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Protein

Nuclear pore complex protein Nup160

Gene

Nup160

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in poly(A)+ RNA transport.1 Publication

GO - Molecular functioni

  • nucleocytoplasmic transporter activity Source: UniProtKB

GO - Biological processi

  • mRNA export from nucleus Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup160
Alternative name(s):
160 kDa nucleoporin
Gene trap locus 1-13 protein
Short name:
GTL-13
Nucleoporin Nup160
Gene namesi
Name:Nup160
Synonyms:Gtl1-13, Kiaa0197
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926227. Nup160.

Subcellular locationi

GO - Cellular componenti

  • kinetochore Source: Ensembl
  • nuclear pore Source: UniProtKB
  • nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14021402Nuclear pore complex protein Nup160PRO_0000204852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561PhosphoserineCombined sources
Modified residuei1123 – 11231PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z0W3.
MaxQBiQ9Z0W3.
PaxDbiQ9Z0W3.
PRIDEiQ9Z0W3.

PTM databases

iPTMnetiQ9Z0W3.
PhosphoSiteiQ9Z0W3.

Expressioni

Gene expression databases

BgeeiQ9Z0W3.
CleanExiMM_NUP160.
GenevisibleiQ9Z0W3. MM.

Interactioni

Subunit structurei

Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.2 Publications

Protein-protein interaction databases

BioGridi208486. 1 interaction.
IntActiQ9Z0W3. 1 interaction.
STRINGi10090.ENSMUSP00000059289.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4521. Eukaryota.
ENOG410YYM5. LUCA.
GeneTreeiENSGT00390000000972.
HOVERGENiHBG052681.
InParanoidiQ9Z0W3.
KOiK14303.
OMAiGFYYMES.
OrthoDBiEOG7B31MH.
PhylomeDBiQ9Z0W3.
TreeFamiTF353082.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGSLERS FVELSGAERE RPRHFREFTV CDIGTASAAF GTVKYSESAG
60 70 80 90 100
GFYYVESGKL FSITRNRFIH WKTSGDTLEL VEESLDLNLL NNAVRLKFQN
110 120 130 140 150
YNILPGGVHV SETQNHVIIL ILTNQTVHRL ILPHPSRMYR SELVTESQMQ
160 170 180 190 200
SIFTDIGKVD FRDPCNSQLI PSVPGLSPGS TTSAAWLSSD GEALFALPSA
210 220 230 240 250
SGGIFVLKLP PYDVPGIASV VELKQSSVMQ RLLTGWMPTA IRGDHGPSDR
260 270 280 290 300
ALSLAVHCVE HDAFIFALCQ DHKLRMWSYK DQMCLMVADM LEYVPVNKDL
310 320 330 340 350
RLTAGTGHKL RLAYSPSMGL YLGIYMHAPK RGQFCVFQLV STENNRYSLD
360 370 380 390 400
HISSLFTSQE TLVDFALTST DIWALWHDAE NQTIVKYINF EHNVAGQWNP
410 420 430 440 450
VFMQPLPEEE IVIRDDQDPR EMYLRSLFTP GHFINAALCK ALQIFCRGTE
460 470 480 490 500
RNLDLSWNEL KKEITLAVEN ELQGSVTEYE FSQDEFRTLQ QEFWCKFYAC
510 520 530 540 550
VLQYQEALSH PLALHLNPVT NMVCLLKKGY LSFLVPSSLV DHLYLLPDEH
560 570 580 590 600
LLTEDETTIS DDADVARDVL CLIKCLRMIG ESVTMDMAVL METSCYNLQS
610 620 630 640 650
PEKAAEHILE DLITIDVENV MEDICSKLQE IRNPVHAIGL LIREMDYETE
660 670 680 690 700
VEMEKGFDPA QPLNVRMNLS QLYGSSTAGY IVCRGVYKIA STRFLICRDL
710 720 730 740 750
LILQQLLTRL GDAVILGAGQ LFQAQQDLLH RTAPLLLSYY LIKWASQCLA
760 770 780 790 800
TDVPVDTLES NLQHLSVLEL TDSGALMANK LVSSPQTIME LFFQEVARKQ
810 820 830 840 850
IISHLFSQPK APLSQTGLNW PEMITAVTGY LLQLLWPSNP GCLFLECLMG
860 870 880 890 900
NCQYVQLQDY IQLLHPWCQV NVGSCRFMLG RCYLVTGEVQ KALECFCQAA
910 920 930 940 950
SEVGKEEFLD RLIRSEDGEI VSTPKLQYYD KVLRLLDVVG LPELVIQLAT
960 970 980 990 1000
SAITEAGDDW KSQATLRTCI FKHHLDLGHN SQAYEALTQI PDSSRQLDCL
1010 1020 1030 1040 1050
RQLVVVLCER SQLQDLVEFP YVNLHNEVVG IIESRARAVD LMTHNYYELL
1060 1070 1080 1090 1100
YAFHIYRHNY RKAGTVMFEY GMRLGREVRT LRGLEKQGNC YLAAINCLRL
1110 1120 1130 1140 1150
IRPEYAWIVQ PASGAVSDRP GASPKRNHDG ECTAAPTNRQ IEILELEDLE
1160 1170 1180 1190 1200
KEYSLARIRL TLARHDPSVI AIAGSSSAKE MSALLVQAGL FDTAISLCQT
1210 1220 1230 1240 1250
FTLPLTPVFE GLAFKCIKLQ FGGEAAQGEA WSWLATNQLS SVITTKESSA
1260 1270 1280 1290 1300
TDEAWRLLST YLERYKVQNN LYHHCVINKL LSHGVPLPNW LINSYKKVDA
1310 1320 1330 1340 1350
AELLRLYLNY DLLEEAVDLV SEYVDAVLGK GHQYFGIEFP LSATAPMVWL
1360 1370 1380 1390 1400
PYSSIDQLLQ ALGENSANSH NIILSQKILD KLEDYQQKVD KATRDLLYRR

