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Protein

Chloride intracellular channel protein 4

Gene

Clic4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).By similarity2 Publications

GO - Molecular functioni

  • chloride channel activity Source: RGD
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 4
Alternative name(s):
Intracellular chloride ion channel protein p64H1
Gene namesi
Name:Clic4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61857 Clic4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001442122 – 253Chloride intracellular channel protein 4Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei130N6-acetyllysineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei244PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z0W7
PRIDEiQ9Z0W7

2D gel databases

World-2DPAGEi0004:Q9Z0W7

PTM databases

iPTMnetiQ9Z0W7
PhosphoSitePlusiQ9Z0W7
SwissPalmiQ9Z0W7

Expressioni

Tissue specificityi

Detected in brain, in cell bodies and dendrites of Purkinje cells in cerebellar neurons (at protein level). Marked expression was found in hippocampus and cerebellum, and in many other tissues.1 Publication

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with HRH3.By similarity1 Publication

Protein-protein interaction databases

BioGridi249813, 6 interactors
CORUMiQ9Z0W7
STRINGi10116.ENSRNOP00000024464

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W7
SMRiQ9Z0W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 244GST C-terminalAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 101Required for insertion into the membraneBy similarityAdd BLAST100

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiQ9Z0W7
KOiK05024
PhylomeDBiQ9Z0W7

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030257 CLIC-4
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF7 PTHR43920:SF7, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV
60 70 80 90 100
VFSVTTVDLK RKPAHLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC
110 120 130 140 150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK
160 170 180 190 200
LDEYLNSPLP GEIDENSMED IKSSTRRFLD GDEMTLADCN LLPKLHIVKV
210 220 230 240 250
VAKKYRNFDI PKGMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR

LTK
Length:253
Mass (Da):28,633
Last modified:January 23, 2007 - v3
Checksum:iDC2A66C3258AAFCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104119 mRNA Translation: AAD16875.1
PIRiS70484
RefSeqiNP_114006.1, NM_031818.1
UniGeneiRn.104756

Genome annotation databases

GeneIDi83718
KEGGirno:83718

Similar proteinsi

Entry informationi

Entry nameiCLIC4_RAT
AccessioniPrimary (citable) accession number: Q9Z0W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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