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Protein

Krueppel-like factor 5

Gene

Klf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cellular response to leukemia inhibitory factor Source: MGI
  • cellular response to organic cyclic compound Source: Ensembl
  • cellular response to peptide Source: Ensembl
  • intestinal epithelial cell development Source: MGI
  • microvillus assembly Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of microvillus assembly Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:Klf5
Synonyms:Bteb2, Iklf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338056. Klf5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471701 – 446Krueppel-like factor 5Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9Z0Z7.
PaxDbiQ9Z0Z7.
PeptideAtlasiQ9Z0Z7.
PRIDEiQ9Z0Z7.

PTM databases

iPTMnetiQ9Z0Z7.
PhosphoSitePlusiQ9Z0Z7.

Expressioni

Tissue specificityi

Highest expression in digestive track.

Gene expression databases

BgeeiENSMUSG00000005148.
CleanExiMM_KLF5.
GenevisibleiQ9Z0Z7. MM.

Interactioni

Subunit structurei

Interacts with WWP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXW7Q969H02EBI-647919,EBI-359574From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198396. 6 interactors.
CORUMiQ9Z0Z7.
DIPiDIP-49582N.
IntActiQ9Z0Z7. 6 interactors.
STRINGi10090.ENSMUSP00000005279.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Z7.
SMRiQ9Z0Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni313 – 317Interaction with WWP1By similarity5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ9Z0Z7.
KOiK09206.
OMAiMPNQFLQ.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9Z0Z7.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR030401. KLF5.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR44295:SF4. PTHR44295:SF4. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9Z0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD
60 70 80 90 100
LKHAHHHPPA PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK
110 120 130 140 150
YRRDSASVVD QFFTDTEGIP YSINMNVFLP DITHLRTGLY KSQRPCVTQI
160 170 180 190 200
KTEPVTIFSH QSESTAPPPP PAPTQALPEF TSIFSSHQTT APPQEVNNIF
210 220 230 240 250
IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA VMDTLNVSMA
260 270 280 290 300
GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS
310 320 330 340 350
PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR
360 370 380 390 400
RSNPDLEKRR IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD
410 420 430 440
WRFARSDELT RHYRKHTGAK PFQCMVCQRS FSRSDHLALH MKRHQN
Length:446
Mass (Da):49,754
Last modified:January 23, 2002 - v2
Checksum:iD8D1DBB952448AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → A in AAD17696 (PubMed:10767086).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079852 mRNA. Translation: AAD17696.1.
AB025099 mRNA. Translation: BAA92284.3.
BC012958 mRNA. Translation: AAH12958.1.
CCDSiCCDS27311.1.
RefSeqiNP_033899.2. NM_009769.4.
UniGeneiMm.30262.

Genome annotation databases

EnsembliENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148.
GeneIDi12224.
KEGGimmu:12224.
UCSCiuc007uvf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKLF5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Z7
Secondary accession number(s): Q9JMI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: November 22, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families