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Protein

LIM/homeobox protein Lhx2

Gene

Lhx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcription factor activity, RNA polymerase II transcription factor binding Source: MGI

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • axon extension Source: MGI
  • axon guidance Source: CACAO
  • brain development Source: MGI
  • cerebral cortex development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • hair follicle development Source: MGI
  • maintenance of epithelial cell apical/basal polarity Source: MGI
  • mesoderm development Source: MGI
  • negative regulation of transcription regulatory region DNA binding Source: MGI
  • nervous system development Source: MGI
  • neural tube closure Source: MGI
  • neurogenesis Source: MGI
  • neuron differentiation Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • retina development in camera-type eye Source: MGI
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:Lhx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96785 Lhx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53C → A: Reduces transcriptional activation; when associated with A-56. 1 Publication1
Mutagenesisi56C → A: Reduces transcriptional activation; when associated with A-53. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757791 – 406LIM/homeobox protein Lhx2Add BLAST406

Proteomic databases

MaxQBiQ9Z0S2
PaxDbiQ9Z0S2
PRIDEiQ9Z0S2

PTM databases

PhosphoSitePlusiQ9Z0S2

Expressioni

Gene expression databases

BgeeiENSMUSG00000000247
CleanExiMM_LHX2
ExpressionAtlasiQ9Z0S2 baseline and differential
GenevisibleiQ9Z0S2 MM

Interactioni

Subunit structurei

Interacts (via LIM domains) with CITED2 (PubMed:10593900). Interacts with POU4F2 isoform 1 (PubMed:24643061).2 Publications

Protein-protein interaction databases

BioGridi201155, 6 interactors
STRINGi10090.ENSMUSP00000000253

Structurei

3D structure databases

ProteinModelPortaliQ9Z0S2
SMRiQ9Z0S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini115 – 168LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 323Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 196Poly-Ala10

Domaini

LIM domains are necessary for transcription activation.

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiQ9Z0S2
KOiK09373
OMAiTHFNHAD
OrthoDBiEOG091G13BH
PhylomeDBiQ9Z0S2
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9Z0S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,419
Last modified:May 1, 1999 - v1
Checksum:iFE7B4E76454D6A90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124734 mRNA Translation: AAD20012.1
BC055741 mRNA Translation: AAH55741.1
CCDSiCCDS16008.1
RefSeqiNP_034840.1, NM_010710.4
UniGeneiMm.142856

Genome annotation databases

EnsembliENSMUST00000000253; ENSMUSP00000000253; ENSMUSG00000000247
GeneIDi16870
KEGGimmu:16870
UCSCiuc008jnk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLHX2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health