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Q9Z0W1

- TNR16_MOUSE

UniProt

Q9Z0W1 - TNR16_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 16

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells By similarity. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Binds to rabies virus glycoprotein Gs. Necessary for the circadian oscilllation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.By similarity2 Publications

    GO - Molecular functioni

    1. death receptor activity Source: MGI
    2. nerve growth factor binding Source: MGI
    3. protein binding Source: UniProtKB
    4. Rab GTPase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. axon guidance Source: MGI
    3. central nervous system development Source: MGI
    4. circadian regulation of gene expression Source: UniProtKB
    5. circadian rhythm Source: UniProtKB
    6. detection of temperature stimulus Source: MGI
    7. glucose homeostasis Source: UniProtKB
    8. hair follicle morphogenesis Source: MGI
    9. intracellular protein transport Source: UniProtKB
    10. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    11. negative regulation of hair follicle development Source: MGI
    12. nerve development Source: MGI
    13. positive regulation of apoptotic signaling pathway Source: MGI
    14. positive regulation of fibroblast proliferation Source: MGI
    15. positive regulation of odontogenesis of dentin-containing tooth Source: MGI
    16. regulation of gene expression Source: MGI
    17. regulation of glucose import in response to insulin stimulus Source: UniProtKB
    18. skin development Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis, Biological rhythms, Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_202271. NRIF signals cell death from the nucleus.
    REACT_209641. NRAGE signals death through JNK.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 16
    Alternative name(s):
    Low affinity neurotrophin receptor p75NTR
    Low-affinity nerve growth factor receptor
    Short name:
    NGF receptor
    CD_antigen: CD271
    Gene namesi
    Name:Ngfr
    Synonyms:Tnfrsf16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97323. Ngfr.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. cytoplasm Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal postsynaptic density Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 417396Tumor necrosis factor receptor superfamily member 16PRO_0000034592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 36PROSITE-ProRule annotation
    Disulfide bondi37 ↔ 50PROSITE-ProRule annotation
    Disulfide bondi40 ↔ 57PROSITE-ProRule annotation
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi79 ↔ 92PROSITE-ProRule annotation
    Disulfide bondi82 ↔ 100PROSITE-ProRule annotation
    Disulfide bondi102 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
    Disulfide bondi142 ↔ 157PROSITE-ProRule annotation
    Disulfide bondi160 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi163 ↔ 181PROSITE-ProRule annotation

    Post-translational modificationi

    N- and O-glycosylated.By similarity
    Phosphorylated on serine residues.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z0W1.
    PaxDbiQ9Z0W1.
    PRIDEiQ9Z0W1.

    PTM databases

    PhosphoSiteiQ9Z0W1.

    Expressioni

    Inductioni

    Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain and in liver. Expression seen at higher levels during the light period and lower during the dark period.1 Publication

    Gene expression databases

    GenevestigatoriQ9Z0W1.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (via death domain) with RAB31. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.2 Publications

    Protein-protein interaction databases

    IntActiQ9Z0W1. 5 interactions.
    MINTiMINT-243918.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0W1.
    SMRiQ9Z0W1. Positions 24-223, 326-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 246225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 417152CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26519HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 5734TNFR-Cys 1Add
    BLAST
    Repeati59 – 10042TNFR-Cys 2Add
    BLAST
    Repeati101 – 13939TNFR-Cys 3Add
    BLAST
    Repeati141 – 18141TNFR-Cys 4Add
    BLAST
    Domaini346 – 41166DeathPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni319 – 33416Mediates interaction with KIDINS220By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 24152Ser/Thr-richAdd
    BLAST

    Domaini

    Death domain is responsible for interaction with RANBP9.By similarity
    The extracellular domain is responsible for interaction with NTRK1.By similarity

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39106.
    HOVERGENiHBG060431.
    InParanoidiQ9Z0W1.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01966. TNFACTORR16.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0W1-1 [UniParc]FASTAAdd to Basket

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    MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC    50
    GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC 100
    RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE 150
    ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV 200
    TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS 250
    ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI 300
    SVDSQSLHDQ QTHTQTASAQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR 350
    HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR 400
    ADIVESLCSE STATSPV 417
    Length:417
    Mass (Da):44,686
    Last modified:May 1, 1999 - v1
    Checksum:i5D7A4510DB8AF9B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105292 mRNA. Translation: AAD17943.1.
    UniGeneiMm.283893.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105292 mRNA. Translation: AAD17943.1 .
    UniGenei Mm.283893.

    3D structure databases

    ProteinModelPortali Q9Z0W1.
    SMRi Q9Z0W1. Positions 24-223, 326-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z0W1. 5 interactions.
    MINTi MINT-243918.

    PTM databases

    PhosphoSitei Q9Z0W1.

    Proteomic databases

    MaxQBi Q9Z0W1.
    PaxDbi Q9Z0W1.
    PRIDEi Q9Z0W1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97323. Ngfr.

    Phylogenomic databases

    eggNOGi NOG39106.
    HOVERGENi HBG060431.
    InParanoidi Q9Z0W1.

    Enzyme and pathway databases

    Reactomei REACT_202271. NRIF signals cell death from the nucleus.
    REACT_209641. NRAGE signals death through JNK.

    Miscellaneous databases

    PROi Q9Z0W1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9Z0W1.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01966. TNFACTORR16.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus."
      Tuffereau C., Benejean J., Blondel D., Kieffer B., Flamand A.
      EMBO J. 17:7250-7259(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A.
    2. "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis."
      Mukai J., Shoji S., Kimura M.T., Okubo S., Sano H., Suvanto P., Li Y., Irie S., Sato T.-A.
      J. Biol. Chem. 277:13973-13982(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NGFRAP1.
    3. Cited for: FUNCTION, INTERACTION WITH RAB31.
    4. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
      Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
      J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiTNR16_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3