SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z0Y9

- NR1H3_MOUSE

UniProt

Q9Z0Y9 - NR1H3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Oxysterols receptor LXR-alpha
Gene
Nr1h3, Lxra
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi93 – 16876Nuclear receptor
Add
BLAST
Zinc fingeri96 – 11621NR C4-type
Add
BLAST
Zinc fingeri132 – 15625NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. steroid hormone receptor activity Source: InterPro
  7. sterol response element binding Source: Ensembl
  8. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic cell clearance Source: Ensembl
  2. cellular lipid metabolic process Source: MGI
  3. cellular response to lipopolysaccharide Source: BHF-UCL
  4. cholesterol homeostasis Source: BHF-UCL
  5. fatty acid biosynthetic process Source: BHF-UCL
  6. intracellular receptor signaling pathway Source: GOC
  7. lipid homeostasis Source: BHF-UCL
  8. negative regulation of cholesterol storage Source: BHF-UCL
  9. negative regulation of inflammatory response Source: BHF-UCL
  10. negative regulation of lipid transport Source: Ensembl
  11. negative regulation of macrophage activation Source: BHF-UCL
  12. negative regulation of pancreatic juice secretion Source: BHF-UCL
  13. negative regulation of pinocytosis Source: Ensembl
  14. negative regulation of proteolysis Source: BHF-UCL
  15. negative regulation of secretion of lysosomal enzymes Source: BHF-UCL
  16. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  17. negative regulation of transcription, DNA-templated Source: MGI
  18. positive regulation of cellular protein metabolic process Source: Ensembl
  19. positive regulation of cholesterol efflux Source: BHF-UCL
  20. positive regulation of cholesterol homeostasis Source: Ensembl
  21. positive regulation of fatty acid biosynthetic process Source: Ensembl
  22. positive regulation of lipoprotein lipase activity Source: Ensembl
  23. positive regulation of receptor biosynthetic process Source: Ensembl
  24. positive regulation of toll-like receptor 4 signaling pathway Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. positive regulation of transcription, DNA-templated Source: BHF-UCL
  27. positive regulation of triglyceride biosynthetic process Source: Ensembl
  28. regulation of cholesterol homeostasis Source: UniProtKB
  29. regulation of transcription, DNA-templated Source: MGI
  30. response to progesterone Source: Ensembl
  31. sterol homeostasis Source: BHF-UCL
  32. triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-alpha
Alternative name(s):
Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3
Gene namesi
Name:Nr1h3
Synonyms:Lxra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1352462. Nr1h3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Oxysterols receptor LXR-alpha
PRO_0000053536Add
BLAST

Proteomic databases

PRIDEiQ9Z0Y9.

PTM databases

PhosphoSiteiQ9Z0Y9.

Expressioni

Gene expression databases

ArrayExpressiQ9Z0Y9.
BgeeiQ9Z0Y9.
CleanExiMM_NR1H3.
GenevestigatoriQ9Z0Y9.

Interactioni

Subunit structurei

Heterodimer of LXRA and RXR.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRT1Q96EB62EBI-5276764,EBI-1802965From a different organism.

Protein-protein interaction databases

BioGridi204449. 7 interactions.
IntActiQ9Z0Y9. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi206 – 22722
Helixi228 – 2325
Helixi245 – 27228
Turni274 – 2785
Helixi281 – 30121
Turni306 – 3094
Beta strandi310 – 3134
Turni314 – 3163
Beta strandi317 – 3193
Helixi321 – 3255
Turni326 – 3283
Helixi331 – 34717
Helixi351 – 36212
Helixi373 – 39422
Helixi401 – 42828
Helixi435 – 4417

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ACLX-ray2.80B/D/F/H203-445[»]
3FALX-ray2.36B/D200-445[»]
3FC6X-ray2.06B/D200-445[»]
ProteinModelPortaliQ9Z0Y9.
SMRiQ9Z0Y9. Positions 83-443.

