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Protein

Cdc42 effector protein 5

Gene

Cdc42ep5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

ReactomeiR-MMU-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 5
Alternative name(s):
Binder of Rho GTPases 3
Gene namesi
Name:Cdc42ep5
Synonyms:Borg3, Cep5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929745. Cdc42ep5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB-SubCell
  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23 – 24IS → AA: No binding with CDC42. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126541 – 150Cdc42 effector protein 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ9Z0X0.
PaxDbiQ9Z0X0.
PeptideAtlasiQ9Z0X0.
PRIDEiQ9Z0X0.

PTM databases

iPTMnetiQ9Z0X0.
PhosphoSitePlusiQ9Z0X0.

Expressioni

Tissue specificityi

Highly expressed in the skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000063838.
CleanExiMM_CDC42EP5.
ExpressionAtlasiQ9Z0X0. baseline and differential.
GenevisibleiQ9Z0X0. MM.

Interactioni

Subunit structurei

Interacts with CDC42 in a GTP-dependent manner, and with SEPT7.3 Publications

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9Z0X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 37CRIBPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 89Pro-richAdd BLAST34

Domaini

The CRIB domain mediates interaction with CDC42.

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J2KV. Eukaryota.
ENOG410ZF7J. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000043688.
HOVERGENiHBG080905.
InParanoidiQ9Z0X0.
OMAiQHPRARC.
OrthoDBiEOG091G11DR.
PhylomeDBiQ9Z0X0.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVMKQLGPA QPKKRLDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS
60 70 80 90 100
RHGGGPPPEP GAPPVVAPHS VAPPAAPQPP VAVPSPADPL LSFHLDLGPS
110 120 130 140 150
MLDAVLGVMD AERSETTATK PDGDAHPRVQ HPKTRCCSNA DLQLDDVIGL
Length:150
Mass (Da):15,545
Last modified:July 19, 2005 - v2
Checksum:i9AB9A49A9518B200
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → R in AAD17906 (PubMed:11035016).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164119 mRNA. Translation: AAD48816.1.
AF102773 mRNA. Translation: AAD17906.1.
AK008154 mRNA. Translation: BAB25498.1.
BC006758 mRNA. Translation: AAH06758.1.
BC103774 mRNA. Translation: AAI03775.1.
CCDSiCCDS20733.1.
RefSeqiNP_067429.1. NM_021454.3.
XP_006540313.1. XM_006540250.3.
UniGeneiMm.34268.

Genome annotation databases

EnsembliENSMUST00000076831; ENSMUSP00000092508; ENSMUSG00000063838.
GeneIDi58804.
KEGGimmu:58804.
UCSCiuc009exe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164119 mRNA. Translation: AAD48816.1.
AF102773 mRNA. Translation: AAD17906.1.
AK008154 mRNA. Translation: BAB25498.1.
BC006758 mRNA. Translation: AAH06758.1.
BC103774 mRNA. Translation: AAI03775.1.
CCDSiCCDS20733.1.
RefSeqiNP_067429.1. NM_021454.3.
XP_006540313.1. XM_006540250.3.
UniGeneiMm.34268.

3D structure databases

ProteinModelPortaliQ9Z0X0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Z0X0.
PhosphoSitePlusiQ9Z0X0.

Proteomic databases

MaxQBiQ9Z0X0.
PaxDbiQ9Z0X0.
PeptideAtlasiQ9Z0X0.
PRIDEiQ9Z0X0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076831; ENSMUSP00000092508; ENSMUSG00000063838.
GeneIDi58804.
KEGGimmu:58804.
UCSCiuc009exe.1. mouse.

Organism-specific databases

CTDi148170.
MGIiMGI:1929745. Cdc42ep5.

Phylogenomic databases

eggNOGiENOG410J2KV. Eukaryota.
ENOG410ZF7J. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000043688.
HOVERGENiHBG080905.
InParanoidiQ9Z0X0.
OMAiQHPRARC.
OrthoDBiEOG091G11DR.
PhylomeDBiQ9Z0X0.
TreeFamiTF331725.

Enzyme and pathway databases

ReactomeiR-MMU-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

PROiQ9Z0X0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063838.
CleanExiMM_CDC42EP5.
ExpressionAtlasiQ9Z0X0. baseline and differential.
GenevisibleiQ9Z0X0. MM.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBORG3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0X0
Secondary accession number(s): Q3SYK1, Q9QZT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.