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Protein

Bone morphogenetic protein 15

Gene

Bmp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 15
Short name:
BMP-15
Alternative name(s):
Growth/differentiation factor 9B
Short name:
GDF-9B
Gene namesi
Name:Bmp15
Synonyms:Gdf9b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1316745. Bmp15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 267242By similarityPRO_0000033894Add
BLAST
Chaini268 – 392125Bone morphogenetic protein 15PRO_0000033895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis
Modified residuei268 – 2681Pyrrolidone carboxylic acidBy similarity
Disulfide bondi291 ↔ 357By similarity
Disulfide bondi320 ↔ 389By similarity
Disulfide bondi324 ↔ 391By similarity
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9Z0L4.
PRIDEiQ9Z0L4.

PTM databases

PhosphoSiteiQ9Z0L4.

Expressioni

Tissue specificityi

Ovary specific.

Gene expression databases

BgeeiQ9Z0L4.
CleanExiMM_BMP15.
GenevisibleiQ9Z0L4. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). But, in contrast to other members of this family, cannot be disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024049.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0L4.
SMRiQ9Z0L4. Positions 290-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000095242.
HOVERGENiHBG004660.
InParanoidiQ9Z0L4.
KOiK05498.
OMAiNQCSLHP.
OrthoDBiEOG70W3DJ.
PhylomeDBiQ9Z0L4.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR015923. BMP-15.
IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF22. PTHR11848:SF22. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLTILRIL LWGVVLFMEQ RVQMAKPGWP STALLADDPT LPSILDLAKE
60 70 80 90 100
APGKEMKQWP QGYPLRYMLK LYHRSADPHG HPRENRTIGA KMVRLVKPSA
110 120 130 140 150
NTVRPPRGSW HVQTLDFPLA SNQVAYELIR ATVVYRHQLH LVNYHLSCHV
160 170 180 190 200
ETWVPKCRTK HLPSSKSGSS KPSPMSKAWT EIDITHCIQQ KLWNRKGRSV
210 220 230 240 250
LRLRFMCQQQ KGNETREFRW HGMTSLDVAF LLLYFNDTDD RVQGKLLARG
260 270 280 290 300
QEELTDRESS FLMRSVRQAC SIESDASCPS QEHDGSVNNQ CSLHPYKVSF
310 320 330 340 350
HQLGWDHWII APRLYTPNYC KGICTRVLPY GLNSPNHAII QSLVNELVNH
360 370 380 390
SVPQPSCVPY NFLPMSILLI ETNGSILYKE YEGMIAQSCT CR
Length:392
Mass (Da):44,898
Last modified:May 1, 1999 - v1
Checksum:iCA9467FD0AA5737E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082348 mRNA. Translation: AAC99766.1.
AJ010259 mRNA. Translation: CAA09053.1.
AJ132406 mRNA. Translation: CAB40966.1.
AK028735 mRNA. Translation: BAC26090.1.
AK135757 mRNA. Translation: BAE22642.1.
AK139773 mRNA. Translation: BAE24134.1.
BC055363 mRNA. Translation: AAH55363.1.
CCDSiCCDS29958.1.
RefSeqiNP_033887.1. NM_009757.4.
UniGeneiMm.42160.

Genome annotation databases

EnsembliENSMUST00000024049; ENSMUSP00000024049; ENSMUSG00000023279.
GeneIDi12155.
KEGGimmu:12155.
UCSCiuc009skx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082348 mRNA. Translation: AAC99766.1.
AJ010259 mRNA. Translation: CAA09053.1.
AJ132406 mRNA. Translation: CAB40966.1.
AK028735 mRNA. Translation: BAC26090.1.
AK135757 mRNA. Translation: BAE22642.1.
AK139773 mRNA. Translation: BAE24134.1.
BC055363 mRNA. Translation: AAH55363.1.
CCDSiCCDS29958.1.
RefSeqiNP_033887.1. NM_009757.4.
UniGeneiMm.42160.

3D structure databases

ProteinModelPortaliQ9Z0L4.
SMRiQ9Z0L4. Positions 290-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024049.

PTM databases

PhosphoSiteiQ9Z0L4.

Proteomic databases

PaxDbiQ9Z0L4.
PRIDEiQ9Z0L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024049; ENSMUSP00000024049; ENSMUSG00000023279.
GeneIDi12155.
KEGGimmu:12155.
UCSCiuc009skx.2. mouse.

Organism-specific databases

CTDi9210.
MGIiMGI:1316745. Bmp15.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000095242.
HOVERGENiHBG004660.
InParanoidiQ9Z0L4.
KOiK05498.
OMAiNQCSLHP.
OrthoDBiEOG70W3DJ.
PhylomeDBiQ9Z0L4.
TreeFamiTF316134.

Miscellaneous databases

NextBioi280495.
PROiQ9Z0L4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0L4.
CleanExiMM_BMP15.
GenevisibleiQ9Z0L4. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR015923. BMP-15.
IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF22. PTHR11848:SF22. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes."
    Dube J.L., Wang P., Elvin J., Lyons K.M., Celeste A.J., Matzuk M.M.
    Mol. Endocrinol. 12:1809-1817(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X 129/Sv.
    Tissue: Ovary.
  2. "A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis."
    Laitinen M., Vuojolainen K., Jaatinen R., Ketola I., Aaltonen J., Lehtonen E., Heikinheimo M., Ritvos O.
    Mech. Dev. 78:135-140(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-392.
    Strain: NMRI.
    Tissue: Ovary.
  3. "Localization of growth differentiation factor-9 (GDF-9) mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B."
    Jaatinen R., Laitinen M.P., Vuojolainen K., Aaltonen J., Louhio H., Heikinheimo K., Lehtonen E., Ritvos O.
    Mol. Cell. Endocrinol. 156:189-193(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Ovary.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg and Skin.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiBMP15_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L4
Secondary accession number(s): Q3UT46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.