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Q9Z0T9 (ITB6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta-6
Gene names
Name:Itgb6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length787 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 787766Integrin beta-6
PRO_0000016351

Regions

Topological domain22 – 708687Extracellular Potential
Transmembrane709 – 72921Helical; Potential
Topological domain730 – 78758Cytoplasmic Potential
Domain131 – 371241VWFA
Repeat456 – 50146I
Repeat502 – 54342II
Repeat544 – 58239III
Repeat583 – 61937IV
Region456 – 619164Cysteine-rich tandem repeats
Region730 – 75728Interaction with HAX1 By similarity

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4711N-linked (GlcNAc...) Potential
Glycosylation5411N-linked (GlcNAc...) Potential
Glycosylation5751N-linked (GlcNAc...) Potential
Disulfide bond23 ↔ 454 By similarity
Disulfide bond31 ↔ 41 By similarity
Disulfide bond34 ↔ 70 By similarity
Disulfide bond44 ↔ 59 By similarity
Disulfide bond197 ↔ 204 By similarity
Disulfide bond252 ↔ 293 By similarity
Disulfide bond394 ↔ 406 By similarity
Disulfide bond426 ↔ 669 By similarity
Disulfide bond452 ↔ 456 By similarity
Disulfide bond467 ↔ 479 By similarity
Disulfide bond476 ↔ 511 By similarity
Disulfide bond481 ↔ 490 By similarity
Disulfide bond492 ↔ 502 By similarity
Disulfide bond517 ↔ 522 By similarity
Disulfide bond519 ↔ 552 By similarity
Disulfide bond524 ↔ 537 By similarity
Disulfide bond539 ↔ 544 By similarity
Disulfide bond558 ↔ 563 By similarity
Disulfide bond560 ↔ 591 By similarity
Disulfide bond565 ↔ 574 By similarity
Disulfide bond576 ↔ 583 By similarity
Disulfide bond597 ↔ 602 By similarity
Disulfide bond599 ↔ 645 By similarity
Disulfide bond604 ↔ 614 By similarity
Disulfide bond617 ↔ 620 By similarity
Disulfide bond624 ↔ 633 By similarity
Disulfide bond630 ↔ 701 By similarity
Disulfide bond649 ↔ 677 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z0T9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C6438C6F1E6B7FBD

FASTA78786,042
        10         20         30         40         50         60 
MGIELVCLFL LLLGRNDHVQ GGCAWGGAES CSDCLLTGPH CAWCSQENFT HLSGAGERCD 

        70         80         90        100        110        120 
TPANLLAKGC QLPFIENPVS RIEVLQNKPL SVGRQKNSSD IVQIAPQSLV LKLRPGREQT 

       130        140        150        160        170        180 
LQVQVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLA KEMSKLTSNF RLGFGSFVEK 

       190        200        210        220        230        240 
PVSPFMKTTP EEITNPCSSI PYFCLPTFGF KHILPLTDDA ERFNEIVRKQ KISANIDTPE 

       250        260        270        280        290        300 
GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDHRNE 

       310        320        330        340        350        360 
YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI 

       370        380        390        400        410        420 
LQLIISAYEE LRSEVELEVL GDTEGLNLSF TALCNNGVLF PHQKKCSHMK VGDTASFNVT 

       430        440        450        460        470        480 
VSVSNCEKRS RNLIIKPVGL GDTLEILVSA ECDCDCQREI ETNSSKCHNG NGSFQCGVCT 

       490        500        510        520        530        540 
CNPGHMGPHC ECGEDMVSTD SCKESPGHPS CSGRGDCYCG QCICHLSPYG SIYGPYCQCD 

       550        560        570        580        590        600 
NFSCLRHKGL LCGDNGDCDC GECVCRDGWT GEYCNCTTNR DSCTSEDGVL CSGRGDCVCG 

       610        620        630        640        650        660 
KCVCRNPGAS GPTCERCPTC GDPCNSKRSC IECYLSADGQ AQEECADKCK AIGATISEED 

       670        680        690        700        710        720 
FSKDTSVSCS LQGENECLIT FLITTDNEGK TIIHNINEKD CPKPPNIPMI MLGVSLAILL 

       730        740        750        760        770        780 
IGVVLLCIWK LLVSFHDRKE VAKFEAERSK AKWQTGTNPL YRGSTSTFKN VTYKHREKHK 


AGLSSDG

« Hide

References

« Hide 'large scale' references
[1]"Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development."
Arend L.J., Smart A.M., Briggs J.P.
J. Am. Soc. Nephrol. 11:2297-2305(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF115376 mRNA. Translation: AAD17212.1.
AK036439 mRNA. Translation: BAC29430.1.
BC049185 mRNA. Translation: AAH49185.1.
IPIIPI00129434.
RefSeqNP_001153036.1. NM_001159564.1.
NP_067334.1. NM_021359.3.
UniGeneMm.98193.

3D structure databases

ProteinModelPortalQ9Z0T9.
SMRQ9Z0T9. Positions 23-774.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Z0T9.

Proteomic databases

PaxDbQ9Z0T9.
PRIDEQ9Z0T9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028348; ENSMUSP00000028348; ENSMUSG00000026971.
ENSMUST00000059888; ENSMUSP00000054944; ENSMUSG00000026971.
GeneID16420.
KEGGmmu:16420.
UCSCuc008juj.2. mouse.

Organism-specific databases

CTD3694.
MGIMGI:96615. Itgb6.

Phylogenomic databases

eggNOGNOG145803.
GeneTreeENSGT00700000104058.
HOGENOMHOG000252936.
HOVERGENHBG006190.
InParanoidQ9Z0T9.
KOK06589.
OMAEYCNCTT.
OrthoDBEOG49GKFZ.

Gene expression databases

ArrayExpressQ9Z0T9.
BgeeQ9Z0T9.
CleanExMM_ITGB6.
GenevestigatorQ9Z0T9.
GermOnlineENSMUSG00000026971. Mus musculus.

Family and domain databases

Gene3D1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProIPR015812. Integrin_bsu.
IPR015436. Integrin_bsu-6.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF11. PTHR10082:SF11. 1 hit.
PfamPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF69687. Integrin_bsu_tail. 1 hit.
SSF103575. Plexin-like_fold. 1 hit.
PROSITEPS00022. EGF_1. 2 hits. Uncertain.
PS01186. EGF_2. 1 hit. Uncertain.
PS00243. INTEGRIN_BETA. 2 hits.
PS50234. VWFA. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio289625.
SOURCESearch...

Entry information

Entry nameITB6_MOUSE
AccessionPrimary (citable) accession number: Q9Z0T9
Secondary accession number(s): Q544J9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents