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Q9Z0W0

- GLP2R_RAT

UniProt

Q9Z0W0 - GLP2R_RAT

Protein

Glucagon-like peptide 2 receptor

Gene

Glp2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. glucagon receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
    2. cellular response to glucagon stimulus Source: GOC
    3. homeostatic process Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucagon-like peptide 2 receptor
    Short name:
    GLP-2 receptor
    Short name:
    GLP-2-R
    Short name:
    GLP-2R
    Gene namesi
    Name:Glp2r
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi620270. Glp2r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Glucagon-like peptide 2 receptorPRO_0000012839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 105By similarity
    Disulfide bondi96 ↔ 137By similarity
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 159By similarity
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Z0W0.
    PRIDEiQ9Z0W0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z0W0.

    Interactioni

    Protein-protein interaction databases

    BioGridi248832. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0W0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 173173ExtracellularBy similarityAdd
    BLAST
    Topological domaini199 – 21012CytoplasmicBy similarityAdd
    BLAST
    Topological domaini236 – 26126ExtracellularBy similarityAdd
    BLAST
    Topological domaini286 – 29914CytoplasmicBy similarityAdd
    BLAST
    Topological domaini322 – 33918ExtracellularBy similarityAdd
    BLAST
    Topological domaini363 – 38624CytoplasmicBy similarityAdd
    BLAST
    Topological domaini406 – 41712ExtracellularBy similarityAdd
    BLAST
    Topological domaini439 – 550112CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei174 – 19825Helical; Name=1By similarityAdd
    BLAST
    Transmembranei211 – 23525Helical; Name=2By similarityAdd
    BLAST
    Transmembranei262 – 28524Helical; Name=3By similarityAdd
    BLAST
    Transmembranei300 – 32122Helical; Name=4By similarityAdd
    BLAST
    Transmembranei340 – 36223Helical; Name=5By similarityAdd
    BLAST
    Transmembranei387 – 40519Helical; Name=6By similarityAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267068.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    InParanoidiQ9Z0W0.
    KOiK04582.
    OMAiCNGTFDQ.
    OrthoDBiEOG7TF78W.
    PhylomeDBiQ9Z0W0.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPQPSPAVP SRCREAPVPR VRAQPVGIPE AQGPVPLHSQ QMRLLWGPGR    50
    PFLALLLLVS IKQVTGSLLK ETTQKWANYK EKCLEDLHNR LSGIFCNGTF 100
    DRYVCWPHSY PGNVSVPCPS YLPWWNAESP GRAYRHCLAQ GTWQTRENTT 150
    DIWQDESECS ENHSFRQNVD HYALLYTLQL MYTVGYSVSL ISLFLALTLF 200
    LFLRKLHCTR NYIHMNLFAS FILKVLAVLV KDMVSHNSYS KRPDDESGWM 250
    SYLSETSVSC RSVQVLLHYF VGTNHLWLLV EGLYLHTLLE PTVFPERRLW 300
    PKYLVVGWAF PMLFVIPWGF ARAHLENTRC WATNGNLKIW WIIRGPMLLC 350
    VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLLL IPLLGVHEVL 400
    FTFFPDDQVQ GFSKRIRLFI QLTLSSVHGF LVALQYGFAN GEVKAELRKS 450
    WGRFLLARHW GCRTCVLGKN FRFLGKCSKK LSEGDGSETL QKLRFSTCSS 500
    HLASETLGDV GVQPHRGRGA WPRGSSLSES SEGDFTLANT MEEILEESEI 550
    Length:550
    Mass (Da):63,102
    Last modified:May 1, 1999 - v1
    Checksum:i22E269F811E25226
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105368 mRNA. Translation: AAD16896.1.
    RefSeqiNP_068620.1. NM_021848.1.
    UniGeneiRn.163105.

    Genome annotation databases

    EnsembliENSRNOT00000004946; ENSRNOP00000004946; ENSRNOG00000003683.
    GeneIDi60432.
    KEGGirno:60432.
    UCSCiRGD:620270. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105368 mRNA. Translation: AAD16896.1 .
    RefSeqi NP_068620.1. NM_021848.1.
    UniGenei Rn.163105.

    3D structure databases

    ProteinModelPortali Q9Z0W0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248832. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 250.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi Q9Z0W0.
    PRIDEi Q9Z0W0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004946 ; ENSRNOP00000004946 ; ENSRNOG00000003683 .
    GeneIDi 60432.
    KEGGi rno:60432.
    UCSCi RGD:620270. rat.

    Organism-specific databases

    CTDi 9340.
    RGDi 620270. Glp2r.

    Phylogenomic databases

    eggNOGi NOG267068.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    InParanoidi Q9Z0W0.
    KOi K04582.
    OMAi CNGTFDQ.
    OrthoDBi EOG7TF78W.
    PhylomeDBi Q9Z0W0.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 612158.
    PROi Q9Z0W0.

    Gene expression databases

    Genevestigatori Q9Z0W0.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiGLP2R_RAT
    AccessioniPrimary (citable) accession number: Q9Z0W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3