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Q9Z0S2

- LHX2_MOUSE

UniProt

Q9Z0S2 - LHX2_MOUSE

Protein

LIM/homeobox protein Lhx2

Gene

Lhx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: UniProtKB
    3. RNA polymerase II transcription factor binding transcription factor activity Source: MGI
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: InterPro
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: MGI
    2. axon extension Source: MGI
    3. axon guidance Source: MGI
    4. brain development Source: MGI
    5. cerebral cortex development Source: MGI
    6. dorsal/ventral pattern formation Source: MGI
    7. mesoderm development Source: MGI
    8. negative regulation of transcription regulatory region DNA binding Source: MGI
    9. nervous system development Source: MGI
    10. neural tube closure Source: MGI
    11. neurogenesis Source: MGI
    12. neuron differentiation Source: MGI
    13. olfactory bulb development Source: MGI
    14. positive regulation of transcription, DNA-templated Source: UniProtKB
    15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    16. retina development in camera-type eye Source: MGI
    17. telencephalon development Source: MGI
    18. telencephalon regionalization Source: MGI
    19. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM/homeobox protein Lhx2
    Short name:
    Homeobox protein LH-2
    Short name:
    LIM homeobox protein 2
    Gene namesi
    Name:Lhx2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96785. Lhx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi53 – 531C → A: Reduces transcriptional activation; when associated with A-56. 1 Publication
    Mutagenesisi56 – 561C → A: Reduces transcriptional activation; when associated with A-53. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406LIM/homeobox protein Lhx2PRO_0000075779Add
    BLAST

    Proteomic databases

    PaxDbiQ9Z0S2.
    PRIDEiQ9Z0S2.

    PTM databases

    PhosphoSiteiQ9Z0S2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z0S2.
    BgeeiQ9Z0S2.
    CleanExiMM_LHX2.
    GenevestigatoriQ9Z0S2.

    Interactioni

    Subunit structurei

    interacts (via LIM domains) with CITED2.1 Publication

    Protein-protein interaction databases

    BioGridi201155. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0S2.
    SMRiQ9Z0S2. Positions 53-165, 262-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 10553LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini115 – 16854LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi307 – 32317Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi187 – 19610Poly-Ala

    Domaini

    LIM domains are necessary for transcription activation.

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG240987.
    GeneTreeiENSGT00750000117279.
    HOGENOMiHOG000034022.
    HOVERGENiHBG006262.
    InParanoidiQ9Z0S2.
    KOiK09373.
    OMAiHECRSPS.
    PhylomeDBiQ9Z0S2.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA    50
    ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI 100
    YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML 150
    TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG 200
    LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND 250
    AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 300
    QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA 350
    SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT 400
    TLTNLF 406
    Length:406
    Mass (Da):44,419
    Last modified:May 1, 1999 - v1
    Checksum:iFE7B4E76454D6A90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124734 mRNA. Translation: AAD20012.1.
    BC055741 mRNA. Translation: AAH55741.1.
    CCDSiCCDS16008.1.
    RefSeqiNP_034840.1. NM_010710.4.
    UniGeneiMm.142856.

    Genome annotation databases

    EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247.
    GeneIDi16870.
    KEGGimmu:16870.
    UCSCiuc008jnk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124734 mRNA. Translation: AAD20012.1 .
    BC055741 mRNA. Translation: AAH55741.1 .
    CCDSi CCDS16008.1.
    RefSeqi NP_034840.1. NM_010710.4.
    UniGenei Mm.142856.

    3D structure databases

    ProteinModelPortali Q9Z0S2.
    SMRi Q9Z0S2. Positions 53-165, 262-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201155. 6 interactions.

    PTM databases

    PhosphoSitei Q9Z0S2.

    Proteomic databases

    PaxDbi Q9Z0S2.
    PRIDEi Q9Z0S2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000253 ; ENSMUSP00000000253 ; ENSMUSG00000000247 .
    GeneIDi 16870.
    KEGGi mmu:16870.
    UCSCi uc008jnk.1. mouse.

    Organism-specific databases

    CTDi 9355.
    MGIi MGI:96785. Lhx2.

    Phylogenomic databases

    eggNOGi NOG240987.
    GeneTreei ENSGT00750000117279.
    HOGENOMi HOG000034022.
    HOVERGENi HBG006262.
    InParanoidi Q9Z0S2.
    KOi K09373.
    OMAi HECRSPS.
    PhylomeDBi Q9Z0S2.
    TreeFami TF315442.

    Miscellaneous databases

    NextBioi 290834.
    PROi Q9Z0S2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0S2.
    Bgeei Q9Z0S2.
    CleanExi MM_LHX2.
    Genevestigatori Q9Z0S2.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of the expression and function of apterous orthologs in Drosophila and mammals."
      Rincon-Limas D.E., Lu C.-H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J.-C., Botas J.
      Proc. Natl. Acad. Sci. U.S.A. 96:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
      Glenn D.J., Maurer R.A.
      J. Biol. Chem. 274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CITED2, MUTAGENESIS OF CYS-53 AND CYS-56.

    Entry informationi

    Entry nameiLHX2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3