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Protein

Taste receptor type 1 member 1

Gene

Tas1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

GO - Molecular functioni

  1. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 1
Alternative name(s):
G-protein coupled receptor 70
Gene namesi
Name:Tas1r1
Synonyms:Gpr70, T1r1, Tr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi61891. Tas1r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 566547ExtracellularSequence AnalysisAdd
BLAST
Transmembranei567 – 58721HelicalSequence AnalysisAdd
BLAST
Topological domaini588 – 60215CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei603 – 62321HelicalSequence AnalysisAdd
BLAST
Topological domaini624 – 63815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei639 – 65921HelicalSequence AnalysisAdd
BLAST
Topological domaini660 – 67920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei680 – 70021HelicalSequence AnalysisAdd
BLAST
Topological domaini701 – 72424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei725 – 74521HelicalSequence AnalysisAdd
BLAST
Topological domaini746 – 76015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei761 – 78121HelicalSequence AnalysisAdd
BLAST
Topological domaini782 – 7865ExtracellularSequence Analysis
Transmembranei787 – 80721HelicalSequence AnalysisAdd
BLAST
Topological domaini808 – 84033CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 840821Taste receptor type 1 member 1PRO_0000012956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z0R8.
PRIDEiQ9Z0R8.

PTM databases

PhosphoSiteiQ9Z0R8.

Expressioni

Tissue specificityi

Expressed in many cells in the fungiform and geschmackstreifen taste buds.1 Publication

Gene expression databases

GenevestigatoriQ9Z0R8.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013385.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248202.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R8.
KOiK04624.
OMAiQLVFIFK.
OrthoDBiEOG722J7V.
PhylomeDBiQ9Z0R8.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWAAHLLL SLQLVYCWAF SCQRTESSPG FSLPGDFLLA GLFSLHGDCL
60 70 80 90 100
QVRHRPLVTS CDRPDSFNGH GYHLFQAMRF TVEEINNSSA LLPNITLGYE
110 120 130 140 150
LYDVCSESAN VYATLRVLAL QGPRHIEIQK DLRNHSSKVV AFIGPDNTDH
160 170 180 190 200
AVTTAALLGP FLMPLVSYEA SSVVLSAKRK FPSFLRTVPS DRHQVEVMVQ
210 220 230 240 250
LLQSFGWVWI SLIGSYGDYG QLGVQALEEL AVPRGICVAF KDIVPFSARV
260 270 280 290 300
GDPRMQSMMQ HLAQARTTVV VVFSNRHLAR VFFRSVVLAN LTGKVWVASE
310 320 330 340 350
DWAISTYITS VTGIQGIGTV LGVAVQQRQV PGLKEFEESY VRAVTAAPSA
360 370 380 390 400
CPEGSWCSTN QLCRECHTFT TRNMPTLGAF SMSAAYRVYE AVYAVAHGLH
410 420 430 440 450
QLLGCTSEIC SRGPVYPWQL LQQIYKVNFL LHENTVAFDD NGDTLGYYDI
460 470 480 490 500
IAWDWNGPEW TFEIIGSASL SPVHLDINKT KIQWHGKNNQ VPVSVCTTDC
510 520 530 540 550
LAGHHRVVVG SHHCCFECVP CEAGTFLNMS ELHICQPCGT EEWAPKESTT
560 570 580 590 600
CFPRTVEFLA WHEPISLVLI AANTLLLLLL VGTAGLFAWH FHTPVVRSAG
610 620 630 640 650
GRLCFLMLGS LVAGSCSFYS FFGEPTVPAC LLRQPLFSLG FAIFLSCLTI
660 670 680 690 700
RSFQLVIIFK FSTKVPTFYR TWAQNHGAGL FVIVSSTVHL LICLTWLVMW
710 720 730 740 750
TPRPTREYQR FPHLVILECT EVNSVGFLLA FTHNILLSIS TFVCSYLGKE
760 770 780 790 800
LPENYNEAKC VTFSLLLNFV SWIAFFTMAS IYQGSYLPAV NVLAGLTTLS
810 820 830 840
GGFSGYFLPK CYVILCRPEL NNTEHFQASI QDYTRRCGTT
Length:840
Mass (Da):93,497
Last modified:May 1, 1999 - v1
Checksum:i1FCFB7EFC6BB45DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127389 mRNA. Translation: AAD18069.1.
RefSeqiNP_445757.1. NM_053305.1.
UniGeneiRn.92309.

Genome annotation databases

EnsembliENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
GeneIDi29407.
KEGGirno:29407.
UCSCiRGD:61891. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127389 mRNA. Translation: AAD18069.1.
RefSeqiNP_445757.1. NM_053305.1.
UniGeneiRn.92309.

3D structure databases

ProteinModelPortaliQ9Z0R8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013385.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z0R8.

Proteomic databases

PaxDbiQ9Z0R8.
PRIDEiQ9Z0R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
GeneIDi29407.
KEGGirno:29407.
UCSCiRGD:61891. rat.

Organism-specific databases

CTDi80835.
RGDi61891. Tas1r1.

Phylogenomic databases

eggNOGiNOG248202.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R8.
KOiK04624.
OMAiQLVFIFK.
OrthoDBiEOG722J7V.
PhylomeDBiQ9Z0R8.

Enzyme and pathway databases

ReactomeiREACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi609056.
PROiQ9Z0R8.

Gene expression databases

GenevestigatoriQ9Z0R8.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity."
    Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.
    Cell 96:541-551(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiTS1R1_RAT
AccessioniPrimary (citable) accession number: Q9Z0R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.