Miscellaneous databases

EvolutionaryTraceiQ9Z0Y9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 432220Ligand-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG285805.
GeneTreeiENSGT00720000108423.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiQ9Z0Y9.
KOiK08536.
OMAiCILREEA.
OrthoDBiEOG7DC25S.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MSLWLEASMP DVSPDSATEL WKTEPQDAGD QGGNTCILRE EARMPQSTGV    50
ALGIGLESAE PTALLPRAET LPEPTELRPQ KRKKGPAPKM LGNELCSVCG 100
DKASGFHYNV LSCEGCKGFF RRSVIKGARY VCHSGGHCPM DTYMRRKCQE 150
CRLRKCRQAG MREECVLSEE QIRLKKLKRQ EEEQAQATSV SPRVSSPPQV 200
LPQLSPEQLG MIEKLVAAQQ QCNRRSFSDR LRVTPWPIAP DPQSREARQQ 250
RFAHFTELAI VSVQEIVDFA KQLPGFLQLS REDQIALLKT SAIEVMLLET 300
SRRYNPGSES ITFLKDFSYN REDFAKAGLQ VEFINPIFEF SRAMNELQLN 350
DAEFALLIAI SIFSADRPNV QDQLQVERLQ HTYVEALHAY VSINHPHDPL 400
MFPRMLMKLV SLRTLSSVHS EQVFALRLQD KKLPPLLSEI WDVHE 445
Length:445
Mass (Da):50,418
Last modified:July 27, 2011 - v3
Checksum:i1A426DF38D935731
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti399 – 3991P → R in CAB51952. 1 Publication
Sequence conflicti399 – 3991P → R in CAB51923. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132599, AJ132600 Genomic DNA. Translation: CAB51952.1.
AJ132601 mRNA. Translation: CAB51923.1.
AF085745 mRNA. Translation: AAD16050.1.
AL691450 Genomic DNA. No translation available.
CCDSiCCDS16426.1.
RefSeqiNP_001171201.1. NM_001177730.1.
NP_038867.2. NM_013839.4.
XP_006499229.1. XM_006499166.1.
XP_006499230.1. XM_006499167.1.
XP_006499231.1. XM_006499168.1.
UniGeneiMm.22690.

Genome annotation databases

EnsembliENSMUST00000002177; ENSMUSP00000002177; ENSMUSG00000002108.
ENSMUST00000111354; ENSMUSP00000106986; ENSMUSG00000002108.
ENSMUST00000111356; ENSMUSP00000106988; ENSMUSG00000002108.
GeneIDi22259.
KEGGimmu:22259.
UCSCiuc008kvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132599 , AJ132600 Genomic DNA. Translation: CAB51952.1 .
AJ132601 mRNA. Translation: CAB51923.1 .
AF085745 mRNA. Translation: AAD16050.1 .
AL691450 Genomic DNA. No translation available.
CCDSi CCDS16426.1.
RefSeqi NP_001171201.1. NM_001177730.1.
NP_038867.2. NM_013839.4.
XP_006499229.1. XM_006499166.1.
XP_006499230.1. XM_006499167.1.
XP_006499231.1. XM_006499168.1.
UniGenei Mm.22690.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ACL X-ray 2.80 B/D/F/H 203-445 [» ]
3FAL X-ray 2.36 B/D 200-445 [» ]
3FC6 X-ray 2.06 B/D 200-445 [» ]
ProteinModelPortali Q9Z0Y9.
SMRi Q9Z0Y9. Positions 83-443.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204449. 7 interactions.
IntActi Q9Z0Y9. 2 interactions.

Chemistry

ChEMBLi CHEMBL2189152.

PTM databases

PhosphoSitei Q9Z0Y9.

Proteomic databases

PRIDEi Q9Z0Y9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002177 ; ENSMUSP00000002177 ; ENSMUSG00000002108 .
ENSMUST00000111354 ; ENSMUSP00000106986 ; ENSMUSG00000002108 .
ENSMUST00000111356 ; ENSMUSP00000106988 ; ENSMUSG00000002108 .
GeneIDi 22259.
KEGGi mmu:22259.
UCSCi uc008kvc.2. mouse.

Organism-specific databases

CTDi 10062.
MGIi MGI:1352462. Nr1h3.

Phylogenomic databases

eggNOGi NOG285805.
GeneTreei ENSGT00720000108423.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
InParanoidi Q9Z0Y9.
KOi K08536.
OMAi CILREEA.
OrthoDBi EOG7DC25S.
TreeFami TF352167.

Miscellaneous databases

EvolutionaryTracei Q9Z0Y9.
NextBioi 302349.
PROi Q9Z0Y9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z0Y9.
Bgeei Q9Z0Y9.
CleanExi MM_NR1H3.
Genevestigatori Q9Z0Y9.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta."
    Alberti S., Steffensen K.R., Gustafsson J.-A.
    Gene 243:93-103(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  2. "LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression."
    Tamura K., Chen Y.E., Horiuchi M., Chen Q., Daviet L., Yang Z., Lopez-Ilasaca M., Mu H., Pratt R.E., Dzau V.J.
    Proc. Natl. Acad. Sci. U.S.A. 97:8513-8518(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
    Wada T., Kang H.S., Angers M., Gong H., Bhatia S., Khadem S., Ren S., Ellis E., Strom S.C., Jetten A.M., Xie W.
    Mol. Pharmacol. 73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN METABOLISM REGULATION.
  5. "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."
    Zelcer N., Hong C., Boyadjian R., Tontonoz P.
    Science 325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
    Hong C., Duit S., Jalonen P., Out R., Scheer L., Sorrentino V., Boyadjian R., Rodenburg K.W., Foley E., Korhonen L., Lindholm D., Nimpf J., van Berkel T.J., Tontonoz P., Zelcer N.
    J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNR1H3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Y9
Secondary accession number(s): Q9QUH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi