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Q9Z0K8

- VNN1_MOUSE

UniProt

Q9Z0K8 - VNN1_MOUSE

Protein

Pantetheinase

Gene

Vnn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.2 Publications

    Catalytic activityi

    (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811Proton acceptorPROSITE-ProRule annotation
    Active sitei180 – 1801Proton donorPROSITE-ProRule annotation
    Active sitei213 – 2131NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. GPI anchor binding Source: BHF-UCL
    2. pantetheine hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acute inflammatory response Source: BHF-UCL
    2. chronic inflammatory response Source: BHF-UCL
    3. inflammatory response Source: BHF-UCL
    4. innate immune response Source: BHF-UCL
    5. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
    6. pantothenate metabolic process Source: Ensembl
    7. positive regulation of T cell differentiation in thymus Source: BHF-UCL
    8. single organismal cell-cell adhesion Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantetheinase (EC:3.5.1.92)
    Alternative name(s):
    Pantetheine hydrolase
    Vascular non-inflammatory molecule 1
    Short name:
    Vanin-1
    Gene namesi
    Name:Vnn1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:108395. Vnn1.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. integral component of membrane Source: BHF-UCL
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 488465PantetheinasePRO_0000019714Add
    BLAST
    Propeptidei489 – 51224Removed in mature formSequence AnalysisPRO_0000019715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Lipidationi488 – 4881GPI-anchor amidated asparagineSequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiQ9Z0K8.
    PaxDbiQ9Z0K8.
    PRIDEiQ9Z0K8.

    PTM databases

    PhosphoSiteiQ9Z0K8.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9Z0K8.
    BgeeiQ9Z0K8.
    CleanExiMM_VNN1.
    GenevestigatoriQ9Z0K8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z0K8.
    SMRiQ9Z0K8. Positions 56-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 330304CN hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0388.
    GeneTreeiENSGT00390000013823.
    HOGENOMiHOG000007627.
    HOVERGENiHBG003996.
    InParanoidiQ3TJI0.
    KOiK08069.
    OMAiRYYLQIC.
    OrthoDBiEOG7HF1J0.
    TreeFamiTF323645.

    Family and domain databases

    Gene3Di3.60.110.10. 1 hit.
    InterProiIPR012101. Biotinidase_euk.
    IPR003010. C-N_Hydrolase.
    [Graphical view]
    PANTHERiPTHR10609. PTHR10609. 1 hit.
    PfamiPF00795. CN_hydrolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011861. Biotinidase. 1 hit.
    SUPFAMiSSF56317. SSF56317. 1 hit.
    PROSITEiPS50263. CN_HYDROLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z0K8-1 [UniParc]FASTAAdd to Basket

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    MGMSWWLACA AAFSALCVLK ASSLDTFLAA VYEHAVILPK DTLLPVSHSE    50
    ALALMNQNLD LLEGAIVSAA KQGAHIIVTP EDGIYGVRFT RDTIYPYLEE 100
    IPDPQVNWIP CDNPKRFGST PVQERLSCLA KNNSIYVVAN MGDKKPCNTS 150
    DSHCPPDGRF QYNTDVVFDS QGKLVARYHK QNIFMGEDQF NVPMEPEFVT 200
    FDTPFGKFGV FTCFDILFHD PAVTLVTEFQ VDTILFPTAW MDVLPHLAAI 250
    EFHSAWAMGM GVNFLAANLH NPSRRMTGSG IYAPDSPRVF HYDRKTQEGK 300
    LLFAQLKSHP IHSPVNWTSY ASSVESTPTK TQEFQSIVFF DEFTFVELKG 350
    IKGNYTVCQN DLCCHLSYQM SEKRADEVYA FGAFDGLHTV EGQYYLQICI 400
    LLKCKTTNLR TCGSSVDTAF TRFEMFSLSG TFGTRYVFPE VLLSEVKLAP 450
    GEFQVSSDGR LVSLKPTSGP VLTIGLFGRL YGKDWASNAS SDFIAHSLII 500
    MLIVTPIIHY LC 512
    Length:512
    Mass (Da):57,091
    Last modified:July 27, 2011 - v3
    Checksum:iD55E192765A8282C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31M → T in CAA10567. (PubMed:8934567)Curated
    Sequence conflicti3 – 31M → T in AAH19203. (PubMed:15489334)Curated
    Sequence conflicti49 – 491S → G in CAA10567. (PubMed:8934567)Curated
    Sequence conflicti71 – 722KQ → NE in BAB22347. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132098 mRNA. Translation: CAA10567.1.
    AK002773 mRNA. Translation: BAB22347.1.
    AK145984 mRNA. Translation: BAE26806.1.
    AK167427 mRNA. Translation: BAE39515.1.
    CH466540 Genomic DNA. Translation: EDL04771.1.
    BC019203 mRNA. Translation: AAH19203.1.
    CCDSiCCDS35868.1.
    RefSeqiNP_035834.2. NM_011704.3.
    UniGeneiMm.27154.

    Genome annotation databases

    EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440.
    GeneIDi22361.
    KEGGimmu:22361.
    UCSCiuc007eqc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132098 mRNA. Translation: CAA10567.1 .
    AK002773 mRNA. Translation: BAB22347.1 .
    AK145984 mRNA. Translation: BAE26806.1 .
    AK167427 mRNA. Translation: BAE39515.1 .
    CH466540 Genomic DNA. Translation: EDL04771.1 .
    BC019203 mRNA. Translation: AAH19203.1 .
    CCDSi CCDS35868.1.
    RefSeqi NP_035834.2. NM_011704.3.
    UniGenei Mm.27154.

    3D structure databases

    ProteinModelPortali Q9Z0K8.
    SMRi Q9Z0K8. Positions 56-243.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z0K8.

    Proteomic databases

    MaxQBi Q9Z0K8.
    PaxDbi Q9Z0K8.
    PRIDEi Q9Z0K8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041416 ; ENSMUSP00000040599 ; ENSMUSG00000037440 .
    GeneIDi 22361.
    KEGGi mmu:22361.
    UCSCi uc007eqc.2. mouse.

    Organism-specific databases

    CTDi 8876.
    MGIi MGI:108395. Vnn1.

    Phylogenomic databases

    eggNOGi COG0388.
    GeneTreei ENSGT00390000013823.
    HOGENOMi HOG000007627.
    HOVERGENi HBG003996.
    InParanoidi Q3TJI0.
    KOi K08069.
    OMAi RYYLQIC.
    OrthoDBi EOG7HF1J0.
    TreeFami TF323645.

    Miscellaneous databases

    NextBioi 302669.
    PROi Q9Z0K8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z0K8.
    Bgeei Q9Z0K8.
    CleanExi MM_VNN1.
    Genevestigatori Q9Z0K8.

    Family and domain databases

    Gene3Di 3.60.110.10. 1 hit.
    InterProi IPR012101. Biotinidase_euk.
    IPR003010. C-N_Hydrolase.
    [Graphical view ]
    PANTHERi PTHR10609. PTHR10609. 1 hit.
    Pfami PF00795. CN_hydrolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011861. Biotinidase. 1 hit.
    SUPFAMi SSF56317. SSF56317. 1 hit.
    PROSITEi PS50263. CN_HYDROLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing."
      Aurrand-Lions M., Galland F., Bazin H., Zakharyev V.M., Imhof B.A., Naquet P.
      Immunity 5:391-405(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-47, GLYCOSYLATION.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Placenta.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"
      Maras B., Barra D., Dupre S., Pitari G.
      FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice."
      Pitari G., Malergue F., Martin F., Philippe J.-M., Massucci M.T., Chabret C., Maras B., Dupre S., Naquet P., Galland F.
      FEBS Lett. 483:149-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiVNN1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z0K8
    Secondary accession number(s): Q3TJI0, Q8VCT1, Q9DCH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3