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Protein

Interleukin-18-binding protein

Gene

Il18bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18-binding protein
Short name:
IL-18BP
Alternative name(s):
Interferon gamma-inducing factor-binding protein
Gene namesi
Name:Il18bp
Synonyms:Igifbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1333800. Il18bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001477929 – 193Interleukin-18-binding proteinAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi81 ↔ 145PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Z0M9.
PaxDbiQ9Z0M9.
PeptideAtlasiQ9Z0M9.
PRIDEiQ9Z0M9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070427.
CleanExiMM_IL18BP.
GenevisibleiQ9Z0M9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091685.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0M9.
SMRiQ9Z0M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 161Ig-like C2-typeAdd BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J0UT. Eukaryota.
ENOG4111EES. LUCA.
GeneTreeiENSGT00390000004026.
HOGENOMiHOG000056459.
HOVERGENiHBG052064.
InParanoidiQ9Z0M9.
OMAiEHGSTGT.
OrthoDBiEOG091G0WAG.
PhylomeDBiQ9Z0M9.
TreeFamiTF337962.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMRHCWTAG PSSWWVLLLY VHVILARATS APQTTATVLT GSSKDPCSSW
60 70 80 90 100
SPAVPTKQYP ALDVIWPEKE VPLNGTLTLS CTACSRFPYF SILYWLGNGS
110 120 130 140 150
FIEHLPGRLK EGHTSREHRN TSTWLHRALV LEELSPTLRS TNFSCLFVDP
160 170 180 190
GQVAQYHIIL AQLWDGLKTA PSPSQETLSS HSPVSRSAGP GVA
Length:193
Mass (Da):21,257
Last modified:July 7, 2009 - v2
Checksum:iD7AD4B0AB07C8248
GO

Sequence cautioni

The sequence AAD17193 differs from that shown. Intron retention.Curated
The sequence AAD17194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172S → P in AAD17194 (PubMed:10023777).Curated1
Sequence conflicti172S → P in CAJ18542 (Ref. 5) Curated1
Sequence conflicti172S → P in AAH18332 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019505 mRNA. Translation: BAA76375.1.
AF110802 mRNA. Translation: AAD17193.1. Sequence problems.
AF110803 mRNA. Translation: AAD17194.1. Different initiation.
AF122907 mRNA. Translation: AAD41052.1.
AK009721 mRNA. Translation: BAB26462.1.
AK003370 mRNA. Translation: BAB22744.1.
AK008452 mRNA. Translation: BAB25677.1.
AK009877 mRNA. Translation: BAB26558.1.
CT010164 mRNA. Translation: CAJ18372.1.
CT010334 mRNA. Translation: CAJ18542.1.
CH466531 Genomic DNA. Translation: EDL16557.1.
CH466531 Genomic DNA. Translation: EDL16558.1.
CH466531 Genomic DNA. Translation: EDL16559.1.
BC018332 mRNA. Translation: AAH18332.1.
CCDSiCCDS21522.1.
RefSeqiNP_034661.1. NM_010531.1.
UniGeneiMm.422756.

Genome annotation databases

EnsembliENSMUST00000094134; ENSMUSP00000091685; ENSMUSG00000070427.
ENSMUST00000209844; ENSMUSP00000148080; ENSMUSG00000070427.
GeneIDi16068.
KEGGimmu:16068.
UCSCiuc009iqd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019505 mRNA. Translation: BAA76375.1.
AF110802 mRNA. Translation: AAD17193.1. Sequence problems.
AF110803 mRNA. Translation: AAD17194.1. Different initiation.
AF122907 mRNA. Translation: AAD41052.1.
AK009721 mRNA. Translation: BAB26462.1.
AK003370 mRNA. Translation: BAB22744.1.
AK008452 mRNA. Translation: BAB25677.1.
AK009877 mRNA. Translation: BAB26558.1.
CT010164 mRNA. Translation: CAJ18372.1.
CT010334 mRNA. Translation: CAJ18542.1.
CH466531 Genomic DNA. Translation: EDL16557.1.
CH466531 Genomic DNA. Translation: EDL16558.1.
CH466531 Genomic DNA. Translation: EDL16559.1.
BC018332 mRNA. Translation: AAH18332.1.
CCDSiCCDS21522.1.
RefSeqiNP_034661.1. NM_010531.1.
UniGeneiMm.422756.

3D structure databases

ProteinModelPortaliQ9Z0M9.
SMRiQ9Z0M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091685.

Proteomic databases

MaxQBiQ9Z0M9.
PaxDbiQ9Z0M9.
PeptideAtlasiQ9Z0M9.
PRIDEiQ9Z0M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094134; ENSMUSP00000091685; ENSMUSG00000070427.
ENSMUST00000209844; ENSMUSP00000148080; ENSMUSG00000070427.
GeneIDi16068.
KEGGimmu:16068.
UCSCiuc009iqd.1. mouse.

Organism-specific databases

CTDi10068.
MGIiMGI:1333800. Il18bp.

Phylogenomic databases

eggNOGiENOG410J0UT. Eukaryota.
ENOG4111EES. LUCA.
GeneTreeiENSGT00390000004026.
HOGENOMiHOG000056459.
HOVERGENiHBG052064.
InParanoidiQ9Z0M9.
OMAiEHGSTGT.
OrthoDBiEOG091G0WAG.
PhylomeDBiQ9Z0M9.
TreeFamiTF337962.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ9Z0M9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070427.
CleanExiMM_IL18BP.
GenevisibleiQ9Z0M9. MM.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI18BP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0M9
Secondary accession number(s): Q4FJR8
, Q4FK87, Q9CV30, Q9QUH2, Q9Z0N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.