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Q9Z0R8 (TS1R1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 1 member 1
Alternative name(s):
G-protein coupled receptor 70
Gene names
Name:Tas1r1
Synonyms:Gpr70, T1r1, Tr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length840 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Subunit structure

Forms heterodimers with TAS1R3.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in many cells in the fungiform and geschmackstreifen taste buds. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of umami taste

Inferred from direct assay PubMed 11917125. Source: UniProtKB

   Cellular_componentintegral to membrane

Inferred by curator PubMed 11917125. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontaste receptor activity

Inferred from direct assay PubMed 11917125. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 840821Taste receptor type 1 member 1
PRO_0000012956

Regions

Topological domain20 – 566547Extracellular Potential
Transmembrane567 – 58721Helical; Potential
Topological domain588 – 60215Cytoplasmic Potential
Transmembrane603 – 62321Helical; Potential
Topological domain624 – 63815Extracellular Potential
Transmembrane639 – 65921Helical; Potential
Topological domain660 – 67920Cytoplasmic Potential
Transmembrane680 – 70021Helical; Potential
Topological domain701 – 72424Extracellular Potential
Transmembrane725 – 74521Helical; Potential
Topological domain746 – 76015Cytoplasmic Potential
Transmembrane761 – 78121Helical; Potential
Topological domain782 – 7865Extracellular Potential
Transmembrane787 – 80721Helical; Potential
Topological domain808 – 84033Cytoplasmic Potential

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Z0R8 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1FCFB7EFC6BB45DB

FASTA84093,497
        10         20         30         40         50         60 
MLFWAAHLLL SLQLVYCWAF SCQRTESSPG FSLPGDFLLA GLFSLHGDCL QVRHRPLVTS 

        70         80         90        100        110        120 
CDRPDSFNGH GYHLFQAMRF TVEEINNSSA LLPNITLGYE LYDVCSESAN VYATLRVLAL 

       130        140        150        160        170        180 
QGPRHIEIQK DLRNHSSKVV AFIGPDNTDH AVTTAALLGP FLMPLVSYEA SSVVLSAKRK 

       190        200        210        220        230        240 
FPSFLRTVPS DRHQVEVMVQ LLQSFGWVWI SLIGSYGDYG QLGVQALEEL AVPRGICVAF 

       250        260        270        280        290        300 
KDIVPFSARV GDPRMQSMMQ HLAQARTTVV VVFSNRHLAR VFFRSVVLAN LTGKVWVASE 

       310        320        330        340        350        360 
DWAISTYITS VTGIQGIGTV LGVAVQQRQV PGLKEFEESY VRAVTAAPSA CPEGSWCSTN 

       370        380        390        400        410        420 
QLCRECHTFT TRNMPTLGAF SMSAAYRVYE AVYAVAHGLH QLLGCTSEIC SRGPVYPWQL 

       430        440        450        460        470        480 
LQQIYKVNFL LHENTVAFDD NGDTLGYYDI IAWDWNGPEW TFEIIGSASL SPVHLDINKT 

       490        500        510        520        530        540 
KIQWHGKNNQ VPVSVCTTDC LAGHHRVVVG SHHCCFECVP CEAGTFLNMS ELHICQPCGT 

       550        560        570        580        590        600 
EEWAPKESTT CFPRTVEFLA WHEPISLVLI AANTLLLLLL VGTAGLFAWH FHTPVVRSAG 

       610        620        630        640        650        660 
GRLCFLMLGS LVAGSCSFYS FFGEPTVPAC LLRQPLFSLG FAIFLSCLTI RSFQLVIIFK 

       670        680        690        700        710        720 
FSTKVPTFYR TWAQNHGAGL FVIVSSTVHL LICLTWLVMW TPRPTREYQR FPHLVILECT 

       730        740        750        760        770        780 
EVNSVGFLLA FTHNILLSIS TFVCSYLGKE LPENYNEAKC VTFSLLLNFV SWIAFFTMAS 

       790        800        810        820        830        840 
IYQGSYLPAV NVLAGLTTLS GGFSGYFLPK CYVILCRPEL NNTEHFQASI QDYTRRCGTT

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References

[1]"Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity."
Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.
Cell 96:541-551(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Circumvallate papilla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF127389 mRNA. Translation: AAD18069.1.
IPIIPI00326776.
RefSeqNP_445757.1. NM_053305.1.
UniGeneRn.92309.

3D structure databases

ProteinModelPortalQ9Z0R8.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013385.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Z0R8.

Proteomic databases

PaxDbQ9Z0R8.
PRIDEQ9Z0R8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
GeneID29407.
KEGGrno:29407.
UCSCRGD:61891. rat.

Organism-specific databases

CTD80835.
RGD61891. Tas1r1.

Phylogenomic databases

eggNOGNOG248202.
GeneTreeENSGT00690000101951.
HOGENOMHOG000038047.
HOVERGENHBG108601.
InParanoidQ9Z0R8.
KOK04624.
OrthoDBEOG4NKBTW.

Gene expression databases

GenevestigatorQ9Z0R8.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609056.

Entry information

Entry nameTS1R1_RAT
AccessionPrimary (citable) accession number: Q9Z0R8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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