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Protein

Mitochondrial import inner membrane translocase subunit Tim17-B

Gene

Timm17b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-B
Gene namesi
Name:Timm17b
Synonyms:Tim17b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1343176. Timm17b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Mitochondrial import inner membrane translocase subunit Tim17-BPRO_0000210288Add
BLAST

Proteomic databases

EPDiQ9Z0V7.
MaxQBiQ9Z0V7.
PaxDbiQ9Z0V7.
PRIDEiQ9Z0V7.

PTM databases

iPTMnetiQ9Z0V7.
PhosphoSiteiQ9Z0V7.

Expressioni

Gene expression databases

BgeeiQ9Z0V7.
CleanExiMM_TIMM17B.
ExpressionAtlasiQ9Z0V7. baseline and differential.
GenevisibleiQ9Z0V7. MM.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. The complex also interacts with DNAJC15 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204200. 1 interaction.
STRINGi10090.ENSMUSP00000033498.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1652. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiQ9Z0V7.
KOiK17795.
OMAiWVILNDL.
OrthoDBiEOG7JX35C.
PhylomeDBiQ9Z0V7.
TreeFamiTF106195.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z0V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRFRG
60 70 80 90 100
SVNAVRIRAP QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSISSGALTG
110 120 130 140 150
AVLAARSGPL AMVGSAMMGG ILLALIEGVG ILLTRYTAQQ FRNAPPFLED
160 170
PSQLTPKEGS PAPGYPNYQQ YH
Length:172
Mass (Da):18,352
Last modified:May 1, 1999 - v1
Checksum:iF5B1E31FD37469C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106621 mRNA. Translation: AAD19595.1.
BC008275 mRNA. Translation: AAH08275.1.
CCDSiCCDS29978.1.
RefSeqiNP_035721.1. NM_011591.5.
UniGeneiMm.27393.

Genome annotation databases

EnsembliENSMUST00000033498; ENSMUSP00000033498; ENSMUSG00000031158.
GeneIDi21855.
KEGGimmu:21855.
UCSCiuc009sne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106621 mRNA. Translation: AAD19595.1.
BC008275 mRNA. Translation: AAH08275.1.
CCDSiCCDS29978.1.
RefSeqiNP_035721.1. NM_011591.5.
UniGeneiMm.27393.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204200. 1 interaction.
STRINGi10090.ENSMUSP00000033498.

PTM databases

iPTMnetiQ9Z0V7.
PhosphoSiteiQ9Z0V7.

Proteomic databases

EPDiQ9Z0V7.
MaxQBiQ9Z0V7.
PaxDbiQ9Z0V7.
PRIDEiQ9Z0V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033498; ENSMUSP00000033498; ENSMUSG00000031158.
GeneIDi21855.
KEGGimmu:21855.
UCSCiuc009sne.1. mouse.

Organism-specific databases

CTDi10245.
MGIiMGI:1343176. Timm17b.

Phylogenomic databases

eggNOGiKOG1652. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiQ9Z0V7.
KOiK17795.
OMAiWVILNDL.
OrthoDBiEOG7JX35C.
PhylomeDBiQ9Z0V7.
TreeFamiTF106195.

Miscellaneous databases

PROiQ9Z0V7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0V7.
CleanExiMM_TIMM17B.
ExpressionAtlasiQ9Z0V7. baseline and differential.
GenevisibleiQ9Z0V7. MM.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic and structural characterization of the human mitochondrial inner membrane translocase."
    Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P., Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.
    J. Mol. Biol. 289:69-82(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTI17B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.