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Q9Z0U9

- S1PR3_MOUSE

UniProt

Q9Z0U9 - S1PR3_MOUSE

Protein

Sphingosine 1-phosphate receptor 3

Gene

S1pr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. sphingosine-1-phosphate receptor activity Source: InterPro

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
    2. cytokine production Source: MGI
    3. inflammatory response Source: MGI
    4. regulation of interleukin-1 beta production Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine 1-phosphate receptor 3
    Short name:
    S1P receptor 3
    Short name:
    S1P3
    Alternative name(s):
    Endothelial differentiation G-protein coupled receptor 3
    Lysophospholipid receptor B3
    Sphingosine 1-phosphate receptor Edg-3
    Short name:
    S1P receptor Edg-3
    Gene namesi
    Name:S1pr3
    Synonyms:Edg3, Lpb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1339365. S1pr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Sphingosine 1-phosphate receptor 3PRO_0000069422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Z0U9.

    PTM databases

    PhosphoSiteiQ9Z0U9.

    Expressioni

    Tissue specificityi

    Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder.1 Publication

    Gene expression databases

    BgeeiQ9Z0U9.
    GenevestigatoriQ9Z0U9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0U9.
    SMRiQ9Z0U9. Positions 16-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularBy similarityAdd
    BLAST
    Topological domaini66 – 749CytoplasmicBy similarity
    Topological domaini96 – 11520ExtracellularBy similarityAdd
    BLAST
    Topological domaini137 – 15418CytoplasmicBy similarityAdd
    BLAST
    Topological domaini176 – 19621ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 24427CytoplasmicBy similarityAdd
    BLAST
    Topological domaini266 – 28116ExtracellularBy similarityAdd
    BLAST
    Topological domaini303 – 37876CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1By similarityAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2By similarityAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3By similarityAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4By similarityAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5By similarityAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6By similarityAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148018.
    GeneTreeiENSGT00750000117544.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiQ9Z0U9.
    KOiK04290.
    OMAiHYNYVGK.
    OrthoDBiEOG708W0B.
    PhylomeDBiQ9Z0U9.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004062. EDG3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01524. EDG3RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0U9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTHAQGHQ PVLGNDTLRE HYDYVGKLAG RLRDPPEGGT LITTILFLVT    50
    CSFIVLENLM VLIAIWKNNK FHNRMYFFIG NLALCDLLAG IAYKVNILMS 100
    GRKTFSLSPT VWFLREGSMF VALGASTCSL LAIAIERHLT MIKMRPYDAN 150
    KKHRVFLLIG MCWLIAFSLG ALPILGWNCL ENFPDCSTIL PLYSKKYIAF 200
    LISIFTAILV TIVILYARIY CLVKSSSRRV ANHNSERSMA LLRTVVIVVS 250
    VFIACWSPLF ILFLIDVACR AKECSILFKS QWFIMLAVLN SAMNPVIYTL 300
    ASKEMRRAFF RLVCGCLVKG KGTQASPMQP ALDPSRSKSS SSNNSSHSPK 350
    VKEDLPRVAT SSCIIDKNRS FQNGVLCK 378
    Length:378
    Mass (Da):42,270
    Last modified:May 1, 1999 - v1
    Checksum:iF466B25E77ECDCC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061S → R in BAC37277. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF108021 Genomic DNA. Translation: AAD16977.1.
    AK028043 mRNA. Translation: BAC25715.1.
    AK029852 mRNA. Translation: BAC26645.1.
    AK030134 mRNA. Translation: BAC26800.1.
    AK047268 mRNA. Translation: BAC33008.1.
    AK081919 mRNA. Translation: BAC38373.1.
    AK084944 mRNA. Translation: BAC39316.1.
    AK085180 mRNA. Translation: BAC39383.1.
    AK078443 mRNA. Translation: BAC37277.1.
    AB028143 mRNA. Translation: BAA78207.1.
    BC064007 mRNA. Translation: AAH64007.1.
    BC068176 mRNA. Translation: AAH68176.1.
    CCDSiCCDS26512.1.
    RefSeqiNP_034231.1. NM_010101.4.
    UniGeneiMm.136736.

    Genome annotation databases

    EnsembliENSMUST00000087978; ENSMUSP00000085293; ENSMUSG00000067586.
    GeneIDi13610.
    KEGGimmu:13610.
    UCSCiuc007qmf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF108021 Genomic DNA. Translation: AAD16977.1 .
    AK028043 mRNA. Translation: BAC25715.1 .
    AK029852 mRNA. Translation: BAC26645.1 .
    AK030134 mRNA. Translation: BAC26800.1 .
    AK047268 mRNA. Translation: BAC33008.1 .
    AK081919 mRNA. Translation: BAC38373.1 .
    AK084944 mRNA. Translation: BAC39316.1 .
    AK085180 mRNA. Translation: BAC39383.1 .
    AK078443 mRNA. Translation: BAC37277.1 .
    AB028143 mRNA. Translation: BAA78207.1 .
    BC064007 mRNA. Translation: AAH64007.1 .
    BC068176 mRNA. Translation: AAH68176.1 .
    CCDSi CCDS26512.1.
    RefSeqi NP_034231.1. NM_010101.4.
    UniGenei Mm.136736.

    3D structure databases

    ProteinModelPortali Q9Z0U9.
    SMRi Q9Z0U9. Positions 16-313.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 277.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Z0U9.

    Proteomic databases

    PRIDEi Q9Z0U9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087978 ; ENSMUSP00000085293 ; ENSMUSG00000067586 .
    GeneIDi 13610.
    KEGGi mmu:13610.
    UCSCi uc007qmf.2. mouse.

    Organism-specific databases

    CTDi 1903.
    MGIi MGI:1339365. S1pr3.

    Phylogenomic databases

    eggNOGi NOG148018.
    GeneTreei ENSGT00750000117544.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi Q9Z0U9.
    KOi K04290.
    OMAi HYNYVGK.
    OrthoDBi EOG708W0B.
    PhylomeDBi Q9Z0U9.
    TreeFami TF330052.

    Miscellaneous databases

    ChiTaRSi S1PR3. mouse.
    NextBioi 284258.
    PROi Q9Z0U9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0U9.
    Genevestigatori Q9Z0U9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004062. EDG3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01524. EDG3RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
      Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
      Gene 227:89-99(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/SvJ.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Head, Lung, Mesonephros and Testis.
    3. "Mus musculus sphingosine 1-phosphate receptor Edg3 gene, complete."
      Ohta K., Wada A., Igarashi Y.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Bone and Eye.

    Entry informationi

    Entry nameiS1PR3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0U9
    Secondary accession number(s): Q8BP20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3