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Protein

Mitochondrial import inner membrane translocase subunit Tim17-B

Gene

Timm17b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-B
Gene namesi
Name:Timm17b
Synonyms:Tim17b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1343176 Timm17b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei61 – 77HelicalSequence analysisAdd BLAST17
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102881 – 172Mitochondrial import inner membrane translocase subunit Tim17-BAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9Z0V7
MaxQBiQ9Z0V7
PaxDbiQ9Z0V7
PRIDEiQ9Z0V7

PTM databases

iPTMnetiQ9Z0V7
PhosphoSitePlusiQ9Z0V7

Expressioni

Gene expression databases

BgeeiENSMUSG00000031158
CleanExiMM_TIMM17B
ExpressionAtlasiQ9Z0V7 baseline and differential
GenevisibleiQ9Z0V7 MM

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204200, 3 interactors
STRINGi10090.ENSMUSP00000033498

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1652 Eukaryota
COG5596 LUCA
GeneTreeiENSGT00390000017780
HOGENOMiHOG000183190
HOVERGENiHBG054233
InParanoidiQ9Z0V7
KOiK17795
OMAiPIIAGNF
OrthoDBiEOG091G0PGZ
PhylomeDBiQ9Z0V7
TreeFamiTF106195

Family and domain databases

InterProiView protein in InterPro
IPR005678 Tim17
TIGRFAMsiTIGR00980 3a0801so1tim17, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z0V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRFRG
60 70 80 90 100
SVNAVRIRAP QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSISSGALTG
110 120 130 140 150
AVLAARSGPL AMVGSAMMGG ILLALIEGVG ILLTRYTAQQ FRNAPPFLED
160 170
PSQLTPKEGS PAPGYPNYQQ YH
Length:172
Mass (Da):18,352
Last modified:May 1, 1999 - v1
Checksum:iF5B1E31FD37469C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106621 mRNA Translation: AAD19595.1
BC008275 mRNA Translation: AAH08275.1
CCDSiCCDS29978.1
RefSeqiNP_035721.1, NM_011591.5
UniGeneiMm.27393

Genome annotation databases

EnsembliENSMUST00000033498; ENSMUSP00000033498; ENSMUSG00000031158
GeneIDi21855
KEGGimmu:21855
UCSCiuc009sne.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTI17B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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