DL
Length:1,402
Mass (Da):158,232
Last modified:November 1, 1999 - v2
Checksum:i3BF5D9F057D28772
GO
Isoform 2 (identifier: Q9Z0W3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     836-839: WPSN → YPFA
     840-1402: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):94,530
Checksum:i4EB2C8B809FCB38E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti562 – 5632Missing in AAH52450 (PubMed:15489334).Curated
Sequence conflicti562 – 5632Missing in AAH54523 (PubMed:15489334).Curated
Sequence conflicti1156 – 11561A → T (PubMed:16141072).Curated
Sequence conflicti1314 – 13141E → G in AK012715 (PubMed:16141072).Curated
Sequence conflicti1368 – 13681N → D in AK012715 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei836 – 8394WPSN → YPFA in isoform 2. 1 PublicationVSP_018500
Alternative sequencei840 – 1402563Missing in isoform 2. 1 PublicationVSP_018501Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104415 mRNA. Translation: AAD17922.2.
AK012715 mRNA. No translation available.
AK155492 mRNA. Translation: BAE33292.1.
AK164802 mRNA. Translation: BAE37926.1.
AK171218 mRNA. Translation: BAE42322.1.
BC052450 mRNA. Translation: AAH52450.1.
BC054523 mRNA. Translation: AAH54523.1.
AK172911 mRNA. Translation: BAD32189.1.
CCDSiCCDS16413.1. [Q9Z0W3-1]
RefSeqiNP_067487.1. NM_021512.2. [Q9Z0W3-1]
XP_006500031.1. XM_006499968.2. [Q9Z0W3-1]
UniGeneiMm.24532.

Genome annotation databases

EnsembliENSMUST00000057481; ENSMUSP00000059289; ENSMUSG00000051329. [Q9Z0W3-1]
GeneIDi59015.
KEGGimmu:59015.
UCSCiuc008ksw.1. mouse. [Q9Z0W3-1]
uc008ksy.1. mouse. [Q9Z0W3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104415 mRNA. Translation: AAD17922.2.
AK012715 mRNA. No translation available.
AK155492 mRNA. Translation: BAE33292.1.
AK164802 mRNA. Translation: BAE37926.1.
AK171218 mRNA. Translation: BAE42322.1.
BC052450 mRNA. Translation: AAH52450.1.
BC054523 mRNA. Translation: AAH54523.1.
AK172911 mRNA. Translation: BAD32189.1.
CCDSiCCDS16413.1. [Q9Z0W3-1]
RefSeqiNP_067487.1. NM_021512.2. [Q9Z0W3-1]
XP_006500031.1. XM_006499968.2. [Q9Z0W3-1]
UniGeneiMm.24532.

3D structure databases

ProteinModelPortaliQ9Z0W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208486. 1 interaction.
IntActiQ9Z0W3. 1 interaction.
STRINGi10090.ENSMUSP00000059289.

PTM databases

iPTMnetiQ9Z0W3.
PhosphoSiteiQ9Z0W3.

Proteomic databases

EPDiQ9Z0W3.
MaxQBiQ9Z0W3.
PaxDbiQ9Z0W3.
PRIDEiQ9Z0W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057481; ENSMUSP00000059289; ENSMUSG00000051329. [Q9Z0W3-1]
GeneIDi59015.
KEGGimmu:59015.
UCSCiuc008ksw.1. mouse. [Q9Z0W3-1]
uc008ksy.1. mouse. [Q9Z0W3-2]

Organism-specific databases

CTDi23279.
MGIiMGI:1926227. Nup160.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4521. Eukaryota.
ENOG410YYM5. LUCA.
GeneTreeiENSGT00390000000972.
HOVERGENiHBG052681.
InParanoidiQ9Z0W3.
KOiK14303.
OMAiGFYYMES.
OrthoDBiEOG7B31MH.
PhylomeDBiQ9Z0W3.
TreeFamiTF353082.

Enzyme and pathway databases

ReactomeiR-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

NextBioi314572.
PROiQ9Z0W3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0W3.
CleanExiMM_NUP160.
GenevisibleiQ9Z0W3. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus mRNA for gtl-13 (gene trap locus-13), similar to human KIAA0197 gene (D83781), complete cds."
    Van de Putte T., Cozijnsen M., Dewulf N., Tylzanowski P., Lonnoy O., Huylebroeck D.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-985 AND 1151-1402 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell, Embryo and Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 542-1402 (ISOFORM 1).
    Tissue: Natural killer cell.
  5. "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells."
    Belgareh N., Rabut G., Bai S.W., van Overbeek M., Beaudouin J., Daigle N., Zatsepina O.V., Pasteau F., Labas V., Fromont-Racine M., Ellenberg J., Doye V.
    J. Cell Biol. 154:1147-1160(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
  6. "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export."
    Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J.
    J. Cell Biol. 155:339-354(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456 AND SER-1123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNU160_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0W3
Secondary accession number(s): Q3TBI7
, Q3TP11, Q3U250, Q6A0A7, Q7TME1, Q9CZD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.