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Protein

Taste receptor type 1 member 1

Gene

Tas1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 1
Alternative name(s):
G-protein coupled receptor 70
Gene namesi
Name:Tas1r1
Synonyms:Gpr70, T1r1, Tr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61891. Tas1r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 566ExtracellularSequence analysisAdd BLAST547
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21
Topological domaini588 – 602CytoplasmicSequence analysisAdd BLAST15
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Topological domaini624 – 638ExtracellularSequence analysisAdd BLAST15
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 679CytoplasmicSequence analysisAdd BLAST20
Transmembranei680 – 700HelicalSequence analysisAdd BLAST21
Topological domaini701 – 724ExtracellularSequence analysisAdd BLAST24
Transmembranei725 – 745HelicalSequence analysisAdd BLAST21
Topological domaini746 – 760CytoplasmicSequence analysisAdd BLAST15
Transmembranei761 – 781HelicalSequence analysisAdd BLAST21
Topological domaini782 – 786ExtracellularSequence analysis5
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 840CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001295620 – 840Taste receptor type 1 member 1Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z0R8.

PTM databases

PhosphoSitePlusiQ9Z0R8.

Expressioni

Tissue specificityi

Expressed in many cells in the fungiform and geschmackstreifen taste buds.1 Publication

Gene expression databases

BgeeiENSRNOG00000009708.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013385.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R8.
KOiK04624.
OMAiREYQRFP.
OrthoDBiEOG091G02T4.
PhylomeDBiQ9Z0R8.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWAAHLLL SLQLVYCWAF SCQRTESSPG FSLPGDFLLA GLFSLHGDCL
60 70 80 90 100
QVRHRPLVTS CDRPDSFNGH GYHLFQAMRF TVEEINNSSA LLPNITLGYE
110 120 130 140 150
LYDVCSESAN VYATLRVLAL QGPRHIEIQK DLRNHSSKVV AFIGPDNTDH
160 170 180 190 200
AVTTAALLGP FLMPLVSYEA SSVVLSAKRK FPSFLRTVPS DRHQVEVMVQ
210 220 230 240 250
LLQSFGWVWI SLIGSYGDYG QLGVQALEEL AVPRGICVAF KDIVPFSARV
260 270 280 290 300
GDPRMQSMMQ HLAQARTTVV VVFSNRHLAR VFFRSVVLAN LTGKVWVASE
310 320 330 340 350
DWAISTYITS VTGIQGIGTV LGVAVQQRQV PGLKEFEESY VRAVTAAPSA
360 370 380 390 400
CPEGSWCSTN QLCRECHTFT TRNMPTLGAF SMSAAYRVYE AVYAVAHGLH
410 420 430 440 450
QLLGCTSEIC SRGPVYPWQL LQQIYKVNFL LHENTVAFDD NGDTLGYYDI
460 470 480 490 500
IAWDWNGPEW TFEIIGSASL SPVHLDINKT KIQWHGKNNQ VPVSVCTTDC
510 520 530 540 550
LAGHHRVVVG SHHCCFECVP CEAGTFLNMS ELHICQPCGT EEWAPKESTT
560 570 580 590 600
CFPRTVEFLA WHEPISLVLI AANTLLLLLL VGTAGLFAWH FHTPVVRSAG
610 620 630 640 650
GRLCFLMLGS LVAGSCSFYS FFGEPTVPAC LLRQPLFSLG FAIFLSCLTI
660 670 680 690 700
RSFQLVIIFK FSTKVPTFYR TWAQNHGAGL FVIVSSTVHL LICLTWLVMW
710 720 730 740 750
TPRPTREYQR FPHLVILECT EVNSVGFLLA FTHNILLSIS TFVCSYLGKE
760 770 780 790 800
LPENYNEAKC VTFSLLLNFV SWIAFFTMAS IYQGSYLPAV NVLAGLTTLS
810 820 830 840
GGFSGYFLPK CYVILCRPEL NNTEHFQASI QDYTRRCGTT
Length:840
Mass (Da):93,497
Last modified:May 1, 1999 - v1
Checksum:i1FCFB7EFC6BB45DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127389 mRNA. Translation: AAD18069.1.
RefSeqiNP_445757.1. NM_053305.1.
UniGeneiRn.92309.

Genome annotation databases

EnsembliENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
GeneIDi29407.
KEGGirno:29407.
UCSCiRGD:61891. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127389 mRNA. Translation: AAD18069.1.
RefSeqiNP_445757.1. NM_053305.1.
UniGeneiRn.92309.

3D structure databases

ProteinModelPortaliQ9Z0R8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013385.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9Z0R8.

Proteomic databases

PaxDbiQ9Z0R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
GeneIDi29407.
KEGGirno:29407.
UCSCiRGD:61891. rat.

Organism-specific databases

CTDi80835.
RGDi61891. Tas1r1.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R8.
KOiK04624.
OMAiREYQRFP.
OrthoDBiEOG091G02T4.
PhylomeDBiQ9Z0R8.

Enzyme and pathway databases

ReactomeiR-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

PROiQ9Z0R8.

Gene expression databases

BgeeiENSRNOG00000009708.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTS1R1_RAT
AccessioniPrimary (citable) accession number: Q9Z0R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.