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Protein

Intersectin-1

Gene

Itsn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1. Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi66 – 781PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi267 – 2792PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • ephrin receptor signaling pathway Source: Reactome
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-1
Alternative name(s):
EH and SH3 domains protein 1
Gene namesi
Name:Itsn1
Synonyms:Ese1, Itsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1338069. Itsn1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • clathrin-coated pit Source: MGI
  • cytosol Source: Reactome
  • endocytic vesicle Source: MGI
  • lamellipodium Source: MGI
  • neuron projection Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Coated pit, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809581 – 1714Intersectin-1Add BLAST1714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei685PhosphoserineBy similarity1
Modified residuei890PhosphothreonineCombined sources1
Modified residuei894PhosphoserineBy similarity1
Modified residuei895PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei971PhosphoserineBy similarity1
Modified residuei977PhosphothreonineCombined sources1
Modified residuei979PhosphoserineBy similarity1
Modified residuei988PhosphoserineBy similarity1
Modified residuei1130PhosphoserineCombined sources1
Modified residuei1137PhosphothreonineCombined sources1
Modified residuei1638PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z0R4.
PaxDbiQ9Z0R4.
PeptideAtlasiQ9Z0R4.
PRIDEiQ9Z0R4.

PTM databases

iPTMnetiQ9Z0R4.
PhosphoSitePlusiQ9Z0R4.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in brain, heart and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000022957.
CleanExiMM_ITSN1.
ExpressionAtlasiQ9Z0R4. baseline and differential.
GenevisibleiQ9Z0R4. MM.

Interactioni

Subunit structurei

Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Interacts with clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2, STON2, FCHO1, FCHO2 and DAB2. Interacts (via SH3 domains) with REPS1 and SGIP1. Interacts with ARHGAP31. Interacts with ADAM15.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgap31A6X8Z53EBI-645386,EBI-4325995
Dennd1aQ8K3823EBI-645386,EBI-7186684
Inppl1Q6P5492EBI-8052786,EBI-2642932

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200851. 10 interactors.
IntActiQ9Z0R4. 16 interactors.
MINTiMINT-86500.
STRINGi10090.ENSMUSP00000109635.

Structurei

Secondary structure

11714
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1151 – 1157Combined sources7
Beta strandi1174 – 1179Combined sources6
Beta strandi1185 – 1190Combined sources6
Beta strandi1193 – 1198Combined sources6
Helixi1199 – 1201Combined sources3
Beta strandi1202 – 1204Combined sources3
Helixi1205 – 1207Combined sources3
Helixi1210 – 1214Combined sources5
Helixi1221 – 1223Combined sources3
Helixi1226 – 1255Combined sources30
Helixi1258 – 1261Combined sources4
Helixi1268 – 1275Combined sources8
Helixi1278 – 1299Combined sources22
Helixi1309 – 1315Combined sources7
Helixi1316 – 1320Combined sources5
Helixi1321 – 1342Combined sources22
Helixi1344 – 1353Combined sources10
Helixi1357 – 1359Combined sources3
Helixi1364 – 1367Combined sources4
Helixi1370 – 1386Combined sources17
Helixi1396 – 1422Combined sources27
Helixi1423 – 1425Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HS8X-ray1.90P840-851[»]
3JV3X-ray2.40A/B1151-1431[»]
ProteinModelPortaliQ9Z0R4.
SMRiQ9Z0R4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z0R4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 109EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini53 – 88EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini221 – 310EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini254 – 289EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini738 – 799SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini906 – 964SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini995 – 1053SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1067 – 1131SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1148 – 1207SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1230 – 1416DHPROSITE-ProRule annotationAdd BLAST187
Domaini1455 – 1564PHPROSITE-ProRule annotationAdd BLAST110
Domaini1576 – 1672C2PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 702KLERQAdd BLAST377

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 662Sequence analysisAdd BLAST311

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 324Poly-Ser4

Domaini

SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.By similarity
The KLERQ domain binds to SNAP-25 and SNAP-23.By similarity
In an autoinhibited form the SH3 domain 5 may bind intramolecularly to the DH domain, thus blocking the CDC42-binding site.1 Publication

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000010175.
HOVERGENiHBG052159.
InParanoidiQ9Z0R4.
KOiK20045.
TreeFamiTF324293.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9Z0R4-1) [UniParc]FASTAAdd to basket
Also known as: Ese1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDVWAITVE ERAKHDQQFL SLKPIAGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSTLPP
110 120 130 140 150
VMKQQPVAIS SAPAFGIGGI ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV
160 170 180 190 200
PPAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
210 220 230 240 250
AQSFDVASAP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
260 270 280 290 300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350
PEYIPPSFRR VRSGSGMSVI SSSSVDQRLP EEPSSEDEQQ PEKKLPVTFE
360 370 380 390 400
DKKRENFERG SVELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ
410 420 430 440 450
ERKRQLELEK QLEKQRELER QREEERRKEI ERREAAKREL ERQRQLEWER
460 470 480 490 500
NRRQELLNQR NKEQEGTVVL KARRKTLEFE LEALNDKKHQ LEGKLQDIRC
510 520 530 540 550
RLATQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL IPEKQILSDQ
560 570 580 590 600
LKQVQQNSLH RDSLLTLKRA LEAKELARQQ LREQLDEVER ETRSKLQEID
610 620 630 640 650
VFNNQLKELR EIHSKQQLQK QRSLEAARLK QKEQERKSLE LEKQKEDAQR
660 670 680 690 700
RVQERDKQWL EHVQQEEQPR PRKPHEEDRL KREDSVRKKE AEERAKPEMQ
710 720 730 740 750
DKQSRLFHPH QEPAKLATQA PWSTTEKGPL TISAQESVKV VYYRALYPFE
760 770 780 790 800
SRSHDEITIQ PGDIVMVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN
810 820 830 840 850
EVPTPAKPVT DLTSAPAPKL ALRETPAPLP VTSSEPSTTP NNWADFSSTW
860 870 880 890 900
PSSSNEKPET DNWDTWAAQP SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL
910 920 930 940 950
GQGEKVEGLQ AQALYPWRAK KDNHLNFNKS DVITVLEQQD MWWFGEVQGQ
960 970 980 990 1000
KGWFPKSYVK LISGPVRKST SIDTGPTESP ASLKRVASPA AKPAIPGEEF
1010 1020 1030 1040 1050
IAMYTYESSE QGDLTFQQGD VIVVTKKDGD WWTGTVGDKS GVFPSNYVRL
1060 1070 1080 1090 1100
KDSEGSGTAG KTGSLGKKPE IAQVIASYAA TGPEQLTLAP GQLILIRKKN
1110 1120 1130 1140 1150
PGGWWEGELQ ARGKKRQIGW FPANYVKLLS PGTSKITPTE LPKTAVQPAV
1160 1170 1180 1190 1200
CQVIGMYDYT AQNDDELAFS KGQIINVLNK EDPDWWKGEV SGQVGLFPSN
1210 1220 1230 1240 1250
YVKLTTDMDP SQQWCSDLHL LDMLTPTERK RQGYIHELIV TEENYVNDLQ
1260 1270 1280 1290 1300
LVTEIFQKPL TESELLTEKE VAMIFVNWKE LIMCNIKLLK ALRVRKKMSG
1310 1320 1330 1340 1350
EKMPVKMIGD ILSAQLPHMQ PYIRFCSCQL NGAALIQQKT DEAPDFKEFV
1360 1370 1380 1390 1400
KRLAMDPRCK GMPLSSFILK PMQRVTRYPL IIKNILENTP ENHPDHSHLK
1410 1420 1430 1440 1450
HALEKAEELC SQVNEGVREK ENSDRLEWIQ AHVQCEGLSE QLVFNSVTNC
1460 1470 1480 1490 1500
LGPRKFLHSG KLYKAKSNKE LYGFLFNDFL LLTQITKPLG SSGTDKVFSP
1510 1520 1530 1540 1550
KSNLQYKMYK TPIFLNEVLV KLPTDPSGDE PIFHISHIDR VYTLRAESIN
1560 1570 1580 1590 1600
ERTAWVQKIK AASELYIETE KKKREKAYLV RSQRATGIGR LMVNVVEGIE
1610 1620 1630 1640 1650
LKPCRSHGKS NPYCEVTMGS QCHITKTIQD TLNPKWNSNC QFFIRDLEQE
1660 1670 1680 1690 1700
VLCITVFERD QFSPDDFLGR TEIRVADIKK DQGSKGPVTK CLLLHEVPTG
1710
EIVVRLDLQL FDEP
Length:1,714
Mass (Da):194,297
Last modified:October 3, 2012 - v2
Checksum:iBCF5038160E8208E
GO
Isoform 2 (identifier: Q9Z0R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1714: Missing.

Show »
Length:1,213
Mass (Da):136,607
Checksum:i1376AD0DFBD503C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179L → W in AAD19749 (PubMed:10064583).Curated1
Sequence conflicti179L → W in AAD19746 (PubMed:10064583).Curated1
Sequence conflicti402R → A in AAD19749 (PubMed:10064583).Curated1
Sequence conflicti402R → A in AAD19746 (PubMed:10064583).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0042961214 – 1714Missing in isoform 2. 1 PublicationAdd BLAST501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132481 mRNA. Translation: AAD19749.1.
AF132478 mRNA. Translation: AAD19746.1.
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
AF169621 mRNA. Translation: AAD48848.1.
AF356517 Genomic DNA. Translation: AAK40228.1.
CCDSiCCDS37402.1. [Q9Z0R4-1]
CCDS49913.1. [Q9Z0R4-2]
RefSeqiNP_001103745.1. NM_001110275.1. [Q9Z0R4-2]
NP_034717.2. NM_010587.2. [Q9Z0R4-1]
UniGeneiMm.40546.

Genome annotation databases

EnsembliENSMUST00000056482; ENSMUSP00000056011; ENSMUSG00000022957. [Q9Z0R4-2]
ENSMUST00000114002; ENSMUSP00000109635; ENSMUSG00000022957. [Q9Z0R4-1]
GeneIDi16443.
KEGGimmu:16443.
UCSCiuc007zyi.2. mouse. [Q9Z0R4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132481 mRNA. Translation: AAD19749.1.
AF132478 mRNA. Translation: AAD19746.1.
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
AF169621 mRNA. Translation: AAD48848.1.
AF356517 Genomic DNA. Translation: AAK40228.1.
CCDSiCCDS37402.1. [Q9Z0R4-1]
CCDS49913.1. [Q9Z0R4-2]
RefSeqiNP_001103745.1. NM_001110275.1. [Q9Z0R4-2]
NP_034717.2. NM_010587.2. [Q9Z0R4-1]
UniGeneiMm.40546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HS8X-ray1.90P840-851[»]
3JV3X-ray2.40A/B1151-1431[»]
ProteinModelPortaliQ9Z0R4.
SMRiQ9Z0R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200851. 10 interactors.
IntActiQ9Z0R4. 16 interactors.
MINTiMINT-86500.
STRINGi10090.ENSMUSP00000109635.

PTM databases

iPTMnetiQ9Z0R4.
PhosphoSitePlusiQ9Z0R4.

Proteomic databases

EPDiQ9Z0R4.
PaxDbiQ9Z0R4.
PeptideAtlasiQ9Z0R4.
PRIDEiQ9Z0R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056482; ENSMUSP00000056011; ENSMUSG00000022957. [Q9Z0R4-2]
ENSMUST00000114002; ENSMUSP00000109635; ENSMUSG00000022957. [Q9Z0R4-1]
GeneIDi16443.
KEGGimmu:16443.
UCSCiuc007zyi.2. mouse. [Q9Z0R4-1]

Organism-specific databases

CTDi6453.
MGIiMGI:1338069. Itsn1.

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000010175.
HOVERGENiHBG052159.
InParanoidiQ9Z0R4.
KOiK20045.
TreeFamiTF324293.

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiItsn1. mouse.
EvolutionaryTraceiQ9Z0R4.
PROiQ9Z0R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022957.
CleanExiMM_ITSN1.
ExpressionAtlasiQ9Z0R4. baseline and differential.
GenevisibleiQ9Z0R4. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITSN1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0R4
Secondary accession number(s): F8VQE5, Q9R143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.