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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 704704CytoplasmicSequence analysisAdd
BLAST
Transmembranei705 – 72824HelicalSequence analysisAdd
BLAST
Transmembranei734 – 77138HelicalSequence analysisAdd
BLAST
Transmembranei791 – 81323HelicalSequence analysisAdd
BLAST
Transmembranei823 – 84422HelicalSequence analysisAdd
BLAST
Topological domaini845 – 89753ExtracellularSequence analysisAdd
BLAST
Transmembranei898 – 91518HelicalSequence analysisAdd
BLAST
Topological domaini916 – 93015CytoplasmicSequence analysisAdd
BLAST
Transmembranei931 – 95121HelicalSequence analysisAdd
BLAST
Transmembranei985 – 100723HelicalSequence analysisAdd
BLAST
Transmembranei1033 – 105422HelicalSequence analysisAdd
BLAST
Transmembranei1088 – 113346HelicalSequence analysisAdd
BLAST
Transmembranei1160 – 119637HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12381238Anion exchange protein 2PRO_0000079214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei170 – 1701PhosphoserineBy similarity
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei253 – 2531PhosphothreonineBy similarity
Modified residuei439 – 4391PhosphoserineBy similarity
Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence analysis
Glycosylationi865 – 8651N-linked (GlcNAc...)Sequence analysis
Glycosylationi879 – 8791N-linked (GlcNAc...)Sequence analysis
Lipidationi1170 – 11701S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011907.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S8.
SMRiQ9Z0S8. Positions 689-730, 1130-1162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni705 – 1238534Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 316312Pro-richAdd
BLAST
Compositional biasi74 – 8815His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiQ9Z0S8.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTPRRPAS GADSFHKPEP EIVGPGTPGF PEQEEDDLHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE ELGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GQVRKPRRRP GATPAGETPT IEEGEEDEDE TSEAEGPVSH TDPSPASTPT
160 170 180 190 200
SVQFFLQEDE GTDRKAERTS PSPPAQLPHQ EAAPQATKKA QPDALVEEAI
210 220 230 240 250
MVSGGTAGGD DGGASGRPLS KAQPGHRSYN LQERRRIGSM TGVEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSSQSSREGR
310 320 330 340 350
EPGPTPRTRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HTQGAESDPH VTEPLIGGVP ETRLEVERER ELPPPAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGVGLEPKS
660 670 680 690 700
AQEKAFLQMV EAVGAVEDDD PLRRTGRPFG GLIRDVKRRY PHYLSDFRDA
710 720 730 740 750
LDPQCLAAVI FIYFAALSPA ITFGGLLGEK THDLIGVSEL IMSTALQGVT
760 770 780 790 800
FCLLGAQPLL VIGFSGPLLV FEEAFYSFCR SNELEYLVGR VWIGFWLVLS
810 820 830 840 850
ALLMVALEGS FLVRFGSRFT QEIFAFLISL IFIYETFYKL VKIFQEHPLH
860 870 880 890 900
GCLASNSSEA DGGKNTTWTE AAPTPGHGNT SSAEQAGVER PQGQPNTALL
910 920 930 940 950
SLVLMAGTFF IAFFLRKFKN SRFFPGRIRR VIGDFGVPIA ILIMVLVDYS
960 970 980 990 1000
IQDTYTQKLS VPSGFSVTAP EKRGWIINPL GEEEPFPVWM MVASLLPAIL
1010 1020 1030 1040 1050
VFILIFMETQ ITTLIISKKE RMLQKGSGFH LDLLLIVAMG GICALFGLLW
1060 1070 1080 1090 1100
LAAATVRSVT HANALTVMSK AVAPGDKPKI QEVKEQRVTG LLVALLVGLS
1110 1120 1130 1140 1150
LVIGDLLRQI PLAVLFGIFL YMGVTSLNGI QFYERLHLLL MPPKHHPDVM
1160 1170 1180 1190 1200
YVKKVRTMRM HLFKALQLLC LALLWAVMST AASLAFPFIL ILTVPLRMVV
1210 1220 1230
LTRIFTEREM KCLDANEAEP VFDEREGVDE YNEMPMPV
Length:1,238
Mass (Da):137,360
Last modified:May 1, 1999 - v1
Checksum:iFA1739862ED5ADBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121253 mRNA. Translation: AAD19700.1.
RefSeqiNP_001166488.1. NM_001173017.1.

Genome annotation databases

GeneIDi100135618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121253 mRNA. Translation: AAD19700.1.
RefSeqiNP_001166488.1. NM_001173017.1.

3D structure databases

ProteinModelPortaliQ9Z0S8.
SMRiQ9Z0S8. Positions 689-730, 1130-1162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135618.

Organism-specific databases

CTDi6522.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiQ9Z0S8.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The guinea pig cochlear AE2 anion exchanger: cDNA cloning and in situ localization within the cochlea."
    Mhatre A.N., Charachon G., Alper A.L., Lalwani A.K.
    Biochim. Biophys. Acta 1414:1-15(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH 2.
    Tissue: Organ of Corti.

Entry informationi

Entry nameiB3A2_CAVPO
AccessioniPrimary (citable) accession number: Q9Z0S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.