Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sphingosine 1-phosphate receptor 3

Gene

S1pr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. integrin binding Source: MGI
  3. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  2. cytokine production Source: MGI
  3. inflammatory response Source: MGI
  4. negative regulation of establishment of endothelial barrier Source: MGI
  5. regulation of interleukin-1 beta production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_317886. Lysosphingolipid and LPA receptors.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Lysophospholipid receptor B3
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:S1pr3
Synonyms:Edg3, Lpb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1339365. S1pr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularBy similarityAdd
BLAST
Transmembranei45 – 6521Helical; Name=1By similarityAdd
BLAST
Topological domaini66 – 749CytoplasmicBy similarity
Transmembranei75 – 9521Helical; Name=2By similarityAdd
BLAST
Topological domaini96 – 11520ExtracellularBy similarityAdd
BLAST
Transmembranei116 – 13621Helical; Name=3By similarityAdd
BLAST
Topological domaini137 – 15418CytoplasmicBy similarityAdd
BLAST
Transmembranei155 – 17521Helical; Name=4By similarityAdd
BLAST
Topological domaini176 – 19621ExtracellularBy similarityAdd
BLAST
Transmembranei197 – 21721Helical; Name=5By similarityAdd
BLAST
Topological domaini218 – 24427CytoplasmicBy similarityAdd
BLAST
Transmembranei245 – 26521Helical; Name=6By similarityAdd
BLAST
Topological domaini266 – 28116ExtracellularBy similarityAdd
BLAST
Transmembranei282 – 30221Helical; Name=7By similarityAdd
BLAST
Topological domaini303 – 37876CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Sphingosine 1-phosphate receptor 3PRO_0000069422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Z0U9.
PRIDEiQ9Z0U9.

PTM databases

PhosphoSiteiQ9Z0U9.

Expressioni

Tissue specificityi

Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder.1 Publication

Gene expression databases

BgeeiQ9Z0U9.
GenevestigatoriQ9Z0U9.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0U9.
SMRiQ9Z0U9. Positions 16-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148018.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0U9.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG708W0B.
PhylomeDBiQ9Z0U9.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT
60 70 80 90 100
CSFIVLENLM VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS
110 120 130 140 150
GRKTFSLSPT VWFLREGSMF VALGASTCSL LAIAIERHLT MIKMRPYDAN
160 170 180 190 200
KKHRVFLLIG MCWLIAFSLG ALPILGWNCL ENFPDCSTIL PLYSKKYIAF
210 220 230 240 250
LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA LLRTVVIVVS
260 270 280 290 300
VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL
310 320 330 340 350
ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK
360 370
VKEDLPRVAT SSCIIDKNRS FQNGVLCK
Length:378
Mass (Da):42,270
Last modified:May 1, 1999 - v1
Checksum:iF466B25E77ECDCC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061S → R in BAC37277 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSiCCDS26512.1.
RefSeqiNP_034231.1. NM_010101.4.
UniGeneiMm.136736.

Genome annotation databases

EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneIDi13610.
KEGGimmu:13610.
UCSCiuc007qmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108021 Genomic DNA. Translation: AAD16977.1.
AK028043 mRNA. Translation: BAC25715.1.
AK029852 mRNA. Translation: BAC26645.1.
AK030134 mRNA. Translation: BAC26800.1.
AK047268 mRNA. Translation: BAC33008.1.
AK081919 mRNA. Translation: BAC38373.1.
AK084944 mRNA. Translation: BAC39316.1.
AK085180 mRNA. Translation: BAC39383.1.
AK078443 mRNA. Translation: BAC37277.1.
AB028143 mRNA. Translation: BAA78207.1.
BC064007 mRNA. Translation: AAH64007.1.
BC068176 mRNA. Translation: AAH68176.1.
CCDSiCCDS26512.1.
RefSeqiNP_034231.1. NM_010101.4.
UniGeneiMm.136736.

3D structure databases

ProteinModelPortaliQ9Z0U9.
SMRiQ9Z0U9. Positions 16-313.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi277.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z0U9.

Proteomic databases

MaxQBiQ9Z0U9.
PRIDEiQ9Z0U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
GeneIDi13610.
KEGGimmu:13610.
UCSCiuc007qmf.2. mouse.

Organism-specific databases

CTDi1903.
MGIiMGI:1339365. S1pr3.

Phylogenomic databases

eggNOGiNOG148018.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0U9.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG708W0B.
PhylomeDBiQ9Z0U9.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiREACT_317886. Lysosphingolipid and LPA receptors.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiS1pr3. mouse.
NextBioi284258.
PROiQ9Z0U9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0U9.
GenevestigatoriQ9Z0U9.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
    Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
    Gene 227:89-99(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head, Lung, Mesonephros and Testis.
  3. "Mus musculus sphingosine 1-phosphate receptor Edg3 gene, complete."
    Ohta K., Wada A., Igarashi Y.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Bone and Eye.

Entry informationi

Entry nameiS1PR3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0U9
Secondary accession number(s): Q8BP20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.