Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z0R4

- ITSN1_MOUSE

UniProt

Q9Z0R4 - ITSN1_MOUSE

Protein

Intersectin-1

Gene

Itsn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1. Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi66 – 78131PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi267 – 279132PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. kinase activator activity Source: MGI
    3. protein binding Source: IntAct
    4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. negative regulation of neuron apoptotic process Source: MGI
    3. positive regulation of phosphorylation Source: GOC
    4. positive regulation of protein kinase B signaling Source: MGI
    5. small GTPase mediated signal transduction Source: MGI

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intersectin-1
    Alternative name(s):
    EH and SH3 domains protein 1
    Gene namesi
    Name:Itsn1
    Synonyms:Ese1, Itsn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1338069. Itsn1.

    Subcellular locationi

    Endomembrane system By similarity. Cell junctionsynapsesynaptosome By similarity. Cell projectionlamellipodium By similarity. Membraneclathrin-coated pit By similarity
    Note: Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. coated pit Source: UniProtKB-SubCell
    3. endocytic vesicle Source: MGI
    4. lamellipodium Source: MGI
    5. neuron projection Source: UniProtKB-SubCell
    6. plasma membrane Source: Ensembl
    7. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell projection, Coated pit, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17141714Intersectin-1PRO_0000080958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei203 – 2031Phosphoserine1 Publication
    Modified residuei334 – 3341Phosphoserine1 Publication
    Modified residuei335 – 3351Phosphoserine1 Publication
    Modified residuei895 – 8951Phosphoserine1 Publication
    Modified residuei897 – 8971Phosphoserine1 Publication
    Modified residuei977 – 9771Phosphothreonine1 Publication
    Modified residuei1130 – 11301Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z0R4.
    PaxDbiQ9Z0R4.
    PRIDEiQ9Z0R4.

    PTM databases

    PhosphoSiteiQ9Z0R4.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high levels in brain, heart and skeletal muscle.

    Gene expression databases

    ArrayExpressiQ9Z0R4.
    CleanExiMM_ITSN1.
    GenevestigatoriQ9Z0R4.

    Interactioni

    Subunit structurei

    Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2. Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arhgap31A6X8Z53EBI-645386,EBI-4325995
    Dennd1aQ8K3823EBI-645386,EBI-7186684
    Inppl1Q6P5492EBI-8052786,EBI-2642932

    Protein-protein interaction databases

    BioGridi200851. 10 interactions.
    IntActiQ9Z0R4. 11 interactions.
    MINTiMINT-86500.
    STRINGi10090.ENSMUSP00000066361.

    Structurei

    Secondary structure

    1
    1714
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1151 – 11577
    Beta strandi1174 – 11796
    Beta strandi1185 – 11906
    Beta strandi1193 – 11986
    Helixi1199 – 12013
    Beta strandi1202 – 12043
    Helixi1205 – 12073
    Helixi1210 – 12145
    Helixi1221 – 12233
    Helixi1226 – 125530
    Helixi1258 – 12614
    Helixi1268 – 12758
    Helixi1278 – 129922
    Helixi1309 – 13157
    Helixi1316 – 13205
    Helixi1321 – 134222
    Helixi1344 – 135310
    Helixi1357 – 13593
    Helixi1364 – 13674
    Helixi1370 – 138617
    Helixi1396 – 142227
    Helixi1423 – 14253

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HS8X-ray1.90P840-851[»]
    3JV3X-ray2.40A/B1151-1431[»]
    ProteinModelPortaliQ9Z0R4.
    SMRiQ9Z0R4. Positions 1-111, 210-312, 909-962, 998-1053, 1063-1574, 1588-1711.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Z0R4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 10989EH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini53 – 8836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini221 – 31090EH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 28936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini738 – 79962SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini906 – 96459SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini995 – 105359SH3 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1067 – 113165SH3 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1148 – 120760SH3 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1230 – 1416187DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1455 – 1564110PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1576 – 167297C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni326 – 702377KLERQAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili352 – 662311Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi321 – 3244Poly-Ser

    Domaini

    SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin By similarity. SH3-1 and SH3-4 bind to ARHGAP31.By similarity
    The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
    In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.1 Publication

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 EH domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 5 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    GeneTreeiENSGT00750000117388.
    HOGENOMiHOG000010175.
    HOVERGENiHBG052159.
    TreeFamiTF324293.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 4 hits.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00027. EH. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 5 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 5 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50031. EH. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9Z0R4-1) [UniParc]FASTAAdd to Basket

    Also known as: Ese1L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFPTPFGG SLDVWAITVE ERAKHDQQFL SLKPIAGFIT GDQARNFFFQ     50
    SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSTLPP 100
    VMKQQPVAIS SAPAFGIGGI ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV 150
    PPAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK 200
    AQSFDVASAP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM 250
    QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 300
    PEYIPPSFRR VRSGSGMSVI SSSSVDQRLP EEPSSEDEQQ PEKKLPVTFE 350
    DKKRENFERG SVELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ 400
    ERKRQLELEK QLEKQRELER QREEERRKEI ERREAAKREL ERQRQLEWER 450
    NRRQELLNQR NKEQEGTVVL KARRKTLEFE LEALNDKKHQ LEGKLQDIRC 500
    RLATQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL IPEKQILSDQ 550
    LKQVQQNSLH RDSLLTLKRA LEAKELARQQ LREQLDEVER ETRSKLQEID 600
    VFNNQLKELR EIHSKQQLQK QRSLEAARLK QKEQERKSLE LEKQKEDAQR 650
    RVQERDKQWL EHVQQEEQPR PRKPHEEDRL KREDSVRKKE AEERAKPEMQ 700
    DKQSRLFHPH QEPAKLATQA PWSTTEKGPL TISAQESVKV VYYRALYPFE 750
    SRSHDEITIQ PGDIVMVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN 800
    EVPTPAKPVT DLTSAPAPKL ALRETPAPLP VTSSEPSTTP NNWADFSSTW 850
    PSSSNEKPET DNWDTWAAQP SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL 900
    GQGEKVEGLQ AQALYPWRAK KDNHLNFNKS DVITVLEQQD MWWFGEVQGQ 950
    KGWFPKSYVK LISGPVRKST SIDTGPTESP ASLKRVASPA AKPAIPGEEF 1000
    IAMYTYESSE QGDLTFQQGD VIVVTKKDGD WWTGTVGDKS GVFPSNYVRL 1050
    KDSEGSGTAG KTGSLGKKPE IAQVIASYAA TGPEQLTLAP GQLILIRKKN 1100
    PGGWWEGELQ ARGKKRQIGW FPANYVKLLS PGTSKITPTE LPKTAVQPAV 1150
    CQVIGMYDYT AQNDDELAFS KGQIINVLNK EDPDWWKGEV SGQVGLFPSN 1200
    YVKLTTDMDP SQQWCSDLHL LDMLTPTERK RQGYIHELIV TEENYVNDLQ 1250
    LVTEIFQKPL TESELLTEKE VAMIFVNWKE LIMCNIKLLK ALRVRKKMSG 1300
    EKMPVKMIGD ILSAQLPHMQ PYIRFCSCQL NGAALIQQKT DEAPDFKEFV 1350
    KRLAMDPRCK GMPLSSFILK PMQRVTRYPL IIKNILENTP ENHPDHSHLK 1400
    HALEKAEELC SQVNEGVREK ENSDRLEWIQ AHVQCEGLSE QLVFNSVTNC 1450
    LGPRKFLHSG KLYKAKSNKE LYGFLFNDFL LLTQITKPLG SSGTDKVFSP 1500
    KSNLQYKMYK TPIFLNEVLV KLPTDPSGDE PIFHISHIDR VYTLRAESIN 1550
    ERTAWVQKIK AASELYIETE KKKREKAYLV RSQRATGIGR LMVNVVEGIE 1600
    LKPCRSHGKS NPYCEVTMGS QCHITKTIQD TLNPKWNSNC QFFIRDLEQE 1650
    VLCITVFERD QFSPDDFLGR TEIRVADIKK DQGSKGPVTK CLLLHEVPTG 1700
    EIVVRLDLQL FDEP 1714
    Length:1,714
    Mass (Da):194,297
    Last modified:October 3, 2012 - v2
    Checksum:iBCF5038160E8208E
    GO
    Isoform 2 (identifier: Q9Z0R4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1214-1714: Missing.

    Show »
    Length:1,213
    Mass (Da):136,607
    Checksum:i1376AD0DFBD503C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791L → W in AAD19749. (PubMed:10064583)Curated
    Sequence conflicti179 – 1791L → W in AAD19746. (PubMed:10064583)Curated
    Sequence conflicti402 – 4021R → A in AAD19749. (PubMed:10064583)Curated
    Sequence conflicti402 – 4021R → A in AAD19746. (PubMed:10064583)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1214 – 1714501Missing in isoform 2. 1 PublicationVSP_004296Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132481 mRNA. Translation: AAD19749.1.
    AF132478 mRNA. Translation: AAD19746.1.
    AC126053 Genomic DNA. No translation available.
    AC131691 Genomic DNA. No translation available.
    AC134837 Genomic DNA. No translation available.
    AF169621 mRNA. Translation: AAD48848.1.
    AF356517 Genomic DNA. Translation: AAK40228.1.
    CCDSiCCDS37402.1. [Q9Z0R4-1]
    CCDS49913.1. [Q9Z0R4-2]
    RefSeqiNP_001103745.1. NM_001110275.1. [Q9Z0R4-2]
    NP_034717.2. NM_010587.2. [Q9Z0R4-1]
    UniGeneiMm.40546.

    Genome annotation databases

    EnsembliENSMUST00000056482; ENSMUSP00000056011; ENSMUSG00000022957. [Q9Z0R4-2]
    ENSMUST00000114002; ENSMUSP00000109635; ENSMUSG00000022957. [Q9Z0R4-1]
    GeneIDi16443.
    KEGGimmu:16443.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132481 mRNA. Translation: AAD19749.1 .
    AF132478 mRNA. Translation: AAD19746.1 .
    AC126053 Genomic DNA. No translation available.
    AC131691 Genomic DNA. No translation available.
    AC134837 Genomic DNA. No translation available.
    AF169621 mRNA. Translation: AAD48848.1 .
    AF356517 Genomic DNA. Translation: AAK40228.1 .
    CCDSi CCDS37402.1. [Q9Z0R4-1 ]
    CCDS49913.1. [Q9Z0R4-2 ]
    RefSeqi NP_001103745.1. NM_001110275.1. [Q9Z0R4-2 ]
    NP_034717.2. NM_010587.2. [Q9Z0R4-1 ]
    UniGenei Mm.40546.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HS8 X-ray 1.90 P 840-851 [» ]
    3JV3 X-ray 2.40 A/B 1151-1431 [» ]
    ProteinModelPortali Q9Z0R4.
    SMRi Q9Z0R4. Positions 1-111, 210-312, 909-962, 998-1053, 1063-1574, 1588-1711.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200851. 10 interactions.
    IntActi Q9Z0R4. 11 interactions.
    MINTi MINT-86500.
    STRINGi 10090.ENSMUSP00000066361.

    PTM databases

    PhosphoSitei Q9Z0R4.

    Proteomic databases

    MaxQBi Q9Z0R4.
    PaxDbi Q9Z0R4.
    PRIDEi Q9Z0R4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056482 ; ENSMUSP00000056011 ; ENSMUSG00000022957 . [Q9Z0R4-2 ]
    ENSMUST00000114002 ; ENSMUSP00000109635 ; ENSMUSG00000022957 . [Q9Z0R4-1 ]
    GeneIDi 16443.
    KEGGi mmu:16443.

    Organism-specific databases

    CTDi 6453.
    MGIi MGI:1338069. Itsn1.

    Phylogenomic databases

    eggNOGi COG5422.
    GeneTreei ENSGT00750000117388.
    HOGENOMi HOG000010175.
    HOVERGENi HBG052159.
    TreeFami TF324293.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi ITSN1. mouse.
    EvolutionaryTracei Q9Z0R4.
    NextBioi 289695.
    PROi Q9Z0R4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0R4.
    CleanExi MM_ITSN1.
    Genevestigatori Q9Z0R4.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 4 hits.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00027. EH. 2 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 5 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50031. EH. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15."
      Sengar A.S., Wang W., Bishay J., Cohen S., Egan S.E.
      EMBO J. 18:1159-1171(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Mouse homologues of human chromosome 21 genes."
      Skripkina I.Y., Tsyba L.O., Anoprienko O.V., Slavov D., Tassone F., Rynditch A.V., Gardiner K.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 966-1714, NUCLEOTIDE SEQUENCE [MRNA] OF 545-599 (ISOFORMS 1 AND 2).
      Strain: 129/Ola.
      Tissue: Spleen.
    4. "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."
      Jenna S., Hussain N.K., Danek E.I., Triki I., Wasiak S., McPherson P.S., Lamarche-Vane N.
      J. Biol. Chem. 277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGAP31.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-335; SER-895; SER-897 AND THR-977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "FCHo proteins are nucleators of clathrin-mediated endocytosis."
      Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T.
      Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHO2.
    11. "The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin."
      Ahmad K.F., Lim W.A.
      PLoS ONE 5:E11291-E11291(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1151-1431, SH3 DOMAIN, FUNCTION.

    Entry informationi

    Entry nameiITSN1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0R4
    Secondary accession number(s): F8VQE5, Q9R143
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3