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Q9Z0L1

- S1PR4_MOUSE

UniProt

Q9Z0L1 - S1PR4_MOUSE

Protein

Sphingosine 1-phosphate receptor 4

Gene

S1pr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. sphingosine-1-phosphate receptor activity Source: InterPro

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine 1-phosphate receptor 4
    Short name:
    S1P receptor 4
    Short name:
    S1P4
    Alternative name(s):
    Endothelial differentiation G-protein coupled receptor 6
    Lysophospholipid receptor C1
    Sphingosine 1-phosphate receptor Edg-6
    Short name:
    S1P receptor Edg-6
    Gene namesi
    Name:S1pr4
    Synonyms:Edg6, Lpc1, S1p4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1333809. S1pr4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Sphingosine 1-phosphate receptor 4PRO_0000069432Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Lipidationi325 – 3251S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9Z0L1.
    PRIDEiQ9Z0L1.

    PTM databases

    PhosphoSiteiQ9Z0L1.

    Expressioni

    Tissue specificityi

    Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung.1 Publication

    Gene expression databases

    BgeeiQ9Z0L1.
    GenevestigatoriQ9Z0L1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0L1.
    SMRiQ9Z0L1. Positions 26-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularBy similarityAdd
    BLAST
    Topological domaini78 – 8710CytoplasmicBy similarity
    Topological domaini109 – 12012ExtracellularBy similarityAdd
    BLAST
    Topological domaini142 – 16322CytoplasmicBy similarityAdd
    BLAST
    Topological domaini185 – 20824ExtracellularBy similarityAdd
    BLAST
    Topological domaini230 – 25425CytoplasmicBy similarityAdd
    BLAST
    Topological domaini276 – 29015ExtracellularBy similarityAdd
    BLAST
    Topological domaini312 – 38675CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721Helical; Name=1By similarityAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=2By similarityAdd
    BLAST
    Transmembranei121 – 14121Helical; Name=3By similarityAdd
    BLAST
    Transmembranei164 – 18421Helical; Name=4By similarityAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5By similarityAdd
    BLAST
    Transmembranei255 – 27521Helical; Name=6By similarityAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150569.
    GeneTreeiENSGT00740000115422.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiQ9Z0L1.
    KOiK04293.
    OMAiRANGQKA.
    OrthoDBiEOG708W0B.
    PhylomeDBiQ9Z0L1.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004064. EDG6_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view]
    PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01526. EDG6RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z0L1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNISTWSTLV TPESCHRLAA SGHSLLIVLH YNHSGRLASR GGSEDGGGLG    50
    MLRGPSVAAG CLVVLENAMV LAAIAIYMRS RRWVYYCLLN ITLSDLLTGL 100
    AYVVNVLLSG TRTFQLSPVH WFLREGLLFM ALAASTFSLL FTAGERFATM 150
    VRVAESGATK TSRVYGCIGL CWLLAAILGL LPLLGWNCVC AFPRCSSLLP 200
    LYSKGYVLFC VVVFALILVA ILSLYGAIFR VVRANGQKSP RPPARRKSRR 250
    LLNTVLMILV AFVVCWGPLF GLLLADIFGS NVWAQEYLRG MDWILALAVF 300
    NSAINPLIYS FRSREVQRAV LAFLCCGCLW LGLRGPGDCL TRITEAHSGA 350
    STTDSSLRPR DSFRTSRSLS FRMREPLSSI SSVRST 386
    Length:386
    Mass (Da):42,263
    Last modified:May 1, 1999 - v1
    Checksum:i8AB32CB602BA9922
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461R → A in CAD33254. (PubMed:12401211)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006074 mRNA. Translation: CAA06847.1.
    AJ489247 Genomic DNA. Translation: CAD33254.1.
    AK154242 mRNA. Translation: BAE32458.1.
    BC107000 mRNA. Translation: AAI07001.1.
    CCDSiCCDS24059.1.
    RefSeqiNP_034232.1. NM_010102.2.
    UniGeneiMm.33065.

    Genome annotation databases

    EnsembliENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199.
    GeneIDi13611.
    KEGGimmu:13611.
    UCSCiuc007gih.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006074 mRNA. Translation: CAA06847.1 .
    AJ489247 Genomic DNA. Translation: CAD33254.1 .
    AK154242 mRNA. Translation: BAE32458.1 .
    BC107000 mRNA. Translation: AAI07001.1 .
    CCDSi CCDS24059.1.
    RefSeqi NP_034232.1. NM_010102.2.
    UniGenei Mm.33065.

    3D structure databases

    ProteinModelPortali Q9Z0L1.
    SMRi Q9Z0L1. Positions 26-321.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 278.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Z0L1.

    Proteomic databases

    PaxDbi Q9Z0L1.
    PRIDEi Q9Z0L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053646 ; ENSMUSP00000050412 ; ENSMUSG00000044199 .
    GeneIDi 13611.
    KEGGi mmu:13611.
    UCSCi uc007gih.2. mouse.

    Organism-specific databases

    CTDi 8698.
    MGIi MGI:1333809. S1pr4.

    Phylogenomic databases

    eggNOGi NOG150569.
    GeneTreei ENSGT00740000115422.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi Q9Z0L1.
    KOi K04293.
    OMAi RANGQKA.
    OrthoDBi EOG708W0B.
    PhylomeDBi Q9Z0L1.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 284262.
    PROi Q9Z0L1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z0L1.
    Genevestigatori Q9Z0L1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004064. EDG6_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view ]
    PANTHERi PTHR22750:SF13. PTHR22750:SF13. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01526. EDG6RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue."
      Graeler M.H., Bernhardt G., Lipp M.
      Genomics 53:164-169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Fetal skin.
    2. "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene."
      Contos J.J.A., Ye X., Sah V.P., Chun J.
      FEBS Lett. 531:99-102(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Dendritic cell.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiS1PR4_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0L1
    Secondary accession number(s): Q3U4H3, Q8C6E2, Q8K1R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3