Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 5

Gene

Klf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri362 – 38625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cellular response to organic cyclic compound Source: Ensembl
  • cellular response to peptide Source: Ensembl
  • intestinal epithelial cell development Source: MGI
  • microvillus assembly Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of microvillus assembly Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:Klf5
Synonyms:Bteb2, Iklf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338056. Klf5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Krueppel-like factor 5PRO_0000047170Add
BLAST

Post-translational modificationi

Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9Z0Z7.
PRIDEiQ9Z0Z7.

PTM databases

PhosphoSiteiQ9Z0Z7.

Expressioni

Tissue specificityi

Highest expression in digestive track.

Gene expression databases

BgeeiQ9Z0Z7.
CleanExiMM_KLF5.
GenevisibleiQ9Z0Z7. MM.

Interactioni

Subunit structurei

Interacts with WWP1.By similarity

Protein-protein interaction databases

BioGridi198396. 2 interactions.
DIPiDIP-49582N.
IntActiQ9Z0Z7. 5 interactions.
STRINGi10090.ENSMUSP00000005279.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Z7.
SMRiQ9Z0Z7. Positions 352-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni313 – 3175Interaction with WWP1By similarity

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri362 – 38625C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41625C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ9Z0Z7.
KOiK09206.
OMAiIPYSINM.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9Z0Z7.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030401. KLF5.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23223:SF144. PTHR23223:SF144. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD
60 70 80 90 100
LKHAHHHPPA PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK
110 120 130 140 150
YRRDSASVVD QFFTDTEGIP YSINMNVFLP DITHLRTGLY KSQRPCVTQI
160 170 180 190 200
KTEPVTIFSH QSESTAPPPP PAPTQALPEF TSIFSSHQTT APPQEVNNIF
210 220 230 240 250
IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA VMDTLNVSMA
260 270 280 290 300
GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS
310 320 330 340 350
PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR
360 370 380 390 400
RSNPDLEKRR IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD
410 420 430 440
WRFARSDELT RHYRKHTGAK PFQCMVCQRS FSRSDHLALH MKRHQN
Length:446
Mass (Da):49,754
Last modified:January 23, 2002 - v2
Checksum:iD8D1DBB952448AC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231D → A in AAD17696 (PubMed:10767086).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079852 mRNA. Translation: AAD17696.1.
AB025099 mRNA. Translation: BAA92284.3.
BC012958 mRNA. Translation: AAH12958.1.
CCDSiCCDS27311.1.
RefSeqiNP_033899.2. NM_009769.4.
UniGeneiMm.30262.

Genome annotation databases

EnsembliENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148.
GeneIDi12224.
KEGGimmu:12224.
UCSCiuc007uvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079852 mRNA. Translation: AAD17696.1.
AB025099 mRNA. Translation: BAA92284.3.
BC012958 mRNA. Translation: AAH12958.1.
CCDSiCCDS27311.1.
RefSeqiNP_033899.2. NM_009769.4.
UniGeneiMm.30262.

3D structure databases

ProteinModelPortaliQ9Z0Z7.
SMRiQ9Z0Z7. Positions 352-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198396. 2 interactions.
DIPiDIP-49582N.
IntActiQ9Z0Z7. 5 interactions.
STRINGi10090.ENSMUSP00000005279.

PTM databases

PhosphoSiteiQ9Z0Z7.

Proteomic databases

MaxQBiQ9Z0Z7.
PRIDEiQ9Z0Z7.

Protocols and materials databases

DNASUi12224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148.
GeneIDi12224.
KEGGimmu:12224.
UCSCiuc007uvf.1. mouse.

Organism-specific databases

CTDi688.
MGIiMGI:1338056. Klf5.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ9Z0Z7.
KOiK09206.
OMAiIPYSINM.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9Z0Z7.
TreeFamiTF350556.

Enzyme and pathway databases

ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

NextBioi280631.
PROiQ9Z0Z7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0Z7.
CleanExiMM_KLF5.
GenevisibleiQ9Z0Z7. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030401. KLF5.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23223:SF144. PTHR23223:SF144. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells."
    Conkright M.D., Wani M.A., Anderson K.P., Lingrel J.B.
    Nucleic Acids Res. 27:1263-1270(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  2. "Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5."
    Ohnishi S., Laub F., Matsumoto N., Asaka M., Ramirez F., Yoshida T., Terada M.
    Dev. Dyn. 217:421-429(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiKLF5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Z7
Secondary accession number(s): Q9JMI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: June 24, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.