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Q9Z0R4

- ITSN1_MOUSE

UniProt

Q9Z0R4 - ITSN1_MOUSE

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Protein

Intersectin-1

Gene

Itsn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1. Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi66 – 78131PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi267 – 279132PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. kinase activator activity Source: MGI
  3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. negative regulation of neuron apoptotic process Source: MGI
  3. positive regulation of phosphorylation Source: GOC
  4. positive regulation of protein kinase B signaling Source: MGI
  5. small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-1
Alternative name(s):
EH and SH3 domains protein 1
Gene namesi
Name:Itsn1
Synonyms:Ese1, Itsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1338069. Itsn1.

Subcellular locationi

Endomembrane system By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionlamellipodium By similarity. Membraneclathrin-coated pit By similarity
Note: Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. coated pit Source: UniProtKB-KW
  3. endocytic vesicle Source: MGI
  4. lamellipodium Source: MGI
  5. neuron projection Source: UniProtKB-KW
  6. plasma membrane Source: Ensembl
  7. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Coated pit, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17141714Intersectin-1PRO_0000080958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei335 – 3351Phosphoserine1 Publication
Modified residuei895 – 8951Phosphoserine1 Publication
Modified residuei897 – 8971Phosphoserine1 Publication
Modified residuei977 – 9771Phosphothreonine1 Publication
Modified residuei1130 – 11301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z0R4.
PaxDbiQ9Z0R4.
PRIDEiQ9Z0R4.

PTM databases

PhosphoSiteiQ9Z0R4.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in brain, heart and skeletal muscle.

Gene expression databases

CleanExiMM_ITSN1.
ExpressionAtlasiQ9Z0R4. baseline and differential.
GenevestigatoriQ9Z0R4.

Interactioni

Subunit structurei

Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2. Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgap31A6X8Z53EBI-645386,EBI-4325995
Dennd1aQ8K3823EBI-645386,EBI-7186684
Inppl1Q6P5492EBI-8052786,EBI-2642932

Protein-protein interaction databases

BioGridi200851. 10 interactions.
IntActiQ9Z0R4. 11 interactions.
MINTiMINT-86500.
STRINGi10090.ENSMUSP00000066361.

Structurei

Secondary structure

1
1714
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1151 – 11577
Beta strandi1174 – 11796
Beta strandi1185 – 11906
Beta strandi1193 – 11986
Helixi1199 – 12013
Beta strandi1202 – 12043
Helixi1205 – 12073
Helixi1210 – 12145
Helixi1221 – 12233
Helixi1226 – 125530
Helixi1258 – 12614
Helixi1268 – 12758
Helixi1278 – 129922
Helixi1309 – 13157
Helixi1316 – 13205
Helixi1321 – 134222
Helixi1344 – 135310
Helixi1357 – 13593
Helixi1364 – 13674
Helixi1370 – 138617
Helixi1396 – 142227
Helixi1423 – 14253

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HS8X-ray1.90P840-851[»]
3JV3X-ray2.40A/B1151-1431[»]
ProteinModelPortaliQ9Z0R4.
SMRiQ9Z0R4. Positions 1-111, 210-312, 909-962, 998-1053, 1063-1574, 1588-1711.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z0R4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10989EH 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 31090EH 2PROSITE-ProRule annotationAdd
BLAST
Domaini254 – 28936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini738 – 79962SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini906 – 96459SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini995 – 105359SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini1067 – 113165SH3 4PROSITE-ProRule annotationAdd
BLAST
Domaini1148 – 120760SH3 5PROSITE-ProRule annotationAdd
BLAST
Domaini1230 – 1416187DHPROSITE-ProRule annotationAdd
BLAST
Domaini1455 – 1564110PHPROSITE-ProRule annotationAdd
BLAST
Domaini1576 – 167297C2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni326 – 702377KLERQAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili352 – 662311Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi321 – 3244Poly-Ser

Domaini

SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.By similarity
The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.1 Publication

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000010175.
HOVERGENiHBG052159.
InParanoidiQ9Z0R4.
TreeFamiTF324293.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 4 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Z0R4-1) [UniParc]FASTAAdd to Basket

Also known as: Ese1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDVWAITVE ERAKHDQQFL SLKPIAGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSTLPP
110 120 130 140 150
VMKQQPVAIS SAPAFGIGGI ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV
160 170 180 190 200
PPAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
210 220 230 240 250
AQSFDVASAP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
260 270 280 290 300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350
PEYIPPSFRR VRSGSGMSVI SSSSVDQRLP EEPSSEDEQQ PEKKLPVTFE
360 370 380 390 400
DKKRENFERG SVELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ
410 420 430 440 450
ERKRQLELEK QLEKQRELER QREEERRKEI ERREAAKREL ERQRQLEWER
460 470 480 490 500
NRRQELLNQR NKEQEGTVVL KARRKTLEFE LEALNDKKHQ LEGKLQDIRC
510 520 530 540 550
RLATQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL IPEKQILSDQ
560 570 580 590 600
LKQVQQNSLH RDSLLTLKRA LEAKELARQQ LREQLDEVER ETRSKLQEID
610 620 630 640 650
VFNNQLKELR EIHSKQQLQK QRSLEAARLK QKEQERKSLE LEKQKEDAQR
660 670 680 690 700
RVQERDKQWL EHVQQEEQPR PRKPHEEDRL KREDSVRKKE AEERAKPEMQ
710 720 730 740 750
DKQSRLFHPH QEPAKLATQA PWSTTEKGPL TISAQESVKV VYYRALYPFE
760 770 780 790 800
SRSHDEITIQ PGDIVMVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN
810 820 830 840 850
EVPTPAKPVT DLTSAPAPKL ALRETPAPLP VTSSEPSTTP NNWADFSSTW
860 870 880 890 900
PSSSNEKPET DNWDTWAAQP SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL
910 920 930 940 950
GQGEKVEGLQ AQALYPWRAK KDNHLNFNKS DVITVLEQQD MWWFGEVQGQ
960 970 980 990 1000
KGWFPKSYVK LISGPVRKST SIDTGPTESP ASLKRVASPA AKPAIPGEEF
1010 1020 1030 1040 1050
IAMYTYESSE QGDLTFQQGD VIVVTKKDGD WWTGTVGDKS GVFPSNYVRL
1060 1070 1080 1090 1100
KDSEGSGTAG KTGSLGKKPE IAQVIASYAA TGPEQLTLAP GQLILIRKKN
1110 1120 1130 1140 1150
PGGWWEGELQ ARGKKRQIGW FPANYVKLLS PGTSKITPTE LPKTAVQPAV
1160 1170 1180 1190 1200
CQVIGMYDYT AQNDDELAFS KGQIINVLNK EDPDWWKGEV SGQVGLFPSN
1210 1220 1230 1240 1250
YVKLTTDMDP SQQWCSDLHL LDMLTPTERK RQGYIHELIV TEENYVNDLQ
1260 1270 1280 1290 1300
LVTEIFQKPL TESELLTEKE VAMIFVNWKE LIMCNIKLLK ALRVRKKMSG
1310 1320 1330 1340 1350
EKMPVKMIGD ILSAQLPHMQ PYIRFCSCQL NGAALIQQKT DEAPDFKEFV
1360 1370 1380 1390 1400
KRLAMDPRCK GMPLSSFILK PMQRVTRYPL IIKNILENTP ENHPDHSHLK
1410 1420 1430 1440 1450
HALEKAEELC SQVNEGVREK ENSDRLEWIQ AHVQCEGLSE QLVFNSVTNC
1460 1470 1480 1490 1500
LGPRKFLHSG KLYKAKSNKE LYGFLFNDFL LLTQITKPLG SSGTDKVFSP
1510 1520 1530 1540 1550
KSNLQYKMYK TPIFLNEVLV KLPTDPSGDE PIFHISHIDR VYTLRAESIN
1560 1570 1580 1590 1600
ERTAWVQKIK AASELYIETE KKKREKAYLV RSQRATGIGR LMVNVVEGIE
1610 1620 1630 1640 1650
LKPCRSHGKS NPYCEVTMGS QCHITKTIQD TLNPKWNSNC QFFIRDLEQE
1660 1670 1680 1690 1700
VLCITVFERD QFSPDDFLGR TEIRVADIKK DQGSKGPVTK CLLLHEVPTG
1710
EIVVRLDLQL FDEP
Length:1,714
Mass (Da):194,297
Last modified:October 3, 2012 - v2
Checksum:iBCF5038160E8208E
GO
Isoform 2 (identifier: Q9Z0R4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1714: Missing.

