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Q9Z0U9 (S1PR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingosine 1-phosphate receptor 3

Short name=S1P receptor 3
Short name=S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Lysophospholipid receptor B3
Sphingosine 1-phosphate receptor Edg-3
Short name=S1P receptor Edg-3
Gene names
Name:S1pr3
Synonyms:Edg3, Lpb3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Sphingosine 1-phosphate receptor 3
PRO_0000069422

Regions

Topological domain1 – 4444Extracellular By similarity
Transmembrane45 – 6521Helical; Name=1; By similarity
Topological domain66 – 749Cytoplasmic By similarity
Transmembrane75 – 9521Helical; Name=2; By similarity
Topological domain96 – 11520Extracellular By similarity
Transmembrane116 – 13621Helical; Name=3; By similarity
Topological domain137 – 15418Cytoplasmic By similarity
Transmembrane155 – 17521Helical; Name=4; By similarity
Topological domain176 – 19621Extracellular By similarity
Transmembrane197 – 21721Helical; Name=5; By similarity
Topological domain218 – 24427Cytoplasmic By similarity
Transmembrane245 – 26521Helical; Name=6; By similarity
Topological domain266 – 28116Extracellular By similarity
Transmembrane282 – 30221Helical; Name=7; By similarity
Topological domain303 – 37876Cytoplasmic By similarity

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1061S → R in BAC37277. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z0U9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F466B25E77ECDCC8

FASTA37842,270
        10         20         30         40         50         60 
MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT CSFIVLENLM 

        70         80         90        100        110        120 
VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS GRKTFSLSPT VWFLREGSMF 

       130        140        150        160        170        180 
VALGASTCSL LAIAIERHLT MIKMRPYDAN KKHRVFLLIG MCWLIAFSLG ALPILGWNCL 

       190        200        210        220        230        240 
ENFPDCSTIL PLYSKKYIAF LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA 

       250        260        270        280        290        300 
LLRTVVIVVS VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL 

       310        320        330        340        350        360 
ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK VKEDLPRVAT 

       370 
SSCIIDKNRS FQNGVLCK 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
Gene 227:89-99(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/SvJ.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Head, Lung, Mesonephros and Testis.
[3]"Mus musculus sphingosine 1-phosphate receptor Edg3 gene, complete."
Ohta K., Wada A., Igarashi Y.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Bone and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSCCDS26512.1.
RefSeqNP_034231.1. NM_010101.4.
UniGeneMm.136736.

3D structure databases

ProteinModelPortalQ9Z0U9.
SMRQ9Z0U9. Positions 16-313.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY277.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Z0U9.

Proteomic databases

PRIDEQ9Z0U9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneID13610.
KEGGmmu:13610.
UCSCuc007qmf.2. mouse.

Organism-specific databases

CTD1903.
MGIMGI:1339365. S1pr3.

Phylogenomic databases

eggNOGNOG148018.
GeneTreeENSGT00750000117544.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidQ9Z0U9.
KOK04290.
OMAHYNYVGK.
OrthoDBEOG708W0B.
PhylomeDBQ9Z0U9.
TreeFamTF330052.

Gene expression databases

BgeeQ9Z0U9.
GenevestigatorQ9Z0U9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSS1PR3. mouse.
NextBio284258.
PROQ9Z0U9.
SOURCESearch...

Entry information

Entry nameS1PR3_MOUSE
AccessionPrimary (citable) accession number: Q9Z0U9
Secondary accession number(s): Q8BP20
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries