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Protein

Artemin

Gene

Artn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.By similarity1 Publication

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • axon guidance Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • induction of positive chemotaxis Source: MGI
  • lymphocyte migration into lymphoid organs Source: UniProtKB
  • peripheral nervous system development Source: MGI
  • Peyer's patch morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Artemin
Gene namesi
Name:Artn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333791. Artn.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
PropeptideiPRO_000024028840 – 111Sequence analysisAdd BLAST72
ChainiPRO_0000240289112 – 224ArteminAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi127 ↔ 192By similarity
Disulfide bondi154 ↔ 220By similarity
Disulfide bondi158 ↔ 222By similarity
Disulfide bondi191InterchainBy similarity
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0L2.
PeptideAtlasiQ9Z0L2.
PRIDEiQ9Z0L2.

PTM databases

PhosphoSitePlusiQ9Z0L2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028539.
CleanExiMM_ARTN.
GenevisibleiQ9Z0L2. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Binds to RET.By similarity

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor binding Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi198213. 1 interactor.
STRINGi10090.ENSMUSP00000064521.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0L2.
SMRiQ9Z0L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 101Pro-richAdd BLAST59

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ9Z0L2.
OMAiISQPCCR.
OrthoDBiEOG091G0L16.
PhylomeDBiQ9Z0L2.
TreeFamiTF332366.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0L2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA
60 70 80 90 100
RDGPSPVLAP PTDHLPGGHT AHLCSERTLR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Length:224
Mass (Da):23,726
Last modified:May 1, 1999 - v1
Checksum:i3328FB794581DF0B
GO
Isoform 2 (identifier: Q9Z0L2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: GGHTAHLCSERTL → AGYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:79
Mass (Da):8,332
Checksum:i46E0B1FCC18A06E1
GO
Isoform 3 (identifier: Q9Z0L2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     67-79: GGHTAHLCSERTL → GYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:35
Mass (Da):3,544
Checksum:iEF371EAEDD356812
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193371 – 43Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_01933867 – 79GGHTA…SERTL → AGYGGCRAQAPGR in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_01933967 – 79GGHTA…SERTL → GYGGCRAQAPGR in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_01934080 – 224Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA. Translation: AAC98691.1.
AK015393 mRNA. Translation: BAB29827.1.
AK053914 mRNA. Translation: BAC35590.1.
AK156507 mRNA. Translation: BAE33737.1.
BC104328 mRNA. Translation: AAI04329.1.
BC104329 mRNA. Translation: AAI04330.1.
CCDSiCCDS18543.1. [Q9Z0L2-1]
RefSeqiNP_001271120.1. NM_001284191.1. [Q9Z0L2-1]
NP_001271121.1. NM_001284192.1.
NP_001271122.1. NM_001284193.1. [Q9Z0L2-1]
NP_033841.1. NM_009711.4. [Q9Z0L2-1]
XP_006502753.1. XM_006502690.3. [Q9Z0L2-1]
XP_006502754.1. XM_006502691.3. [Q9Z0L2-1]
XP_006502755.1. XM_006502692.3. [Q9Z0L2-1]
XP_006502756.1. XM_006502693.3. [Q9Z0L2-1]
XP_011238721.1. XM_011240419.2. [Q9Z0L2-1]
UniGeneiMm.56897.

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539. [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539. [Q9Z0L2-1]
GeneIDi11876.
KEGGimmu:11876.
UCSCiuc008ujh.2. mouse. [Q9Z0L2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA. Translation: AAC98691.1.
AK015393 mRNA. Translation: BAB29827.1.
AK053914 mRNA. Translation: BAC35590.1.
AK156507 mRNA. Translation: BAE33737.1.
BC104328 mRNA. Translation: AAI04329.1.
BC104329 mRNA. Translation: AAI04330.1.
CCDSiCCDS18543.1. [Q9Z0L2-1]
RefSeqiNP_001271120.1. NM_001284191.1. [Q9Z0L2-1]
NP_001271121.1. NM_001284192.1.
NP_001271122.1. NM_001284193.1. [Q9Z0L2-1]
NP_033841.1. NM_009711.4. [Q9Z0L2-1]
XP_006502753.1. XM_006502690.3. [Q9Z0L2-1]
XP_006502754.1. XM_006502691.3. [Q9Z0L2-1]
XP_006502755.1. XM_006502692.3. [Q9Z0L2-1]
XP_006502756.1. XM_006502693.3. [Q9Z0L2-1]
XP_011238721.1. XM_011240419.2. [Q9Z0L2-1]
UniGeneiMm.56897.

3D structure databases

ProteinModelPortaliQ9Z0L2.
SMRiQ9Z0L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198213. 1 interactor.
STRINGi10090.ENSMUSP00000064521.

PTM databases

PhosphoSitePlusiQ9Z0L2.

Proteomic databases

PaxDbiQ9Z0L2.
PeptideAtlasiQ9Z0L2.
PRIDEiQ9Z0L2.

Protocols and materials databases

DNASUi11876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539. [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539. [Q9Z0L2-1]
GeneIDi11876.
KEGGimmu:11876.
UCSCiuc008ujh.2. mouse. [Q9Z0L2-1]

Organism-specific databases

CTDi9048.
MGIiMGI:1333791. Artn.

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ9Z0L2.
OMAiISQPCCR.
OrthoDBiEOG091G0L16.
PhylomeDBiQ9Z0L2.
TreeFamiTF332366.

Enzyme and pathway databases

ReactomeiR-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-8853659. RET signaling.

Miscellaneous databases

PROiQ9Z0L2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028539.
CleanExiMM_ARTN.
GenevisibleiQ9Z0L2. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARTN_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L2
Secondary accession number(s): Q3SXF4, Q3SXF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.