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Protein

Glucagon-like peptide 2 receptor

Gene

Glp2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  2. cellular response to glucagon stimulus Source: GOC
  3. homeostatic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_326473. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:Glp2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620270. Glp2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 173173ExtracellularBy similarityAdd
BLAST
Transmembranei174 – 19825Helical; Name=1By similarityAdd
BLAST
Topological domaini199 – 21012CytoplasmicBy similarityAdd
BLAST
Transmembranei211 – 23525Helical; Name=2By similarityAdd
BLAST
Topological domaini236 – 26126ExtracellularBy similarityAdd
BLAST
Transmembranei262 – 28524Helical; Name=3By similarityAdd
BLAST
Topological domaini286 – 29914CytoplasmicBy similarityAdd
BLAST
Transmembranei300 – 32122Helical; Name=4By similarityAdd
BLAST
Topological domaini322 – 33918ExtracellularBy similarityAdd
BLAST
Transmembranei340 – 36223Helical; Name=5By similarityAdd
BLAST
Topological domaini363 – 38624CytoplasmicBy similarityAdd
BLAST
Transmembranei387 – 40519Helical; Name=6By similarityAdd
BLAST
Topological domaini406 – 41712ExtracellularBy similarityAdd
BLAST
Transmembranei418 – 43821Helical; Name=7By similarityAdd
BLAST
Topological domaini439 – 550112CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucagon-like peptide 2 receptorPRO_0000012839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0W0.
PRIDEiQ9Z0W0.

Expressioni

Gene expression databases

ExpressionAtlasiQ9Z0W0. baseline.
GenevestigatoriQ9Z0W0.

Interactioni

Protein-protein interaction databases

BioGridi248832. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267068.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ9Z0W0.
KOiK04582.
OMAiCNGTFDQ.
OrthoDBiEOG7TF78W.
PhylomeDBiQ9Z0W0.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQPSPAVP SRCREAPVPR VRAQPVGIPE AQGPVPLHSQ QMRLLWGPGR
60 70 80 90 100
PFLALLLLVS IKQVTGSLLK ETTQKWANYK EKCLEDLHNR LSGIFCNGTF
110 120 130 140 150
DRYVCWPHSY PGNVSVPCPS YLPWWNAESP GRAYRHCLAQ GTWQTRENTT
160 170 180 190 200
DIWQDESECS ENHSFRQNVD HYALLYTLQL MYTVGYSVSL ISLFLALTLF
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILKVLAVLV KDMVSHNSYS KRPDDESGWM
260 270 280 290 300
SYLSETSVSC RSVQVLLHYF VGTNHLWLLV EGLYLHTLLE PTVFPERRLW
310 320 330 340 350
PKYLVVGWAF PMLFVIPWGF ARAHLENTRC WATNGNLKIW WIIRGPMLLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLLL IPLLGVHEVL
410 420 430 440 450
FTFFPDDQVQ GFSKRIRLFI QLTLSSVHGF LVALQYGFAN GEVKAELRKS
460 470 480 490 500
WGRFLLARHW GCRTCVLGKN FRFLGKCSKK LSEGDGSETL QKLRFSTCSS
510 520 530 540 550
HLASETLGDV GVQPHRGRGA WPRGSSLSES SEGDFTLANT MEEILEESEI
Length:550
Mass (Da):63,102
Last modified:April 30, 1999 - v1
Checksum:i22E269F811E25226
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105368 mRNA. Translation: AAD16896.1.
RefSeqiNP_068620.1. NM_021848.1.
UniGeneiRn.163105.

Genome annotation databases

EnsembliENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683.
GeneIDi60432.
KEGGirno:60432.
UCSCiRGD:620270. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105368 mRNA. Translation: AAD16896.1.
RefSeqiNP_068620.1. NM_021848.1.
UniGeneiRn.163105.

3D structure databases

ProteinModelPortaliQ9Z0W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248832. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi250.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9Z0W0.
PRIDEiQ9Z0W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683.
GeneIDi60432.
KEGGirno:60432.
UCSCiRGD:620270. rat.

Organism-specific databases

CTDi9340.
RGDi620270. Glp2r.

Phylogenomic databases

eggNOGiNOG267068.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ9Z0W0.
KOiK04582.
OMAiCNGTFDQ.
OrthoDBiEOG7TF78W.
PhylomeDBiQ9Z0W0.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_326473. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi612158.
PROiQ9Z0W0.

Gene expression databases

ExpressionAtlasiQ9Z0W0. baseline.
GenevestigatoriQ9Z0W0.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiGLP2R_RAT
AccessioniPrimary (citable) accession number: Q9Z0W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2001
Last sequence update: April 30, 1999
Last modified: March 31, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.