Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pantetheinase

Gene

Vnn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.1 Publication

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Proton acceptorPROSITE-ProRule annotation1
Active sitei180Proton donorPROSITE-ProRule annotation1
Active sitei213NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • GPI anchor binding Source: BHF-UCL
  • pantetheine hydrolase activity Source: UniProtKB

GO - Biological processi

  • acute inflammatory response Source: BHF-UCL
  • biotin metabolic process Source: GO_Central
  • central nervous system development Source: GO_Central
  • chronic inflammatory response Source: BHF-UCL
  • inflammatory response Source: BHF-UCL
  • innate immune response Source: BHF-UCL
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
  • nitrogen compound metabolic process Source: InterPro
  • pantothenate metabolic process Source: UniProtKB
  • positive regulation of T cell differentiation in thymus Source: BHF-UCL
  • single organismal cell-cell adhesion Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.921 Publication)
Alternative name(s):
Pantetheine hydrolase
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:Vnn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:108395. Vnn1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • integral component of membrane Source: BHF-UCL
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice lack detectable levels of cysteamine in liver and kidney.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001971424 – 488PantetheinaseAdd BLAST465
PropeptideiPRO_0000019715489 – 512Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Lipidationi488GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9Z0K8.
PaxDbiQ9Z0K8.
PeptideAtlasiQ9Z0K8.
PRIDEiQ9Z0K8.

PTM databases

iPTMnetiQ9Z0K8.
PhosphoSitePlusiQ9Z0K8.

Expressioni

Tissue specificityi

Detected in kidney (at protein level). Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000037440.
CleanExiMM_VNN1.
GenevisibleiQ9Z0K8. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040599.

Structurei

3D structure databases

ProteinModelPortaliQ9Z0K8.
SMRiQ9Z0K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 330CN hydrolasePROSITE-ProRule annotationAdd BLAST304

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ9Z0K8.
KOiK08069.
OMAiRYYLQIC.
OrthoDBiEOG091G04QD.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z0K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSWWLACA AAFSALCVLK ASSLDTFLAA VYEHAVILPK DTLLPVSHSE
60 70 80 90 100
ALALMNQNLD LLEGAIVSAA KQGAHIIVTP EDGIYGVRFT RDTIYPYLEE
110 120 130 140 150
IPDPQVNWIP CDNPKRFGST PVQERLSCLA KNNSIYVVAN MGDKKPCNTS
160 170 180 190 200
DSHCPPDGRF QYNTDVVFDS QGKLVARYHK QNIFMGEDQF NVPMEPEFVT
210 220 230 240 250
FDTPFGKFGV FTCFDILFHD PAVTLVTEFQ VDTILFPTAW MDVLPHLAAI
260 270 280 290 300
EFHSAWAMGM GVNFLAANLH NPSRRMTGSG IYAPDSPRVF HYDRKTQEGK
310 320 330 340 350
LLFAQLKSHP IHSPVNWTSY ASSVESTPTK TQEFQSIVFF DEFTFVELKG
360 370 380 390 400
IKGNYTVCQN DLCCHLSYQM SEKRADEVYA FGAFDGLHTV EGQYYLQICI
410 420 430 440 450
LLKCKTTNLR TCGSSVDTAF TRFEMFSLSG TFGTRYVFPE VLLSEVKLAP
460 470 480 490 500
GEFQVSSDGR LVSLKPTSGP VLTIGLFGRL YGKDWASNAS SDFIAHSLII
510
MLIVTPIIHY LC
Length:512
Mass (Da):57,091
Last modified:July 27, 2011 - v3
Checksum:iD55E192765A8282C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → T in CAA10567 (PubMed:8934567).Curated1
Sequence conflicti3M → T in AAH19203 (PubMed:15489334).Curated1
Sequence conflicti49S → G in CAA10567 (PubMed:8934567).Curated1
Sequence conflicti71 – 72KQ → NE in BAB22347 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA. Translation: CAA10567.1.
AK002773 mRNA. Translation: BAB22347.1.
AK145984 mRNA. Translation: BAE26806.1.
AK167427 mRNA. Translation: BAE39515.1.
CH466540 Genomic DNA. Translation: EDL04771.1.
BC019203 mRNA. Translation: AAH19203.1.
CCDSiCCDS35868.1.
RefSeqiNP_035834.2. NM_011704.3.
UniGeneiMm.27154.

Genome annotation databases

EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440.
GeneIDi22361.
KEGGimmu:22361.
UCSCiuc007eqc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132098 mRNA. Translation: CAA10567.1.
AK002773 mRNA. Translation: BAB22347.1.
AK145984 mRNA. Translation: BAE26806.1.
AK167427 mRNA. Translation: BAE39515.1.
CH466540 Genomic DNA. Translation: EDL04771.1.
BC019203 mRNA. Translation: AAH19203.1.
CCDSiCCDS35868.1.
RefSeqiNP_035834.2. NM_011704.3.
UniGeneiMm.27154.

3D structure databases

ProteinModelPortaliQ9Z0K8.
SMRiQ9Z0K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040599.

PTM databases

iPTMnetiQ9Z0K8.
PhosphoSitePlusiQ9Z0K8.

Proteomic databases

MaxQBiQ9Z0K8.
PaxDbiQ9Z0K8.
PeptideAtlasiQ9Z0K8.
PRIDEiQ9Z0K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041416; ENSMUSP00000040599; ENSMUSG00000037440.
GeneIDi22361.
KEGGimmu:22361.
UCSCiuc007eqc.2. mouse.

Organism-specific databases

CTDi8876.
MGIiMGI:108395. Vnn1.

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ9Z0K8.
KOiK08069.
OMAiRYYLQIC.
OrthoDBiEOG091G04QD.
TreeFamiTF323645.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9Z0K8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037440.
CleanExiMM_VNN1.
GenevisibleiQ9Z0K8. MM.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVNN1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z0K8
Secondary accession number(s): Q3TJI0, Q8VCT1, Q9DCH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.