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Protein
Submitted name:

Aldosterone synthase

Gene

CYP11B2

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Aldosterone synthaseImported (EC:1.14.15.4Imported)
Gene namesi
Name:CYP11B2Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9Z0M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000013161.
HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRLKADTR LAGSWLRLRG ARALGTRAVM GPKATVLPFE AIPQYLGNKW
60 70 80 90 100
LRVLQIWKDQ GIEDIHLEMH RTFQELGPIF RYDVGRRQMV CVMLPEDAER
110 120 130 140 150
LHRAESLYPC RMHLEPWMAY REHRGQKPGV FLLNGPEWRY NRLRLNPNVL
160 170 180 190 200
SPKAVQKFLP MVDTVARDFS DALKEKVLQS GQGSLTLDIQ PSIFNYTIEA
210 220 230 240 250
SNFALFGERL GLFGHNPSTD SLDFTRALHA MLKSTGKLMF LPRSLSRWMS
260 270 280 290 300
SQVWKEHFEA WDYIFDYADS WIQKTYQKLV CSYPQYYSGI MADLLLQGDL
310 320 330 340 350
SVNAIKANSI ELTAGSVDTT AFPLMMTLFE LARNSTMQQA LHQESVAAEP
360 370 380 390 400
IISVDPQRAT TELPLLRAAL KETLRLYPVG LFLERILSSD LVLQNYHIPA
410 420 430 440 450
GTLVHLYLYS MGRNPAMFLS PELYNPQRWL DNRQTFHHLA FGFGVRQCLG
460 470 480 490 500
RRLAEVEMLL LLHHILKSFH VEAPLQEDVK FSYHFVLMPT SFPLLTFRPV

F
Length:501
Mass (Da):57,723
Last modified:May 1, 1999 - v1
Checksum:iFD01D6AEEC57E12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018569 mRNA. Translation: AAD01633.1.
RefSeqiNP_001166566.1. NM_001173095.1.

Genome annotation databases

GeneIDi100379213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018569 mRNA. Translation: AAD01633.1.
RefSeqiNP_001166566.1. NM_001173095.1.

3D structure databases

ProteinModelPortaliQ9Z0M2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100379213.

Organism-specific databases

CTDi1585.

Phylogenomic databases

HOGENOMiHOG000013161.
HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9Z0M2_CAVPO
AccessioniPrimary (citable) accession number: Q9Z0M2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.