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Q9Z0N7 (KCNQ1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily KQT member 1
Alternative name(s):
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
Voltage-gated potassium channel subunit Kv7.1
Gene names
Name:Kcnq1
Synonyms:Kcna9, Kvlqt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current.

Subunit structure

Heterotetramer with KCNE1 (MinK) or KCNE3 (MiRP2). Interacts with CALM By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. [View classification]

Sequence caution

The sequence AAB51395.1 differs from that shown. Reason: Frameshift at position 321.

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentCell membrane
Cytoplasmic vesicle
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandCalmodulin-binding
Potassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cardiovascular system development

Inferred from electronic annotation. Source: Ensembl

cellular response to cAMP

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

gene silencing

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from expression pattern PubMed 15389592. Source: RGD

negative regulation of insulin secretion

Inferred from direct assay PubMed 16133261. Source: RGD

positive regulation of gastric acid secretion

Inferred from mutant phenotype PubMed 11313306. Source: RGD

positive regulation of potassium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

potassium ion export

Inferred from electronic annotation. Source: Ensembl

potassium ion transport

Inferred from direct assay PubMed 16133261. Source: RGD

regulation of atrial cardiac muscle cell membrane repolarization

Inferred from electronic annotation. Source: Ensembl

regulation of gene expression by genetic imprinting

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate by cardiac conduction

Inferred from electronic annotation. Source: Ensembl

regulation of membrane potential

Inferred from direct assay PubMed 11804849. Source: RGD

regulation of ventricular cardiac muscle cell membrane repolarization

Inferred from electronic annotation. Source: Ensembl

response to anesthetic

Inferred from direct assay PubMed 12616988. Source: RGD

   Cellular_componentbasolateral plasma membrane

Inferred from direct assay PubMed 15843438. Source: RGD

cytoplasmic vesicle membrane

Inferred from direct assay PubMed 18395087. Source: RGD

early endosome

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from direct assay PubMed 11804849. Source: RGD

late endosome

Inferred from electronic annotation. Source: Ensembl

lysosome

Inferred from electronic annotation. Source: Ensembl

sarcolemma

Inferred from direct assay PubMed 14670813. Source: RGD

voltage-gated potassium channel complex

Inferred from direct assay PubMed 15389592. Source: RGD

zymogen granule membrane

Inferred from direct assay PubMed 18216164. Source: RGD

   Molecular_functiondelayed rectifier potassium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

outward rectifier potassium channel activity

Inferred from direct assay PubMed 16133261. Source: RGD

potassium channel activity

Inferred from direct assay PubMed 11804849. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 20962273. Source: RGD

voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

Inferred from electronic annotation. Source: Ensembl

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Potassium voltage-gated channel subfamily KQT member 1
PRO_0000054027

Regions

Transmembrane122 – 14221Helical; Name=Segment S1; Potential
Topological domain143 – 1475Extracellular Potential
Transmembrane148 – 16821Helical; Name=Segment S2; Potential
Topological domain169 – 19628Cytoplasmic Potential
Transmembrane197 – 21721Helical; Name=Segment S3; Potential
Topological domain218 – 2258Extracellular Potential
Transmembrane226 – 24823Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain249 – 26113Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=Segment S5; Potential
Topological domain283 – 29917Extracellular Potential
Intramembrane300 – 32021Pore-forming; Name=Segment H5; Potential
Topological domain321 – 33111Extracellular Potential
Transmembrane332 – 35221Helical; Name=Segment S6; Potential
Topological domain353 – 669317Cytoplasmic Potential
Motif312 – 3176Selectivity filter By similarity

Amino acid modifications

Glycosylation2891N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1701E → K in AAB51395. Ref.2
Sequence conflict1821S → T in AAB51395. Ref.2
Sequence conflict1851V → L in AAB51395. Ref.2
Sequence conflict2551V → F in AAB51395. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z0N7 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 2374CA1290020939

FASTA66974,579
        10         20         30         40         50         60 
MDTASSPPNA ERKRAGWGRL LGARRGSAGL AKKCPFSLEL AEGGPTGGTV YAPIAPTGAP 

        70         80         90        100        110        120 
GLAPPMSPPV SPVPAPADLG PRPRVSLDPR VSIYSTRRPL LARTHIQGRV YNFLERPTGW 

       130        140        150        160        170        180 
KCFVYHFTVF LIVLVCLIFS VLSTIEQYAA LATGTLFWME IVLVVFFGTE YVVRLWSAGC 

       190        200        210        220        230        240 
RSKYVGIWGR LRFARKPISI IDLIVVVASM VVLCVGSKGQ VFATSAIRGI RFLQILRMLH 

       250        260        270        280        290        300 
VDRQGGTWRL LGSVVFIHRQ ELITTLYIGF LGLIFSSYFV YLAEKDAVNE SGRIEFGSYA 

       310        320        330        340        350        360 
DALWWGVVTV TTIGYGDKVP QTWVGKTIAS CFSVFAISFF ALPAGILGSG FALKVQQKQR 

       370        380        390        400        410        420 
QKHFNRQIPA AASLIQTAWR CYAAENPDSS TWKIYVRKPA RSHTLLSPSP KPKKSVMVKK 

       430        440        450        460        470        480 
KKFKLDKDNG LSPGEKIFNV PHITCDPPED RRPDHFSIDG YDSSVRKSPT LLEVSTPHFL 

       490        500        510        520        530        540 
RTNSFAEDLD LEGETLLTPI THVSQLRDHH RATIKVIRRM QYFVAKKKFQ QARKPYDVRD 

       550        560        570        580        590        600 
VIEQYSQGHL NLMVRIKELQ RRLDQSIGKP SLFIPISEKS KDRGSNTIGA RLNRVEDKVT 

       610        620        630        640        650        660 
QLDQRLVIIT DMLHQLLSLQ QGGPTCNNRS QVVASDERGS INPELFLPSN SLPTYEQLTV 


PQTGPDEGS 

« Hide

References

[1]"Cloning and function of the rat colonic epithelial K+ channel KVLQT1."
Kunzelmann K., Huebner M., Schreiber R., Levy-Holzman R., Garty H., Bleich M., Warth R., Slavik M., von Hahn T., Greger R.
J. Membr. Biol. 179:155-164(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon.
[2]"Decreased expression of Kv4.2 and novel Kv4.3 K+ channel subunit mRNAs in ventricles of renovascular hypertensive rats."
Takimoto K., Li D., Hershman K.M., Li P., Jackson E.K., Levitan E.S.
Circ. Res. 81:533-539(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 134-352.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133685 mRNA. Translation: CAB38863.1.
U92655 mRNA. Translation: AAB51395.1. Frameshift.
RefSeqNP_114462.1. NM_032073.1.
UniGeneRn.9779.

3D structure databases

ProteinModelPortalQ9Z0N7.
SMRQ9Z0N7. Positions 584-620.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249886. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID84020.
KEGGrno:84020.
UCSCRGD:621503. rat.

Organism-specific databases

CTD3784.
RGD621503. Kcnq1.

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000220839.
HOVERGENHBG059014.
InParanoidQ9Z0N7.
KOK04926.
PhylomeDBQ9Z0N7.

Gene expression databases

GenevestigatorQ9Z0N7.

Family and domain databases

InterProIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF9. PTHR11537:SF9. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetSearch...

Other

NextBio616577.
PROQ9Z0N7.

Entry information

Entry nameKCNQ1_RAT
AccessionPrimary (citable) accession number: Q9Z0N7
Secondary accession number(s): O08655
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families