Q9Z0L5 (Q9Z0L5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Epiregulin EMBL AAD10631.1

Submitted name:
Protein Ereg Ensembl ENSRNOP00000003716

Gene names

Name:	Ereg Ensembl ENSRNOP00000003716 RGD 620299 EMBL EDL88580.1
ORF Names:	rCG_60401 EMBL EDL88580.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Signal EMBL AAD10631.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Inferred from sequence or structural similarity. Source: UniProtKB cytokine-mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB epidermal growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB female meiosis Inferred from direct assay PubMed 15459120. Source: UniProtKB keratinocyte proliferation Inferred from sequence or structural similarity. Source: UniProtKB luteinizing hormone signaling pathway Inferred from direct assay PubMed 15459120. Source: UniProtKB mRNA transcription Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of smooth muscle cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB oocyte maturation Inferred from direct assay PubMed 15459120. Source: UniProtKB ovarian cumulus expansion Inferred from direct assay PubMed 15459120. Source: UniProtKB ovulation Inferred from direct assay PubMed 15459120. Source: UniProtKB positive regulation of DNA replication Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of angiogenesis Traceable author statement Ref.1. Source: UniProtKB positive regulation of cytokine production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of epidermal growth factor-activated receptor activity Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of fibroblast proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of innate immune response Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of interleukin-6 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of mitosis Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of smooth muscle cell proliferation Inferred from direct assay Ref.1. Source: UniProtKB primary follicle stage Inferred from direct assay PubMed 15459120. Source: UniProtKB response to peptide hormone stimulus Inferred from expression pattern PubMed 15459120. Source: RGD
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	epidermal growth factor receptor binding Inferred from sequence or structural similarity. Source: UniProtKB growth factor activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential EMBL AAD10631.1
	Chain	23 – 162	140	Potential EMBL AAD10631.1		PRO_5000054710
	Chain	56 – 101	46	epiregulin EMBL AAD10631.1		PRO_5000054711

Sequences

	Sequence		Length	Mass (Da)
	Q9Z0L5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EA660DE2B34990C4	FASTA	162	18,404
	10 20 30 40 50 60 METFPAAWVL ALLCLGSHLL QAVISTTVIP SCIPEESEDN CTALVQMEDD PRVAQVLITK 70 80 90 100 110 120 CSSDMDGYCL HGHCIYLVDM SEKYCRCEVG YTGLRCEHFF LTVHQPLSRE YVALTVILVF 130 140 150 160 LFLIVTAGSM YYFCRWYRNR KSKKSREEYE RVTSGGPGLP QV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin." Taylor D.S., Cheng X., Pawlowski J.E., Wallace A.R., Ferrer P., Molloy C.J. Proc. Natl. Acad. Sci. U.S.A. 96:1633-1638(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aortic smooth muscle EMBL AAD10631.1.
[2]	"Transcriptional regulation of the epiregulin gene in the rat ovary." Sekiguchi T., Mizutani T., Yamada K., Yazawa T., Kawata H., Yoshino M., Kajitani T., Kameda T., Minegishi T., Miyamoto K. Endocrinology 143:4718-4729(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL BAC44880.1.
[3]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000003716.
[4]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL88580.1.
[5]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL88580.1.
[6]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000003716.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06077841 Genomic DNA. No translation available. AF074952 mRNA. Translation: AAD10631.1. AB078739 Genomic DNA. Translation: BAC44880.1. CH474060 Genomic DNA. Translation: EDL88580.1.
IPI	IPI00326730.
RefSeq	NP_067721.1. NM_021689.1.
UniGene	Rn.42897.
3D structure databases
HSSP	HSSP built from PDB template 1K37 based on UniProtKB O14944.
SMR	Q9Z0L5. Positions 56-101.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003716; ENSRNOP00000003716; ENSRNOG00000002771.
GeneID	59325.
KEGG	rno:59325.
UCSC	RGD:620299. rat.
Organism-specific databases
CTD	2069.
RGD	620299. Ereg.
Phylogenomic databases
GeneTree	ENSGT00510000048748.
HOGENOM	HOG000059635.
HOVERGEN	HBG005601.
InParanoid	Q9Z0L5.
KO	K09784.
OMA	TEDNPRV.
Gene expression databases
Genevestigator	Q9Z0L5.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. [Graphical view]
Pfam	PF00008. EGF. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	611917.

Entry information

Entry name

Q9Z0L5_RAT

Accession

Primary (citable) accession number: Q9Z0L5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)