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Protein

Tumor necrosis factor receptor superfamily member 16

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Binds to rabies virus glycoprotein Gs. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.By similarity2 Publications

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • coreceptor activity Source: MGI
  • death receptor activity Source: MGI
  • nerve growth factor binding Source: MGI
  • Rab GTPase binding Source: UniProtKB
  • tumor necrosis factor-activated receptor activity Source: GO_Central
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • axon guidance Source: MGI
  • cellular response to amyloid-beta Source: MGI
  • central nervous system development Source: MGI
  • circadian regulation of gene expression Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • detection of temperature stimulus Source: MGI
  • dorsal aorta development Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • hair follicle morphogenesis Source: MGI
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • intracellular protein transport Source: UniProtKB
  • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: MGI
  • negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • negative regulation of hair follicle development Source: MGI
  • negative regulation of neuron projection development Source: GO_Central
  • nerve development Source: MGI
  • neuron apoptotic process Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
  • positive regulation of protein localization to nucleus Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of glucose import in response to insulin stimulus Source: UniProtKB
  • response to lipopolysaccharide Source: GO_Central
  • Rho protein signal transduction Source: MGI
  • skin development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis, Biological rhythms, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor
CD_antigen: CD271
Gene namesi
Name:Ngfr
Synonyms:Tnfrsf16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97323 Ngfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 246ExtracellularSequence analysisAdd BLAST225
Transmembranei247 – 265HelicalSequence analysisAdd BLAST19
Topological domaini266 – 417CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003459222 – 417Tumor necrosis factor receptor superfamily member 16Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 36PROSITE-ProRule annotation
Disulfide bondi37 ↔ 50PROSITE-ProRule annotation
Disulfide bondi40 ↔ 57PROSITE-ProRule annotation
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi79 ↔ 92PROSITE-ProRule annotation
Disulfide bondi82 ↔ 100PROSITE-ProRule annotation
Disulfide bondi102 ↔ 115PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Disulfide bondi142 ↔ 157PROSITE-ProRule annotation
Disulfide bondi160 ↔ 173PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

N- and O-glycosylated.By similarity
Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z0W1
PaxDbiQ9Z0W1
PeptideAtlasiQ9Z0W1
PRIDEiQ9Z0W1

PTM databases

iPTMnetiQ9Z0W1
PhosphoSitePlusiQ9Z0W1

Expressioni

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain and in liver. Expression seen at higher levels during the light period and lower during the dark period.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (via death domain) with RAB31. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1. Interacts with RTN4R (PubMed:22923615).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Sorcs2Q9EPR54EBI-4411273,EBI-9915438

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • nerve growth factor binding Source: MGI
  • Rab GTPase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

CORUMiQ9Z0W1
IntActiQ9Z0W1, 6 interactors
MINTiQ9Z0W1
STRINGi10090.ENSMUSP00000000122

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W1
SMRiQ9Z0W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 57TNFR-Cys 1Add BLAST34
Repeati59 – 100TNFR-Cys 2Add BLAST42
Repeati101 – 139TNFR-Cys 3Add BLAST39
Repeati141 – 181TNFR-Cys 4Add BLAST41
Domaini346 – 411DeathPROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni319 – 334Mediates interaction with KIDINS220By similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi190 – 241Ser/Thr-richAdd BLAST52

Domaini

Death domain is responsible for interaction with RANBP9.By similarity
The extracellular domain is responsible for interaction with NTRK1.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQFC Eukaryota
ENOG4111F3C LUCA
HOVERGENiHBG060431
InParanoidiQ9Z0W1

Family and domain databases

CDDicd13416 TNFRSF16, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022325 TNFR_16
IPR034046 TNFRSF16_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01966 TNFACTORR16
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC
60 70 80 90 100
GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC
110 120 130 140 150
RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE
160 170 180 190 200
ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV
210 220 230 240 250
TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS
260 270 280 290 300
ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI
310 320 330 340 350
SVDSQSLHDQ QTHTQTASAQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR
360 370 380 390 400
HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR
410
ADIVESLCSE STATSPV
Length:417
Mass (Da):44,686
Last modified:May 1, 1999 - v1
Checksum:i5D7A4510DB8AF9B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105292 mRNA Translation: AAD17943.1
UniGeneiMm.283893

Similar proteinsi

Entry informationi

Entry nameiTNR16_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health