Show »
Length:1,213
Mass (Da):136,607
Checksum:i1376AD0DFBD503C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791L → W in AAD19749. (PubMed:10064583)Curated
Sequence conflicti179 – 1791L → W in AAD19746. (PubMed:10064583)Curated
Sequence conflicti402 – 4021R → A in AAD19749. (PubMed:10064583)Curated
Sequence conflicti402 – 4021R → A in AAD19746. (PubMed:10064583)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1214 – 1714501Missing in isoform 2. 1 PublicationVSP_004296Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132481 mRNA. Translation: AAD19749.1.
AF132478 mRNA. Translation: AAD19746.1.
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
AF169621 mRNA. Translation: AAD48848.1.
AF356517 Genomic DNA. Translation: AAK40228.1.
CCDSiCCDS37402.1. [Q9Z0R4-1]
CCDS49913.1. [Q9Z0R4-2]
RefSeqiNP_001103745.1. NM_001110275.1. [Q9Z0R4-2]
NP_034717.2. NM_010587.2. [Q9Z0R4-1]
UniGeneiMm.40546.

Genome annotation databases

EnsembliENSMUST00000056482; ENSMUSP00000056011; ENSMUSG00000022957. [Q9Z0R4-2]
ENSMUST00000114002; ENSMUSP00000109635; ENSMUSG00000022957. [Q9Z0R4-1]
GeneIDi16443.
KEGGimmu:16443.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132481 mRNA. Translation: AAD19749.1 .
AF132478 mRNA. Translation: AAD19746.1 .
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
AF169621 mRNA. Translation: AAD48848.1 .
AF356517 Genomic DNA. Translation: AAK40228.1 .
CCDSi CCDS37402.1. [Q9Z0R4-1 ]
CCDS49913.1. [Q9Z0R4-2 ]
RefSeqi NP_001103745.1. NM_001110275.1. [Q9Z0R4-2 ]
NP_034717.2. NM_010587.2. [Q9Z0R4-1 ]
UniGenei Mm.40546.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HS8 X-ray 1.90 P 840-851 [» ]
3JV3 X-ray 2.40 A/B 1151-1431 [» ]
ProteinModelPortali Q9Z0R4.
SMRi Q9Z0R4. Positions 1-111, 210-312, 909-962, 998-1053, 1063-1574, 1588-1711.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200851. 10 interactions.
IntActi Q9Z0R4. 11 interactions.
MINTi MINT-86500.
STRINGi 10090.ENSMUSP00000066361.

PTM databases

PhosphoSitei Q9Z0R4.

Proteomic databases

MaxQBi Q9Z0R4.
PaxDbi Q9Z0R4.
PRIDEi Q9Z0R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056482 ; ENSMUSP00000056011 ; ENSMUSG00000022957 . [Q9Z0R4-2 ]
ENSMUST00000114002 ; ENSMUSP00000109635 ; ENSMUSG00000022957 . [Q9Z0R4-1 ]
GeneIDi 16443.
KEGGi mmu:16443.

Organism-specific databases

CTDi 6453.
MGIi MGI:1338069. Itsn1.

Phylogenomic databases

eggNOGi COG5422.
GeneTreei ENSGT00760000118985.
HOGENOMi HOG000010175.
HOVERGENi HBG052159.
InParanoidi Q9Z0R4.
TreeFami TF324293.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ITSN1. mouse.
EvolutionaryTracei Q9Z0R4.
NextBioi 289695.
PROi Q9Z0R4.
SOURCEi Search...

Gene expression databases

CleanExi MM_ITSN1.
ExpressionAtlasi Q9Z0R4. baseline and differential.
Genevestigatori Q9Z0R4.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 4 hits.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
PROSITEi PS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15."
    Sengar A.S., Wang W., Bishay J., Cohen S., Egan S.E.
    EMBO J. 18:1159-1171(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mouse homologues of human chromosome 21 genes."
    Skripkina I.Y., Tsyba L.O., Anoprienko O.V., Slavov D., Tassone F., Rynditch A.V., Gardiner K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 966-1714, NUCLEOTIDE SEQUENCE [MRNA] OF 545-599 (ISOFORMS 1 AND 2).
    Strain: 129/Ola.
    Tissue: Spleen.
  4. "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."
    Jenna S., Hussain N.K., Danek E.I., Triki I., Wasiak S., McPherson P.S., Lamarche-Vane N.
    J. Biol. Chem. 277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGAP31.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-895; SER-897 AND THR-977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "FCHo proteins are nucleators of clathrin-mediated endocytosis."
    Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T.
    Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FCHO2.
  11. "The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin."
    Ahmad K.F., Lim W.A.
    PLoS ONE 5:E11291-E11291(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1151-1431, SH3 DOMAIN, FUNCTION.

Entry informationi

Entry nameiITSN1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0R4
Secondary accession number(s): F8VQE5, Q9R143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3