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Q9Z100

- CPXM1_MOUSE

UniProt

Q9Z100 - CPXM1_MOUSE

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Protein

Probable carboxypeptidase X1

Gene
Cpxm1, Cpx1, Cpxm
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi349 – 3491Zinc By similarity
Metal bindingi352 – 3521Zinc By similarity
Metal bindingi487 – 4871Zinc By similarity
Active sitei580 – 5801Nucleophile By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase X1 (EC:3.4.17.-)
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene namesi
Name:Cpxm1
Synonyms:Cpx1, Cpxm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1934569. Cpxm1.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 722702Probable carboxypeptidase X1PRO_0000004408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi105 ↔ 263 By similarity
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9Z100.

PTM databases

PhosphoSiteiQ9Z100.

Expressioni

Tissue specificityi

Strongly expressed in testis and spleen. Moderatly expressed in salivary gland, brain, heart, lung, and kidney. Extremely low expression in liver and muscle. No expression in eye, adrenal, and white adipose tissues.1 Publication

Developmental stagei

First expressed at 13.5 dpc, in the meninges, nasal mesenchyme, primordial cartilage and skeletal structures.1 Publication

Gene expression databases

ArrayExpressiQ9Z100.
BgeeiQ9Z100.
GenevestigatoriQ9Z100.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028897.

Structurei

3D structure databases

ProteinModelPortaliQ9Z100.
SMRiQ9Z100. Positions 107-263, 284-667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 263161F5/8 type CAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 654Poly-Lys
Compositional biasi358 – 3625Poly-Leu

Sequence similaritiesi

Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG322453.
GeneTreeiENSGT00730000110373.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiA2BI86.
KOiK08638.
OMAiRYDWVTS.
OrthoDBiEOG7B8S32.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z100-1 [UniParc]FASTAAdd to Basket

« Hide

MWGLLLAVTA FAPSVGLGLG APSASVPGLA PGSTLAPHSS VAQPSTKANE    50
TSERHVRLRV IKKKKIVVKK RKKLRHPGPL GTARPVVPTH PAKTLTLPEK 100
QEPGCPPLGL ESLRVSDSQL EASSSQSFGL GAHRGRLNIQ SGLEDGDLYD 150
GAWCAEQQDT EPWLQVDAKN PVRFAGIVTQ GRNSVWRYDW VTSFKVQFSN 200
DSQTWWKSRN STGMDIVFPA NSDAETPVLN LLPEPQVARF IRLLPQTWFQ 250
GGAPCLRAEI LACPVSDPND LFPEAHTLGS SNSLDFRHHN YKAMRKLMKQ 300
VNEQCPNITR IYSIGKSHQG LKLYVMEMSD HPGEHELGEP EVRYVAGMHG 350
NEALGRELLL LLMQFLCHEF LRGDPRVTRL LTETRIHLLP SMNPDGYETA 400
YHRGSELVGW AEGRWTHQGI DLNHNFADLN TQLWYAEDDG LVPDTVPNHH 450
LPLPTYYTLP NATVAPETWA VIKWMKRIPF VLSANLHGGE LVVSYPFDMT 500
RTPWAARELT PTPDDAVFRW LSTVYAGTNR AMQDTDRRPC HSQDFSLHGN 550
VINGADWHTV PGSMNDFSYL HTNCFEVTVE LSCDKFPHEK ELPQEWENNK 600
DALLTYLEQV RMGITGVVRD KDTELGIADA VIAVEGINHD VTTAWGGDYW 650
RLLTPGDYVV TASAEGYHTV RQHCQVTFEE GPVPCNFLLT KTPKERLREL 700
LATRGKLPPD LRRKLERLRG QK 722
Length:722
Mass (Da):80,907
Last modified:July 27, 2011 - v2
Checksum:iCC365C119420A9D4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2531A → V in AAD15985. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077738 mRNA. Translation: AAD15985.1.
BX890605 Genomic DNA. Translation: CAM20117.1.
CH466519 Genomic DNA. Translation: EDL28262.1.
BC003713 mRNA. Translation: AAH03713.1.
CCDSiCCDS16740.1.
RefSeqiNP_062670.2. NM_019696.2.
UniGeneiMm.112701.

Genome annotation databases

EnsembliENSMUST00000028897; ENSMUSP00000028897; ENSMUSG00000027408.
GeneIDi56264.
KEGGimmu:56264.
UCSCiuc008mir.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077738 mRNA. Translation: AAD15985.1 .
BX890605 Genomic DNA. Translation: CAM20117.1 .
CH466519 Genomic DNA. Translation: EDL28262.1 .
BC003713 mRNA. Translation: AAH03713.1 .
CCDSi CCDS16740.1.
RefSeqi NP_062670.2. NM_019696.2.
UniGenei Mm.112701.

3D structure databases

ProteinModelPortali Q9Z100.
SMRi Q9Z100. Positions 107-263, 284-667.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000028897.

Protein family/group databases

MEROPSi M14.952.

PTM databases

PhosphoSitei Q9Z100.

Proteomic databases

PRIDEi Q9Z100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028897 ; ENSMUSP00000028897 ; ENSMUSG00000027408 .
GeneIDi 56264.
KEGGi mmu:56264.
UCSCi uc008mir.2. mouse.

Organism-specific databases

CTDi 56265.
MGIi MGI:1934569. Cpxm1.

Phylogenomic databases

eggNOGi NOG322453.
GeneTreei ENSGT00730000110373.
HOGENOMi HOG000232185.
HOVERGENi HBG003410.
InParanoidi A2BI86.
KOi K08638.
OMAi RYDWVTS.
OrthoDBi EOG7B8S32.
TreeFami TF315592.

Miscellaneous databases

NextBioi 312152.
PROi Q9Z100.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z100.
Bgeei Q9Z100.
Genevestigatori Q9Z100.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProi IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
PRINTSi PR00765. CRBOXYPTASEA.
SMARTi SM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view ]
SUPFAMi SSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2."
    Lei Y., Xin X., Morgan D., Pintar J.E., Fricker L.D.
    DNA Cell Biol. 18:175-185(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCPXM1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z100
Secondary accession number(s): A2BI86, Q99LA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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