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Protein

Paralemmin-1

Gene

Palm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.1 Publication

GO - Molecular functioni

  • D3 dopamine receptor binding Source: MGI

GO - Biological processi

  • cellular response to electrical stimulus Source: UniProtKB
  • cytoskeleton organization Source: MGI
  • negative regulation of adenylate cyclase activity Source: MGI
  • negative regulation of cAMP biosynthetic process Source: MGI
  • negative regulation of dopamine receptor signaling pathway Source: MGI
  • positive regulation of dendritic spine development Source: UniProtKB
  • positive regulation of filopodium assembly Source: UniProtKB
  • protein localization Source: MGI
  • protein targeting to plasma membrane Source: UniProtKB
  • regulation of cell shape Source: MGI
  • synapse maturation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-1
Alternative name(s):
Paralemmin
Gene namesi
Name:Palm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1261814. Palm.

Subcellular locationi

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB-SubCell
  • axon Source: UniProtKB-SubCell
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • dendritic spine Source: UniProtKB-SubCell
  • dendritic spine membrane Source: Ensembl
  • filopodium Source: UniProtKB
  • filopodium membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • neuron spine Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi377 – 380CRCC → SRSS: Inhibits axonal and dendritic filopodia formation and reduces axonal and dendritic branching. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582191 – 380Paralemmin-1Add BLAST380
PropeptideiPRO_0000396690381 – 383Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei124PhosphoserineCombined sources1
Modified residuei141PhosphothreonineCombined sources1
Modified residuei145PhosphothreonineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei242PhosphothreonineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei345PhosphoserineCombined sources1
Modified residuei361PhosphothreonineCombined sources1
Modified residuei362PhosphothreonineCombined sources1
Modified residuei363PhosphothreonineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Lipidationi377S-palmitoyl cysteineSequence analysis1
Lipidationi379S-palmitoyl cysteineSequence analysis1
Modified residuei380Cysteine methyl esterSequence analysis1
Lipidationi380S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ9Z0P4.
PeptideAtlasiQ9Z0P4.
PRIDEiQ9Z0P4.

PTM databases

iPTMnetiQ9Z0P4.
PhosphoSitePlusiQ9Z0P4.
SwissPalmiQ9Z0P4.

Expressioni

Tissue specificityi

Expression is highest in brain, intermediate in adrenal gland and kidney, and much lower or undetectable in other tissues. Isoform 1 is the predominant isoform in most tissues except brain and kidney where isoform 2 predominates.1 Publication

Developmental stagei

In brain, expression is highest in neonates and declines to approximately 50% in adults. Isoform 2 is the predominant isoform in neonates with isoform 1 being barely detectable at this stage. Levels of isoform 1 increase with age, with the most pronounced increase between postnatal days 10 and 20.1 Publication

Gene expression databases

BgeeiENSMUSG00000035863.
CleanExiMM_PALM.
ExpressionAtlasiQ9Z0P4. baseline and differential.
GenevisibleiQ9Z0P4. MM.

Interactioni

Subunit structurei

Interacts with dopamine receptor DRD3.By similarity

GO - Molecular functioni

  • D3 dopamine receptor binding Source: MGI

Protein-protein interaction databases

BioGridi202022. 2 interactors.
IntActiQ9Z0P4. 2 interactors.
MINTiMINT-4106536.
STRINGi10090.ENSMUSP00000040596.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 102Sequence analysisAdd BLAST98

