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Q9Z0L6

- Q9Z0L6_MOUSE

UniProt

Q9Z0L6 - Q9Z0L6_MOUSE

Protein
Submitted name:

Parathyroid hormone

Gene

Pth

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. hormone activity Source: MGI
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. cell-cell signaling Source: Ensembl
    3. cellular calcium ion homeostasis Source: MGI
    4. cellular macromolecule biosynthetic process Source: MGI
    5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. positive regulation of bone mineralization Source: Ensembl
    7. positive regulation of cAMP biosynthetic process Source: MGI
    8. positive regulation of glucose import Source: Ensembl
    9. positive regulation of glycogen biosynthetic process Source: Ensembl
    10. positive regulation of signal transduction Source: MGI
    11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    12. regulation of gene expression Source: MGI
    13. response to cadmium ion Source: Ensembl
    14. response to drug Source: Ensembl
    15. response to ethanol Source: Ensembl
    16. response to fibroblast growth factor Source: Ensembl
    17. response to lead ion Source: Ensembl
    18. response to parathyroid hormone Source: Ensembl
    19. response to vitamin D Source: Ensembl
    20. Rho protein signal transduction Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Parathyroid hormoneImported
    Submitted name:
    Protein PthImported
    Gene namesi
    Name:PthImported
    ORF Names:mCG_15838Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:97799. Pth.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 PotentialImportedAdd
    BLAST
    Chaini26 – 11590 PotentialImportedPRO_5000054331Add
    BLAST
    Chaini32 – 11584parathyroid hormoneImportedPRO_5000054332Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z0L6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000078723.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiNOG41709.
    GeneTreeiENSGT00390000018603.
    HOGENOMiHOG000033707.
    HOVERGENiHBG008319.
    InParanoidiQ9Z0L6.
    KOiK05261.
    OMAiEIQFMHN.
    OrthoDBiEOG7ZGX5Q.
    TreeFamiTF336197.

    Family and domain databases

    InterProiIPR003625. PTH.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR10541. PTHR10541. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001832. PTH. 1 hit.
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSANTVAKV MIIMLAVCLL TQTDGKPVRK RAVSEIQLMH NLGKHLASME    50
    RMQWLRRKLQ DMHNFVSLGV QMAARDGSHQ KPTKKEENVL VDGNPKSLGE 100
    GDKADVDVLV KSKSQ 115
    Length:115
    Mass (Da):12,825
    Last modified:May 1, 1999 - v1
    Checksum:iDA43FABBCB4E2FD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156987 Genomic DNA. No translation available.
    AF066075 Genomic DNA. Translation: AAC99656.1.
    BC099456 mRNA. Translation: AAH99456.1.
    AK138677 mRNA. Translation: BAE23743.1.
    CH466531 Genomic DNA. Translation: EDL17048.1.
    RefSeqiNP_065648.1. NM_020623.2.
    UniGeneiMm.284168.

    Genome annotation databases

    EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077.
    GeneIDi19226.
    KEGGimmu:19226.
    UCSCiuc009jhm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156987 Genomic DNA. No translation available.
    AF066075 Genomic DNA. Translation: AAC99656.1 .
    BC099456 mRNA. Translation: AAH99456.1 .
    AK138677 mRNA. Translation: BAE23743.1 .
    CH466531 Genomic DNA. Translation: EDL17048.1 .
    RefSeqi NP_065648.1. NM_020623.2.
    UniGenei Mm.284168.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000078723.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079793 ; ENSMUSP00000078723 ; ENSMUSG00000059077 .
    GeneIDi 19226.
    KEGGi mmu:19226.
    UCSCi uc009jhm.1. mouse.

    Organism-specific databases

    CTDi 5741.
    MGIi MGI:97799. Pth.

    Phylogenomic databases

    eggNOGi NOG41709.
    GeneTreei ENSGT00390000018603.
    HOGENOMi HOG000033707.
    HOVERGENi HBG008319.
    InParanoidi Q9Z0L6.
    KOi K05261.
    OMAi EIQFMHN.
    OrthoDBi EOG7ZGX5Q.
    TreeFami TF336197.

    Miscellaneous databases

    NextBioi 296016.
    PROi Q9Z0L6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9Z0L6.

    Family and domain databases

    InterProi IPR003625. PTH.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR10541. PTHR10541. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001832. PTH. 1 hit.
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the murine gene encoding parathyroid hormone: genomic organization and nucleotide sequence."
      Karaplis A.C., He B., Hiou-Tim F.F.T., Al-Akad B., Kronenberg H.M.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    2. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ThyroidImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    14. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9Z0L6_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0L6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3