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Q9Z0U9

- S1PR3_MOUSE

UniProt

Q9Z0U9 - S1PR3_MOUSE

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Protein
Sphingosine 1-phosphate receptor 3
Gene
S1pr3, Edg3, Lpb3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  2. cytokine production Source: MGI
  3. inflammatory response Source: MGI
  4. regulation of interleukin-1 beta production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Lysophospholipid receptor B3
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:S1pr3
Synonyms:Edg3, Lpb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1339365. S1pr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Extracellular By similarity
Add
BLAST
Transmembranei45 – 6521Helical; Name=1; By similarity
Add
BLAST
Topological domaini66 – 749Cytoplasmic By similarity
Transmembranei75 – 9521Helical; Name=2; By similarity
Add
BLAST
Topological domaini96 – 11520Extracellular By similarity
Add
BLAST
Transmembranei116 – 13621Helical; Name=3; By similarity
Add
BLAST
Topological domaini137 – 15418Cytoplasmic By similarity
Add
BLAST
Transmembranei155 – 17521Helical; Name=4; By similarity
Add
BLAST
Topological domaini176 – 19621Extracellular By similarity
Add
BLAST
Transmembranei197 – 21721Helical; Name=5; By similarity
Add
BLAST
Topological domaini218 – 24427Cytoplasmic By similarity
Add
BLAST
Transmembranei245 – 26521Helical; Name=6; By similarity
Add
BLAST
Topological domaini266 – 28116Extracellular By similarity
Add
BLAST
Transmembranei282 – 30221Helical; Name=7; By similarity
Add
BLAST
Topological domaini303 – 37876Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Sphingosine 1-phosphate receptor 3
PRO_0000069422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0U9.

PTM databases

PhosphoSiteiQ9Z0U9.

Expressioni

Tissue specificityi

Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder.1 Publication

Gene expression databases

BgeeiQ9Z0U9.
GenevestigatoriQ9Z0U9.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0U9.
SMRiQ9Z0U9. Positions 16-313.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148018.
GeneTreeiENSGT00750000117544.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0U9.
KOiK04290.
OMAiHYNYVGK.
OrthoDBiEOG708W0B.
PhylomeDBiQ9Z0U9.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0U9-1 [UniParc]FASTAAdd to Basket

« Hide

MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT    50
CSFIVLENLM VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS 100
GRKTFSLSPT VWFLREGSMF VALGASTCSL LAIAIERHLT MIKMRPYDAN 150
KKHRVFLLIG MCWLIAFSLG ALPILGWNCL ENFPDCSTIL PLYSKKYIAF 200
LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA LLRTVVIVVS 250
VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL 300
ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK 350
VKEDLPRVAT SSCIIDKNRS FQNGVLCK 378
Length:378
Mass (Da):42,270
Last modified:May 1, 1999 - v1
Checksum:iF466B25E77ECDCC8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061S → R in BAC37277. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSiCCDS26512.1.
RefSeqiNP_034231.1. NM_010101.4.
UniGeneiMm.136736.

Genome annotation databases

EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneIDi13610.
KEGGimmu:13610.
UCSCiuc007qmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1 .
AK028043 mRNA. Translation: BAC25715.1 .
AK029852 mRNA. Translation: BAC26645.1 .
AK030134 mRNA. Translation: BAC26800.1 .
AK047268 mRNA. Translation: BAC33008.1 .
AK081919 mRNA. Translation: BAC38373.1 .
AK084944 mRNA. Translation: BAC39316.1 .
AK085180 mRNA. Translation: BAC39383.1 .
AK078443 mRNA. Translation: BAC37277.1 .
AB028143 mRNA. Translation: BAA78207.1 .
BC064007 mRNA. Translation: AAH64007.1 .
BC068176 mRNA. Translation: AAH68176.1 .
CCDSi CCDS26512.1.
RefSeqi NP_034231.1. NM_010101.4.
UniGenei Mm.136736.

3D structure databases

ProteinModelPortali Q9Z0U9.
SMRi Q9Z0U9. Positions 16-313.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 277.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9Z0U9.

Proteomic databases

PRIDEi Q9Z0U9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087978 ; ENSMUSP00000085293 ; ENSMUSG00000067586 .
GeneIDi 13610.
KEGGi mmu:13610.
UCSCi uc007qmf.2. mouse.

Organism-specific databases

CTDi 1903.
MGIi MGI:1339365. S1pr3.

Phylogenomic databases

eggNOGi NOG148018.
GeneTreei ENSGT00750000117544.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi Q9Z0U9.
KOi K04290.
OMAi HYNYVGK.
OrthoDBi EOG708W0B.
PhylomeDBi Q9Z0U9.
TreeFami TF330052.

Miscellaneous databases

ChiTaRSi S1PR3. mouse.
NextBioi 284258.
PROi Q9Z0U9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0U9.
Genevestigatori Q9Z0U9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
    Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
    Gene 227:89-99(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head, Lung, Mesonephros and Testis.
  3. "Mus musculus sphingosine 1-phosphate receptor Edg3 gene, complete."
    Ohta K., Wada A., Igarashi Y.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Bone and Eye.

Entry informationi

Entry nameiS1PR3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0U9
Secondary accession number(s): Q8BP20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi