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Reviewed, UniProtKB/Swiss-Prot Q9Z0Y2 (PA21B_MOUSE)

Last modified June 16, 2009. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phospholipase A2
    EC=3.1.1.4
Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase
    Group IB phospholipase A2
    PLA2-Ib
Gene names
Name: Pla2g1b
Synonyms: Pla2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activity

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the phospholipase A2 family.

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Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   Molecular functionHydrolase
   PTMDisulfide bond
Gene Ontology (GO)
   Biological processcell proliferation

Traceable author statement. Source: MGI

phospholipid catabolic process

Traceable author statement. Source: MGI

response to stress

Traceable author statement. Source: MGI

   Cellular componentextracellular region

Inferred from direct assay. Source: MGI

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phospholipase A2 activity

Inferred from direct assay. Source: MGI

receptor binding Ref.2

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 By similarity
Propeptide16 – 227Activation peptide By similarity
PRO_0000022741
Chain23 – 146124Phospholipase A2
PRO_0000022742

Sites

Active site701 By similarity
Active site1211 By similarity
Metal binding501Calcium; via carbonyl oxygen By similarity
Metal binding521Calcium; via carbonyl oxygen By similarity
Metal binding541Calcium; via carbonyl oxygen By similarity
Metal binding711Calcium By similarity

Amino acid modifications

Disulfide bond33 ↔ 99 By similarity
Disulfide bond49 ↔ 146 By similarity
Disulfide bond51 ↔ 67 By similarity
Disulfide bond66 ↔ 127 By similarity
Disulfide bond73 ↔ 120 By similarity
Disulfide bond83 ↔ 113 By similarity
Disulfide bond106 ↔ 118 By similarity

Experimental info

Sequence conflict521G → S in BAB26212. Ref.6
Sequence conflict581T → P in BAB26212. Ref.6
Sequence conflict78 – 792KK → EN in BAB26212. Ref.6
Sequence conflict871I → R in BAB26212. Ref.6
Sequence conflict951Y → F in BAB26212. Ref.6
Sequence conflict1021S → G in BAB26212. Ref.6
Sequence conflict1221R → S in BAB25608. Ref.6

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Sequences

Sequence LengthMass (Da)Tools
Q9Z0Y2-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 59500C68845B7C81

FASTA14616,290
        10         20         30         40         50         60 
MKLLLLAALL TAGAAAHSIS PRAVWQFRNM IKCTIPGSDP LKDYNNYGCY CGLGGWGTPV 

        70         80         90        100        110        120 
DDLDRCCQTH DHCYSQAKKL ESCKFLIDNP YTNTYSYSCS GSEITCSAKN NKCEDFICNC 

       130        140 
DREAAICFSK VPYNKEYKNL DTGKFC

« Hide

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References

« Hide 'large scale' references
[1]"Isolation, characterization and chromosomal localization of mouse sPLA2-Ib gene."
Mandal A.K., Zhang Z., Mukherjee A.B.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[2]"Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor."
Cupillard L., Mulherkar R., Gomez N., Kadam S., Valentin E., Lazdunski M., Lambeau G.
J. Biol. Chem. 274:7043-7051(1999) [PubMed: 10066760] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells."
Bingham C.O. III, Fijneman R.J.A., Friend D.S., Goddeau R.P., Rogers R.A., Austen K.F., Arm J.P.
J. Biol. Chem. 274:31476-31484(1999) [PubMed: 10531350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Lung.
[4]"Molecular structure and tissue-specific expression of the mouse pancreatic phospholipase A2 gene."
Richmond B.L., Hui D.Y.
Gene 244:65-72(2000) [PubMed: 10689188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Role of sPLA2-I in colorectal tumorigenesis."
Mandal A.K., Zhang Z., Popescu N., Mukherjee A.B.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
Tissue: Pancreas.
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas, Small intestine, Stomach and Tongue.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF094611 Genomic DNA. Translation: AAF02298.1.
AF097637 mRNA. Translation: AAD19896.1.
AF162712 mRNA. Translation: AAD45806.1.
AF187852 mRNA. Translation: AAF44297.1.
AF094610 mRNA. Translation: AAG27064.1.
AK028104 mRNA. Translation: BAC25749.1.
AK028134 mRNA. Translation: BAC25763.1.
AK008936 mRNA. Translation: BAB25978.1.
AK007730 mRNA. Translation: BAB25218.1.
AK007797 mRNA. Translation: BAB25263.1.
AK008664 mRNA. Translation: BAB25819.1.
AK008668 mRNA. Translation: BAB25822.1.
AK008841 mRNA. Translation: BAB25922.1.
AK008934 mRNA. Translation: BAB25976.1.
AK008331 mRNA. Translation: BAB25608.1.
AK009314 mRNA. Translation: BAB26212.1.
IPIIPI00129638.
RefSeqNP_035237.1.
UniGeneMm.20190

3D structure databases

HSSPHSSP built from PDB template 1GH4 based on UniProtKB P00593.
SMRQ9Z0Y2. Positions 19-141.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Z0Y2.

Genome annotation databases

EnsemblENSMUSG00000029522. Mus musculus. [Contig view]
GeneID18778.
KEGGmmu:18778.

Organism-specific databases

MGIMGI:101842. Pla2g1b.

Phylogenomic databases

HOGENOMQ9Z0Y2.
HOVERGENQ9Z0Y2.
OMAQ9Z0Y2. AKKLDSC.

Enzyme and pathway databases

BRENDA3.1.1.4. 244.

Gene expression databases

ArrayExpressQ9Z0Y2.
BgeeQ9Z0Y2.
CleanExMM_PLA2G1B.
GermOnlineENSMUSG00000029522. Mus musculus.

Family and domain databases

InterProIPR016090. Phospholipase_A2.
IPR013090. Phospholipase_A2_AS.
IPR001211. Phospholipase_A2_euk.
[Graphical view]
Gene3DG3DSA:1.20.90.10. Phospholipase_A2. 1 hit.
PANTHERPTHR11716. Phospholipase_A2. 1 hit.
PfamPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSPR00389. PHPHLIPASEA2.
ProDomPD000303. PhospholipaseA2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00085. PA2c. 1 hit.
[Graphical view]
PROSITEPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio295023.
SOURCESearch...

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Entry information

Entry namePA21B_MOUSE
AccessionPrimary (citable) accession number: Q9Z0Y2
Secondary accession number(s): Q9D7E2, Q9D884
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents