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Q9Z0W0

- GLP2R_RAT

UniProt

Q9Z0W0 - GLP2R_RAT

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Protein
Glucagon-like peptide 2 receptor
Gene
Glp2r
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  2. cellular response to glucagon stimulus Source: GOC
  3. homeostatic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:Glp2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi620270. Glp2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 173173Extracellular By similarity
Add
BLAST
Transmembranei174 – 19825Helical; Name=1; By similarity
Add
BLAST
Topological domaini199 – 21012Cytoplasmic By similarity
Add
BLAST
Transmembranei211 – 23525Helical; Name=2; By similarity
Add
BLAST
Topological domaini236 – 26126Extracellular By similarity
Add
BLAST
Transmembranei262 – 28524Helical; Name=3; By similarity
Add
BLAST
Topological domaini286 – 29914Cytoplasmic By similarity
Add
BLAST
Transmembranei300 – 32122Helical; Name=4; By similarity
Add
BLAST
Topological domaini322 – 33918Extracellular By similarity
Add
BLAST
Transmembranei340 – 36223Helical; Name=5; By similarity
Add
BLAST
Topological domaini363 – 38624Cytoplasmic By similarity
Add
BLAST
Transmembranei387 – 40519Helical; Name=6; By similarity
Add
BLAST
Topological domaini406 – 41712Extracellular By similarity
Add
BLAST
Transmembranei418 – 43821Helical; Name=7; By similarity
Add
BLAST
Topological domaini439 – 550112Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucagon-like peptide 2 receptor
PRO_0000012839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 105 By similarity
Disulfide bondi96 ↔ 137 By similarity
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 159 By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0W0.
PRIDEiQ9Z0W0.

Expressioni

Gene expression databases

GenevestigatoriQ9Z0W0.

Interactioni

Protein-protein interaction databases

BioGridi248832. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267068.
GeneTreeiENSGT00740000115231.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ9Z0W0.
KOiK04582.
OMAiCNGTFDQ.
OrthoDBiEOG7TF78W.
PhylomeDBiQ9Z0W0.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0W0-1 [UniParc]FASTAAdd to Basket

« Hide

MRPQPSPAVP SRCREAPVPR VRAQPVGIPE AQGPVPLHSQ QMRLLWGPGR    50
PFLALLLLVS IKQVTGSLLK ETTQKWANYK EKCLEDLHNR LSGIFCNGTF 100
DRYVCWPHSY PGNVSVPCPS YLPWWNAESP GRAYRHCLAQ GTWQTRENTT 150
DIWQDESECS ENHSFRQNVD HYALLYTLQL MYTVGYSVSL ISLFLALTLF 200
LFLRKLHCTR NYIHMNLFAS FILKVLAVLV KDMVSHNSYS KRPDDESGWM 250
SYLSETSVSC RSVQVLLHYF VGTNHLWLLV EGLYLHTLLE PTVFPERRLW 300
PKYLVVGWAF PMLFVIPWGF ARAHLENTRC WATNGNLKIW WIIRGPMLLC 350
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLLL IPLLGVHEVL 400
FTFFPDDQVQ GFSKRIRLFI QLTLSSVHGF LVALQYGFAN GEVKAELRKS 450
WGRFLLARHW GCRTCVLGKN FRFLGKCSKK LSEGDGSETL QKLRFSTCSS 500
HLASETLGDV GVQPHRGRGA WPRGSSLSES SEGDFTLANT MEEILEESEI 550
Length:550
Mass (Da):63,102
Last modified:May 1, 1999 - v1
Checksum:i22E269F811E25226
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105368 mRNA. Translation: AAD16896.1.
RefSeqiNP_068620.1. NM_021848.1.
UniGeneiRn.163105.

Genome annotation databases

EnsembliENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683.
GeneIDi60432.
KEGGirno:60432.
UCSCiRGD:620270. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105368 mRNA. Translation: AAD16896.1 .
RefSeqi NP_068620.1. NM_021848.1.
UniGenei Rn.163105.

3D structure databases

ProteinModelPortali Q9Z0W0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248832. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 250.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q9Z0W0.
PRIDEi Q9Z0W0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004946 ; ENSRNOP00000004946 ; ENSRNOG00000003683 .
GeneIDi 60432.
KEGGi rno:60432.
UCSCi RGD:620270. rat.

Organism-specific databases

CTDi 9340.
RGDi 620270. Glp2r.

Phylogenomic databases

eggNOGi NOG267068.
GeneTreei ENSGT00740000115231.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi Q9Z0W0.
KOi K04582.
OMAi CNGTFDQ.
OrthoDBi EOG7TF78W.
PhylomeDBi Q9Z0W0.
TreeFami TF315710.

Miscellaneous databases

NextBioi 612158.
PROi Q9Z0W0.

Gene expression databases

Genevestigatori Q9Z0W0.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiGLP2R_RAT
AccessioniPrimary (citable) accession number: Q9Z0W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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