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Q9Z0V1 (KCND3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily D member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv4.3
Gene names
Name:Kcnd3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Subunit structure

Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DLG1, KCNE1, KCNE2, SCN1B and KCNAB1 By similarity. Ref.3 Ref.4

Subcellular location

Membrane; Multi-pass membrane protein. Cell membranesarcolemma By similarity. Cell projectiondendrite By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification

Regulated through phosphorylation at Ser-569 by CaMK2D.

Sequence similarities

Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. [View classification]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z0V1-1)

Also known as: Kv4.3L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z0V1-2)

Also known as: Kv4.3M;

The sequence of this isoform differs from the canonical sequence as follows:
     488-506: Missing.
Isoform 3 (identifier: Q9Z0V1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     488-531: GLSYLVDDPL...ESSMQNYPST → VSSSLLPPPA...SKTIVSLPLG
     532-655: Missing.
Note: May be due to intron retention. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 655655Potassium voltage-gated channel subfamily D member 3
PRO_0000054069

Regions

Topological domain1 – 181181Cytoplasmic Potential
Transmembrane182 – 20221Helical; Name=Segment S1; Potential
Transmembrane222 – 24221Helical; Name=Segment S2; Potential
Topological domain243 – 25614Cytoplasmic Potential
Transmembrane257 – 27721Helical; Name=Segment S3; Potential
Transmembrane287 – 30721Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain308 – 32013Cytoplasmic Potential
Transmembrane321 – 34121Helical; Name=Segment S5; Potential
Intramembrane360 – 38021Pore-forming; Name=Segment H5; Potential
Transmembrane382 – 40221Helical; Name=Segment S6; Potential
Topological domain403 – 655253Cytoplasmic Potential
Region2 – 2019Interaction with KCNIP2 By similarity
Region472 – 48716Mediates dendritic targeting By similarity
Motif367 – 3726Selectivity filter By similarity

Sites

Metal binding1041Zinc By similarity
Metal binding1311Zinc By similarity
Metal binding1321Zinc By similarity

Amino acid modifications

Modified residue5691Phosphoserine; by CaMK2D By similarity

Natural variations

Alternative sequence488 – 53144GLSYL…NYPST → VSSSLLPPPASSLTSQGCTH VIIPRRESSSVPFQSKTIVS LPLG in isoform 3.
VSP_008828
Alternative sequence488 – 50619Missing in isoform 2.
VSP_008827
Alternative sequence532 – 655124Missing in isoform 3.
VSP_008829

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv4.3L) [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 17FCE5AEC2868B33

FASTA65573,462
        10         20         30         40         50         60 
MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER 

        70         80         90        100        110        120 
YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF 

       130        140        150        160        170        180 
YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST 

       190        200        210        220        230        240 
LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE 

       250        260        270        280        290        300 
YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF 

       310        320        330        340        350        360 
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY 

       370        380        390        400        410        420 
TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR 

       430        440        450        460        470        480 
AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEQMGKTTS LIESQHHHLL 

       490        500        510        520        530        540 
HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHS 

       550        560        570        580        590        600 
GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTLHIQG SEQPSLTTSR SSLNLKADDG 

       610        620        630        640        650 
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSITSNVV KVSAL 

« Hide

Isoform 2 (Kv4.3M) [UniParc].

Checksum: ABC972B74CA982AA
Show »

FASTA63671,403
Isoform 3 [UniParc].

Checksum: 5580144E7899BE5F
Show »

FASTA53159,862

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of mouse heart K+ channel alpha subunits, Kv1.5, Kv4.2 and Kv4.3."
Tanaka H., Janzen K., Winkfein R.J., Fiset C., Clark R.B., Giles W.R.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: Swiss Webster.
Tissue: Heart ventricle.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6J.
Tissue: Diencephalon.
[3]"Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription."
Liss B., Franz O., Sewing S., Bruns R., Neuhoff H., Roeper J.
EMBO J. 20:5715-5724(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KCNIP3.
[4]"Role of heteromultimers in the generation of myocardial transient outward K+ currents."
Guo W., Li H., Aimond F., Johns D.C., Rhodes K.J., Trimmer J.S., Nerbonne J.M.
Circ. Res. 90:586-593(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KCND2 AND KCNIP2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF107781 mRNA. Translation: AAD16973.1.
AF107782 mRNA. Translation: AAD16974.1.
AK033962 mRNA. Translation: BAC28529.1.
RefSeqNP_001034436.1. NM_001039347.1.
NP_064315.1. NM_019931.1.
XP_006501818.1. XM_006501755.1.
XP_006501819.1. XM_006501756.1.
UniGeneMm.44530.

3D structure databases

ProteinModelPortalQ9Z0V1.
SMRQ9Z0V1. Positions 6-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Z0V1. 1 interaction.
MINTMINT-4099679.
STRING10090.ENSMUSP00000113436.

Chemistry

GuidetoPHARMACOLOGY554.

PTM databases

PhosphoSiteQ9Z0V1.

Proteomic databases

PaxDbQ9Z0V1.
PRIDEQ9Z0V1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079169; ENSMUSP00000078169; ENSMUSG00000040896. [Q9Z0V1-1]
ENSMUST00000098761; ENSMUSP00000096357; ENSMUSG00000040896. [Q9Z0V1-2]
ENSMUST00000118360; ENSMUSP00000113436; ENSMUSG00000040896. [Q9Z0V1-1]
GeneID56543.
KEGGmmu:56543.
UCSCuc008qux.1. mouse. [Q9Z0V1-3]
uc008quz.1. mouse. [Q9Z0V1-1]

Organism-specific databases

CTD3752.
MGIMGI:1928743. Kcnd3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115211.
HOGENOMHOG000231013.
HOVERGENHBG106687.
InParanoidQ9Z0V1.
KOK04893.
OMAPEVFRCI.
OrthoDBEOG7SR4MG.
PhylomeDBQ9Z0V1.
TreeFamTF313103.

Gene expression databases

ArrayExpressQ9Z0V1.
BgeeQ9Z0V1.
GenevestigatorQ9Z0V1.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004056. K_chnl_volt-dep_Kv4.3.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01518. KV43CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio312914.
PROQ9Z0V1.
SOURCESearch...

Entry information

Entry nameKCND3_MOUSE
AccessionPrimary (citable) accession number: Q9Z0V1
Secondary accession number(s): Q8CC44, Q9Z0V0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot