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Q9Z0R8

- TS1R1_RAT

UniProt

Q9Z0R8 - TS1R1_RAT

Protein

Taste receptor type 1 member 1

Gene

Tas1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

    GO - Molecular functioni

    1. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. sensory perception of umami taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 1 member 1
    Alternative name(s):
    G-protein coupled receptor 70
    Gene namesi
    Name:Tas1r1
    Synonyms:Gpr70, T1r1, Tr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi61891. Tas1r1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 840821Taste receptor type 1 member 1PRO_0000012956Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Z0R8.
    PRIDEiQ9Z0R8.

    PTM databases

    PhosphoSiteiQ9Z0R8.

    Expressioni

    Tissue specificityi

    Expressed in many cells in the fungiform and geschmackstreifen taste buds.1 Publication

    Gene expression databases

    GenevestigatoriQ9Z0R8.

    Interactioni

    Subunit structurei

    Forms heterodimers with TAS1R3.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 566547ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini588 – 60215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini624 – 63815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini660 – 67920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini701 – 72424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini746 – 76015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini782 – 7865ExtracellularSequence Analysis
    Topological domaini808 – 84033CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei567 – 58721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei603 – 62321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei639 – 65921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei680 – 70021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei725 – 74521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei761 – 78121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei787 – 80721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248202.
    GeneTreeiENSGT00740000115154.
    HOGENOMiHOG000038047.
    HOVERGENiHBG108601.
    InParanoidiQ9Z0R8.
    KOiK04624.
    OMAiYGQLGVQ.
    OrthoDBiEOG722J7V.
    PhylomeDBiQ9Z0R8.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFWAAHLLL SLQLVYCWAF SCQRTESSPG FSLPGDFLLA GLFSLHGDCL    50
    QVRHRPLVTS CDRPDSFNGH GYHLFQAMRF TVEEINNSSA LLPNITLGYE 100
    LYDVCSESAN VYATLRVLAL QGPRHIEIQK DLRNHSSKVV AFIGPDNTDH 150
    AVTTAALLGP FLMPLVSYEA SSVVLSAKRK FPSFLRTVPS DRHQVEVMVQ 200
    LLQSFGWVWI SLIGSYGDYG QLGVQALEEL AVPRGICVAF KDIVPFSARV 250
    GDPRMQSMMQ HLAQARTTVV VVFSNRHLAR VFFRSVVLAN LTGKVWVASE 300
    DWAISTYITS VTGIQGIGTV LGVAVQQRQV PGLKEFEESY VRAVTAAPSA 350
    CPEGSWCSTN QLCRECHTFT TRNMPTLGAF SMSAAYRVYE AVYAVAHGLH 400
    QLLGCTSEIC SRGPVYPWQL LQQIYKVNFL LHENTVAFDD NGDTLGYYDI 450
    IAWDWNGPEW TFEIIGSASL SPVHLDINKT KIQWHGKNNQ VPVSVCTTDC 500
    LAGHHRVVVG SHHCCFECVP CEAGTFLNMS ELHICQPCGT EEWAPKESTT 550
    CFPRTVEFLA WHEPISLVLI AANTLLLLLL VGTAGLFAWH FHTPVVRSAG 600
    GRLCFLMLGS LVAGSCSFYS FFGEPTVPAC LLRQPLFSLG FAIFLSCLTI 650
    RSFQLVIIFK FSTKVPTFYR TWAQNHGAGL FVIVSSTVHL LICLTWLVMW 700
    TPRPTREYQR FPHLVILECT EVNSVGFLLA FTHNILLSIS TFVCSYLGKE 750
    LPENYNEAKC VTFSLLLNFV SWIAFFTMAS IYQGSYLPAV NVLAGLTTLS 800
    GGFSGYFLPK CYVILCRPEL NNTEHFQASI QDYTRRCGTT 840
    Length:840
    Mass (Da):93,497
    Last modified:May 1, 1999 - v1
    Checksum:i1FCFB7EFC6BB45DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF127389 mRNA. Translation: AAD18069.1.
    RefSeqiNP_445757.1. NM_053305.1.
    UniGeneiRn.92309.

    Genome annotation databases

    EnsembliENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
    GeneIDi29407.
    KEGGirno:29407.
    UCSCiRGD:61891. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF127389 mRNA. Translation: AAD18069.1 .
    RefSeqi NP_445757.1. NM_053305.1.
    UniGenei Rn.92309.

    3D structure databases

    ProteinModelPortali Q9Z0R8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013385.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Z0R8.

    Proteomic databases

    PaxDbi Q9Z0R8.
    PRIDEi Q9Z0R8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013385 ; ENSRNOP00000013385 ; ENSRNOG00000009708 .
    GeneIDi 29407.
    KEGGi rno:29407.
    UCSCi RGD:61891. rat.

    Organism-specific databases

    CTDi 80835.
    RGDi 61891. Tas1r1.

    Phylogenomic databases

    eggNOGi NOG248202.
    GeneTreei ENSGT00740000115154.
    HOGENOMi HOG000038047.
    HOVERGENi HBG108601.
    InParanoidi Q9Z0R8.
    KOi K04624.
    OMAi YGQLGVQ.
    OrthoDBi EOG722J7V.
    PhylomeDBi Q9Z0R8.

    Miscellaneous databases

    NextBioi 609056.
    PROi Q9Z0R8.

    Gene expression databases

    Genevestigatori Q9Z0R8.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity."
      Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.
      Cell 96:541-551(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Circumvallate papilla.

    Entry informationi

    Entry nameiTS1R1_RAT
    AccessioniPrimary (citable) accession number: Q9Z0R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3