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Protein

Parathyroid hormone

Gene

Pth

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormoneUniRule annotation
Short name:
PTHUniRule annotation
Gene namesi
Name:PthImported
ORF Names:mCG_15838Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97799. Pth.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501112976126 – 115Parathyroid hormoneUniRule annotationAdd BLAST90

Expressioni

Gene expression databases

BgeeiENSMUSG00000059077.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078723.

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
GeneTreeiENSGT00390000018603.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
KOiK05261.
OMAiEIQFMHN.
OrthoDBiEOG091G13ZF.
TreeFamiTF336197.

Family and domain databases

InterProiView protein in InterPro
IPR003625. PTH.
IPR001415. PTH/PTH-rel.
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiView protein in Pfam
PF01279. Parathyroid. 1 hit.
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiView protein in SMART
SM00087. PTH. 1 hit.
PROSITEiView protein in PROSITE
PS00335. PARATHYROID. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSANTVAKV MIIMLAVCLL TQTDGKPVRK RAVSEIQLMH NLGKHLASME
60 70 80 90 100
RMQWLRRKLQ DMHNFVSLGV QMAARDGSHQ KPTKKEENVL VDGNPKSLGE
110
GDKADVDVLV KSKSQ
Length:115
Mass (Da):12,825
Last modified:May 1, 1999 - v1
Checksum:iDA43FABBCB4E2FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156987 Genomic DNA. No translation available.
AH007117 Genomic DNA. Translation: AAC99656.1.
BC099456 mRNA. Translation: AAH99456.1.
AK138677 mRNA. Translation: BAE23743.1.
CH466531 Genomic DNA. Translation: EDL17048.1.
RefSeqiNP_065648.1. NM_020623.2.
UniGeneiMm.284168.

Genome annotation databases

EnsembliENSMUST00000079793; ENSMUSP00000078723; ENSMUSG00000059077.
GeneIDi19226.
KEGGimmu:19226.
UCSCiuc009jhm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ9Z0L6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported