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Protein

Claudin-14

Gene

Cldn14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-14
Gene namesi
Name:Cldn14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1860425. Cldn14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 11513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 16226ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 23956CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Claudin-14PRO_0000144770Add
BLAST

Proteomic databases

PRIDEiQ9Z0S3.

PTM databases

PhosphoSiteiQ9Z0S3.

Expressioni

Tissue specificityi

Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney.1 Publication

Developmental stagei

At postnatal day 4, expression is apically located in the inner and outer hair cell region of the entire organ of Corti. By postnatal day 8, expression is highest in the supporting cells of the organ of Corti.

Gene expression databases

BgeeiQ9Z0S3.
CleanExiMM_CLDN14.
ExpressionAtlasiQ9Z0S3. baseline and differential.
GenevisibleiQ9Z0S3. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLDN16Q9Y5I73EBI-7774956,EBI-7774981From a different organism.

Protein-protein interaction databases

IntActiQ9Z0S3. 2 interactions.
MINTiMINT-8387825.
STRINGi10090.ENSMUSP00000062045.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S3.
SMRiQ9Z0S3. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41985.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0S3.
KOiK06087.
OMAiCACAVVG.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z0S3.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003556. Claudin14.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF82. PTHR12002:SF82. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL
60 70 80 90 100
WMECVWHSTG IYQCQIYRSL LALPRDLQAA RALMVISCLL SGMACACAVV
110 120 130 140 150
GMKCTRCAKG TPAKTTFAVL GGALFLLAGL LCMVAVSWTT NDVVQNFYNP
160 170 180 190 200
LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYPPQSRA
210 220 230
GATTTATAPA YRPPAAYKDN RAPSVTSAAH SGYRLNDYV
Length:239
Mass (Da):25,614
Last modified:August 14, 2001 - v2
Checksum:i24DE6AEADA56BB61
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151T → N in AAD17323 (Ref. 1) Curated
Sequence conflicti119 – 1191V → M in BAB32041 (PubMed:16141072).Curated
Sequence conflicti129 – 1291G → A in AAD17323 (Ref. 1) Curated
Sequence conflicti166 – 1661L → M in AAD17323 (Ref. 1) Curated
Sequence conflicti187 – 1871D → E in AAD17323 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124429 mRNA. Translation: AAD17323.1.
AF314089 mRNA. Translation: AAG60051.2.
AK020255 mRNA. Translation: BAB32041.1.
CCDSiCCDS28345.1.
RefSeqiNP_001159397.1. NM_001165925.1.
NP_001159398.1. NM_001165926.1.
NP_062373.3. NM_019500.4.
XP_006523130.1. XM_006523067.2.
UniGeneiMm.328716.

Genome annotation databases

EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109.
ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109.
ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109.
GeneIDi56173.
KEGGimmu:56173.
UCSCiuc008aad.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124429 mRNA. Translation: AAD17323.1.
AF314089 mRNA. Translation: AAG60051.2.
AK020255 mRNA. Translation: BAB32041.1.
CCDSiCCDS28345.1.
RefSeqiNP_001159397.1. NM_001165925.1.
NP_001159398.1. NM_001165926.1.
NP_062373.3. NM_019500.4.
XP_006523130.1. XM_006523067.2.
UniGeneiMm.328716.

3D structure databases

ProteinModelPortaliQ9Z0S3.
SMRiQ9Z0S3. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z0S3. 2 interactions.
MINTiMINT-8387825.
STRINGi10090.ENSMUSP00000062045.

PTM databases

PhosphoSiteiQ9Z0S3.

Proteomic databases

PRIDEiQ9Z0S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050962; ENSMUSP00000062045; ENSMUSG00000047109.
ENSMUST00000169391; ENSMUSP00000126455; ENSMUSG00000047109.
ENSMUST00000177648; ENSMUSP00000136156; ENSMUSG00000047109.
GeneIDi56173.
KEGGimmu:56173.
UCSCiuc008aad.2. mouse.

Organism-specific databases

CTDi23562.
MGIiMGI:1860425. Cldn14.

Phylogenomic databases

eggNOGiNOG41985.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z0S3.
KOiK06087.
OMAiCACAVVG.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z0S3.
TreeFamiTF331936.

Miscellaneous databases

NextBioi311936.
PROiQ9Z0S3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0S3.
CleanExiMM_CLDN14.
ExpressionAtlasiQ9Z0S3. baseline and differential.
GenevisibleiQ9Z0S3. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003556. Claudin14.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF82. PTHR12002:SF82. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Morita K., Furuse M., Tsukita S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  3. Cited for: SEQUENCE REVISION TO 115; 129; 166 AND 187.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.

Entry informationi

Entry nameiCLD14_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S3
Secondary accession number(s): Q9D284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.