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Q9Z0S3

- CLD14_MOUSE

UniProt

Q9Z0S3 - CLD14_MOUSE

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Protein
Claudin-14
Gene
Cldn14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-14
Gene namesi
Name:Cldn14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1860425. Cldn14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Reviewed prediction
Add
BLAST
Topological domaini29 – 8153Extracellular Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 11513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 16226Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 23956Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
  4. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Claudin-14
PRO_0000144770Add
BLAST

Proteomic databases

PRIDEiQ9Z0S3.

PTM databases

PhosphoSiteiQ9Z0S3.

Expressioni

Tissue specificityi

Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney.1 Publication

Developmental stagei

At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti.

Gene expression databases

BgeeiQ9Z0S3.
CleanExiMM_CLDN14.
GenevestigatoriQ9Z0S3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLDN16Q9Y5I73EBI-7774956,EBI-7774981From a different organism.

Protein-protein interaction databases

IntActiQ9Z0S3. 2 interactions.
MINTiMINT-8387825.
STRINGi10090.ENSMUSP00000062045.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S3.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41985.
GeneTreeiENSGT00740000115004.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0S3.
KOiK06087.
OMAiCACAVVG.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z0S3.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003556. Claudin14.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01385. CLAUDIN14.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S3-1 [UniParc]FASTAAdd to Basket

« Hide

MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL    50
WMECVWHSTG IYQCQIYRSL LALPRDLQAA RALMVISCLL SGMACACAVV 100
GMKCTRCAKG TPAKTTFAVL GGALFLLAGL LCMVAVSWTT NDVVQNFYNP 150
LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYPPQSRA 200
GATTTATAPA YRPPAAYKDN RAPSVTSAAH SGYRLNDYV 239
Length:239
Mass (Da):25,614
Last modified:August 14, 2001 - v2
Checksum:i24DE6AEADA56BB61
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151T → N in AAD17323. 1 Publication
Sequence conflicti119 – 1191V → M in BAB32041. 1 Publication
Sequence conflicti129 – 1291G → A in AAD17323. 1 Publication
Sequence conflicti166 – 1661L → M in AAD17323. 1 Publication
Sequence conflicti187 – 1871D → E in AAD17323. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124429 mRNA. Translation: AAD17323.1.
AF314089 mRNA. Translation: AAG60051.2.
AK020255 mRNA. Translation: BAB32041.1.
CCDSiCCDS28345.1.
RefSeqiNP_001159397.1. NM_001165925.1.
NP_001159398.1. NM_001165926.1.
NP_062373.3. NM_019500.4.
XP_006523130.1. XM_006523067.1.
UniGeneiMm.328716.

Genome annotation databases

EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109.
ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109.
ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109.
GeneIDi56173.
KEGGimmu:56173.
UCSCiuc008aad.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124429 mRNA. Translation: AAD17323.1 .
AF314089 mRNA. Translation: AAG60051.2 .
AK020255 mRNA. Translation: BAB32041.1 .
CCDSi CCDS28345.1.
RefSeqi NP_001159397.1. NM_001165925.1.
NP_001159398.1. NM_001165926.1.
NP_062373.3. NM_019500.4.
XP_006523130.1. XM_006523067.1.
UniGenei Mm.328716.

3D structure databases

ProteinModelPortali Q9Z0S3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Z0S3. 2 interactions.
MINTi MINT-8387825.
STRINGi 10090.ENSMUSP00000062045.

PTM databases

PhosphoSitei Q9Z0S3.

Proteomic databases

PRIDEi Q9Z0S3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050962 ; ENSMUSP00000062045 ; ENSMUSG00000047109 .
ENSMUST00000169391 ; ENSMUSP00000126455 ; ENSMUSG00000047109 .
ENSMUST00000177648 ; ENSMUSP00000136156 ; ENSMUSG00000047109 .
GeneIDi 56173.
KEGGi mmu:56173.
UCSCi uc008aad.2. mouse.

Organism-specific databases

CTDi 23562.
MGIi MGI:1860425. Cldn14.

Phylogenomic databases

eggNOGi NOG41985.
GeneTreei ENSGT00740000115004.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi Q9Z0S3.
KOi K06087.
OMAi CACAVVG.
OrthoDBi EOG76HQ2T.
PhylomeDBi Q9Z0S3.
TreeFami TF331936.

Miscellaneous databases

NextBioi 311936.
PROi Q9Z0S3.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0S3.
CleanExi MM_CLDN14.
Genevestigatori Q9Z0S3.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003556. Claudin14.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01385. CLAUDIN14.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Morita K., Furuse M., Tsukita S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  3. Cited for: SEQUENCE REVISION TO 115; 129; 166 AND 187.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.

Entry informationi

Entry nameiCLD14_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S3
Secondary accession number(s): Q9D284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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