466519 Genomic DNA. Translation: EDL28262.1 .
    BC003713 mRNA. Translation: AAH03713.1 .
    CCDSi CCDS16740.1.
    RefSeqi NP_062670.2. NM_019696.2.
    UniGenei Mm.112701.

    3D structure databases

    ProteinModelPortali Q9Z100.
    SMRi Q9Z100. Positions 107-263, 284-667.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000028897.

    Protein family/group databases

    MEROPSi M14.952.

    PTM databases

    PhosphoSitei Q9Z100.

    Proteomic databases

    PRIDEi Q9Z100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028897 ; ENSMUSP00000028897 ; ENSMUSG00000027408 .
    GeneIDi 56264.
    KEGGi mmu:56264.
    UCSCi uc008mir.2. mouse.

    Organism-specific databases

    CTDi 56265.
    MGIi MGI:1934569. Cpxm1.

    Phylogenomic databases

    eggNOGi NOG322453.
    GeneTreei ENSGT00730000110373.
    HOGENOMi HOG000232185.
    HOVERGENi HBG003410.
    InParanoidi A2BI86.
    KOi K08638.
    OMAi RYDWVTS.
    OrthoDBi EOG7B8S32.
    TreeFami TF315592.

    Miscellaneous databases

    NextBioi 312152.
    PROi Q9Z100.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z100.
    Bgeei Q9Z100.
    Genevestigatori Q9Z100.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProi IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    PRINTSi PR00765. CRBOXYPTASEA.
    SMARTi SM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS00133. CARBOXYPEPT_ZN_2. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2."
      Lei Y., Xin X., Morgan D., Pintar J.E., Fricker L.D.
      DNA Cell Biol. 18:175-185(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCPXM1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z100
    Secondary accession number(s): A2BI86, Q99LA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3