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Protein

Dynactin subunit 3

Gene

Dctn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with dynein may be involved in spindle assembly and cytokinesis.By similarity

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • microtubule-based process Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 3
Alternative name(s):
Dynactin light chain p24
Gene namesi
Name:Dctn3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1859251. Dctn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 186185Dynactin subunit 3PRO_0000225604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z0Y1.
MaxQBiQ9Z0Y1.
PaxDbiQ9Z0Y1.
PeptideAtlasiQ9Z0Y1.
PRIDEiQ9Z0Y1.

PTM databases

iPTMnetiQ9Z0Y1.
PhosphoSiteiQ9Z0Y1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028447.
CleanExiMM_DCTN3.
ExpressionAtlasiQ9Z0Y1. baseline and differential.
GenevisibleiQ9Z0Y1. MM.

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein.

Protein-protein interaction databases

BioGridi207318. 73 interactions.
IntActiQ9Z0Y1. 73 interactions.
STRINGi10090.ENSMUSP00000030158.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili46 – 6621Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynactin subunit 3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXN7. Eukaryota.
ENOG410Y8FP. LUCA.
GeneTreeiENSGT00390000016210.
HOGENOMiHOG000231666.
HOVERGENiHBG053181.
InParanoidiQ9Z0Y1.
KOiK10425.
OMAiYNKMMFL.
OrthoDBiEOG091G0MGW.
PhylomeDBiQ9Z0Y1.
TreeFamiTF105248.

Family and domain databases

InterProiIPR009991. Dynactin_p22.
[Graphical view]
PfamiPF07426. Dynactin_p22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTDVQRL QSRVEELERW VYGPGGTRGS RKVADGLVKV QVALGNIASK
60 70 80 90 100
RERVKILYKK IEDLIKYLDP EYIDRIAIPE ASKLQFILAE EQFILSQVAL
110 120 130 140 150
LEQVNALVPV LDSASIKAVP EHAARLQRLA QIHIQQQDQC VAITEESKAL
160 170 180
LEGYNKTTML LSKQFVQWDE LLCQLEAAKQ VKPAEE
Length:186
Mass (Da):20,978
Last modified:March 7, 2006 - v2
Checksum:i2630EA16F629D414
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31A → G in BAB27872 (PubMed:16141072).Curated
Sequence conflicti131 – 1311Q → E in AAD16226 (PubMed:9786090).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098508 mRNA. Translation: AAD16226.1.
AK003255 mRNA. Translation: BAB22671.1.
AK002720 mRNA. Translation: BAB22307.1.
AK011840 mRNA. Translation: BAB27872.1.
AK159344 mRNA. Translation: BAE35006.1.
BC061120 mRNA. Translation: AAH61120.1.
CCDSiCCDS18069.1.
RefSeqiNP_001153037.1. NM_001159565.1.
NP_058586.3. NM_016890.4.
UniGeneiMm.29025.

Genome annotation databases

EnsembliENSMUST00000030158; ENSMUSP00000030158; ENSMUSG00000028447.
GeneIDi53598.
KEGGimmu:53598.
UCSCiuc008sji.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098508 mRNA. Translation: AAD16226.1.
AK003255 mRNA. Translation: BAB22671.1.
AK002720 mRNA. Translation: BAB22307.1.
AK011840 mRNA. Translation: BAB27872.1.
AK159344 mRNA. Translation: BAE35006.1.
BC061120 mRNA. Translation: AAH61120.1.
CCDSiCCDS18069.1.
RefSeqiNP_001153037.1. NM_001159565.1.
NP_058586.3. NM_016890.4.
UniGeneiMm.29025.

3D structure databases

ProteinModelPortaliQ9Z0Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207318. 73 interactions.
IntActiQ9Z0Y1. 73 interactions.
STRINGi10090.ENSMUSP00000030158.

PTM databases

iPTMnetiQ9Z0Y1.
PhosphoSiteiQ9Z0Y1.

Proteomic databases

EPDiQ9Z0Y1.
MaxQBiQ9Z0Y1.
PaxDbiQ9Z0Y1.
PeptideAtlasiQ9Z0Y1.
PRIDEiQ9Z0Y1.

Protocols and materials databases

DNASUi53598.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030158; ENSMUSP00000030158; ENSMUSG00000028447.
GeneIDi53598.
KEGGimmu:53598.
UCSCiuc008sji.2. mouse.

Organism-specific databases

CTDi11258.
MGIiMGI:1859251. Dctn3.

Phylogenomic databases

eggNOGiENOG410IXN7. Eukaryota.
ENOG410Y8FP. LUCA.
GeneTreeiENSGT00390000016210.
HOGENOMiHOG000231666.
HOVERGENiHBG053181.
InParanoidiQ9Z0Y1.
KOiK10425.
OMAiYNKMMFL.
OrthoDBiEOG091G0MGW.
PhylomeDBiQ9Z0Y1.
TreeFamiTF105248.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ9Z0Y1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028447.
CleanExiMM_DCTN3.
ExpressionAtlasiQ9Z0Y1. baseline and differential.
GenevisibleiQ9Z0Y1. MM.

Family and domain databases

InterProiIPR009991. Dynactin_p22.
[Graphical view]
PfamiPF07426. Dynactin_p22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Y1
Secondary accession number(s): Q9CR43, Q9D039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.