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Q9Z0S3

- CLD14_MOUSE

UniProt

Q9Z0S3 - CLD14_MOUSE

Protein

Claudin-14

Gene

Cldn14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-14
    Gene namesi
    Name:Cldn14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1860425. Cldn14.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI
    4. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Claudin-14PRO_0000144770Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z0S3.

    PTM databases

    PhosphoSiteiQ9Z0S3.

    Expressioni

    Tissue specificityi

    Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney.1 Publication

    Developmental stagei

    At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti.

    Gene expression databases

    BgeeiQ9Z0S3.
    CleanExiMM_CLDN14.
    GenevestigatoriQ9Z0S3.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLDN16Q9Y5I73EBI-7774956,EBI-7774981From a different organism.

    Protein-protein interaction databases

    IntActiQ9Z0S3. 2 interactions.
    MINTiMINT-8387825.
    STRINGi10090.ENSMUSP00000062045.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0S3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 16226ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 23956CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41985.
    GeneTreeiENSGT00740000115004.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiQ9Z0S3.
    KOiK06087.
    OMAiCACAVVG.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiQ9Z0S3.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003556. Claudin14.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01385. CLAUDIN14.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0S3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL    50
    WMECVWHSTG IYQCQIYRSL LALPRDLQAA RALMVISCLL SGMACACAVV 100
    GMKCTRCAKG TPAKTTFAVL GGALFLLAGL LCMVAVSWTT NDVVQNFYNP 150
    LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYPPQSRA 200
    GATTTATAPA YRPPAAYKDN RAPSVTSAAH SGYRLNDYV 239
    Length:239
    Mass (Da):25,614
    Last modified:August 14, 2001 - v2
    Checksum:i24DE6AEADA56BB61
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti115 – 1151T → N in AAD17323. 1 PublicationCurated
    Sequence conflicti119 – 1191V → M in BAB32041. (PubMed:16141072)Curated
    Sequence conflicti129 – 1291G → A in AAD17323. 1 PublicationCurated
    Sequence conflicti166 – 1661L → M in AAD17323. 1 PublicationCurated
    Sequence conflicti187 – 1871D → E in AAD17323. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124429 mRNA. Translation: AAD17323.1.
    AF314089 mRNA. Translation: AAG60051.2.
    AK020255 mRNA. Translation: BAB32041.1.
    CCDSiCCDS28345.1.
    RefSeqiNP_001159397.1. NM_001165925.1.
    NP_001159398.1. NM_001165926.1.
    NP_062373.3. NM_019500.4.
    XP_006523130.1. XM_006523067.1.
    UniGeneiMm.328716.

    Genome annotation databases

    EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109.
    ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109.
    ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109.
    GeneIDi56173.
    KEGGimmu:56173.
    UCSCiuc008aad.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124429 mRNA. Translation: AAD17323.1 .
    AF314089 mRNA. Translation: AAG60051.2 .
    AK020255 mRNA. Translation: BAB32041.1 .
    CCDSi CCDS28345.1.
    RefSeqi NP_001159397.1. NM_001165925.1.
    NP_001159398.1. NM_001165926.1.
    NP_062373.3. NM_019500.4.
    XP_006523130.1. XM_006523067.1.
    UniGenei Mm.328716.

    3D structure databases

    ProteinModelPortali Q9Z0S3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z0S3. 2 interactions.
    MINTi MINT-8387825.
    STRINGi 10090.ENSMUSP00000062045.

    PTM databases

    PhosphoSitei Q9Z0S3.

    Proteomic databases

    PRIDEi Q9Z0S3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050962 ; ENSMUSP00000062045 ; ENSMUSG00000047109 .
    ENSMUST00000169391 ; ENSMUSP00000126455 ; ENSMUSG00000047109 .
    ENSMUST00000177648 ; ENSMUSP00000136156 ; ENSMUSG00000047109 .
    GeneIDi 56173.
    KEGGi mmu:56173.
    UCSCi uc008aad.2. mouse.

    Organism-specific databases

    CTDi 23562.
    MGIi MGI:1860425. Cldn14.

    Phylogenomic databases

    eggNOGi NOG41985.
    GeneTreei ENSGT00740000115004.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi Q9Z0S3.
    KOi K06087.
    OMAi CACAVVG.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi Q9Z0S3.
    TreeFami TF331936.

    Miscellaneous databases

    NextBioi 311936.
    PROi Q9Z0S3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0S3.
    CleanExi MM_CLDN14.
    Genevestigatori Q9Z0S3.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003556. Claudin14.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01385. CLAUDIN14.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Morita K., Furuse M., Tsukita S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    3. Cited for: SEQUENCE REVISION TO 115; 129; 166 AND 187.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.

    Entry informationi

    Entry nameiCLD14_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0S3
    Secondary accession number(s): Q9D284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3