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ9Z0P4.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG091G0713.
PhylomeDBiQ9Z0P4.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0P4-1) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLATDTAS QQERLQAIAE KRRKQAEIES KRRQLEDDRR QLQYLKSKAL
60 70 80 90 100
RERWLLEGTP SSASEGDEDM RKQMQEDEQK ARGLEESITR LEKEIDVLEF
110 120 130 140 150
GESAPAASKE NSAAPSPGRP QSASPAKEEQ KSETLVNAQQ TPLGTPKENR
160 170 180 190 200
TSTPVRSPGG STMMKAAMYS VEITVEKDKV TGETRVLSST TVLPRDPLPQ
210 220 230 240 250
GVKVYEDETK VVHAVDGIAE NGIQPLSSSE VDELIHKADE VTLSEAGSTA
260 270 280 290 300
GPAEPRGLAE DVTRTTPSRR EITGVEAQPG EATSGPPGIQ PGQEPPVTMV
310 320 330 340 350
FMGYQNVEDE AETKKVLGLQ DTIKAELVVI EDAATPREPA PLNGSAAELP
360 370 380
ATKEENQTGP TTTPSDTQDL DMKKPRCRCC SVM
Length:383
Mass (Da):41,614
Last modified:May 1, 1999 - v1
Checksum:iD63CAF5CFB1A70AB
GO
Isoform 2 (identifier: Q9Z0P4-2) [UniParc]FASTAAdd to basket
Also known as: Paralemmin-S

The sequence of this isoform differs from the canonical sequence as follows:
     167-210: Missing.

Note: Mutagenesis of Cys-333, Cys-335 and Cys-336 to Ser inhibit filopodia and spines induction and synapse maturation.
Show »
Length:339
Mass (Da):36,722
Checksum:i2D50A6DC5AF8A3FF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003919167 – 210Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14771 mRNA. Translation: CAB37403.1.
Y14771 mRNA. Translation: CAB37404.1.
CCDSiCCDS23991.1. [Q9Z0P4-1]
CCDS48621.1. [Q9Z0P4-2]
RefSeqiNP_001155219.1. NM_001161747.1. [Q9Z0P4-2]
NP_075617.3. NM_023128.4. [Q9Z0P4-1]
UniGeneiMm.34650.

Genome annotation databases

EnsembliENSMUST00000046945; ENSMUSP00000040596; ENSMUSG00000035863. [Q9Z0P4-1]
ENSMUST00000105379; ENSMUSP00000101018; ENSMUSG00000035863. [Q9Z0P4-2]
GeneIDi18483.
KEGGimmu:18483.
UCSCiuc007fzw.2. mouse. [Q9Z0P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14771 mRNA. Translation: CAB37403.1.
Y14771 mRNA. Translation: CAB37404.1.
CCDSiCCDS23991.1. [Q9Z0P4-1]
CCDS48621.1. [Q9Z0P4-2]
RefSeqiNP_001155219.1. NM_001161747.1. [Q9Z0P4-2]
NP_075617.3. NM_023128.4. [Q9Z0P4-1]
UniGeneiMm.34650.

3D structure databases

ProteinModelPortaliQ9Z0P4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202022. 2 interactors.
IntActiQ9Z0P4. 2 interactors.
MINTiMINT-4106536.
STRINGi10090.ENSMUSP00000040596.

PTM databases

iPTMnetiQ9Z0P4.
PhosphoSitePlusiQ9Z0P4.
SwissPalmiQ9Z0P4.

Proteomic databases

PaxDbiQ9Z0P4.
PeptideAtlasiQ9Z0P4.
PRIDEiQ9Z0P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046945; ENSMUSP00000040596; ENSMUSG00000035863. [Q9Z0P4-1]
ENSMUST00000105379; ENSMUSP00000101018; ENSMUSG00000035863. [Q9Z0P4-2]
GeneIDi18483.
KEGGimmu:18483.
UCSCiuc007fzw.2. mouse. [Q9Z0P4-1]

Organism-specific databases

CTDi5064.
MGIiMGI:1261814. Palm.

Phylogenomic databases

eggNOGiENOG410IKZ0. Eukaryota.
ENOG410ZG4W. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ9Z0P4.
KOiK16519.
OMAiREENQVG.
OrthoDBiEOG091G0713.
PhylomeDBiQ9Z0P4.
TreeFamiTF105402.

Miscellaneous databases

PROiQ9Z0P4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035863.
CleanExiMM_PALM.
ExpressionAtlasiQ9Z0P4. baseline and differential.
GenevisibleiQ9Z0P4. MM.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0P4
Secondary accession number(s): Q9Z0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.