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Protein

Sphingosine 1-phosphate receptor 4

Gene

S1pr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_232027. Lysosphingolipid and LPA receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 4
Short name:
S1P receptor 4
Short name:
S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Lysophospholipid receptor C1
Sphingosine 1-phosphate receptor Edg-6
Short name:
S1P receptor Edg-6
Gene namesi
Name:S1pr4
Synonyms:Edg6, Lpc1, S1p4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1333809. S1pr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularBy similarityAdd
BLAST
Transmembranei57 – 7721Helical; Name=1By similarityAdd
BLAST
Topological domaini78 – 8710CytoplasmicBy similarity
Transmembranei88 – 10821Helical; Name=2By similarityAdd
BLAST
Topological domaini109 – 12012ExtracellularBy similarityAdd
BLAST
Transmembranei121 – 14121Helical; Name=3By similarityAdd
BLAST
Topological domaini142 – 16322CytoplasmicBy similarityAdd
BLAST
Transmembranei164 – 18421Helical; Name=4By similarityAdd
BLAST
Topological domaini185 – 20824ExtracellularBy similarityAdd
BLAST
Transmembranei209 – 22921Helical; Name=5By similarityAdd
BLAST
Topological domaini230 – 25425CytoplasmicBy similarityAdd
BLAST
Transmembranei255 – 27521Helical; Name=6By similarityAdd
BLAST
Topological domaini276 – 29015ExtracellularBy similarityAdd
BLAST
Transmembranei291 – 31121Helical; Name=7By similarityAdd
BLAST
Topological domaini312 – 38675CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Sphingosine 1-phosphate receptor 4PRO_0000069432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Lipidationi325 – 3251S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9Z0L1.
PRIDEiQ9Z0L1.

PTM databases

PhosphoSiteiQ9Z0L1.

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung.1 Publication

Gene expression databases

BgeeiQ9Z0L1.
GenevestigatoriQ9Z0L1.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0L1.
SMRiQ9Z0L1. Positions 26-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150569.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0L1.
KOiK04293.
OMAiRANGQKA.
OrthoDBiEOG708W0B.
PhylomeDBiQ9Z0L1.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z0L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISTWSTLV TPESCHRLAA SGHSLLIVLH YNHSGRLASR GGSEDGGGLG
60 70 80 90 100
MLRGPSVAAG CLVVLENAMV LAAIAIYMRS RRWVYYCLLN ITLSDLLTGL
110 120 130 140 150
AYVVNVLLSG TRTFQLSPVH WFLREGLLFM ALAASTFSLL FTAGERFATM
160 170 180 190 200
VRVAESGATK TSRVYGCIGL CWLLAAILGL LPLLGWNCVC AFPRCSSLLP
210 220 230 240 250
LYSKGYVLFC VVVFALILVA ILSLYGAIFR VVRANGQKSP RPPARRKSRR
260 270 280 290 300
LLNTVLMILV AFVVCWGPLF GLLLADIFGS NVWAQEYLRG MDWILALAVF
310 320 330 340 350
NSAINPLIYS FRSREVQRAV LAFLCCGCLW LGLRGPGDCL TRITEAHSGA
360 370 380
STTDSSLRPR DSFRTSRSLS FRMREPLSSI SSVRST
Length:386
Mass (Da):42,263
Last modified:May 1, 1999 - v1
Checksum:i8AB32CB602BA9922
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461R → A in CAD33254 (PubMed:12401211).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006074 mRNA. Translation: CAA06847.1.
AJ489247 Genomic DNA. Translation: CAD33254.1.
AK154242 mRNA. Translation: BAE32458.1.
BC107000 mRNA. Translation: AAI07001.1.
CCDSiCCDS24059.1.
RefSeqiNP_034232.1. NM_010102.2.
UniGeneiMm.33065.

Genome annotation databases

EnsembliENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199.
GeneIDi13611.
KEGGimmu:13611.
UCSCiuc007gih.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006074 mRNA. Translation: CAA06847.1.
AJ489247 Genomic DNA. Translation: CAD33254.1.
AK154242 mRNA. Translation: BAE32458.1.
BC107000 mRNA. Translation: AAI07001.1.
CCDSiCCDS24059.1.
RefSeqiNP_034232.1. NM_010102.2.
UniGeneiMm.33065.

3D structure databases

ProteinModelPortaliQ9Z0L1.
SMRiQ9Z0L1. Positions 26-321.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi278.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z0L1.

Proteomic databases

PaxDbiQ9Z0L1.
PRIDEiQ9Z0L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199.
GeneIDi13611.
KEGGimmu:13611.
UCSCiuc007gih.2. mouse.

Organism-specific databases

CTDi8698.
MGIiMGI:1333809. S1pr4.

Phylogenomic databases

eggNOGiNOG150569.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9Z0L1.
KOiK04293.
OMAiRANGQKA.
OrthoDBiEOG708W0B.
PhylomeDBiQ9Z0L1.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiREACT_232027. Lysosphingolipid and LPA receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi284262.
PROiQ9Z0L1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z0L1.
GenevestigatoriQ9Z0L1.

Family and domain databases

InterProiIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue."
    Graeler M.H., Bernhardt G., Lipp M.
    Genomics 53:164-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Fetal skin.
  2. "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene."
    Contos J.J.A., Ye X., Sah V.P., Chun J.
    FEBS Lett. 531:99-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Dendritic cell.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiS1PR4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0L1
Secondary accession number(s): Q3U4H3, Q8C6E2, Q8K1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.