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Q9Z0M1

- Q9Z0M1_MOUSE

UniProt

Q9Z0M1 - Q9Z0M1_MOUSE

Protein
Submitted name:

Enamel matrix serine proteinase 1

Gene

Klk4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. amelogenesis Source: MGI
    2. extracellular matrix disassembly Source: MGI
    3. protein catabolic process Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotation

    Protein family/group databases

    MEROPSiS01.251.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Enamel matrix serine proteinase 1Imported
    Submitted name:
    Kallikrein 1-related peptidase-like b4Imported
    Submitted name:
    Kallikrein 4 (Prostase, enamel matrix, prostate)Imported
    Submitted name:
    Kallikrein related-peptidase 4 (Prostase, enamel matrix, prostate)Imported
    Gene namesi
    Name:Klk4Imported
    ORF Names:mCG_22153Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1861379. Klk4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 PotentialImportedAdd
    BLAST
    Chaini26 – 255230 PotentialImportedPRO_5000053390Add
    BLAST
    Chaini32 – 255224matrix serine proteinase 1ImportedPRO_5000053391Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z0M1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S1 family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    GeneTreeiENSGT00750000117409.
    HOVERGENiHBG013304.
    InParanoidiQ9Z0M1.
    KOiK08666.
    OMAiASEETCR.
    OrthoDBiEOG75B84T.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVTARTPWG WFLGCLILEV TGASASSVSS RIIQGQDCSP HSQPWQAALF    50
    SEDGFFCSGV LVHPQWVLSA AHCLQESYIV GLGLHNLKGS QEPGSRMLEA 100
    HLSIQHPNFN DPSFANDLML IKLNESVIES NTIRSIPVAT QCPTPGDTCL 150
    VSGWGQLKNG KLPSLLQCVN LSVASEETCR LLYDPVYHLS MFCAGGGQDQ 200
    KDSCNGDSGG PIVCNRSLQG LVSMGQGKCG QPGIPSVYTN LCKFTNWIQT 250
    IIQTN 255
    Length:255
    Mass (Da):27,488
    Last modified:May 1, 1999 - v1
    Checksum:i6FD2E7DEA0660A2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134858 Genomic DNA. No translation available.
    AF019979 mRNA. Translation: AAC98894.1.
    BC100716 mRNA. Translation: AAI00717.1.
    BC100717 mRNA. Translation: AAI00718.1.
    BC100718 mRNA. Translation: AAI00719.1.
    BC100719 mRNA. Translation: AAI00720.1.
    CH466603 Genomic DNA. Translation: EDL22687.1.
    RefSeqiNP_064312.1. NM_019928.1.
    UniGeneiMm.42080.

    Genome annotation databases

    EnsembliENSMUST00000007161; ENSMUSP00000007161; ENSMUSG00000006948.
    GeneIDi56640.
    KEGGimmu:56640.
    UCSCiuc009gny.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134858 Genomic DNA. No translation available.
    AF019979 mRNA. Translation: AAC98894.1 .
    BC100716 mRNA. Translation: AAI00717.1 .
    BC100717 mRNA. Translation: AAI00718.1 .
    BC100718 mRNA. Translation: AAI00719.1 .
    BC100719 mRNA. Translation: AAI00720.1 .
    CH466603 Genomic DNA. Translation: EDL22687.1 .
    RefSeqi NP_064312.1. NM_019928.1.
    UniGenei Mm.42080.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007161 ; ENSMUSP00000007161 ; ENSMUSG00000006948 .
    GeneIDi 56640.
    KEGGi mmu:56640.
    UCSCi uc009gny.1. mouse.

    Organism-specific databases

    CTDi 9622.
    MGIi MGI:1861379. Klk4.

    Phylogenomic databases

    GeneTreei ENSGT00750000117409.
    HOVERGENi HBG013304.
    InParanoidi Q9Z0M1.
    KOi K08666.
    OMAi ASEETCR.
    OrthoDBi EOG75B84T.
    TreeFami TF331065.

    Miscellaneous databases

    NextBioi 313085.
    PROi Q9Z0M1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9Z0M1.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Enamel Matrix Serine Proteinase 1 (EMSP1)."
      Simmer J.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Swiss-WebsterImported.
    2. "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors."
      Hu J.C.-C., Zhang C., Sun X., Yang Y., Cao X., Ryu O., Simmer J.P.
      Gene 251:1-8(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Swiss-WebsterImported.
    3. "Localization of EMSP1 expression during tooth formation and cloning of mouse cDNA."
      Hu J.C.-C., Ryu O.H., Chen J.J., Uchida T., Wakida K., Murakami C., Jiang H., Qian Q., Zhang C., Ottmers V., Bartlett J.D., Simmer J.P.
      J. Dent. Res. 79:70-76(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Swiss-WebsterImported.
    4. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    8. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9Z0M1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0M1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3