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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Non-erythroid band 3-like protein
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 704CytoplasmicSequence analysisAdd BLAST704
Transmembranei705 – 728HelicalSequence analysisAdd BLAST24
Transmembranei734 – 771HelicalSequence analysisAdd BLAST38
Transmembranei791 – 813HelicalSequence analysisAdd BLAST23
Transmembranei823 – 844HelicalSequence analysisAdd BLAST22
Topological domaini845 – 897ExtracellularSequence analysisAdd BLAST53
Transmembranei898 – 915HelicalSequence analysisAdd BLAST18
Topological domaini916 – 930CytoplasmicSequence analysisAdd BLAST15
Transmembranei931 – 951HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1007HelicalSequence analysisAdd BLAST23
Transmembranei1033 – 1054HelicalSequence analysisAdd BLAST22
Transmembranei1088 – 1133HelicalSequence analysisAdd BLAST46
Transmembranei1160 – 1196HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792141 – 1238Anion exchange protein 2Add BLAST1238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphoserineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei253PhosphothreonineBy similarity1
Modified residuei270N6-methyllysineBy similarity1
Modified residuei297Omega-N-methylarginineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Glycosylationi856N-linked (GlcNAc...)Sequence analysis1
Glycosylationi865N-linked (GlcNAc...)Sequence analysis1
Glycosylationi879N-linked (GlcNAc...)Sequence analysis1
Lipidationi1170S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011907.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni705 – 1238Membrane (anion exchange)Add BLAST534

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 316Pro-richAdd BLAST312
Compositional biasi74 – 88His-richAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiQ9Z0S8.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTPRRPAS GADSFHKPEP EIVGPGTPGF PEQEEDDLHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE ELGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GQVRKPRRRP GATPAGETPT IEEGEEDEDE TSEAEGPVSH TDPSPASTPT
160 170 180 190 200
SVQFFLQEDE GTDRKAERTS PSPPAQLPHQ EAAPQATKKA QPDALVEEAI
210 220 230 240 250
MVSGGTAGGD DGGASGRPLS KAQPGHRSYN LQERRRIGSM TGVEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSSQSSREGR
310 320 330 340 350
EPGPTPRTRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HTQGAESDPH VTEPLIGGVP ETRLEVERER ELPPPAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGVGLEPKS
660 670 680 690 700
AQEKAFLQMV EAVGAVEDDD PLRRTGRPFG GLIRDVKRRY PHYLSDFRDA
710 720 730 740 750
LDPQCLAAVI FIYFAALSPA ITFGGLLGEK THDLIGVSEL IMSTALQGVT
760 770 780 790 800
FCLLGAQPLL VIGFSGPLLV FEEAFYSFCR SNELEYLVGR VWIGFWLVLS
810 820 830 840 850
ALLMVALEGS FLVRFGSRFT QEIFAFLISL IFIYETFYKL VKIFQEHPLH
860 870 880 890 900
GCLASNSSEA DGGKNTTWTE AAPTPGHGNT SSAEQAGVER PQGQPNTALL
910 920 930 940 950
SLVLMAGTFF IAFFLRKFKN SRFFPGRIRR VIGDFGVPIA ILIMVLVDYS
960 970 980 990 1000
IQDTYTQKLS VPSGFSVTAP EKRGWIINPL GEEEPFPVWM MVASLLPAIL
1010 1020 1030 1040 1050
VFILIFMETQ ITTLIISKKE RMLQKGSGFH LDLLLIVAMG GICALFGLLW
1060 1070 1080 1090 1100
LAAATVRSVT HANALTVMSK AVAPGDKPKI QEVKEQRVTG LLVALLVGLS
1110 1120 1130 1140 1150
LVIGDLLRQI PLAVLFGIFL YMGVTSLNGI QFYERLHLLL MPPKHHPDVM
1160 1170 1180 1190 1200
YVKKVRTMRM HLFKALQLLC LALLWAVMST AASLAFPFIL ILTVPLRMVV
1210 1220 1230
LTRIFTEREM KCLDANEAEP VFDEREGVDE YNEMPMPV
Length:1,238
Mass (Da):137,360
Last modified:May 1, 1999 - v1
Checksum:iFA1739862ED5ADBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121253 mRNA. Translation: AAD19700.1.
RefSeqiNP_001166488.1. NM_001173017.1.

Genome annotation databases

GeneIDi100135618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121253 mRNA. Translation: AAD19700.1.
RefSeqiNP_001166488.1. NM_001173017.1.

3D structure databases

ProteinModelPortaliQ9Z0S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135618.

Organism-specific databases

CTDi6522.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiQ9Z0S8.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A2_CAVPO
AccessioniPrimary (citable) accession number: Q9Z0S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.