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Protein

Artemin

Gene

Artn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.By similarity1 Publication

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • axon guidance Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • induction of positive chemotaxis Source: MGI
  • lymphocyte migration into lymphoid organs Source: UniProtKB
  • peripheral nervous system development Source: MGI
  • Peyer's patch morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Artemin
Gene namesi
Name:Artn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333791. Artn.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Propeptidei40 – 11172Sequence analysisPRO_0000240288Add
BLAST
Chaini112 – 224113ArteminPRO_0000240289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi127 ↔ 192By similarity
Disulfide bondi154 ↔ 220By similarity
Disulfide bondi158 ↔ 222By similarity
Disulfide bondi191 – 191InterchainBy similarity
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z0L2.
PRIDEiQ9Z0L2.

Expressioni

Gene expression databases

BgeeiQ9Z0L2.
CleanExiMM_ARTN.
GenevisibleiQ9Z0L2. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Binds to RET.By similarity

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor binding Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi198213. 1 interaction.
STRINGi10090.ENSMUSP00000064521.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0L2.
SMRiQ9Z0L2. Positions 124-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 10159Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ9Z0L2.
OMAiISQPCCR.
OrthoDBiEOG7TXKK8.
PhylomeDBiQ9Z0L2.
TreeFamiTF332366.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z0L2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGLAEPTA LSHCLRPRWQ SAWWPTLAVL ALLSCVTEAS LDPMSRSPAA
60 70 80 90 100
RDGPSPVLAP PTDHLPGGHT AHLCSERTLR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR TTDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSQHDLSLA SLLGAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Length:224
Mass (Da):23,726
Last modified:May 1, 1999 - v1
Checksum:i3328FB794581DF0B
GO
Isoform 2 (identifier: Q9Z0L2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: GGHTAHLCSERTL → AGYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:79
Mass (Da):8,332
Checksum:i46E0B1FCC18A06E1
GO
Isoform 3 (identifier: Q9Z0L2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     67-79: GGHTAHLCSERTL → GYGGCRAQAPGR
     80-224: Missing.

Note: No experimental confirmation available.
Show »
Length:35
Mass (Da):3,544
Checksum:iEF371EAEDD356812
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 3. 1 PublicationVSP_019337Add
BLAST
Alternative sequencei67 – 7913GGHTA…SERTL → AGYGGCRAQAPGR in isoform 2. 1 PublicationVSP_019338Add
BLAST
Alternative sequencei67 – 7913GGHTA…SERTL → GYGGCRAQAPGR in isoform 3. 1 PublicationVSP_019339Add
BLAST
Alternative sequencei80 – 224145Missing in isoform 2 and isoform 3. 1 PublicationVSP_019340Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA. Translation: AAC98691.1.
AK015393 mRNA. Translation: BAB29827.1.
AK053914 mRNA. Translation: BAC35590.1.
AK156507 mRNA. Translation: BAE33737.1.
BC104328 mRNA. Translation: AAI04329.1.
BC104329 mRNA. Translation: AAI04330.1.
CCDSiCCDS18543.1. [Q9Z0L2-1]
RefSeqiNP_001271120.1. NM_001284191.1. [Q9Z0L2-1]
NP_001271121.1. NM_001284192.1.
NP_001271122.1. NM_001284193.1. [Q9Z0L2-1]
NP_033841.1. NM_009711.4. [Q9Z0L2-1]
XP_006502751.1. XM_006502688.2. [Q9Z0L2-1]
XP_006502752.1. XM_006502689.2. [Q9Z0L2-1]
XP_006502753.1. XM_006502690.2. [Q9Z0L2-1]
XP_006502754.1. XM_006502691.2. [Q9Z0L2-1]
XP_006502755.1. XM_006502692.2. [Q9Z0L2-1]
XP_006502756.1. XM_006502693.2. [Q9Z0L2-1]
XP_011238721.1. XM_011240419.1. [Q9Z0L2-1]
UniGeneiMm.56897.

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539. [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539. [Q9Z0L2-1]
GeneIDi11876.
KEGGimmu:11876.
UCSCiuc008ujh.2. mouse. [Q9Z0L2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109402 mRNA. Translation: AAC98691.1.
AK015393 mRNA. Translation: BAB29827.1.
AK053914 mRNA. Translation: BAC35590.1.
AK156507 mRNA. Translation: BAE33737.1.
BC104328 mRNA. Translation: AAI04329.1.
BC104329 mRNA. Translation: AAI04330.1.
CCDSiCCDS18543.1. [Q9Z0L2-1]
RefSeqiNP_001271120.1. NM_001284191.1. [Q9Z0L2-1]
NP_001271121.1. NM_001284192.1.
NP_001271122.1. NM_001284193.1. [Q9Z0L2-1]
NP_033841.1. NM_009711.4. [Q9Z0L2-1]
XP_006502751.1. XM_006502688.2. [Q9Z0L2-1]
XP_006502752.1. XM_006502689.2. [Q9Z0L2-1]
XP_006502753.1. XM_006502690.2. [Q9Z0L2-1]
XP_006502754.1. XM_006502691.2. [Q9Z0L2-1]
XP_006502755.1. XM_006502692.2. [Q9Z0L2-1]
XP_006502756.1. XM_006502693.2. [Q9Z0L2-1]
XP_011238721.1. XM_011240419.1. [Q9Z0L2-1]
UniGeneiMm.56897.

3D structure databases

ProteinModelPortaliQ9Z0L2.
SMRiQ9Z0L2. Positions 124-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198213. 1 interaction.
STRINGi10090.ENSMUSP00000064521.

Proteomic databases

PaxDbiQ9Z0L2.
PRIDEiQ9Z0L2.

Protocols and materials databases

DNASUi11876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070816; ENSMUSP00000064521; ENSMUSG00000028539. [Q9Z0L2-1]
ENSMUST00000097913; ENSMUSP00000095526; ENSMUSG00000028539. [Q9Z0L2-1]
GeneIDi11876.
KEGGimmu:11876.
UCSCiuc008ujh.2. mouse. [Q9Z0L2-1]

Organism-specific databases

CTDi9048.
MGIiMGI:1333791. Artn.

Phylogenomic databases

eggNOGiENOG410J0YD. Eukaryota.
ENOG4111W7C. LUCA.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG080137.
InParanoidiQ9Z0L2.
OMAiISQPCCR.
OrthoDBiEOG7TXKK8.
PhylomeDBiQ9Z0L2.
TreeFamiTF332366.

Enzyme and pathway databases

ReactomeiR-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiQ9Z0L2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0L2.
CleanExiMM_ARTN.
GenevisibleiQ9Z0L2. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex."
    Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., Leitner M.L., Araki T., Johnson E.M. Jr., Milbrandt J.
    Neuron 21:1291-1302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Oviduct, Spleen and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  4. "Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis."
    Veiga-Fernandes H., Coles M.C., Foster K.E., Patel A., Williams A., Natarajan D., Barlow A., Pachnis V., Kioussis D.
    Nature 446:547-551(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PEYER'S PATCH ORGANOGENESIS, INTERACTION WITH RET.

Entry informationi

Entry nameiARTN_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L2
Secondary accession number(s): Q3SXF4, Q3SXF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.