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Q9Z0V1

- KCND3_MOUSE

UniProt

Q9Z0V1 - KCND3_MOUSE

Protein

Potassium voltage-gated channel subfamily D member 3

Gene

Kcnd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi104 – 1041ZincBy similarity
    Metal bindingi131 – 1311ZincBy similarity
    Metal bindingi132 – 1321ZincBy similarity

    GO - Molecular functioni

    1. A-type (transient outward) potassium channel activity Source: RefGenome
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. membrane repolarization Source: Ensembl
    2. potassium ion export Source: Ensembl
    3. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Metal-binding, Potassium, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily D member 3
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv4.3
    Gene namesi
    Name:Kcnd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1928743. Kcnd3.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: UniProtKB-SubCell
    2. membrane Source: MGI
    3. neuronal cell body Source: Ensembl
    4. perinuclear endoplasmic reticulum Source: Ensembl
    5. sarcolemma Source: UniProtKB-SubCell
    6. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 655655Potassium voltage-gated channel subfamily D member 3PRO_0000054069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei569 – 5691Phosphoserine; by CaMK2DBy similarity

    Post-translational modificationi

    Regulated through phosphorylation at Ser-569 by CaMK2D.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9Z0V1.
    PRIDEiQ9Z0V1.

    PTM databases

    PhosphoSiteiQ9Z0V1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z0V1.
    BgeeiQ9Z0V1.
    GenevestigatoriQ9Z0V1.

    Interactioni

    Subunit structurei

    Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DLG1, KCNE1, KCNE2, SCN1B and KCNAB1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9Z0V1. 1 interaction.
    MINTiMINT-4099679.
    STRINGi10090.ENSMUSP00000113436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0V1.
    SMRiQ9Z0V1. Positions 6-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 181181CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 25614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 32013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini403 – 655253CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei360 – 38021Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei182 – 20221Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2019Interaction with KCNIP2By similarityAdd
    BLAST
    Regioni472 – 48716Mediates dendritic targetingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi367 – 3726Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115211.
    HOGENOMiHOG000231013.
    HOVERGENiHBG106687.
    InParanoidiQ9Z0V1.
    KOiK04893.
    OMAiPEVFRCI.
    OrthoDBiEOG7SR4MG.
    PhylomeDBiQ9Z0V1.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003975. K_chnl_volt-dep_Kv4.
    IPR004056. K_chnl_volt-dep_Kv4.3.
    IPR024587. K_chnl_volt-dep_Kv4_C.
    IPR021645. Shal-type.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF11879. DUF3399. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11601. Shal-type. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01518. KV43CHANNEL.
    PR01491. KVCHANNEL.
    PR01497. SHALCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z0V1-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv4.3L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR    50
    FQTWRTTLER YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT 100
    GKLHYPRYEC ISAYDDELAF YGILPEIIGD CCYEEYKDRK RENAERLMDD 150
    NDSENNQESM PSLSFRQTMW RAFENPHTST LALVFYYVTG FFIAVSVITN 200
    VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE YLLRLFAAPS 250
    RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF 300
    SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK 350
    FTSIPASFWY TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP 400
    VIVSNFSRIY HQNQRADKRR AQKKARLARI RVAKTGSSNA YLHSKRNGLL 450
    NEALELTGTP EEEQMGKTTS LIESQHHHLL HCLEKTTGLS YLVDDPLLSV 500
    RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHS GLTTTCCSRR 550
    SKKTTHLPNS NLPATRLRSM QELSTLHIQG SEQPSLTTSR SSLNLKADDG 600
    LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSITSNVV 650
    KVSAL 655
    Length:655
    Mass (Da):73,462
    Last modified:May 1, 1999 - v1
    Checksum:i17FCE5AEC2868B33
    GO
    Isoform 2 (identifier: Q9Z0V1-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv4.3M

    The sequence of this isoform differs from the canonical sequence as follows:
         488-506: Missing.

    Show »
    Length:636
    Mass (Da):71,403
    Checksum:iABC972B74CA982AA
    GO
    Isoform 3 (identifier: Q9Z0V1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         488-531: GLSYLVDDPL...ESSMQNYPST → VSSSLLPPPA...SKTIVSLPLG
         532-655: Missing.

    Note: May be due to intron retention. No experimental confirmation available.

