Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amelogenin

Gene

AMEL

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Amelogenin
Gene namesi
Name:AMEL
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000119817 – 226AmelogeninAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9Z0K9.

Miscellaneous databases

PMAP-CutDBQ9Z0K9.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000016676.

Family & Domainsi

Sequence similaritiesi

Belongs to the amelogenin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3ZP. Eukaryota.
ENOG410YWZM. LUCA.
HOVERGENiHBG016835.
InParanoidiQ9Z0K9.

Family and domain databases

InterProiIPR004116. Amelogenin.
[Graphical view]
PfamiPF02948. Amelogenin. 2 hits.
[Graphical view]
PRINTSiPR01757. AMELOGENIN.
SMARTiSM00818. Amelogenin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTWILFACL LGTAFAMPLP PHPGHPGYIN FSYEKSHSNA INIDRTALVL
60 70 80 90 100
TPLKWYQSMI RQPYPSYGYE SMGGWVHHQV IPVLSQQHPP SHTTLPPHHH
110 120 130 140 150
IPVGPAQQPV VPQQPLMPVP GHHSMTPNQH HQPNLPPTSQ QPFQQPFPTQ
160 170 180 190 200
PVQPQHHQPI QPIQPIQPIQ PIQPIQPQSP LHPIQPLPPQ QALPPMFSMQ
210 220
PIAPLLPDLP LEAWPATDKT KREEVD
Length:226
Mass (Da):25,379
Last modified:May 1, 1999 - v1
Checksum:i89215B9F1D8AA535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012200 mRNA. Translation: CAA09957.1.
RefSeqiNP_001166340.1. NM_001172869.1.

Genome annotation databases

GeneIDi100379562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012200 mRNA. Translation: CAA09957.1.
RefSeqiNP_001166340.1. NM_001172869.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000016676.

Proteomic databases

PRIDEiQ9Z0K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100379562.

Organism-specific databases

CTDi265.

Phylogenomic databases

eggNOGiENOG410J3ZP. Eukaryota.
ENOG410YWZM. LUCA.
HOVERGENiHBG016835.
InParanoidiQ9Z0K9.

Miscellaneous databases

PMAP-CutDBQ9Z0K9.

Family and domain databases

InterProiIPR004116. Amelogenin.
[Graphical view]
PfamiPF02948. Amelogenin. 2 hits.
[Graphical view]
PRINTSiPR01757. AMELOGENIN.
SMARTiSM00818. Amelogenin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMEL_CAVPO
AccessioniPrimary (citable) accession number: Q9Z0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.