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Protein

Sphingosine 1-phosphate receptor 3

Gene

S1pr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • integrin binding Source: MGI
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • cytokine production Source: MGI
  • inflammatory response Source: MGI
  • negative regulation of establishment of endothelial barrier Source: MGI
  • Notch signaling pathway Source: MGI
  • regulation of interleukin-1 beta production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Lysophospholipid receptor B3
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:S1pr3
Synonyms:Edg3, Lpb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1339365. S1pr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularBy similarityAdd BLAST44
Transmembranei45 – 65Helical; Name=1By similarityAdd BLAST21
Topological domaini66 – 74CytoplasmicBy similarity9
Transmembranei75 – 95Helical; Name=2By similarityAdd BLAST21
Topological domaini96 – 115ExtracellularBy similarityAdd BLAST20
Transmembranei116 – 136Helical; Name=3By similarityAdd BLAST21
Topological domaini137 – 154CytoplasmicBy similarityAdd BLAST18
Transmembranei155 – 175Helical; Name=4By similarityAdd BLAST21
Topological domaini176 – 196ExtracellularBy similarityAdd BLAST21
Transmembranei197 – 217Helical; Name=5By similarityAdd BLAST21
Topological domaini218 – 244CytoplasmicBy similarityAdd BLAST27
Transmembranei245 – 265Helical; Name=6By similarityAdd BLAST21
Topological domaini266 – 281ExtracellularBy similarityAdd BLAST16
Transmembranei282 – 302Helical; Name=7By similarityAdd BLAST21
Topological domaini303 – 378CytoplasmicBy similarityAdd BLAST76

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694221 – 378Sphingosine 1-phosphate receptor 3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Modified residuei326PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z0U9.
PaxDbiQ9Z0U9.
PRIDEiQ9Z0U9.

PTM databases

iPTMnetiQ9Z0U9.
PhosphoSitePlusiQ9Z0U9.

Expressioni

Tissue specificityi

Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder.1 Publication

Gene expression databases

BgeeiENSMUSG00000067586.
GenevisibleiQ9Z0U9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085293.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0U9.
SMRiQ9Z0U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIA7. Eukaryota.
ENOG410XQD3. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0U9.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9Z0U9.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT
60 70 80 90 100
CSFIVLENLM VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS
110 120 130 140 150
GRKTFSLSPT VWFLREGSMF VALGASTCSL LAIAIERHLT MIKMRPYDAN
160 170 180 190 200
KKHRVFLLIG MCWLIAFSLG ALPILGWNCL ENFPDCSTIL PLYSKKYIAF
210 220 230 240 250
LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA LLRTVVIVVS
260 270 280 290 300
VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL
310 320 330 340 350
ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK
360 370
VKEDLPRVAT SSCIIDKNRS FQNGVLCK
Length:378
Mass (Da):42,270
Last modified:May 1, 1999 - v1
Checksum:iF466B25E77ECDCC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106S → R in BAC37277 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSiCCDS26512.1.
RefSeqiNP_034231.1. NM_010101.4.
UniGeneiMm.136736.

Genome annotation databases

EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneIDi13610.
KEGGimmu:13610.
UCSCiuc007qmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSiCCDS26512.1.
RefSeqiNP_034231.1. NM_010101.4.
UniGeneiMm.136736.

3D structure databases

ProteinModelPortaliQ9Z0U9.
SMRiQ9Z0U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085293.

Chemistry databases

GuidetoPHARMACOLOGYi277.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Z0U9.
PhosphoSitePlusiQ9Z0U9.

Proteomic databases

MaxQBiQ9Z0U9.
PaxDbiQ9Z0U9.
PRIDEiQ9Z0U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneIDi13610.
KEGGimmu:13610.
UCSCiuc007qmf.2. mouse.

Organism-specific databases

CTDi1903.
MGIiMGI:1339365. S1pr3.

Phylogenomic databases

eggNOGiENOG410IIA7. Eukaryota.
ENOG410XQD3. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0U9.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9Z0U9.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiS1pr3. mouse.
PROiQ9Z0U9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067586.
GenevisibleiQ9Z0U9. MM.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0U9
Secondary accession number(s): Q8BP20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.