    Show »
    Length:531
    Mass (Da):59,862
    Checksum:i5580144E7899BE5F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei488 – 53144GLSYL…NYPST → VSSSLLPPPASSLTSQGCTH VIIPRRESSSVPFQSKTIVS LPLG in isoform 3. 1 PublicationVSP_008828Add
    BLAST
    Alternative sequencei488 – 50619Missing in isoform 2. 1 PublicationVSP_008827Add
    BLAST
    Alternative sequencei532 – 655124Missing in isoform 3. 1 PublicationVSP_008829Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107781 mRNA. Translation: AAD16973.1.
    AF107782 mRNA. Translation: AAD16974.1.
    AK033962 mRNA. Translation: BAC28529.1.
    CCDSiCCDS17708.1. [Q9Z0V1-2]
    CCDS17709.1. [Q9Z0V1-1]
    RefSeqiNP_001034436.1. NM_001039347.1. [Q9Z0V1-2]
    NP_064315.1. NM_019931.1. [Q9Z0V1-1]
    XP_006501818.1. XM_006501755.1. [Q9Z0V1-1]
    XP_006501819.1. XM_006501756.1. [Q9Z0V1-1]
    UniGeneiMm.44530.

    Genome annotation databases

    EnsembliENSMUST00000079169; ENSMUSP00000078169; ENSMUSG00000040896. [Q9Z0V1-1]
    ENSMUST00000098761; ENSMUSP00000096357; ENSMUSG00000040896. [Q9Z0V1-2]
    ENSMUST00000118360; ENSMUSP00000113436; ENSMUSG00000040896. [Q9Z0V1-1]
    GeneIDi56543.
    KEGGimmu:56543.
    UCSCiuc008qux.1. mouse. [Q9Z0V1-3]
    uc008quz.1. mouse. [Q9Z0V1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107781 mRNA. Translation: AAD16973.1 .
    AF107782 mRNA. Translation: AAD16974.1 .
    AK033962 mRNA. Translation: BAC28529.1 .
    CCDSi CCDS17708.1. [Q9Z0V1-2 ]
    CCDS17709.1. [Q9Z0V1-1 ]
    RefSeqi NP_001034436.1. NM_001039347.1. [Q9Z0V1-2 ]
    NP_064315.1. NM_019931.1. [Q9Z0V1-1 ]
    XP_006501818.1. XM_006501755.1. [Q9Z0V1-1 ]
    XP_006501819.1. XM_006501756.1. [Q9Z0V1-1 ]
    UniGenei Mm.44530.

    3D structure databases

    ProteinModelPortali Q9Z0V1.
    SMRi Q9Z0V1. Positions 6-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z0V1. 1 interaction.
    MINTi MINT-4099679.
    STRINGi 10090.ENSMUSP00000113436.

    Chemistry

    GuidetoPHARMACOLOGYi 554.

    PTM databases

    PhosphoSitei Q9Z0V1.

    Proteomic databases

    PaxDbi Q9Z0V1.
    PRIDEi Q9Z0V1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079169 ; ENSMUSP00000078169 ; ENSMUSG00000040896 . [Q9Z0V1-1 ]
    ENSMUST00000098761 ; ENSMUSP00000096357 ; ENSMUSG00000040896 . [Q9Z0V1-2 ]
    ENSMUST00000118360 ; ENSMUSP00000113436 ; ENSMUSG00000040896 . [Q9Z0V1-1 ]
    GeneIDi 56543.
    KEGGi mmu:56543.
    UCSCi uc008qux.1. mouse. [Q9Z0V1-3 ]
    uc008quz.1. mouse. [Q9Z0V1-1 ]

    Organism-specific databases

    CTDi 3752.
    MGIi MGI:1928743. Kcnd3.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115211.
    HOGENOMi HOG000231013.
    HOVERGENi HBG106687.
    InParanoidi Q9Z0V1.
    KOi K04893.
    OMAi PEVFRCI.
    OrthoDBi EOG7SR4MG.
    PhylomeDBi Q9Z0V1.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 312914.
    PROi Q9Z0V1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0V1.
    Bgeei Q9Z0V1.
    Genevestigatori Q9Z0V1.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003975. K_chnl_volt-dep_Kv4.
    IPR004056. K_chnl_volt-dep_Kv4.3.
    IPR024587. K_chnl_volt-dep_Kv4_C.
    IPR021645. Shal-type.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF11879. DUF3399. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11601. Shal-type. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01518. KV43CHANNEL.
    PR01491. KVCHANNEL.
    PR01497. SHALCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of mouse heart K+ channel alpha subunits, Kv1.5, Kv4.2 and Kv4.3."
      Tanaka H., Janzen K., Winkfein R.J., Fiset C., Clark R.B., Giles W.R.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: Swiss Webster.
      Tissue: Heart ventricle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Diencephalon.
    3. "Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription."
      Liss B., Franz O., Sewing S., Bruns R., Neuhoff H., Roeper J.
      EMBO J. 20:5715-5724(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNIP3.
    4. "Role of heteromultimers in the generation of myocardial transient outward K+ currents."
      Guo W., Li H., Aimond F., Johns D.C., Rhodes K.J., Trimmer J.S., Nerbonne J.M.
      Circ. Res. 90:586-593(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCND2 AND KCNIP2.

    Entry informationi

    Entry nameiKCND3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0V1
    Secondary accession number(s): Q8CC44, Q9Z0V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3