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Protein

Integrin beta-6

Gene

Itgb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.By similarity

GO - Molecular functioni

  • integrin binding Source: MGI
  • receptor activity Source: InterPro

GO - Biological processi

  • cell adhesion mediated by integrin Source: UniProtKB
  • cell-matrix adhesion Source: InterPro
  • inflammatory response Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1566948. Elastic fibre formation.
R-MMU-2129379. Molecules associated with elastic fibres.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-6
Gene namesi
Name:Itgb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96615. Itgb6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 708ExtracellularSequence analysisAdd BLAST687
Transmembranei709 – 729HelicalSequence analysisAdd BLAST21
Topological domaini730 – 787CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001635122 – 787Integrin beta-6Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 454By similarity
Disulfide bondi31 ↔ 41By similarity
Disulfide bondi34 ↔ 70By similarity
Disulfide bondi44 ↔ 59By similarity
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi197 ↔ 204By similarity
Disulfide bondi252 ↔ 293By similarity
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi394 ↔ 406By similarity
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi426 ↔ 669By similarity
Disulfide bondi452 ↔ 456By similarity
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi467 ↔ 479By similarity
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi476 ↔ 511By similarity
Disulfide bondi481 ↔ 490By similarity
Disulfide bondi492 ↔ 502By similarity
Disulfide bondi517 ↔ 522By similarity
Disulfide bondi519 ↔ 552By similarity
Disulfide bondi524 ↔ 537By similarity
Disulfide bondi539 ↔ 544By similarity
Glycosylationi541N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi560 ↔ 591By similarity
Disulfide bondi565 ↔ 574By similarity
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi576 ↔ 583By similarity
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 645By similarity
Disulfide bondi604 ↔ 614By similarity
Disulfide bondi617 ↔ 620By similarity
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi630 ↔ 701By similarity
Disulfide bondi649 ↔ 677By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0T9.
PaxDbiQ9Z0T9.
PRIDEiQ9Z0T9.

PTM databases

iPTMnetiQ9Z0T9.
PhosphoSitePlusiQ9Z0T9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026971.
CleanExiMM_ITGB6.
ExpressionAtlasiQ9Z0T9. baseline and differential.
GenevisibleiQ9Z0T9. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1.By similarity

GO - Molecular functioni

  • integrin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028348.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0T9.
SMRiQ9Z0T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 371VWFAAdd BLAST241
Repeati456 – 501IAdd BLAST46
Repeati502 – 543IIAdd BLAST42
Repeati544 – 582IIIAdd BLAST39
Repeati583 – 619IVAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni456 – 619Cysteine-rich tandem repeatsAdd BLAST164
Regioni730 – 757Interaction with HAX1By similarityAdd BLAST28

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ9Z0T9.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG091G029W.
PhylomeDBiQ9Z0T9.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIELVCLFL LLLGRNDHVQ GGCAWGGAES CSDCLLTGPH CAWCSQENFT
60 70 80 90 100
HLSGAGERCD TPANLLAKGC QLPFIENPVS RIEVLQNKPL SVGRQKNSSD
110 120 130 140 150
IVQIAPQSLV LKLRPGREQT LQVQVRQTED YPVDLYYLMD LSASMDDDLN
160 170 180 190 200
TIKELGSRLA KEMSKLTSNF RLGFGSFVEK PVSPFMKTTP EEITNPCSSI
210 220 230 240 250
PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE GGFDAIMQAA
260 270 280 290 300
VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDHRNE
310 320 330 340 350
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV
360 370 380 390 400
GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCNNGVLF
410 420 430 440 450
PHQKKCSHMK VGDTASFNVT VSVSNCEKRS RNLIIKPVGL GDTLEILVSA
460 470 480 490 500
ECDCDCQREI ETNSSKCHNG NGSFQCGVCT CNPGHMGPHC ECGEDMVSTD
510 520 530 540 550
SCKESPGHPS CSGRGDCYCG QCICHLSPYG SIYGPYCQCD NFSCLRHKGL
560 570 580 590 600
LCGDNGDCDC GECVCRDGWT GEYCNCTTNR DSCTSEDGVL CSGRGDCVCG
610 620 630 640 650
KCVCRNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ AQEECADKCK
660 670 680 690 700
AIGATISEED FSKDTSVSCS LQGENECLIT FLITTDNEGK TIIHNINEKD
710 720 730 740 750
CPKPPNIPMI MLGVSLAILL IGVVLLCIWK LLVSFHDRKE VAKFEAERSK
760 770 780
AKWQTGTNPL YRGSTSTFKN VTYKHREKHK AGLSSDG
Length:787
Mass (Da):86,042
Last modified:May 1, 1999 - v1
Checksum:iC6438C6F1E6B7FBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115376 mRNA. Translation: AAD17212.1.
AK036439 mRNA. Translation: BAC29430.1.
BC049185 mRNA. Translation: AAH49185.1.
CCDSiCCDS16060.1.
RefSeqiNP_001153036.1. NM_001159564.1.
NP_067334.1. NM_021359.3.
XP_006498871.1. XM_006498808.3.
XP_006498872.1. XM_006498809.1.
XP_006498873.1. XM_006498810.3.
XP_006498874.1. XM_006498811.2.
UniGeneiMm.98193.

Genome annotation databases

EnsembliENSMUST00000028348; ENSMUSP00000028348; ENSMUSG00000026971.
ENSMUST00000059888; ENSMUSP00000054944; ENSMUSG00000026971.
GeneIDi16420.
KEGGimmu:16420.
UCSCiuc008juj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115376 mRNA. Translation: AAD17212.1.
AK036439 mRNA. Translation: BAC29430.1.
BC049185 mRNA. Translation: AAH49185.1.
CCDSiCCDS16060.1.
RefSeqiNP_001153036.1. NM_001159564.1.
NP_067334.1. NM_021359.3.
XP_006498871.1. XM_006498808.3.
XP_006498872.1. XM_006498809.1.
XP_006498873.1. XM_006498810.3.
XP_006498874.1. XM_006498811.2.
UniGeneiMm.98193.

3D structure databases

ProteinModelPortaliQ9Z0T9.
SMRiQ9Z0T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028348.

PTM databases

iPTMnetiQ9Z0T9.
PhosphoSitePlusiQ9Z0T9.

Proteomic databases

MaxQBiQ9Z0T9.
PaxDbiQ9Z0T9.
PRIDEiQ9Z0T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028348; ENSMUSP00000028348; ENSMUSG00000026971.
ENSMUST00000059888; ENSMUSP00000054944; ENSMUSG00000026971.
GeneIDi16420.
KEGGimmu:16420.
UCSCiuc008juj.2. mouse.

Organism-specific databases

CTDi3694.
MGIiMGI:96615. Itgb6.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ9Z0T9.
KOiK06589.
OMAiGRGDCYC.
OrthoDBiEOG091G029W.
PhylomeDBiQ9Z0T9.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiR-MMU-1566948. Elastic fibre formation.
R-MMU-2129379. Molecules associated with elastic fibres.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.

Miscellaneous databases

PROiQ9Z0T9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026971.
CleanExiMM_ITGB6.
ExpressionAtlasiQ9Z0T9. baseline and differential.
GenevisibleiQ9Z0T9. MM.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITB6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0T9
Secondary accession number(s): Q544J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.