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Q9Z0W0 (GLP2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucagon-like peptide 2 receptor

Short name=GLP-2 receptor
Short name=GLP-2-R
Short name=GLP-2R
Gene names
Name:Glp2r
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Glucagon-like peptide 2 receptor
PRO_0000012839

Regions

Topological domain1 – 173173Extracellular By similarity
Transmembrane174 – 19825Helical; Name=1; By similarity
Topological domain199 – 21012Cytoplasmic By similarity
Transmembrane211 – 23525Helical; Name=2; By similarity
Topological domain236 – 26126Extracellular By similarity
Transmembrane262 – 28524Helical; Name=3; By similarity
Topological domain286 – 29914Cytoplasmic By similarity
Transmembrane300 – 32122Helical; Name=4; By similarity
Topological domain322 – 33918Extracellular By similarity
Transmembrane340 – 36223Helical; Name=5; By similarity
Topological domain363 – 38624Cytoplasmic By similarity
Transmembrane387 – 40519Helical; Name=6; By similarity
Topological domain406 – 41712Extracellular By similarity
Transmembrane418 – 43821Helical; Name=7; By similarity
Topological domain439 – 550112Cytoplasmic By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 105 By similarity
Disulfide bond96 ↔ 137 By similarity
Disulfide bond118 ↔ 159 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z0W0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 22E269F811E25226

FASTA55063,102
        10         20         30         40         50         60 
MRPQPSPAVP SRCREAPVPR VRAQPVGIPE AQGPVPLHSQ QMRLLWGPGR PFLALLLLVS 

        70         80         90        100        110        120 
IKQVTGSLLK ETTQKWANYK EKCLEDLHNR LSGIFCNGTF DRYVCWPHSY PGNVSVPCPS 

       130        140        150        160        170        180 
YLPWWNAESP GRAYRHCLAQ GTWQTRENTT DIWQDESECS ENHSFRQNVD HYALLYTLQL 

       190        200        210        220        230        240 
MYTVGYSVSL ISLFLALTLF LFLRKLHCTR NYIHMNLFAS FILKVLAVLV KDMVSHNSYS 

       250        260        270        280        290        300 
KRPDDESGWM SYLSETSVSC RSVQVLLHYF VGTNHLWLLV EGLYLHTLLE PTVFPERRLW 

       310        320        330        340        350        360 
PKYLVVGWAF PMLFVIPWGF ARAHLENTRC WATNGNLKIW WIIRGPMLLC VTVNFFIFLK 

       370        380        390        400        410        420 
ILKLLISKLK AHQMCFRDYK YRLAKSTLLL IPLLGVHEVL FTFFPDDQVQ GFSKRIRLFI 

       430        440        450        460        470        480 
QLTLSSVHGF LVALQYGFAN GEVKAELRKS WGRFLLARHW GCRTCVLGKN FRFLGKCSKK 

       490        500        510        520        530        540 
LSEGDGSETL QKLRFSTCSS HLASETLGDV GVQPHRGRGA WPRGSSLSES SEGDFTLANT 

       550 
MEEILEESEI 

« Hide

References

[1]"Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2."
Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H., Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K., Sumner-Smith M., Drucker D.J., Crivici A.
Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Hypothalamus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF105368 mRNA. Translation: AAD16896.1.
RefSeqNP_068620.1. NM_021848.1.
UniGeneRn.163105.

3D structure databases

ProteinModelPortalQ9Z0W0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248832. 1 interaction.

Chemistry

GuidetoPHARMACOLOGY250.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ9Z0W0.
PRIDEQ9Z0W0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683.
GeneID60432.
KEGGrno:60432.
UCSCRGD:620270. rat.

Organism-specific databases

CTD9340.
RGD620270. Glp2r.

Phylogenomic databases

eggNOGNOG267068.
GeneTreeENSGT00740000115231.
HOGENOMHOG000008250.
HOVERGENHBG008318.
InParanoidQ9Z0W0.
KOK04582.
OMACNGTFDQ.
OrthoDBEOG7TF78W.
PhylomeDBQ9Z0W0.
TreeFamTF315710.

Gene expression databases

GenevestigatorQ9Z0W0.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612158.
PROQ9Z0W0.

Entry information

Entry nameGLP2R_RAT
AccessionPrimary (citable) accession number: Q9Z0W0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries