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Q9Z0W1

- TNR16_MOUSE

UniProt

Q9Z0W1 - TNR16_MOUSE

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Protein

Tumor necrosis factor receptor superfamily member 16

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Binds to rabies virus glycoprotein Gs. Necessary for the circadian oscilllation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.By similarity2 Publications

GO - Molecular functioni

  1. death receptor activity Source: MGI
  2. nerve growth factor binding Source: MGI
  3. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. axon guidance Source: MGI
  3. central nervous system development Source: MGI
  4. circadian regulation of gene expression Source: UniProtKB
  5. circadian rhythm Source: UniProtKB
  6. detection of temperature stimulus Source: MGI
  7. glucose homeostasis Source: UniProtKB
  8. hair follicle morphogenesis Source: MGI
  9. intracellular protein transport Source: UniProtKB
  10. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  11. negative regulation of hair follicle development Source: MGI
  12. nerve development Source: MGI
  13. positive regulation of apoptotic signaling pathway Source: MGI
  14. positive regulation of fibroblast proliferation Source: MGI
  15. positive regulation of odontogenesis of dentin-containing tooth Source: MGI
  16. regulation of gene expression Source: MGI
  17. regulation of glucose import in response to insulin stimulus Source: UniProtKB
  18. skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis, Biological rhythms, Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_202271. NRIF signals cell death from the nucleus.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor
CD_antigen: CD271
Gene namesi
Name:Ngfr
Synonyms:Tnfrsf16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97323. Ngfr.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 246225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei247 – 26519HelicalSequence AnalysisAdd
BLAST
Topological domaini266 – 417152CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal postsynaptic density Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 417396Tumor necrosis factor receptor superfamily member 16PRO_0000034592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 36PROSITE-ProRule annotation
Disulfide bondi37 ↔ 50PROSITE-ProRule annotation
Disulfide bondi40 ↔ 57PROSITE-ProRule annotation
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi79 ↔ 92PROSITE-ProRule annotation
Disulfide bondi82 ↔ 100PROSITE-ProRule annotation
Disulfide bondi102 ↔ 115PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Disulfide bondi142 ↔ 157PROSITE-ProRule annotation
Disulfide bondi160 ↔ 173PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.By similarity
Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z0W1.
PaxDbiQ9Z0W1.
PRIDEiQ9Z0W1.

PTM databases

PhosphoSiteiQ9Z0W1.

Expressioni

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain and in liver. Expression seen at higher levels during the light period and lower during the dark period.1 Publication

Gene expression databases

GenevestigatoriQ9Z0W1.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (via death domain) with RAB31. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.2 Publications

Protein-protein interaction databases

IntActiQ9Z0W1. 5 interactions.
MINTiMINT-243918.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W1.
SMRiQ9Z0W1. Positions 24-223, 326-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 5734TNFR-Cys 1Add
BLAST
Repeati59 – 10042TNFR-Cys 2Add
BLAST
Repeati101 – 13939TNFR-Cys 3Add
BLAST
Repeati141 – 18141TNFR-Cys 4Add
BLAST
Domaini346 – 41166DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni319 – 33416Mediates interaction with KIDINS220By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi190 – 24152Ser/Thr-richAdd
BLAST

Domaini

Death domain is responsible for interaction with RANBP9.By similarity
The extracellular domain is responsible for interaction with NTRK1.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39106.
HOVERGENiHBG060431.
InParanoidiQ9Z0W1.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0W1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC
60 70 80 90 100
GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC
110 120 130 140 150
RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE
160 170 180 190 200
ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV
210 220 230 240 250
TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS
260 270 280 290 300
ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI
310 320 330 340 350
SVDSQSLHDQ QTHTQTASAQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR
360 370 380 390 400
HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR
410
ADIVESLCSE STATSPV
Length:417
Mass (Da):44,686
Last modified:May 1, 1999 - v1
Checksum:i5D7A4510DB8AF9B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105292 mRNA. Translation: AAD17943.1.
UniGeneiMm.283893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105292 mRNA. Translation: AAD17943.1 .
UniGenei Mm.283893.

3D structure databases

ProteinModelPortali Q9Z0W1.
SMRi Q9Z0W1. Positions 24-223, 326-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Z0W1. 5 interactions.
MINTi MINT-243918.

PTM databases

PhosphoSitei Q9Z0W1.

Proteomic databases

MaxQBi Q9Z0W1.
PaxDbi Q9Z0W1.
PRIDEi Q9Z0W1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97323. Ngfr.

Phylogenomic databases

eggNOGi NOG39106.
HOVERGENi HBG060431.
InParanoidi Q9Z0W1.

Enzyme and pathway databases

Reactomei REACT_202271. NRIF signals cell death from the nucleus.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

PROi Q9Z0W1.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9Z0W1.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view ]
PRINTSi PR01966. TNFACTORR16.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus."
    Tuffereau C., Benejean J., Blondel D., Kieffer B., Flamand A.
    EMBO J. 17:7250-7259(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A.
  2. "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis."
    Mukai J., Shoji S., Kimura M.T., Okubo S., Sano H., Suvanto P., Li Y., Irie S., Sato T.-A.
    J. Biol. Chem. 277:13973-13982(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NGFRAP1.
  3. Cited for: FUNCTION, INTERACTION WITH RAB31.
  4. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
    Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
    J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiTNR16_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3