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Protein

LIM/homeobox protein Lhx2

Gene

Lhx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • axon extension Source: MGI
  • axon guidance Source: CACAO
  • brain development Source: MGI
  • cerebral cortex development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • hair follicle development Source: MGI
  • maintenance of epithelial cell apical/basal polarity Source: MGI
  • mesoderm development Source: MGI
  • negative regulation of transcription regulatory region DNA binding Source: MGI
  • nervous system development Source: MGI
  • neural tube closure Source: MGI
  • neurogenesis Source: MGI
  • neuron differentiation Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • retina development in camera-type eye Source: MGI
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:Lhx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96785. Lhx2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi53 – 531C → A: Reduces transcriptional activation; when associated with A-56. 1 Publication
Mutagenesisi56 – 561C → A: Reduces transcriptional activation; when associated with A-53. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406LIM/homeobox protein Lhx2PRO_0000075779Add
BLAST

Proteomic databases

PaxDbiQ9Z0S2.
PRIDEiQ9Z0S2.

PTM databases

PhosphoSiteiQ9Z0S2.

Expressioni

Gene expression databases

BgeeiQ9Z0S2.
CleanExiMM_LHX2.
ExpressionAtlasiQ9Z0S2. baseline and differential.
GenevestigatoriQ9Z0S2.

Interactioni

Subunit structurei

interacts (via LIM domains) with CITED2.1 Publication

Protein-protein interaction databases

BioGridi201155. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S2.
SMRiQ9Z0S2. Positions 53-165, 262-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 10553LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini115 – 16854LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 32317Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 19610Poly-Ala

Domaini

LIM domains are necessary for transcription activation.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG240987.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiQ9Z0S2.
KOiK09373.
OMAiHECRSPS.
PhylomeDBiQ9Z0S2.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,419
Last modified:May 1, 1999 - v1
Checksum:iFE7B4E76454D6A90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124734 mRNA. Translation: AAD20012.1.
BC055741 mRNA. Translation: AAH55741.1.
CCDSiCCDS16008.1.
RefSeqiNP_034840.1. NM_010710.4.
UniGeneiMm.142856.

Genome annotation databases

EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247.
GeneIDi16870.
KEGGimmu:16870.
UCSCiuc008jnk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124734 mRNA. Translation: AAD20012.1.
BC055741 mRNA. Translation: AAH55741.1.
CCDSiCCDS16008.1.
RefSeqiNP_034840.1. NM_010710.4.
UniGeneiMm.142856.

3D structure databases

ProteinModelPortaliQ9Z0S2.
SMRiQ9Z0S2. Positions 53-165, 262-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201155. 6 interactions.

PTM databases

PhosphoSiteiQ9Z0S2.

Proteomic databases

PaxDbiQ9Z0S2.
PRIDEiQ9Z0S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247.
GeneIDi16870.
KEGGimmu:16870.
UCSCiuc008jnk.1. mouse.

Organism-specific databases

CTDi9355.
MGIiMGI:96785. Lhx2.

Phylogenomic databases

eggNOGiNOG240987.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiQ9Z0S2.
KOiK09373.
OMAiHECRSPS.
PhylomeDBiQ9Z0S2.
TreeFamiTF315442.

Miscellaneous databases

NextBioi290834.
PROiQ9Z0S2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0S2.
CleanExiMM_LHX2.
ExpressionAtlasiQ9Z0S2. baseline and differential.
GenevestigatoriQ9Z0S2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conservation of the expression and function of apterous orthologs in Drosophila and mammals."
    Rincon-Limas D.E., Lu C.-H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J.-C., Botas J.
    Proc. Natl. Acad. Sci. U.S.A. 96:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
    Glenn D.J., Maurer R.A.
    J. Biol. Chem. 274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CITED2, MUTAGENESIS OF CYS-53 AND CYS-56.

Entry informationi

Entry nameiLHX2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.