Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynactin subunit 3

Gene

Dctn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with dynein may be involved in spindle assembly and cytokinesis.By similarity

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • microtubule-based process Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 3
Alternative name(s):
Dynactin light chain p24
Gene namesi
Name:Dctn3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1859251. Dctn3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002256042 – 186Dynactin subunit 3Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z0Y1.
MaxQBiQ9Z0Y1.
PaxDbiQ9Z0Y1.
PeptideAtlasiQ9Z0Y1.
PRIDEiQ9Z0Y1.

PTM databases

iPTMnetiQ9Z0Y1.
PhosphoSitePlusiQ9Z0Y1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028447.
CleanExiMM_DCTN3.
ExpressionAtlasiQ9Z0Y1. baseline and differential.
GenevisibleiQ9Z0Y1. MM.

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein.

Protein-protein interaction databases

BioGridi207318. 73 interactors.
IntActiQ9Z0Y1. 73 interactors.
STRINGi10090.ENSMUSP00000030158.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili46 – 66Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dynactin subunit 3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXN7. Eukaryota.
ENOG410Y8FP. LUCA.
GeneTreeiENSGT00390000016210.
HOGENOMiHOG000231666.
HOVERGENiHBG053181.
InParanoidiQ9Z0Y1.
KOiK10425.
OMAiYNKMMFL.
OrthoDBiEOG091G0MGW.
PhylomeDBiQ9Z0Y1.
TreeFamiTF105248.

Family and domain databases

InterProiView protein in InterPro
IPR009991. Dynactin_p22.
PfamiView protein in Pfam
PF07426. Dynactin_p22. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTDVQRL QSRVEELERW VYGPGGTRGS RKVADGLVKV QVALGNIASK
60 70 80 90 100
RERVKILYKK IEDLIKYLDP EYIDRIAIPE ASKLQFILAE EQFILSQVAL
110 120 130 140 150
LEQVNALVPV LDSASIKAVP EHAARLQRLA QIHIQQQDQC VAITEESKAL
160 170 180
LEGYNKTTML LSKQFVQWDE LLCQLEAAKQ VKPAEE
Length:186
Mass (Da):20,978
Last modified:March 7, 2006 - v2
Checksum:i2630EA16F629D414
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → G in BAB27872 (PubMed:16141072).Curated1
Sequence conflicti131Q → E in AAD16226 (PubMed:9786090).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098508 mRNA. Translation: AAD16226.1.
AK003255 mRNA. Translation: BAB22671.1.
AK002720 mRNA. Translation: BAB22307.1.
AK011840 mRNA. Translation: BAB27872.1.
AK159344 mRNA. Translation: BAE35006.1.
BC061120 mRNA. Translation: AAH61120.1.
CCDSiCCDS18069.1.
RefSeqiNP_001153037.1. NM_001159565.1.
NP_058586.3. NM_016890.4.
UniGeneiMm.29025.

Genome annotation databases

EnsembliENSMUST00000030158; ENSMUSP00000030158; ENSMUSG00000028447.
GeneIDi53598.
KEGGimmu:53598.
UCSCiuc008sji.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDCTN3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0Y1
Secondary accession number(s): Q9CR43, Q9D039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families