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Q9Z0Z7 (KLF5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name=BTE-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene names
Name:Klf5
Synonyms:Bteb2, Iklf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Subunit structure

Interacts with WWP1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Highest expression in digestive track.

Post-translational modification

Ubiquitinated By similarity. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 12101409. Source: MGI

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to peptide

Inferred from electronic annotation. Source: Ensembl

intestinal epithelial cell development

Inferred from mutant phenotype PubMed 23266329. Source: MGI

microvillus assembly

Inferred from mutant phenotype PubMed 12101409. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 23266329. Source: MGI

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 12101409. Source: MGI

regulation of microvillus assembly

Inferred from mutant phenotype PubMed 23266329. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 23266329. Source: MGI

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay PubMed 21503901. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12101409. Source: MGI

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 12101409. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 12101409. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Krueppel-like factor 5
PRO_0000047170

Regions

Zinc finger362 – 38625C2H2-type 1
Zinc finger392 – 41625C2H2-type 2
Zinc finger422 – 44423C2H2-type 3
Region313 – 3175Interaction with WWP1 By similarity

Experimental info

Sequence conflict231D → A in AAD17696. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z0Z7 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: D8D1DBB952448AC5

FASTA44649,754
        10         20         30         40         50         60 
MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD LKHAHHHPPA 

        70         80         90        100        110        120 
PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK YRRDSASVVD QFFTDTEGIP 

       130        140        150        160        170        180 
YSINMNVFLP DITHLRTGLY KSQRPCVTQI KTEPVTIFSH QSESTAPPPP PAPTQALPEF 

       190        200        210        220        230        240 
TSIFSSHQTT APPQEVNNIF IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA 

       250        260        270        280        290        300 
VMDTLNVSMA GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS 

       310        320        330        340        350        360 
PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR RSNPDLEKRR 

       370        380        390        400        410        420 
IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD WRFARSDELT RHYRKHTGAK 

       430        440 
PFQCMVCQRS FSRSDHLALH MKRHQN 

« Hide

References

« Hide 'large scale' references
[1]"A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells."
Conkright M.D., Wani M.A., Anderson K.P., Lingrel J.B.
Nucleic Acids Res. 27:1263-1270(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Intestine.
[2]"Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5."
Ohnishi S., Laub F., Matsumoto N., Asaka M., Ramirez F., Yoshida T., Terada M.
Dev. Dyn. 217:421-429(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF079852 mRNA. Translation: AAD17696.1.
AB025099 mRNA. Translation: BAA92284.3.
BC012958 mRNA. Translation: AAH12958.1.
CCDSCCDS27311.1.
RefSeqNP_033899.2. NM_009769.4.
UniGeneMm.30262.

3D structure databases

ProteinModelPortalQ9Z0Z7.
SMRQ9Z0Z7. Positions 352-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198396. 2 interactions.
DIPDIP-49582N.
IntActQ9Z0Z7. 5 interactions.

PTM databases

PhosphoSiteQ9Z0Z7.

Proteomic databases

PRIDEQ9Z0Z7.

Protocols and materials databases

DNASU12224.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148.
GeneID12224.
KEGGmmu:12224.
UCSCuc007uvf.1. mouse.

Organism-specific databases

CTD688.
MGIMGI:1338056. Klf5.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117252.
HOGENOMHOG000261607.
HOVERGENHBG003474.
InParanoidQ9Z0Z7.
KOK09206.
OMAMPNQFLQ.
OrthoDBEOG747PJ4.
PhylomeDBQ9Z0Z7.
TreeFamTF350556.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.
REACT_200794. Mus musculus biological processes.

Gene expression databases

BgeeQ9Z0Z7.
CleanExMM_KLF5.
GenevestigatorQ9Z0Z7.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio280631.
PROQ9Z0Z7.
SOURCESearch...

Entry information

Entry nameKLF5_MOUSE
AccessionPrimary (citable) accession number: Q9Z0Z7
Secondary accession number(s): Q9JMI2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot