Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z0K8

- VNN1_MOUSE

UniProt

Q9Z0K8 - VNN1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pantetheinase

Gene

Vnn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.2 Publications

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811Proton acceptorPROSITE-ProRule annotation
Active sitei180 – 1801Proton donorPROSITE-ProRule annotation
Active sitei213 – 2131NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. GPI anchor binding Source: BHF-UCL
  2. pantetheine hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acute inflammatory response Source: BHF-UCL
  2. chronic inflammatory response Source: BHF-UCL
  3. inflammatory response Source: BHF-UCL
  4. innate immune response Source: BHF-UCL
  5. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
  6. pantothenate metabolic process Source: Ensembl
  7. positive regulation of T cell differentiation in thymus Source: BHF-UCL
  8. single organismal cell-cell adhesion Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.92)
Alternative name(s):
Pantetheine hydrolase
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:Vnn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:108395. Vnn1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: BHF-UCL
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 488465PantetheinasePRO_0000019714Add
BLAST
Propeptidei489 – 51224Removed in mature formSequence AnalysisPRO_0000019715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
Lipidationi488 – 4881GPI-anchor amidated asparagineSequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9Z0K8.
PaxDbiQ9Z0K8.
PRIDEiQ9Z0K8.

PTM databases

PhosphoSiteiQ9Z0K8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9Z0K8.
CleanExiMM_VNN1.
ExpressionAtlasiQ9Z0K8. baseline and differential.
GenevestigatoriQ9Z0K8.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K8.
SMRiQ9Z0K8. Positions 56-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 330304CN hydrolasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0388.
GeneTreeiENSGT00390000013823.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ9Z0K8.
KOiK08069.
OMAiRYYLQIC.
OrthoDBiEOG7HF1J0.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMSWWLACA AAFSALCVLK ASSLDTFLAA VYEHAVILPK DTLLPVSHSE
60 70 80 90 100
ALALMNQNLD LLEGAIVSAA KQGAHIIVTP EDGIYGVRFT RDTIYPYLEE
110 120 130 140 150
IPDPQVNWIP CDNPKRFGST PVQERLSCLA KNNSIYVVAN MGDKKPCNTS
160 170 180 190 200
DSHCPPDGRF QYNTDVVFDS QGKLVARYHK QNIFMGEDQF NVPMEPEFVT
210 220 230 240 250
FDTPFGKFGV FTCFDILFHD PAVTLVTEFQ VDTILFPTAW MDVLPHLAAI
260 270 280 290 300
EFHSAWAMGM GVNFLAANLH NPSRRMTGSG IYAPDSPRVF HYDRKTQEGK
310 320 330 340 350
LLFAQLKSHP IHSPVNWTSY ASSVESTPTK TQEFQSIVFF DEFTFVELKG
360 370 380 390 400
IKGNYTVCQN DLCCHLSYQM SEKRADEVYA FGAFDGLHTV EGQYYLQICI
410 420 430 440 450
LLKCKTTNLR TCGSSVDTAF TRFEMFSLSG TFGTRYVFPE VLLSEVKLAP
460 470 480 490 500
GEFQVSSDGR LVSLKPTSGP VLTIGLFGRL YGKDWASNAS SDFIAHSLII
510
MLIVTPIIHY LC
Length:512
Mass (Da):57,091
Last modified:July 27, 2011 - v3
Checksum:iD55E192765A8282C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31M → T in CAA10567. (PubMed:8934567)Curated
Sequence conflicti3 – 31M → T in AAH19203. (PubMed:15489334)Curated
Sequence conflicti49 – 491S → G in CAA10567. (PubMed:8934567)Curated
Sequence conflicti71 – 722KQ → NE in BAB22347. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA. Translation: CAA10567.1.
AK002773 mRNA. Translation: BAB22347.1.
AK145984 mRNA. Translation: BAE26806.1.
AK167427 mRNA. Translation: BAE39515.1.
CH466540 Genomic DNA. Translation: EDL04771.1.
BC019203 mRNA. Translation: AAH19203.1.
CCDSiCCDS35868.1.
RefSeqiNP_035834.2. NM_011704.3.
UniGeneiMm.27154.

Genome annotation databases

EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440.
GeneIDi22361.
KEGGimmu:22361.
UCSCiuc007eqc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA. Translation: CAA10567.1 .
AK002773 mRNA. Translation: BAB22347.1 .
AK145984 mRNA. Translation: BAE26806.1 .
AK167427 mRNA. Translation: BAE39515.1 .
CH466540 Genomic DNA. Translation: EDL04771.1 .
BC019203 mRNA. Translation: AAH19203.1 .
CCDSi CCDS35868.1.
RefSeqi NP_035834.2. NM_011704.3.
UniGenei Mm.27154.

3D structure databases

ProteinModelPortali Q9Z0K8.
SMRi Q9Z0K8. Positions 56-243.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z0K8.

Proteomic databases

MaxQBi Q9Z0K8.
PaxDbi Q9Z0K8.
PRIDEi Q9Z0K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041416 ; ENSMUSP00000040599 ; ENSMUSG00000037440 .
GeneIDi 22361.
KEGGi mmu:22361.
UCSCi uc007eqc.2. mouse.

Organism-specific databases

CTDi 8876.
MGIi MGI:108395. Vnn1.

Phylogenomic databases

eggNOGi COG0388.
GeneTreei ENSGT00390000013823.
HOGENOMi HOG000007627.
HOVERGENi HBG003996.
InParanoidi Q9Z0K8.
KOi K08069.
OMAi RYYLQIC.
OrthoDBi EOG7HF1J0.
TreeFami TF323645.

Miscellaneous databases

NextBioi 302669.
PROi Q9Z0K8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z0K8.
CleanExi MM_VNN1.
ExpressionAtlasi Q9Z0K8. baseline and differential.
Genevestigatori Q9Z0K8.

Family and domain databases

Gene3Di 3.60.110.10. 1 hit.
InterProi IPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view ]
PANTHERi PTHR10609. PTHR10609. 1 hit.
Pfami PF00795. CN_hydrolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF011861. Biotinidase. 1 hit.
SUPFAMi SSF56317. SSF56317. 1 hit.
PROSITEi PS50263. CN_HYDROLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing."
    Aurrand-Lions M., Galland F., Bazin H., Zakharyev V.M., Imhof B.A., Naquet P.
    Immunity 5:391-405(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-47, GLYCOSYLATION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Placenta.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"
    Maras B., Barra D., Dupre S., Pitari G.
    FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice."
    Pitari G., Malergue F., Martin F., Philippe J.-M., Massucci M.T., Chabret C., Maras B., Dupre S., Naquet P., Galland F.
    FEBS Lett. 483:149-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVNN1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K8
Secondary accession number(s): Q3TJI0, Q8VCT1, Q9DCH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3