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Protein

Membrane cofactor protein

Gene

Cd46

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.2 Publications

GO - Molecular functioni

  • complement binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiR-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane cofactor protein
Alternative name(s):
CD_antigen: CD46
Gene namesi
Name:Cd46
Synonyms:Mcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3061. Cd46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 326284ExtracellularSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Topological domaini348 – 3558CytoplasmicSequence analysis

GO - Cellular componenti

  • acrosomal vesicle Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • Golgi apparatus Source: RGD
  • inner acrosomal membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Sequence analysisAdd
BLAST
Chaini43 – 355313Membrane cofactor proteinPRO_0000238974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 149PROSITE-ProRule annotation
Disulfide bondi135 ↔ 166PROSITE-ProRule annotation
Disulfide bondi171 ↔ 219PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi200 ↔ 232PROSITE-ProRule annotation
Disulfide bondi237 ↔ 279PROSITE-ProRule annotation
Disulfide bondi265 ↔ 292PROSITE-ProRule annotation
Glycosylationi301 – 3011O-linked (GalNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0M4.
PRIDEiQ9Z0M4.

Expressioni

Tissue specificityi

Specifically expressed in testis. Within testis, present only in elongated spermatids and spermatozoa (at protein level).3 Publications

Developmental stagei

Not expressed in embryonic and immature rats. Expressed in parallel with synthesis of spermatids.1 Publication

Gene expression databases

BgeeiENSRNOG00000007917.
GenevisibleiQ9Z0M4. RN.

Interactioni

GO - Molecular functioni

  • complement binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053980.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 10462Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 16864Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini169 – 23466Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 29460Sushi 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY7G. Eukaryota.
ENOG4111CPD. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000113502.
HOVERGENiHBG006335.
InParanoidiQ9Z0M4.
KOiK04007.
OMAiFEAMELK.
OrthoDBiEOG091G0DWA.
PhylomeDBiQ9Z0M4.

Family and domain databases

InterProiIPR017341. CD46.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
PIRSFiPIRSF037971. TLX_CD46. 1 hit.
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAPLTPDP THPRRRRKSY TFFSLGIYAE ALLFLLSSLS DACEPPPPFE
60 70 80 90 100
AMELKDKPKP HYAIGEIIEY TCKKGYLYLS PYPMTAICQP NHTWVPISDH
110 120 130 140 150
GCIKVQCTML QDPSFGKVHY IDGRFSWGAR VKYTCMNGYY MVGMSVLQCE
160 170 180 190 200
LNGNGDAFWN GHPPSCKKVY CLPPPKIKNG THTFTDIKVF KYHEAVIYSC
210 220 230 240 250
DPNPGPDKFS LVGPSMLFCA GHNTWSSDPP ECKVVKCPFP VLQNGRQISR
260 270 280 290 300
TEKKFSYQAL VLFQCLEGFY MEGSSMVVCG AKSSWEPSIP QCLKGPKPHS
310 320 330 340 350
TKPPVYSESG YPSPREGIFG QEFDAWIIAL IVVTSVVGVI VICLIILRCS

EYRKK
Length:355
Mass (Da):39,787
Last modified:May 1, 1999 - v1
Checksum:i01DF87033ACD41B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010920 mRNA. Translation: BAA34811.1.
RefSeqiNP_062063.1. NM_019190.1.
UniGeneiRn.163242.

Genome annotation databases

EnsembliENSRNOT00000057151; ENSRNOP00000053980; ENSRNOG00000007917.
GeneIDi29333.
KEGGirno:29333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010920 mRNA. Translation: BAA34811.1.
RefSeqiNP_062063.1. NM_019190.1.
UniGeneiRn.163242.

3D structure databases

ProteinModelPortaliQ9Z0M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053980.

Proteomic databases

PaxDbiQ9Z0M4.
PRIDEiQ9Z0M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057151; ENSRNOP00000053980; ENSRNOG00000007917.
GeneIDi29333.
KEGGirno:29333.

Organism-specific databases

CTDi4179.
RGDi3061. Cd46.

Phylogenomic databases

eggNOGiENOG410IY7G. Eukaryota.
ENOG4111CPD. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000113502.
HOVERGENiHBG006335.
InParanoidiQ9Z0M4.
KOiK04007.
OMAiFEAMELK.
OrthoDBiEOG091G0DWA.
PhylomeDBiQ9Z0M4.

Enzyme and pathway databases

ReactomeiR-RNO-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiQ9Z0M4.

Gene expression databases

BgeeiENSRNOG00000007917.
GenevisibleiQ9Z0M4. RN.

Family and domain databases

InterProiIPR017341. CD46.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
PIRSFiPIRSF037971. TLX_CD46. 1 hit.
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCP_RAT
AccessioniPrimary (citable) accession number: Q9Z0M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.