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Q9Z0L6

- Q9Z0L6_MOUSE

UniProt

Q9Z0L6 - Q9Z0L6_MOUSE

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Protein
Submitted name:

Parathyroid hormone

Gene

Pth

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. cellular calcium ion homeostasis Source: MGI
  4. cellular macromolecule biosynthetic process Source: MGI
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of bone mineralization Source: Ensembl
  7. positive regulation of cAMP biosynthetic process Source: MGI
  8. positive regulation of glucose import Source: Ensembl
  9. positive regulation of glycogen biosynthetic process Source: Ensembl
  10. positive regulation of signal transduction Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. regulation of gene expression Source: MGI
  13. response to cadmium ion Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to ethanol Source: Ensembl
  16. response to fibroblast growth factor Source: Ensembl
  17. response to lead ion Source: Ensembl
  18. response to parathyroid hormone Source: Ensembl
  19. response to vitamin D Source: Ensembl
  20. Rho protein signal transduction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Parathyroid hormoneImported
Submitted name:
Protein PthImported
Gene namesi
Name:PthImported
ORF Names:mCG_15838Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:97799. Pth.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 11590 PotentialImportedPRO_5000054331Add
BLAST
Chaini32 – 11584parathyroid hormoneImportedPRO_5000054332Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ9Z0L6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078723.

Family & Domainsi

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiNOG41709.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG7ZGX5Q.
TreeFamiTF336197.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541. PTHR10541. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSANTVAKV MIIMLAVCLL TQTDGKPVRK RAVSEIQLMH NLGKHLASME
60 70 80 90 100
RMQWLRRKLQ DMHNFVSLGV QMAARDGSHQ KPTKKEENVL VDGNPKSLGE
110
GDKADVDVLV KSKSQ
Length:115
Mass (Da):12,825
Last modified:May 1, 1999 - v1
Checksum:iDA43FABBCB4E2FD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156987 Genomic DNA. No translation available.
AF066075 Genomic DNA. Translation: AAC99656.1.
BC099456 mRNA. Translation: AAH99456.1.
AK138677 mRNA. Translation: BAE23743.1.
CH466531 Genomic DNA. Translation: EDL17048.1.
RefSeqiNP_065648.1. NM_020623.2.
UniGeneiMm.284168.

Genome annotation databases

EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077.
GeneIDi19226.
KEGGimmu:19226.
UCSCiuc009jhm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156987 Genomic DNA. No translation available.
AF066075 Genomic DNA. Translation: AAC99656.1 .
BC099456 mRNA. Translation: AAH99456.1 .
AK138677 mRNA. Translation: BAE23743.1 .
CH466531 Genomic DNA. Translation: EDL17048.1 .
RefSeqi NP_065648.1. NM_020623.2.
UniGenei Mm.284168.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000078723.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079793 ; ENSMUSP00000078723 ; ENSMUSG00000059077 .
GeneIDi 19226.
KEGGi mmu:19226.
UCSCi uc009jhm.1. mouse.

Organism-specific databases

CTDi 5741.
MGIi MGI:97799. Pth.

Phylogenomic databases

eggNOGi NOG41709.
GeneTreei ENSGT00390000018603.
HOGENOMi HOG000033707.
HOVERGENi HBG008319.
KOi K05261.
OMAi EIQFMHN.
OrthoDBi EOG7ZGX5Q.
TreeFami TF336197.

Miscellaneous databases

NextBioi 296016.
PROi Q9Z0L6.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9Z0L6.

Family and domain databases

InterProi IPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view ]
PANTHERi PTHR10541. PTHR10541. 1 hit.
Pfami PF01279. Parathyroid. 1 hit.
[Graphical view ]
PIRSFi PIRSF001832. PTH. 1 hit.
SMARTi SM00087. PTH. 1 hit.
[Graphical view ]
PROSITEi PS00335. PARATHYROID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the murine gene encoding parathyroid hormone: genomic organization and nucleotide sequence."
    Karaplis A.C., He B., Hiou-Tim F.F.T., Al-Akad B., Kronenberg H.M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  2. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ThyroidImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  14. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9Z0L6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3