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Protein

Taste receptor type 1 member 2

Gene

Tas1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of taste Source: GOC
  • sensory perception of sweet taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-70688. Proline catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:Tas1r2
Synonyms:Gpr71, T1r2, Tr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61894. Tas1r2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 570551ExtracellularSequence analysisAdd
BLAST
Transmembranei571 – 59121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini592 – 60615CytoplasmicSequence analysisAdd
BLAST
Transmembranei607 – 62721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini628 – 64215ExtracellularSequence analysisAdd
BLAST
Transmembranei643 – 66321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini664 – 68219CytoplasmicSequence analysisAdd
BLAST
Transmembranei683 – 70321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini704 – 73128ExtracellularSequence analysisAdd
BLAST
Transmembranei732 – 75221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini753 – 76412CytoplasmicSequence analysisAdd
BLAST
Transmembranei765 – 78521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini786 – 7894ExtracellularSequence analysis
Transmembranei790 – 81021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini811 – 84333CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 843824Taste receptor type 1 member 2PRO_0000012959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0R7.

PTM databases

PhosphoSiteiQ9Z0R7.
SwissPalmiQ9Z0R7.

Expressioni

Tissue specificityi

Abundantly expressed in circumvallate and foliate papillae.1 Publication

Gene expression databases

ExpressionAtlasiQ9Z0R7. differential.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00560000077335.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R7.
KOiK04625.
OMAiCSEECDA.
OrthoDBiEOG7T1R9D.
PhylomeDBiQ9Z0R7.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQARTLCL LSLLLHVLPK PGKLVENSDF HLAGDYLLGG LFTLHANVKS
60 70 80 90 100
ISHLSYLQVP KCNEFTMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE
110 120 130 140 150
MVDVCYLSNN IHPGLYFLAQ DDDLLPILKD YSQYMPHVVA VIGPDNSESA
160 170 180 190 200
ITVSNILSHF LIPQITYSAI SDKLRDKRHF PSMLRTVPSA THHIEAMVQL
210 220 230 240 250
MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TKTSDICIAF QEVLPIPESS
260 270 280 290 300
QVMRSEEQRQ LDNILDKLRR TSARVVVVFS PELSLYSFFH EVLRWNFTGF
310 320 330 340 350
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRRDKPG
360 370 380 390 400
YPVPNTTNLR TTCNQDCDAC LNTTKSFNNI LILSGERVVY SVYSAVYAVA
410 420 430 440 450
HALHRLLGCN RVRCTKQKVY PWQLLREIWH VNFTLLGNRL FFDQQGDMPM
460 470 480 490 500
LLDIIQWQWD LSQNPFQSIA SYSPTSKRLT YINNVSWYTP NNTVPVSMCS
510 520 530 540 550
KSCQPGQMKK SVGLHPCCFE CLDCMPGTYL NRSADEFNCL SCPGSMWSYK
560 570 580 590 600
NDITCFQRRP TFLEWHEVPT IVVAILAALG FFSTLAILFI FWRHFQTPMV
610 620 630 640 650
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSICLS
660 670 680 690 700
CITVRSFQIV CVFKMARRLP SAYSFWMRYH GPYVFVAFIT AIKVALVVGN
710 720 730 740 750
MLATTINPIG RTDPDDPNIM ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA
760 770 780 790 800
YMGKELPTNY NEAKFITLSM TFSFTSSISL CTFMSVHDGV LVTIMDLLVT
810 820 830 840
VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM RKS
Length:843
Mass (Da):95,800
Last modified:May 1, 1999 - v1
Checksum:iD23AC22D21E049B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127390 mRNA. Translation: AAD18070.1.
RefSeqiNP_001258195.1. NM_001271266.1.
UniGeneiRn.222086.

Genome annotation databases

EnsembliENSRNOT00000077863; ENSRNOP00000072481; ENSRNOG00000061876.
GeneIDi100270683.
KEGGirno:100270683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127390 mRNA. Translation: AAD18070.1.
RefSeqiNP_001258195.1. NM_001271266.1.
UniGeneiRn.222086.

3D structure databases

ProteinModelPortaliQ9Z0R7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z0R7.
SwissPalmiQ9Z0R7.

Proteomic databases

PRIDEiQ9Z0R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077863; ENSRNOP00000072481; ENSRNOG00000061876.
GeneIDi100270683.
KEGGirno:100270683.

Organism-specific databases

CTDi80834.
RGDi61894. Tas1r2.

Phylogenomic databases

GeneTreeiENSGT00560000077335.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R7.
KOiK04625.
OMAiCSEECDA.
OrthoDBiEOG7T1R9D.
PhylomeDBiQ9Z0R7.

Enzyme and pathway databases

ReactomeiR-RNO-70688. Proline catabolism.

Miscellaneous databases

NextBioi20795849.
PROiQ9Z0R7.

Gene expression databases

ExpressionAtlasiQ9Z0R7. differential.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity."
    Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.
    Cell 96:541-551(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiTS1R2_RAT
AccessioniPrimary (citable) accession number: Q9Z0R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.