ID   PDE3A_MOUSE             Reviewed;        1141 AA.
AC   Q9Z0X4;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=cGMP-inhibited 3',5'-cyclic phosphodiesterase A;
DE            EC=3.1.4.17;
DE   AltName: Full=Cyclic GMP-inhibited phosphodiesterase A;
DE            Short=CGI-PDE A;
GN   Name=Pde3a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Ovary;
RA   Shitsukawa K., Andersen C.B., Richard F.J., Conti M.;
RT   "Characterization of cGMP-inhibited phosphodiesterase (PDE3A)
RT   expressed in mouse oocyte.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
CC   -!- FUNCTION: Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O =
CC       nucleoside 5'-phosphate.
CC   -!- ENZYME REGULATION: Inhibited by cGMP (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family.
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DR   EMBL; AF099187; AAD16300.1; -; mRNA.
DR   IPI; IPI00129586; -.
DR   RefSeq; NP_061249.1; -.
DR   UniGene; Mm.103728; -.
DR   UniGene; Mm.393561; -.
DR   HSSP; Q08499; 1MKD.
DR   SMR; Q9Z0X4; 677-1049.
DR   PhosphoSite; Q9Z0X4; -.
DR   PRIDE; Q9Z0X4; -.
DR   Ensembl; ENSMUSG00000041741; Mus musculus.
DR   GeneID; 54611; -.
DR   KEGG; mmu:54611; -.
DR   MGI; MGI:1860764; Pde3a.
DR   HOGENOM; Q9Z0X4; -.
DR   HOVERGEN; Q9Z0X4; -.
DR   OMA; Q9Z0X4; DSGFTHG.
DR   BRENDA; 3.1.4.17; 244.
DR   NextBio; 311416; -.
DR   ArrayExpress; Q9Z0X4; -.
DR   Bgee; Q9Z0X4; -.
DR   CleanEx; MM_PDE3A; -.
DR   GO; GO:0005626; C:insoluble fraction; IDA:MGI.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005625; C:soluble fraction; IDA:MGI.
DR   GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.
DR   GO; GO:0001556; P:oocyte maturation; IDA:MGI.
DR   GO; GO:0040020; P:regulation of meiosis; IDA:MGI.
DR   GO; GO:0042493; P:response to drug; IDA:MGI.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR003607; Met-dep_phosphohydro_HD.
DR   InterPro; IPR002073; PDEase.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I; 1.
PE   1: Evidence at protein level;
KW   cGMP; Hydrolase; Membrane; Phosphoprotein.
FT   CHAIN         1   1141       cGMP-inhibited 3',5'-cyclic
FT                                phosphodiesterase A.
FT                                /FTId=PRO_0000198800.
FT   MOD_RES     310    310       Phosphoserine (By similarity).
FT   MOD_RES     425    425       Phosphoserine (By similarity).
FT   MOD_RES     437    437       Phosphothreonine (By similarity).
FT   MOD_RES     495    495       Phosphoserine.
SQ   SEQUENCE   1141 AA;  124513 MW;  3D9ACCFF928219D8 CRC64;
     MAVRGEAAQD LAKPGLGGAS PARVARGNHR HRGESSPSPR GSGCCWRALA LQPLRRSPQL
     SSALCAGSLS VLLALLVRLV GGEVGGELEK SQEAAAEEEE EEGARGGVFP GPRGGAPGGG
     AQLSPWLQPA ALLFSLLCAF FWMGLCLLRA GVRLPLAVAL LAACCAGEAL VQLSLGVGDG
     RLLSLPAAGV LLSCLGGATW LVLRLRLGVL MVAWTSVLRT VALVSLERFK VAWRPYLAYL
     AAVLGLLLAR YAEQILPQCS GPAPPRERFG SQLSARTKEE IPGWKRRRRS SSVVAGEMSG
     CSGKSHRRTS LPCIPREQLM GHSEWDHKRG PRGSQSGTSI TVDIAVMGEA HGLITDLLAD
     PSLPPNVCTS LRAVSNLLST QLTFQAIHKP RVNPTVTFSE NYTCSDSEEG LEKDKQAISK
     RLRRSLPPGL LRRVSSTWTT TTSATGLPTL EPAPVRRDRS ASIKPHEAPS PSAVNPDSWN
     APGLTTLTKS RSFTSSYAVS AANHVKAKKQ NRPGGLAKIS PVPSPSSSPP QGSPASSPVS
     NSASQQFPES PEVTIKRGPG SHRALTYTQS APDLSPQIPP PSVICSSCGR PYSQGNPADG
     PSERSGPAML KPNRTDDTSQ VTSDYETNNN SDSSDILQNE EEAECQREPQ RKASACGTYT
     SQTMIFLDKP ILAPEPLVMD NLDSIMDQLN TWNFPIFDLM ENIGRKCGRI LSQVSYRLFE
     DMGLFEAFKI PVREFMNYFH ALEIGYRDIP YHNRIHATDV LHAVWYLTTQ PIPGLPSVIG
     DHGSASDSDS DSGFTHGHMG YVFSKMYHVP DDKYGCLSGN IPALELMALY VAAAMHDYDH
     PGRTNAFLVA TSAPQAVLYN DRSVLENHHA AAAWNLFMSR PEYNFLVNLD HVEFKHFRFL
     VIEAILATDL KKHFDFVAKF NAKVNDDVGI DWTNENDRLL VCQMCIKLAD INGPAKCKEL
     HLRWTEGIAS EFYEQGDEEA SLGLPISPFM DRSAPQLANL QESFISHIVG PLCHSYDSAG
     LMPGKWVDDS DDSGDTDDPE EEEEEAETPH EDEACESSIA PRKKSFKRRR IYCQITQHLL
     QNHMMWKKVI EEEQCLSGTE NQSLDQVPLQ HPSEQIQAIK EEEEEKGKPR AEETLAPQPD
     L
//