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Protein

Claudin-9

Gene

Cldn9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-9
Gene namesi
Name:Cldn9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913100. Cldn9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 81ExtracellularSequence analysisAdd BLAST48
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 159ExtracellularSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 217CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447561 – 217Claudin-9Add BLAST217

Proteomic databases

PaxDbiQ9Z0S7.
PRIDEiQ9Z0S7.

PTM databases

PhosphoSitePlusiQ9Z0S7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066720.
CleanExiMM_CLDN9.
GenevisibleiQ9Z0S7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093236.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S7.
SMRiQ9Z0S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0S7.
KOiK06087.
OMAiCPPPQIE.
OrthoDBiEOG091G0MMR.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVLLLLSGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPSHF ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,897
Last modified:October 3, 2012 - v2
Checksum:i793223BDB09DC398
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → F in AAD17319 (Ref. 1) Curated1
Sequence conflicti11M → R in AAD17319 (Ref. 1) Curated1
Sequence conflicti14A → V in AAD17319 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124424 Genomic DNA. Translation: AAD17319.1.
AC154766 Genomic DNA. No translation available.
CH466606 Genomic DNA. Translation: EDL22263.1.
BC058186 mRNA. Translation: AAH58186.1.
CCDSiCCDS28458.1.
RefSeqiNP_064689.2. NM_020293.3.
UniGeneiMm.491368.

Genome annotation databases

EnsembliENSMUST00000085989; ENSMUSP00000093236; ENSMUSG00000066720.
GeneIDi56863.
KEGGimmu:56863.
UCSCiuc008asx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124424 Genomic DNA. Translation: AAD17319.1.
AC154766 Genomic DNA. No translation available.
CH466606 Genomic DNA. Translation: EDL22263.1.
BC058186 mRNA. Translation: AAH58186.1.
CCDSiCCDS28458.1.
RefSeqiNP_064689.2. NM_020293.3.
UniGeneiMm.491368.

3D structure databases

ProteinModelPortaliQ9Z0S7.
SMRiQ9Z0S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093236.

PTM databases

PhosphoSitePlusiQ9Z0S7.

Proteomic databases

PaxDbiQ9Z0S7.
PRIDEiQ9Z0S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085989; ENSMUSP00000093236; ENSMUSG00000066720.
GeneIDi56863.
KEGGimmu:56863.
UCSCiuc008asx.2. mouse.

Organism-specific databases

CTDi9080.
MGIiMGI:1913100. Cldn9.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0S7.
KOiK06087.
OMAiCPPPQIE.
OrthoDBiEOG091G0MMR.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9Z0S7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066720.
CleanExiMM_CLDN9.
GenevisibleiQ9Z0S7. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S7
Secondary accession number(s): Q6PEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.