Tumor necrosis factor receptor superfamily member 16 precursor

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Q9Z0W1 (TNR16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 16

Alternative name(s):
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name=NGF receptor
CD_antigen=CD271

Gene names

Name:	Ngfr
Synonyms:	Tnfrsf16

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells By similarity. Binds to rabies virus glycoprotein Gs.
Subunit structure	Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts with BEX1. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with NRADD By similarity. Interacts with NGFRAP1/BEX3. Ref.2
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Domain	Death domain is responsible for interaction with RANBP9 By similarity. The extracellular domain is responsible for interaction with NTRK1 By similarity.
Post-translational modification	N- and O-glycosylated By similarity. Phosphorylated on serine residues By similarity. Ref.3
Sequence similarities	Contains 1 death domain. Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis Differentiation Neurogenesis
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cell surface Inferred from direct assay. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

By similarity

Chain

22 – 417

396

Tumor necrosis factor receptor superfamily member 16

PRO_0000034592

Regions

Topological domain

22 – 246

225

Extracellular Potential

Transmembrane

247 – 265

Helical; Potential

Topological domain

266 – 417

152

Cytoplasmic Potential

Repeat

24 – 57

TNFR-Cys 1

Repeat

59 – 100

TNFR-Cys 2

Repeat

101 – 139

TNFR-Cys 3

Repeat

141 – 181

TNFR-Cys 4

Domain

346 – 411

Death

Region

319 – 334

Mediates interaction with KIDINS220 By similarity

Compositional bias

190 – 241

Ser/Thr-rich

Amino acid modifications

Modified residue

286

Phosphothreonine Ref.3

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

25 ↔ 36

By similarity

Disulfide bond

37 ↔ 50

By similarity

Disulfide bond

40 ↔ 57

By similarity

Disulfide bond

60 ↔ 76

By similarity

Disulfide bond

79 ↔ 92

By similarity

Disulfide bond

82 ↔ 100

By similarity

Disulfide bond

102 ↔ 115

By similarity

Disulfide bond

118 ↔ 131

By similarity

Disulfide bond

121 ↔ 139

By similarity

Disulfide bond

142 ↔ 157

By similarity

Disulfide bond

160 ↔ 173

By similarity

Disulfide bond

163 ↔ 181

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Z0W1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 5D7A4510DB8AF9B2
Show »

FASTA

417

44,686

        10         20         30         40         50         60 
MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC GANQTVCEPC 

        70         80         90        100        110        120 
LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC RCSYGYYQDE ETGRCEACSV 

       130        140        150        160        170        180 
CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE ANHVDPCLPC TVCEDTERQL RECTPWADAE 

       190        200        210        220        230        240 
CEEIPGRWIT RSTPPEGSDV TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT 

       250        260        270        280        290        300 
ADNLIPVYCS ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI 

       310        320        330        340        350        360 
SVDSQSLHDQ QTHTQTASAQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR HLAGELGYQP 

       370        380        390        400        410 
EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR ADIVESLCSE STATSPV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus." Tuffereau C., Benejean J., Blondel D., Kieffer B., Flamand A. EMBO J. 17:7250-7259(1998) [PubMed: 9857182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: A.
[2]	"Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis." Mukai J., Shoji S., Kimura M.T., Okubo S., Sano H., Suvanto P., Li Y., Irie S., Sato T.-A. J. Biol. Chem. 277:13973-13982(2002) [PubMed: 11830582] [Abstract] Cited for: INTERACTION WITH NGFRAP1.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF105292 mRNA. Translation: AAD17943.1.
IPI	IPI00407509.
UniGene	Mm.283893.
3D structure databases
ProteinModelPortal	Q9Z0W1.
SMR	Q9Z0W1. Positions 24-182, 326-410.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-243918.
STRING	Q9Z0W1.
PTM databases
PhosphoSite	Q9Z0W1.
Proteomic databases
PRIDE	Q9Z0W1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97323. Ngfr.
Phylogenomic databases
GeneTree	ENSGT00550000074207.
HOVERGEN	HBG060431.
InParanoid	Q9Z0W1.
OrthoDB	EOG4ZKJM8.
Enzyme and pathway databases
Reactome	REACT_115202. Signal Transduction.
Gene expression databases
ArrayExpress	Q9Z0W1.
Bgee	Q9Z0W1.
Genevestigator	Q9Z0W1.
GermOnline	ENSMUSG00000000120. Mus musculus.
Family and domain databases
InterPro	IPR000488. Death. IPR011029. DEATH-like. IPR022325. TNFR_16. IPR001368. TNFR_Cys_rich_reg. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
Pfam	PF00531. Death. 1 hit. PF00020. TNFR_c6. 3 hits. [Graphical view]
PRINTS	PR01966. TNFACTORR16.
SMART	SM00005. DEATH. 1 hit. SM00208. TNFR. 4 hits. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 3 hits. PS50050. TNFR_NGFR_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

TNR16_MOUSE

Accession

Primary (citable) accession number: Q9Z0W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents