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Protein

Paralemmin-1

Gene

Palm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.1 Publication

GO - Molecular functioni

  • D3 dopamine receptor binding Source: MGI

GO - Biological processi

  • cellular response to electrical stimulus Source: UniProtKB
  • cytoskeleton organization Source: MGI
  • negative regulation of adenylate cyclase activity Source: MGI
  • negative regulation of cAMP biosynthetic process Source: MGI
  • negative regulation of dopamine receptor signaling pathway Source: MGI
  • positive regulation of dendritic spine development Source: UniProtKB
  • positive regulation of filopodium assembly Source: UniProtKB
  • protein localization Source: MGI
  • protein targeting to plasma membrane Source: UniProtKB
  • regulation of cell shape Source: MGI
  • synapse maturation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-1
Alternative name(s):
Paralemmin
Gene namesi
Name:Palm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1261814. Palm.

Subcellular locationi

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB-SubCell
  • axon Source: UniProtKB-SubCell
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • dendritic spine Source: UniProtKB-SubCell
  • dendritic spine membrane Source: Ensembl
  • filopodium Source: UniProtKB
  • filopodium membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • neuronal postsynaptic density Source: MGI
  • neuron spine Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi377 – 3804CRCC → SRSS: Inhibits axonal and dendritic filopodia formation and reduces axonal and dendritic branching. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Paralemmin-1PRO_0000058219Add
BLAST
Propeptidei381 – 3833Removed in mature formSequence analysisPRO_0000396690

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei122 – 1221PhosphoserineBy similarity
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei141 – 1411PhosphothreonineCombined sources
Modified residuei145 – 1451PhosphothreonineCombined sources
Modified residuei153 – 1531PhosphothreonineCombined sources
Modified residuei157 – 1571PhosphoserineCombined sources
Modified residuei161 – 1611PhosphoserineCombined sources
Modified residuei242 – 2421PhosphothreonineCombined sources
Modified residuei244 – 2441PhosphoserineBy similarity
Modified residuei345 – 3451PhosphoserineCombined sources
Modified residuei361 – 3611PhosphothreonineCombined sources
Modified residuei362 – 3621PhosphothreonineCombined sources
Modified residuei363 – 3631PhosphothreonineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources
Modified residuei367 – 3671PhosphothreonineCombined sources
Lipidationi377 – 3771S-palmitoyl cysteineSequence analysis
Lipidationi379 – 3791S-palmitoyl cysteineSequence analysis
Modified residuei380 – 3801Cysteine methyl esterSequence analysis
Lipidationi380 – 3801S-farnesyl cysteineSequence analysis

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9Z0P4.
MaxQBiQ9Z0P4.
PaxDbiQ9Z0P4.
PeptideAtlasiQ9Z0P4.
PRIDEiQ9Z0P4.

PTM databases

iPTMnetiQ9Z0P4.
PhosphoSiteiQ9Z0P4.
SwissPalmiQ9Z0P4.

Expressioni

Tissue specificityi

Expression is highest in brain, intermediate in adrenal gland and kidney, and much lower or undetectable in other tissues. Isoform 1 is the predominant isoform in most tissues except brain and kidney where isoform 2 predominates.1 Publication

Developmental stagei

In brain, expression is highest in neonates and declines to approximately 50% in adults. Isoform 2 is the predominant isoform in neonates with isoform 1 being barely detectable at this stage. Levels of isoform 1 increase with age, with the most pronounced increase between postnatal days 10 and 20.1 Publication

Gene expression databases

BgeeiQ9Z0P4.
CleanExiMM_PALM.
ExpressionAtlasiQ9Z0P4. baseline and differential.
GenevisibleiQ9Z0P4. MM.

Interactioni

Subunit structurei

Interacts with dopamine receptor DRD3.By similarity

GO - Molecular functioni

  • D3 dopamine receptor binding Source: MGI

Protein-protein interaction databases

BioGridi202022. 2 interactions.
IntActiQ9Z0P4. 2 interactions.
MINTiMINT-4106536.
STRINGi10090.ENSMUSP00000040596.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 10298Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ9Z0P4.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG7NCV3N.
PhylomeDBiQ9Z0P4.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0P4-1) [UniParc]FASTAAdd to basket

Also known as: Paralemmin-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLATDTAS QQERLQAIAE KRRKQAEIES KRRQLEDDRR QLQYLKSKAL
60 70 80 90 100
RERWLLEGTP SSASEGDEDM RKQMQEDEQK ARGLEESITR LEKEIDVLEF
110 120 130 140 150
GESAPAASKE NSAAPSPGRP QSASPAKEEQ KSETLVNAQQ TPLGTPKENR
160 170 180 190 200
TSTPVRSPGG STMMKAAMYS VEITVEKDKV TGETRVLSST TVLPRDPLPQ
210 220 230 240 250
GVKVYEDETK VVHAVDGIAE NGIQPLSSSE VDELIHKADE VTLSEAGSTA
260 270 280 290 300
GPAEPRGLAE DVTRTTPSRR EITGVEAQPG EATSGPPGIQ PGQEPPVTMV
310 320 330 340 350
FMGYQNVEDE AETKKVLGLQ DTIKAELVVI EDAATPREPA PLNGSAAELP
360 370 380
ATKEENQTGP TTTPSDTQDL DMKKPRCRCC SVM
Length:383
Mass (Da):41,614
Last modified:May 1, 1999 - v1
Checksum:iD63CAF5CFB1A70AB
GO
Isoform 2 (identifier: Q9Z0P4-2) [UniParc]FASTAAdd to basket

Also known as: Paralemmin-S

The sequence of this isoform differs from the canonical sequence as follows:
     167-210: Missing.

Note: Mutagenesis of Cys-333, Cys-335 and Cys-336 to Ser inhibit filopodia and spines induction and synapse maturation.
Show »
Length:339
Mass (Da):36,722
Checksum:i2D50A6DC5AF8A3FF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei167 – 21044Missing in isoform 2. 1 PublicationVSP_003919Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14771 mRNA. Translation: CAB37403.1.
Y14771 mRNA. Translation: CAB37404.1.
CCDSiCCDS23991.1. [Q9Z0P4-1]
CCDS48621.1. [Q9Z0P4-2]
RefSeqiNP_001155219.1. NM_001161747.1. [Q9Z0P4-2]
NP_075617.3. NM_023128.4. [Q9Z0P4-1]
UniGeneiMm.34650.

Genome annotation databases

EnsembliENSMUST00000046945; ENSMUSP00000040596; ENSMUSG00000035863. [Q9Z0P4-1]
ENSMUST00000105379; ENSMUSP00000101018; ENSMUSG00000035863. [Q9Z0P4-2]
GeneIDi18483.
KEGGimmu:18483.
UCSCiuc007fzw.2. mouse. [Q9Z0P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14771 mRNA. Translation: CAB37403.1.
Y14771 mRNA. Translation: CAB37404.1.
CCDSiCCDS23991.1. [Q9Z0P4-1]
CCDS48621.1. [Q9Z0P4-2]
RefSeqiNP_001155219.1. NM_001161747.1. [Q9Z0P4-2]
NP_075617.3. NM_023128.4. [Q9Z0P4-1]
UniGeneiMm.34650.

3D structure databases

ProteinModelPortaliQ9Z0P4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202022. 2 interactions.
IntActiQ9Z0P4. 2 interactions.
MINTiMINT-4106536.
STRINGi10090.ENSMUSP00000040596.

PTM databases

iPTMnetiQ9Z0P4.
PhosphoSiteiQ9Z0P4.
SwissPalmiQ9Z0P4.

Proteomic databases

EPDiQ9Z0P4.
MaxQBiQ9Z0P4.
PaxDbiQ9Z0P4.
PeptideAtlasiQ9Z0P4.
PRIDEiQ9Z0P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046945; ENSMUSP00000040596; ENSMUSG00000035863. [Q9Z0P4-1]
ENSMUST00000105379; ENSMUSP00000101018; ENSMUSG00000035863. [Q9Z0P4-2]
GeneIDi18483.
KEGGimmu:18483.
UCSCiuc007fzw.2. mouse. [Q9Z0P4-1]

Organism-specific databases

CTDi5064.
MGIiMGI:1261814. Palm.

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ9Z0P4.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG7NCV3N.
PhylomeDBiQ9Z0P4.
TreeFamiTF105402.

Miscellaneous databases

PROiQ9Z0P4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0P4.
CleanExiMM_PALM.
ExpressionAtlasiQ9Z0P4. baseline and differential.
GenevisibleiQ9Z0P4. MM.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation."
    Kutzleb C., Sanders G., Yamamoto R., Wang X., Lichte B., Petrasch-Parwez E., Kilimann M.W.
    J. Cell Biol. 143:795-813(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
    Tissue: Brain.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 94-109 AND 325-337, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141; THR-145 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141 AND THR-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: FUNCTION, MUTAGENESIS OF 377-CYS--CYS-380, MUTAGENESIS (ISOFORM 2), SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; THR-141; THR-145; THR-153; SER-157; SER-161; THR-242; SER-345; THR-361; THR-362; THR-363; SER-365 AND THR-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiPALM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0P4
Secondary accession number(s): Q9Z0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.