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Q9Z0L1 (S1PR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingosine 1-phosphate receptor 4

Short name=S1P receptor 4
Short name=S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Lysophospholipid receptor C1
Sphingosine 1-phosphate receptor Edg-6
Short name=S1P receptor Edg-6
Gene names
Name:S1pr4
Synonyms:Edg6, Lpc1, S1p4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Sphingosine 1-phosphate receptor 4
PRO_0000069432

Regions

Topological domain1 – 5656Extracellular By similarity
Transmembrane57 – 7721Helical; Name=1; By similarity
Topological domain78 – 8710Cytoplasmic By similarity
Transmembrane88 – 10821Helical; Name=2; By similarity
Topological domain109 – 12012Extracellular By similarity
Transmembrane121 – 14121Helical; Name=3; By similarity
Topological domain142 – 16322Cytoplasmic By similarity
Transmembrane164 – 18421Helical; Name=4; By similarity
Topological domain185 – 20824Extracellular By similarity
Transmembrane209 – 22921Helical; Name=5; By similarity
Topological domain230 – 25425Cytoplasmic By similarity
Transmembrane255 – 27521Helical; Name=6; By similarity
Topological domain276 – 29015Extracellular By similarity
Transmembrane291 – 31121Helical; Name=7; By similarity
Topological domain312 – 38675Cytoplasmic By similarity

Amino acid modifications

Lipidation3251S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation321N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1461R → A in CAD33254. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z0L1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 8AB32CB602BA9922

FASTA38642,263
        10         20         30         40         50         60 
MNISTWSTLV TPESCHRLAA SGHSLLIVLH YNHSGRLASR GGSEDGGGLG MLRGPSVAAG 

        70         80         90        100        110        120 
CLVVLENAMV LAAIAIYMRS RRWVYYCLLN ITLSDLLTGL AYVVNVLLSG TRTFQLSPVH 

       130        140        150        160        170        180 
WFLREGLLFM ALAASTFSLL FTAGERFATM VRVAESGATK TSRVYGCIGL CWLLAAILGL 

       190        200        210        220        230        240 
LPLLGWNCVC AFPRCSSLLP LYSKGYVLFC VVVFALILVA ILSLYGAIFR VVRANGQKSP 

       250        260        270        280        290        300 
RPPARRKSRR LLNTVLMILV AFVVCWGPLF GLLLADIFGS NVWAQEYLRG MDWILALAVF 

       310        320        330        340        350        360 
NSAINPLIYS FRSREVQRAV LAFLCCGCLW LGLRGPGDCL TRITEAHSGA STTDSSLRPR 

       370        380 
DSFRTSRSLS FRMREPLSSI SSVRST 

« Hide

References

« Hide 'large scale' references
[1]"EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue."
Graeler M.H., Bernhardt G., Lipp M.
Genomics 53:164-169(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Fetal skin.
[2]"Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene."
Contos J.J.A., Ye X., Sah V.P., Chun J.
FEBS Lett. 531:99-102(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Dendritic cell.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006074 mRNA. Translation: CAA06847.1.
AJ489247 Genomic DNA. Translation: CAD33254.1.
AK154242 mRNA. Translation: BAE32458.1.
BC107000 mRNA. Translation: AAI07001.1.
CCDSCCDS24059.1.
RefSeqNP_034232.1. NM_010102.2.
UniGeneMm.33065.

3D structure databases

ProteinModelPortalQ9Z0L1.
SMRQ9Z0L1. Positions 26-321.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY278.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Z0L1.

Proteomic databases

PaxDbQ9Z0L1.
PRIDEQ9Z0L1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199.
GeneID13611.
KEGGmmu:13611.
UCSCuc007gih.2. mouse.

Organism-specific databases

CTD8698.
MGIMGI:1333809. S1pr4.

Phylogenomic databases

eggNOGNOG150569.
GeneTreeENSGT00740000115422.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidQ9Z0L1.
KOK04293.
OMARANGQKA.
OrthoDBEOG708W0B.
PhylomeDBQ9Z0L1.
TreeFamTF330052.

Gene expression databases

BgeeQ9Z0L1.
GenevestigatorQ9Z0L1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284262.
PROQ9Z0L1.
SOURCESearch...

Entry information

Entry nameS1PR4_MOUSE
AccessionPrimary (citable) accession number: Q9Z0L1
Secondary accession number(s): Q3U4H3, Q8C6E2, Q8K1R9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries