Q9Z0S6 (CL10A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Claudin-10A

Gene names

Name:	Cldn10a
Synonyms:	Cldn10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.
Subcellular location	Cell junction › tight junction. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the claudin family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Tight junction
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-independent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell tight junction Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	identical protein binding Inferred from sequence or structural similarity. Source: UniProtKB structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Claudin-10A		PRO_0000144758
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Topological domain	22 – 80	59	Extracellular Potential
	Transmembrane	81 – 101	21	Helical; Potential
	Topological domain	102 – 115	14	Cytoplasmic Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Topological domain	137 – 160	24	Extracellular Potential
	Transmembrane	161 – 181	21	Helical; Potential
	Topological domain	182 – 231	50	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Z0S6 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 80A28863A24FAFB5	FASTA	231	24,693
	10 20 30 40 50 60 MASTALEIVA FVVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYFANLW KICVTDSTGV 70 80 90 100 110 120 ANCKEFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALFG MKCTKVGGSD QAKAKIACLA 130 140 150 160 170 180 GIVFILSGLC SMTGCSLYAN KITTEFFDPL YMEQKYELGA ALFIGWAGAS LCIIGGVIFC 190 200 210 220 230 FSISDNNKTP RMGYTYNGPT SVMSSRTKYQ GGEGDFKTAG PSKQFDKNAY V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Morita K., Furuse M., Tsukita S. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF124425 mRNA. Translation: AAD17320.1. BC029019 mRNA. Translation: AAH29019.1.
IPI	IPI00129394.
UniGene	Mm.390755.
3D structure databases
ProteinModelPortal	Q9Z0S6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48954N.
Protein family/group databases
TCDB	1.H.1.8.1. claudin tight junction (Claudin) family.
PTM databases
PhosphoSite	Q9Z0S6.
Proteomic databases
PaxDb	Q9Z0S6.
PRIDE	Q9Z0S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1913101. Cldn10a.
Phylogenomic databases
eggNOG	NOG42372.
HOGENOM	HOG000220937.
HOVERGEN	HBG000643.
InParanoid	Q9Z0S6.
OrthoDB	EOG441QCM.
Gene expression databases
Genevestigator	Q9Z0S6.
GermOnline	ENSMUSG00000022132. Mus musculus. ENSMUSG00000075473. Mus musculus.
Family and domain databases
InterPro	IPR006187. Claudin. IPR003554. Claudin10. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin. [Graphical view]
PANTHER	PTHR12002. PTHR12002. 1 hit.
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01077. CLAUDIN. PR01383. CLAUDIN10.
PROSITE	PS01346. CLAUDIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CL10A_MOUSE

Accession

Primary (citable) accession number: Q9Z0S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program