Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/hydrogen exchanger 5

Gene

Slc9a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).By similarity

GO - Molecular functioni

  • sodium:proton antiporter activity Source: RGD

GO - Biological processi

  • proton transport Source: RGD
  • regulation of pH Source: InterPro
  • sodium ion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 5
Alternative name(s):
Na(+)/H(+) exchanger 5
Short name:
NHE-5
Solute carrier family 9 member 5
Gene namesi
Name:Slc9a5
Synonyms:Nhe5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620473. Slc9a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523611 – 898Sodium/hydrogen exchanger 5Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z0X2.

PTM databases

PhosphoSitePlusiQ9Z0X2.

Expressioni

Tissue specificityi

Highly expressed in brain.

Interactioni

Subunit structurei

Interacts with ARRB2 (By similarity). Interacts with CHP1 and CHP2.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9Z0X2. 2 interactors.
STRINGi10116.ENSRNOP00000063061.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
InParanoidiQ9Z0X2.
KOiK14723.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 3 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVALLLLP GLPLAGVGAT EEPTQEPGPL GEPPGLALFR WQWHEVEAPY
60 70 80 90 100
LVALWILVAS LAKIVFHLSR KVTSLVPESC LLILLGLALG GIVLAVAKKA
110 120 130 140 150
EYQLEPGTFF LFLLPPIVLD SGYFMPSRLF FDNLGAILTY AVVGTLWNAF
160 170 180 190 200
TTGVALWGLQ QAGLVAPRVQ AGLLDFLLFG SLISAVDPVA VLAVFEEVHV
210 220 230 240 250
NETLFIIVFG ESLLNDAVTA VLYKVCNSFV EMGSANVQAT DYLKGVASLF
260 270 280 290 300
VVSLGGAAVG LVFAFLLALT TRFTKRVRII EPLLVFLLAY AAYLTAEMAS
310 320 330 340 350
LSAILAVTMC GLGCKKYVEA NISHKSRTAV KYTMKTLASS AETVIFMLLG
360 370 380 390 400
ISAVDSSKWA WDSGLVLGTL FFILFFRALG VVLQTWVLNQ FRLAPLDKID
410 420 430 440 450
QVVMSYGGLR GAVAFALVIL LDRTKVPAKD YFVATTIVVV FFTVIVQGLT
460 470 480 490 500
IKPLVKWLRV KRSDYHKPTL NQELHEHTFD HILAAVEDVV GHHGYHYWRD
510 520 530 540 550
RWEQFDKKYL SQLLMRRSAY RIRDQIWDVY YRLNIRDAIS FVDQGGHVLS
560 570 580 590 600
SAGLTLPSMP SRNSVAETSV TNLLRESGSG ACLDLQVIDT VRSGRDREDA
610 620 630 640 650
VMHHLLCGGL YKPRRRYKAS CSRHFISEDA QERQDKEVFQ QNMKRRLESF
660 670 680 690 700
KSTKHNICFT KSKPRPRKTG HKKKDGVANP EATNGKPPRD LGFQDTAAVI
710 720 730 740 750
LTVESEEEEE SESSETEKED DEGIIFVARA TSEVLQEGKV SGSLEVCPSP
760 770 780 790 800
RIIPPSPTCA EKELPWKSGQ GDLAVYVSSE TTKIVPVDMQ TGWNQSISSL
810 820 830 840 850
ESLASPPCTQ PPTLTRLPPH PLVPEEPQVP LDLSSDPRSS FAFPPSLAKA
860 870 880 890
GRSRSESSAD IPQQQELQPL MGHKDHTHLS PGPANSHWCI QFNRGGRL
Length:898
Mass (Da):99,052
Last modified:May 1, 1999 - v1
Checksum:i0D959DD3F18831CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100172 mRNA. Translation: AAD16413.1.
RefSeqiNP_620213.1. NM_138858.1.
UniGeneiRn.24105.

Genome annotation databases

GeneIDi192215.
KEGGirno:192215.
UCSCiRGD:620473. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100172 mRNA. Translation: AAD16413.1.
RefSeqiNP_620213.1. NM_138858.1.
UniGeneiRn.24105.

3D structure databases

ProteinModelPortaliQ9Z0X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0X2. 2 interactors.
STRINGi10116.ENSRNOP00000063061.

PTM databases

PhosphoSitePlusiQ9Z0X2.

Proteomic databases

PaxDbiQ9Z0X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192215.
KEGGirno:192215.
UCSCiRGD:620473. rat.

Organism-specific databases

CTDi6553.
RGDi620473. Slc9a5.

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
InParanoidiQ9Z0X2.
KOiK14723.

Miscellaneous databases

PROiQ9Z0X2.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 3 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSL9A5_RAT
AccessioniPrimary (citable) accession number: Q9Z0X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.