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Protein

Taste receptor type 1 member 2

Gene

Tas1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-389661. Glyoxylate metabolism and glycine degradation.
R-RNO-70688. Proline catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 2
Alternative name(s):
G-protein coupled receptor 71
Sweet taste receptor T1R2
Gene namesi
Name:Tas1r2
Synonyms:Gpr71, T1r2, Tr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61894. Tas1r2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 570ExtracellularSequence analysisAdd BLAST551
Transmembranei571 – 591Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini592 – 606CytoplasmicSequence analysisAdd BLAST15
Transmembranei607 – 627Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini628 – 642ExtracellularSequence analysisAdd BLAST15
Transmembranei643 – 663Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini664 – 682CytoplasmicSequence analysisAdd BLAST19
Transmembranei683 – 703Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini704 – 731ExtracellularSequence analysisAdd BLAST28
Transmembranei732 – 752Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini753 – 764CytoplasmicSequence analysisAdd BLAST12
Transmembranei765 – 785Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini786 – 789ExtracellularSequence analysis4
Transmembranei790 – 810Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini811 – 843CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001295920 – 843Taste receptor type 1 member 2Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z0R7.

PTM databases

PhosphoSitePlusiQ9Z0R7.
SwissPalmiQ9Z0R7.

Expressioni

Tissue specificityi

Abundantly expressed in circumvallate and foliate papillae.1 Publication

Gene expression databases

BgeeiENSRNOG00000061876.
ExpressionAtlasiQ9Z0R7. differential.

Interactioni

Subunit structurei

Forms heterodimers with TAS1R3.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0R7.
SMRiQ9Z0R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00560000077335.
HOGENOMiHOG000038047.
HOVERGENiHBG108601.
InParanoidiQ9Z0R7.
KOiK04625.
OMAiFITLSMT.
PhylomeDBiQ9Z0R7.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQARTLCL LSLLLHVLPK PGKLVENSDF HLAGDYLLGG LFTLHANVKS
60 70 80 90 100
ISHLSYLQVP KCNEFTMKVL GYNLMQAMRF AVEEINNCSS LLPGVLLGYE
110 120 130 140 150
MVDVCYLSNN IHPGLYFLAQ DDDLLPILKD YSQYMPHVVA VIGPDNSESA
160 170 180 190 200
ITVSNILSHF LIPQITYSAI SDKLRDKRHF PSMLRTVPSA THHIEAMVQL
210 220 230 240 250
MVHFQWNWIV VLVSDDDYGR ENSHLLSQRL TKTSDICIAF QEVLPIPESS
260 270 280 290 300
QVMRSEEQRQ LDNILDKLRR TSARVVVVFS PELSLYSFFH EVLRWNFTGF
310 320 330 340 350
VWIASESWAI DPVLHNLTEL RHTGTFLGVT IQRVSIPGFS QFRVRRDKPG
360 370 380 390 400
YPVPNTTNLR TTCNQDCDAC LNTTKSFNNI LILSGERVVY SVYSAVYAVA
410 420 430 440 450
HALHRLLGCN RVRCTKQKVY PWQLLREIWH VNFTLLGNRL FFDQQGDMPM
460 470 480 490 500
LLDIIQWQWD LSQNPFQSIA SYSPTSKRLT YINNVSWYTP NNTVPVSMCS
510 520 530 540 550
KSCQPGQMKK SVGLHPCCFE CLDCMPGTYL NRSADEFNCL SCPGSMWSYK
560 570 580 590 600
NDITCFQRRP TFLEWHEVPT IVVAILAALG FFSTLAILFI FWRHFQTPMV
610 620 630 640 650
RSAGGPMCFL MLVPLLLAFG MVPVYVGPPT VFSCFCRQAF FTVCFSICLS
660 670 680 690 700
CITVRSFQIV CVFKMARRLP SAYSFWMRYH GPYVFVAFIT AIKVALVVGN
710 720 730 740 750
MLATTINPIG RTDPDDPNIM ILSCHPNYRN GLLFNTSMDL LLSVLGFSFA
760 770 780 790 800
YMGKELPTNY NEAKFITLSM TFSFTSSISL CTFMSVHDGV LVTIMDLLVT
810 820 830 840
VLNFLAIGLG YFGPKCYMIL FYPERNTSAY FNSMIQGYTM RKS
Length:843
Mass (Da):95,800
Last modified:May 1, 1999 - v1
Checksum:iD23AC22D21E049B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127390 mRNA. Translation: AAD18070.1.
RefSeqiNP_001258195.1. NM_001271266.1.
UniGeneiRn.222086.

Genome annotation databases

EnsembliENSRNOT00000077863; ENSRNOP00000072481; ENSRNOG00000061876.
GeneIDi100270683.
KEGGirno:100270683.

Similar proteinsi

Entry informationi

Entry nameiTS1R2_RAT
AccessioniPrimary (citable) accession number: Q9Z0R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families