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Q9Z0Z7

- KLF5_MOUSE

UniProt

Q9Z0Z7 - KLF5_MOUSE

Protein

Krueppel-like factor 5

Gene

Klf5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri362 – 38625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. cellular response to organic cyclic compound Source: Ensembl
    3. cellular response to peptide Source: Ensembl
    4. intestinal epithelial cell development Source: MGI
    5. microvillus assembly Source: MGI
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. positive regulation of cell proliferation Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: MGI
    9. regulation of microvillus assembly Source: MGI
    10. regulation of transcription from RNA polymerase II promoter Source: MGI
    11. skeletal muscle cell differentiation Source: MGI
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 5
    Alternative name(s):
    Basic transcription element-binding protein 2
    Short name:
    BTE-binding protein 2
    Intestinal-enriched krueppel-like factor
    Transcription factor BTEB2
    Gene namesi
    Name:Klf5
    Synonyms:Bteb2, Iklf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1338056. Klf5.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. nucleoplasm Source: Reactome
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Krueppel-like factor 5PRO_0000047170Add
    BLAST

    Post-translational modificationi

    Ubiquitinated By similarity. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ9Z0Z7.

    PTM databases

    PhosphoSiteiQ9Z0Z7.

    Expressioni

    Tissue specificityi

    Highest expression in digestive track.

    Gene expression databases

    BgeeiQ9Z0Z7.
    CleanExiMM_KLF5.
    GenevestigatoriQ9Z0Z7.

    Interactioni

    Subunit structurei

    Interacts with WWP1.By similarity

    Protein-protein interaction databases

    BioGridi198396. 2 interactions.
    DIPiDIP-49582N.
    IntActiQ9Z0Z7. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0Z7.
    SMRiQ9Z0Z7. Positions 352-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni313 – 3175Interaction with WWP1By similarity

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri362 – 38625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117252.
    HOGENOMiHOG000261607.
    HOVERGENiHBG003474.
    InParanoidiQ9Z0Z7.
    KOiK09206.
    OMAiMPNQFLQ.
    OrthoDBiEOG747PJ4.
    PhylomeDBiQ9Z0Z7.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0Z7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD    50
    LKHAHHHPPA PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK 100
    YRRDSASVVD QFFTDTEGIP YSINMNVFLP DITHLRTGLY KSQRPCVTQI 150
    KTEPVTIFSH QSESTAPPPP PAPTQALPEF TSIFSSHQTT APPQEVNNIF 200
    IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA VMDTLNVSMA 250
    GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS 300
    PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR 350
    RSNPDLEKRR IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD 400
    WRFARSDELT RHYRKHTGAK PFQCMVCQRS FSRSDHLALH MKRHQN 446
    Length:446
    Mass (Da):49,754
    Last modified:January 23, 2002 - v2
    Checksum:iD8D1DBB952448AC5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231D → A in AAD17696. (PubMed:10767086)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079852 mRNA. Translation: AAD17696.1.
    AB025099 mRNA. Translation: BAA92284.3.
    BC012958 mRNA. Translation: AAH12958.1.
    CCDSiCCDS27311.1.
    RefSeqiNP_033899.2. NM_009769.4.
    UniGeneiMm.30262.

    Genome annotation databases

    EnsembliENSMUST00000005279; ENSMUSP00000005279; ENSMUSG00000005148.
    GeneIDi12224.
    KEGGimmu:12224.
    UCSCiuc007uvf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079852 mRNA. Translation: AAD17696.1 .
    AB025099 mRNA. Translation: BAA92284.3 .
    BC012958 mRNA. Translation: AAH12958.1 .
    CCDSi CCDS27311.1.
    RefSeqi NP_033899.2. NM_009769.4.
    UniGenei Mm.30262.

    3D structure databases

    ProteinModelPortali Q9Z0Z7.
    SMRi Q9Z0Z7. Positions 352-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198396. 2 interactions.
    DIPi DIP-49582N.
    IntActi Q9Z0Z7. 5 interactions.

    PTM databases

    PhosphoSitei Q9Z0Z7.

    Proteomic databases

    PRIDEi Q9Z0Z7.

    Protocols and materials databases

    DNASUi 12224.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005279 ; ENSMUSP00000005279 ; ENSMUSG00000005148 .
    GeneIDi 12224.
    KEGGi mmu:12224.
    UCSCi uc007uvf.1. mouse.

    Organism-specific databases

    CTDi 688.
    MGIi MGI:1338056. Klf5.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117252.
    HOGENOMi HOG000261607.
    HOVERGENi HBG003474.
    InParanoidi Q9Z0Z7.
    KOi K09206.
    OMAi MPNQFLQ.
    OrthoDBi EOG747PJ4.
    PhylomeDBi Q9Z0Z7.
    TreeFami TF350556.

    Enzyme and pathway databases

    Reactomei REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    NextBioi 280631.
    PROi Q9Z0Z7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0Z7.
    CleanExi MM_KLF5.
    Genevestigatori Q9Z0Z7.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells."
      Conkright M.D., Wani M.A., Anderson K.P., Lingrel J.B.
      Nucleic Acids Res. 27:1263-1270(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Intestine.
    2. "Developmental expression of the mouse gene coding for the Kruppel-like transcription factor KLF5."
      Ohnishi S., Laub F., Matsumoto N., Asaka M., Ramirez F., Yoshida T., Terada M.
      Dev. Dyn. 217:421-429(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiKLF5_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0Z7
    Secondary accession number(s): Q9JMI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3